Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.0421 | 0.0361 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0062 | 0.0062 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.094 | 0.4915 | 0.4915 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0136 | 0.0421 | 0.0361 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0084 | 0.0084 |
Echinococcus granulosus | FTZ F1 alpha | 0.0136 | 0.0421 | 0.0421 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0136 | 0.0421 | 0.038 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0136 | 0.0421 | 0.0421 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0136 | 0.0421 | 0.0361 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0072 | 0.0062 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0136 | 0.0421 | 0.038 |
Echinococcus granulosus | glutamate receptor 2 | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0072 | 0.0062 | 0.0062 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0421 | 0.0421 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.01 | 0.022 | 0.022 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0136 | 0.0421 | 0.0421 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0136 | 0.0421 | 0.0421 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.1849 | 1 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0421 | 0.0421 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0062 | 0.0062 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0639 | 0.3236 | 0.3236 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0076 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | SRC-1 | 0.0076 | 0.0084 | 0.0084 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0692 | 0.3527 | 0.35 |
Schistosoma mansoni | protein kinase | 0.0074 | 0.0073 | 0.0012 |
Brugia malayi | hypothetical protein | 0.01 | 0.022 | 0.0179 |
Brugia malayi | ecdysteroid receptor | 0.1287 | 0.6856 | 0.6843 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0076 | 0.0084 | 0.0084 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0372 | 0.1741 | 0.1689 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0421 | 0.0421 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.022 | 0.022 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0068 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.094 | 0.4915 | 0.4915 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0136 | 0.0421 | 0.0421 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0062 | 0.0019 |
Trypanosoma brucei | protein kinase, putative | 0.1849 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0076 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.0136 | 0.0421 | 0.0361 | |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.022 | 0.022 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0074 | 0.0073 | 0.0073 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0084 | 0.0084 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0068 | 0.0042 | 0.0042 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0136 | 0.0421 | 0.038 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.01 | 0.022 | 0.0179 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0639 | 0.3236 | 0.3236 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0136 | 0.0421 | 0.038 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0076 | 0.0084 | 0.0084 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0124 | 0.0353 | 0.0293 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0076 | 0.0084 | 0.0084 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0072 | 0.0062 | 0.0062 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0136 | 0.0421 | 0.038 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0136 | 0.0421 | 0.038 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0136 | 0.0421 | 0.038 |
Echinococcus granulosus | tyrosine kinase | 0.0068 | 0.0042 | 0.0042 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0136 | 0.0421 | 0.0421 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0084 | 0.0084 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0062 | 0.0062 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0072 | 0.0062 | 0.0062 |
Brugia malayi | SRC-1 | 0.0076 | 0.0084 | 0.0041 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0068 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | glutamate receptor | 0.03 | 0.1339 | 0.1339 |
Brugia malayi | nuclear receptor RXR | 0.01 | 0.022 | 0.0179 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0074 | 0.0073 | 0.0073 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0124 | 0.0353 | 0.0353 |
Giardia lamblia | Kinase, CMGC GSK | 0.1849 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0136 | 0.0421 | 0.0421 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0072 | 0.0062 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0136 | 0.0421 | 0.038 |
Echinococcus multilocularis | tyrosine kinase | 0.0074 | 0.0073 | 0.0073 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0084 | 0.0084 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0136 | 0.0421 | 0.038 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0072 | 0.0062 | 0.0062 |
Brugia malayi | nuclear receptor NHR-88 | 0.0136 | 0.0421 | 0.038 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0136 | 0.0421 | 0.038 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0136 | 0.0421 | 0.038 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0136 | 0.0421 | 0.038 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0124 | 0.0353 | 0.0353 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0353 | 0.0293 |
Giardia lamblia | Kinase, CMGC GSK | 0.1849 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0136 | 0.0421 | 0.0421 |
Echinococcus granulosus | glutamate receptor 2 | 0.0072 | 0.0062 | 0.0062 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.1849 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0421 | 0.0421 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0074 | 0.0073 | 0.0031 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.1849 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.0421 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.022 | 0.022 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0136 | 0.0421 | 0.038 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0072 | 0.0062 | 0.0062 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0372 | 0.1741 | 0.1706 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0076 | 0.0084 | 0.0084 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0093 | 0.0183 | 0.0183 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0136 | 0.0421 | 0.0421 |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0084 | 0.0022 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.1849 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0421 | 0.0421 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.01 | 0.022 | 0.022 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1849 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.022 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.022 | 0.022 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.1849 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0076 | 0.0084 | 0.0084 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.1849 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0136 | 0.0421 | 0.038 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0868 | 0.4513 | 0.4479 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.1849 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0639 | 0.3236 | 0.3194 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0136 | 0.0421 | 0.0361 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0136 | 0.0421 | 0.0361 |
Echinococcus multilocularis | protein kinase shaggy | 0.1849 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.0754 | 0.0754 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.01 | 0.022 | 0.016 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0136 | 0.0421 | 0.0421 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.0421 | 0.0421 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0196 | 0.0754 | 0.0715 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0136 | 0.0421 | 0.0421 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0074 | 0.0073 | 0.0012 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0074 | 0.0073 | 0.0073 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0076 | 0.0084 | 0.0084 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0136 | 0.0421 | 0.0421 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0074 | 0.0073 | 0.0031 |
Schistosoma mansoni | coup transcription factor | 0.0136 | 0.0421 | 0.0361 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0136 | 0.0421 | 0.0361 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.01 | 0.022 | 0.016 |
Echinococcus granulosus | protein kinase shaggy | 0.1849 | 1 | 1 |
Onchocerca volvulus | 0.0074 | 0.0073 | 0.0012 | |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0062 | 0.0062 |
Schistosoma mansoni | tyrosine kinase | 0.0074 | 0.0073 | 0.0012 |
Onchocerca volvulus | 0.1849 | 1 | 1 | |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0124 | 0.0353 | 0.0312 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0136 | 0.0421 | 0.0361 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0136 | 0.0421 | 0.0421 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | glutamate receptor | 0.0763 | 0.3929 | 0.3929 |
Brugia malayi | steroid hormone receptor | 0.0136 | 0.0421 | 0.038 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0072 | 0.0062 | 0.0062 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0421 | 0.0421 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | TK protein kinase | 0.0068 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0074 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0196 | 0.0754 | 0.0754 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.094 | 0.4915 | 0.4915 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0136 | 0.0421 | 0.0361 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0074 | 0.0073 | 0.0073 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0136 | 0.0421 | 0.0361 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0072 | 0.0062 | 0.0062 |
Schistosoma mansoni | nuclear hormone receptor | 0.0136 | 0.0421 | 0.0361 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0136 | 0.0421 | 0.0361 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0421 | 0.0421 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0072 | 0.0062 | 0.0019 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0076 | 0.0084 | 0.0084 |
Entamoeba histolytica | protein kinase, putative | 0.1849 | 1 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0124 | 0.0353 | 0.0293 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0136 | 0.0421 | 0.0361 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0136 | 0.0421 | 0.038 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0068 | 0.0042 | 0.0042 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0076 | 0.0084 | 0.0084 |
Brugia malayi | hypothetical protein | 0.01 | 0.022 | 0.0179 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0072 | 0.0062 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0136 | 0.0421 | 0.038 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.1849 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1849 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.1849 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1849 | 1 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1849 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0068 | 0.0042 | 0.0042 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0136 | 0.0421 | 0.0421 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0066 | 0.003 | 0.003 |
Schistosoma mansoni | tyrosine kinase | 0.0074 | 0.0073 | 0.0012 |
Echinococcus granulosus | tyrosine kinase | 0.0074 | 0.0073 | 0.0073 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0076 | 0.0084 | 0.0084 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1287 | 0.6856 | 0.6837 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0763 | 0.3929 | 0.3903 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0136 | 0.0421 | 0.0361 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0072 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0073 | 0.0073 |
Brugia malayi | nuclear hormone receptor | 0.0136 | 0.0421 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.1287 | 0.6856 | 0.6856 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0136 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0353 | 0.0353 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0076 | 0.0084 | 0.0084 |
Schistosoma mansoni | tyrosine kinase | 0.0076 | 0.0084 | 0.0022 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0066 | 0.003 | 0.003 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.01 | 0.022 | 0.022 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.1849 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.01 | 0.022 | 0.0179 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0196 | 0.0754 | 0.0754 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC50 (functional) | > 100 ug ml-1 | Compound was tested for antitumor activity against L1210 cells | ChEMBL. | 3039140 |
MIC50 (functional) | > 100 ug ml-1 | Compound was tested for antitumor activity against FM3A/0 mammary carcinoma cells | ChEMBL. | 3039140 |
MIC50 (functional) | > 100 ug ml-1 | Compound was tested for antitumor activity against FM3A/TK- cells | ChEMBL. | 3039140 |
MIC50 (functional) | > 100 ug ml-1 | Compound was tested for antitumor activity against human B-lymphoblast Raji/0 cells | ChEMBL. | 3039140 |
MIC50 (functional) | > 100 ug ml-1 | Compound was tested for antitumor activity against thymidine kinase deficient human B-lymphoblast Raji/0 cells | ChEMBL. | 3039140 |
MIC50 (functional) | > 100 ug ml-1 | Compound was tested for antitumor activity against human T-lymphoblast Molt/4F cells | ChEMBL. | 3039140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.