TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 254.239 | Formula: C11H14N2O5
H donors: 4 H acceptors: 5 LogP: -2.08 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)c1nccc(c1)C(=O)N
InChi: 1S/C11H14N2O5/c12-11(17)5-1-2-13-6(3-5)10-9(16)8(15)7(4-14)18-10/h1-3,7-10,14-16H,4H2,(H2,12,17)/t7-,8-,9-,10+/m1/s1
InChiKey: GVYLXYAXKHGNAX-KYXWUPHJSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0025	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Onchocerca volvulus		0.0027	0.0025	0.0338
Leishmania major	oligopeptidase b	0.0052	0.0196	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0025	0.0025
Brugia malayi	latrophilin 2 splice variant baaae	0.1007	0.6739	0.6786
Brugia malayi	CHE-14 protein	0.0481	0.3136	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Onchocerca volvulus		0.0027	0.0025	0.0338
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.013	0.073	0.073
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0027	0.0025	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Schistosoma mansoni	lipoxygenase	0.0082	0.0401	0.0401
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0466	0.3035	0.387
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0027	0.0025	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0025	0.0025
Brugia malayi	Animal haem peroxidase family protein	0.009	0.0459	0.0462
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.1474	0.9932	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.1007	0.6739	0.6786
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0027	0.0025	0.5
Onchocerca volvulus		0.0027	0.0025	0.0338
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0027	0.0025	0.0031
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0027	0.0025	0.0025
Onchocerca volvulus		0.0027	0.0025	0.0338
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.1856	0.2343
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0052	0.0196	0.0219
Trypanosoma brucei	prolyl endopeptidase	0.013	0.073	0.0902
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0025	0.0031
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0466	0.3035	0.3056
Trypanosoma cruzi	oligopeptidase b	0.0052	0.0196	0.0219
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Onchocerca volvulus		0.0027	0.0025	0.0338
Schistosoma mansoni	patched 1	0.0481	0.3136	0.3136
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Echinococcus granulosus	microsomal glutathione S transferase 3	0.034	0.217	0.2768
Onchocerca volvulus		0.0027	0.0025	0.0338
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0025	0.0031
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	acetylcholinesterase 1	0.0136	0.0774	0.0779
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0117	0.0642	0.0819
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0481	0.3136	0.3136
Schistosoma mansoni	hypothetical protein	0.0466	0.3035	0.3035
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0796	0.0986
Echinococcus granulosus	acetylcholinesterase	0.0136	0.0774	0.0986
Brugia malayi	hypothetical protein	0.0027	0.0025	0.0025
Brugia malayi	Carboxylesterase family protein	0.0136	0.0774	0.0779
Echinococcus multilocularis	peroxidasin	0.009	0.0459	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1049	0.7021	0.7069
Echinococcus granulosus	acetylcholinesterase	0.0136	0.0774	0.0986
Echinococcus multilocularis	hypothetical protein	0.0027	0.0025	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Onchocerca volvulus		0.0027	0.0025	0.0338
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0025	0.0025
Trichomonas vaginalis	pten, drome, putative	0.0027	0.0025	0.0069
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Echinococcus multilocularis	carboxylesterase 5A	0.0136	0.0774	0.0986
Onchocerca volvulus	Chorion peroxidase homolog	0.009	0.0459	0.6281
Leishmania major	mitochondrial DNA polymerase beta	0.0294	0.1856	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Echinococcus multilocularis	protein patched	0.0481	0.3136	0.3999
Echinococcus granulosus	GPCR family 2	0.0466	0.3035	0.387
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.1169	0.7842	0.7842
Onchocerca volvulus		0.009	0.0459	0.6281
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0025	0.0025
Onchocerca volvulus	Peroxidasin homolog	0.009	0.0459	0.6281
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0027	0.0025	0.0031
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0025	0.0031
Echinococcus granulosus	sterol regulatory element binding protein	0.0481	0.3136	0.3999
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0025	0.0031
Onchocerca volvulus	Peroxidase homolog	0.009	0.0459	0.6281
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Echinococcus multilocularis	GPCR, family 2	0.0466	0.3035	0.387
Onchocerca volvulus	Prolyl endopeptidase homolog	0.013	0.073	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.0352	0.0448
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0027	0.0025	0.0025
Brugia malayi	hypothetical protein	0.0027	0.0025	0.0025
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0126	0.0129
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.1169	0.7842	0.7897
Brugia malayi	hypothetical protein	0.0027	0.0025	0.0025
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0052	0.0196	0.0545
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Mycobacterium ulcerans	hypothetical protein	0.0155	0.0903	0.1152
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0027	0.0025	0.5
Echinococcus granulosus	Protein patched homolog 1	0.0481	0.3136	0.3999
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.1169	0.7842	0.7897
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.013	0.073	0.073
Echinococcus multilocularis	Niemann Pick C1 protein	0.0481	0.3136	0.3999
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1049	0.7021	0.7069
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0466	0.3035	0.3035
Loa Loa (eye worm)	hypothetical protein	0.013	0.073	0.0735
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0466	0.3035	0.3035
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Onchocerca volvulus		0.0027	0.0025	0.0338
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Brugia malayi	hypothetical protein	0.0027	0.0025	0.0025
Schistosoma mansoni	microsomal glutathione s-transferase	0.034	0.217	0.217
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0025	0.0031
Loa Loa (eye worm)	carboxylesterase	0.0136	0.0774	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0548	0.3596	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0481	0.3136	0.3999
Onchocerca volvulus		0.0027	0.0025	0.0338
Brugia malayi	Carboxylesterase family protein	0.0136	0.0774	0.0779
Echinococcus multilocularis	acetylcholinesterase	0.0136	0.0774	0.0986
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0052	0.0196	0.5
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.1169	0.7842	1
Onchocerca volvulus		0.0027	0.0025	0.0338
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.1169	0.7842	1
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0052	0.0196	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0466	0.3035	0.3056
Onchocerca volvulus	Peroxidasin homolog	0.009	0.0459	0.6281
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0294	0.1856	0.2343
Brugia malayi	Animal haem peroxidase family protein	0.009	0.0459	0.0462
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Schistosoma mansoni	peroxidasin	0.009	0.0459	0.0459
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0027	0.0025	0.0025
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0188	0.0209
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus granulosus	carboxylesterase 5A	0.0136	0.0774	0.0986
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.0796	0.0986
Mycobacterium ulcerans	short chain dehydrogenase	0.0547	0.3589	0.4576
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.013	0.073	0.0902
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.034	0.217	0.2768
Brugia malayi	Animal haem peroxidase family protein	0.009	0.0459	0.0462
Echinococcus multilocularis	prolyl endopeptidase	0.013	0.073	0.0931
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1049	0.7021	0.8952
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.1169	0.7842	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.1856	0.2343
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Brugia malayi	Calcitonin receptor-like protein seb-1	0.1474	0.9932	1
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.0459	0.0462
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0117	0.0642	0.0819
Onchocerca volvulus		0.0027	0.0025	0.0338
Onchocerca volvulus		0.009	0.0459	0.6281
Onchocerca volvulus		0.0027	0.0025	0.0338
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0052	0.0196	0.0219
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Loa Loa (eye worm)	blistered cuticle protein 3	0.009	0.0459	0.0462
Trypanosoma cruzi	prolyl endopeptidase	0.013	0.073	0.0902
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.1474	0.9932	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.1007	0.6739	0.6739
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.1169	0.7842	1
Onchocerca volvulus		0.0027	0.0025	0.0338
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0548	0.3596	1
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0052	0.0196	0.0219
Onchocerca volvulus		0.0027	0.0025	0.0338
Onchocerca volvulus		0.0027	0.0025	0.0338
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0025	0.0025
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.1169	0.7842	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1049	0.7021	0.8952
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0774	0.0779
Onchocerca volvulus		0.0027	0.0025	0.0338
Onchocerca volvulus	4.1 G protein, putative homolog	0.0027	0.0025	0.0338
Onchocerca volvulus	Peroxidase homolog	0.009	0.0459	0.6281
Onchocerca volvulus		0.0027	0.0025	0.0338
Onchocerca volvulus	Dual oxidase homolog	0.009	0.0459	0.6281
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.0459	0.0462
Brugia malayi	Animal haem peroxidase family protein	0.009	0.0459	0.0462
Trypanosoma brucei	oligopeptidase b	0.0052	0.0196	0.0219
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0027	0.0025	0.0025
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Toxoplasma gondii	MAPEG family protein	0.034	0.217	1
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0025	0.0025
Echinococcus granulosus	Niemann Pick C1 protein	0.0481	0.3136	0.3999
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0116	0.0637	0.1775
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0126	0.0129
Brugia malayi	hypothetical protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0027	0.0025	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0126	0.0129
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Schistosoma mansoni	pcd6 interacting protein-related	0.0027	0.0025	0.0025
Echinococcus granulosus	prolyl endopeptidase	0.013	0.073	0.0931
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0027	0.0025	0.0025
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.0466	0.3035	0.3056
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.1169	0.7842	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Onchocerca volvulus		0.0027	0.0025	0.0338
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Schistosoma mansoni	hypothetical protein	0.0466	0.3035	0.3035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Echinococcus multilocularis		0.0027	0.0025	0.0031
Onchocerca volvulus		0.0027	0.0025	0.0338
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0025	0.0031
Schistosoma mansoni	lipoxygenase	0.0117	0.0642	0.0642
Brugia malayi	hypothetical protein	0.009	0.0459	0.0462
Echinococcus granulosus	peroxidasin	0.009	0.0459	0.0585
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Brugia malayi	prolyl oligopeptidase family protein	0.013	0.073	0.0735
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0025	0.0025
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0548	0.3596	1
Brugia malayi	Protein-tyrosine phosphatase 1	0.0027	0.0025	0.0025
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Mycobacterium tuberculosis	Probable oxidoreductase	0.0547	0.3589	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0025	0.0031
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.0459	0.0462
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0136	0.0774	0.0774
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0481	0.3136	0.3158
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0466	0.3035	0.3056
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0025	0.0031
Trypanosoma cruzi	oligopeptidase b	0.0052	0.0196	0.0219
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Onchocerca volvulus		0.0027	0.0025	0.0338
Brugia malayi	Blistered cuticle protein 3	0.009	0.0459	0.0462
Brugia malayi	Animal haem peroxidase family protein	0.009	0.0459	0.0462
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1049	0.7021	0.7021
Echinococcus multilocularis	acetylcholinesterase	0.0136	0.0774	0.0986
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.0352	0.0448
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0466	0.3035	0.387
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0796	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0027	0.0025	0.0025
Onchocerca volvulus		0.0027	0.0025	0.0338
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.1169	0.7842	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0052	0.0196	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0481	0.3136	0.3158
Loa Loa (eye worm)	animal heme peroxidase	0.009	0.0459	0.0462
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.0903	0.2517
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0052	0.0196	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0481	0.3136	0.8722
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0027	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.009	0.0459	0.0462
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0027	0.0025	0.0025
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0774	0.0779
Loa Loa (eye worm)	hypothetical protein	0.1474	0.9932	1
Onchocerca volvulus		0.0027	0.0025	0.0338
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0126	0.0129
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0025	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0027	0.0025	0.0025
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0025	0.0025
Mycobacterium tuberculosis	Probable peptidase	0.0052	0.0196	0.0545
Onchocerca volvulus		0.0027	0.0025	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0548	0.3596	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0466	0.3035	0.387
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0027	0.0025	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0025	0.0031
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0466	0.3035	0.387
Onchocerca volvulus		0.009	0.0459	0.6281
Toxoplasma gondii	prolyl endopeptidase	0.013	0.073	0.2808
Echinococcus multilocularis	protein dispatched 1	0.0481	0.3136	0.3999
Brugia malayi	Peroxidasin	0.009	0.0459	0.0462
Schistosoma mansoni	peroxidasin	0.009	0.0459	0.0459

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3144050

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1846159