Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0105 | 1 | 1 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0052 | 0.329 | 0.0575 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.0073 | 0.5954 | 0.6844 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0052 | 0.329 | 0.0575 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0063 | 0.467 | 0.311 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0073 | 0.5954 | 1 |
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.0073 | 0.5954 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.3046 | 0.1012 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0073 | 0.5954 | 1 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0073 | 0.5954 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.3046 | 0.1012 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.3046 | 0.3474 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0051 | 0.3198 | 0.1209 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0052 | 0.329 | 0.1327 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5578 | 0.6362 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0096 | 0.8766 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Brugia malayi | Acyltransferase family protein | 0.0073 | 0.5954 | 0.6792 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2263 | 0.2582 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Schistosoma mansoni | transcription factor | 0.007 | 0.5578 | 0.5958 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.3046 | 0.5 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.0073 | 0.5954 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.3046 | 0.1012 |
Echinococcus granulosus | Msx-like | 0.007 | 0.5578 | 0.4284 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0051 | 0.3198 | 0.1209 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.0073 | 0.5954 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0052 | 0.329 | 0.0575 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.3046 | 0.3474 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2263 | 0.2582 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.5954 | 0.6792 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Schistosoma mansoni | glutamate receptor kainate | 0.0084 | 0.7295 | 1 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0051 | 0.3198 | 0.1209 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0052 | 0.329 | 0.3753 |
Echinococcus multilocularis | NMDA receptor | 0.0051 | 0.3198 | 0.1209 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Echinococcus multilocularis | homeobox | 0.007 | 0.5578 | 0.4284 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.0073 | 0.5954 | 0.5 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Loa Loa (eye worm) | acyltransferase | 0.0073 | 0.5954 | 0.6792 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0073 | 0.5954 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0096 | 0.8766 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.5954 | 0.6792 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Schistosoma mansoni | glutamate receptor kainate | 0.0084 | 0.7295 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0073 | 0.5954 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.3046 | 0.1012 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0063 | 0.467 | 0.311 |
Echinococcus granulosus | glutamate receptor 2 | 0.0086 | 0.7593 | 0.689 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0051 | 0.3198 | 0.1209 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0086 | 0.7593 | 0.689 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0096 | 0.8766 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3046 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0062 | 0.4524 | 0.3478 |
Schistosoma mansoni | glutamate receptor kainate | 0.0052 | 0.329 | 0.0575 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0052 | 0.329 | 0.1327 |
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.0073 | 0.5954 | 0.4771 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0052 | 0.329 | 0.0575 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0096 | 0.8766 | 0.8405 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2263 | 0.2582 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.0073 | 0.5954 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0094 | 0.8529 | 0.8098 |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.0073 | 0.5954 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.