Detailed information for compound 1846219

Basic information

Technical information
  • TDR Targets ID: 1846219
  • Name: (2R,3S,5R)-5-(2-amino-6-methylsulfinylpurin-9 -yl)-2-(hydroxymethyl)oxolan-3-ol
  • MW: 313.333 | Formula: C11H15N5O4S
  • H donors: 4 H acceptors: 6 LogP: -0.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1nc(N)nc2[S+](C)[O-]
  • InChi: 1S/C11H15N5O4S/c1-21(19)10-8-9(14-11(12)15-10)16(4-13-8)7-2-5(18)6(3-17)20-7/h4-7,17-18H,2-3H2,1H3,(H2,12,14,15)/t5-,6+,7+,21?/m0/s1
  • InChiKey: YXZYBDDWOHPFBO-QWEIFEMGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3S,5R)-5-(2-amino-6-methylsulfinyl-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
  • (2R,3S,5R)-5-(2-amino-6-methylsulfinyl-9-purinyl)-2-(hydroxymethyl)-3-tetrahydrofuranol
  • (2R,3S,5R)-5-(2-amino-6-methylsulfinyl-purin-9-yl)-2-methylol-tetrahydrofuran-3-ol
  • (2R,3S,5R)-5-(2-amino-6-methylsulfinyl-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0004 0.0004
Schistosoma mansoni neuropeptide receptor 0.0087 0.113 0.4381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0379 0.1468
Loa Loa (eye worm) hypothetical protein 0.0044 0.0372 0.1074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0383 0.0383
Echinococcus multilocularis geminin 0.0167 0.2547 0.2547
Schistosoma mansoni biogenic amine receptor 0.0087 0.113 0.4381
Schistosoma mansoni growth hormone secretagogue receptor 0.0087 0.113 0.4381
Schistosoma mansoni adenoreceptor 0.0087 0.113 0.4381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Onchocerca volvulus 0.0087 0.113 0.2602
Brugia malayi GnHR receptor homolog 0.0087 0.113 0.3289
Onchocerca volvulus Neuropeptide F receptor homolog 0.0087 0.113 0.2602
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0379 0.1095
Onchocerca volvulus 0.0087 0.113 0.2602
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.113 0.113
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0115 0.0115
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0379 0.0379
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0135 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0087 0.113 0.3289
Schistosoma mansoni cell polarity protein 0.0024 0.0004 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0087 0.113 0.113
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.113 0.113
Echinococcus multilocularis fmrfamide receptor 0.0087 0.113 0.113
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0379 0.0379
Schistosoma mansoni jumonji domain containing protein 0.0061 0.067 0.2598
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0213 0.0824
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.045 0.1745
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0087 0.113 0.4381
Brugia malayi Dopamine receptor 0.0087 0.113 0.3289
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0087 0.113 0.113
Echinococcus multilocularis g protein coupled receptor 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Brugia malayi G-protein coupled receptor 0.0087 0.113 0.3289
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0135 0.0135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0379 0.1095
Echinococcus multilocularis neuropeptide receptor 0.0087 0.113 0.113
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni amine GPCR 0.0087 0.113 0.4381
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0706 0.0706
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.113 0.113
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0379 0.0379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0383 0.0383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0383 0.0383
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0087 0.113 0.3289
Echinococcus granulosus somatostatin receptor 0.0087 0.113 0.113
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0087 0.113 0.113
Onchocerca volvulus 0.0087 0.113 0.2602
Schistosoma mansoni alpha-1 adrenergic receptor 0.0087 0.113 0.4381
Brugia malayi Serotonin receptor 0.0087 0.113 0.3289
Brugia malayi Pre-SET motif family protein 0.0217 0.343 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0379 0.0379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.113 0.113
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0379 0.1095
Echinococcus granulosus neuropeptide receptor 0.0087 0.113 0.113
Brugia malayi ecdysteroid receptor 0.0045 0.0379 0.1095
Onchocerca volvulus 0.0087 0.113 0.2602
Brugia malayi nuclear hormone receptor 0.0045 0.0379 0.1095
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0087 0.113 0.4381
Schistosoma mansoni hypothetical protein 0.0124 0.1785 0.6918
Schistosoma mansoni hypothetical protein 0.0167 0.2547 0.987
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0004 0.0015
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0087 0.113 0.113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Echinococcus multilocularis sex peptide receptor 0.0087 0.113 0.113
Trichomonas vaginalis set domain proteins, putative 0.0247 0.3961 0.5
Onchocerca volvulus 0.0087 0.113 0.2602
Brugia malayi Pre-SET motif family protein 0.0031 0.0135 0.0384
Onchocerca volvulus 0.0087 0.113 0.2602
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.113 0.4381
Schistosoma mansoni hypothetical protein 0.0035 0.0213 0.0824
Echinococcus multilocularis orexin receptor type 2 0.0087 0.113 0.113
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni opsin-like receptor 0.0087 0.113 0.4381
Brugia malayi RE15519p 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.113 0.4381
Brugia malayi putative neuropeptide receptor NPR1 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0074 0.089 0.2589
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.113 0.113
Onchocerca volvulus 0.0247 0.3961 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.113 0.4381
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0379 0.1468
Echinococcus granulosus geminin 0.0167 0.2547 0.2547
Schistosoma mansoni biogenic amine receptor 0.0087 0.113 0.4381
Schistosoma mansoni amine GPCR 0.0087 0.113 0.4381
Schistosoma mansoni neuropeptide receptor 0.0087 0.113 0.4381
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0087 0.113 0.113
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.113 0.113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0706 0.2735
Schistosoma mansoni neuropeptide receptor 0.0087 0.113 0.4381
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0135 0.0523
Echinococcus multilocularis slit 2 protein 0.0024 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0379 0.1095
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.113 0.113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0379 0.1095
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0379 0.0379
Onchocerca volvulus 0.0087 0.113 0.2602
Brugia malayi AKH receptor 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni hypothetical protein 0.0167 0.2547 0.987
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Onchocerca volvulus 0.0087 0.113 0.2602
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0379 0.1468
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0379 0.1095
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0004 0.0014
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0087 0.113 0.4381
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.113 0.113
Brugia malayi G protein-coupled receptor F59B2.13 0.0087 0.113 0.3289
Brugia malayi Dopamine receptor protein 1 0.0087 0.113 0.3289
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.343 1
Brugia malayi hypothetical protein 0.0035 0.0213 0.061
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0087 0.113 0.113
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.113 0.113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0383 0.1485
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0706 0.2049
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0004 0.0004
Brugia malayi larval opioid receptor 0.0087 0.113 0.3289
Echinococcus granulosus pikachurin 0.0024 0.0004 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0213 0.0213
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0687 0.0687
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.113 0.3289
Echinococcus granulosus slit 2 protein 0.0024 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0379 0.1095
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0383 0.1485
Echinococcus granulosus peptide allatostatin:somatostatin 0.0087 0.113 0.113
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0379 0.0637
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Onchocerca volvulus 0.0087 0.113 0.2602
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.113 0.113
Echinococcus multilocularis neuropeptide receptor 0.0087 0.113 0.113
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0379 0.1095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.113 0.4381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0087 0.113 0.3289
Echinococcus multilocularis serotonin receptor 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus multilocularis neuropeptide FF receptor 2 0.0087 0.113 0.113
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0379 0.0379
Echinococcus multilocularis neuropeptide receptor A26 0.0087 0.113 0.113
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.113 0.113
Schistosoma mansoni myosin xvIII 0.0087 0.113 0.4381
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0379 0.0379
Schistosoma mansoni hypothetical protein 0.0087 0.113 0.4381
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Brugia malayi Dopamine receptor protein 2 0.0087 0.113 0.3289
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Onchocerca volvulus 0.0087 0.113 0.2602
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.113 0.3289
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0087 0.113 0.3289
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0087 0.113 0.3289
Onchocerca volvulus 0.0087 0.113 0.2602
Echinococcus multilocularis fmrfamide receptor 0.0087 0.113 0.113
Echinococcus multilocularis G-protein coupled receptor, putative 0.0087 0.113 0.113
Onchocerca volvulus 0.0087 0.113 0.2602
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.113 0.4381
Echinococcus multilocularis allatostatin A receptor 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0001
Brugia malayi G protein-coupled receptor 0.0087 0.113 0.3289
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) melatonin receptor type 1A 0.0087 0.113 0.3289
Echinococcus multilocularis neuropeptide s receptor 0.0087 0.113 0.113
Schistosoma mansoni coup transcription factor 0.0045 0.0379 0.1468
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0379 0.0379
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0087 0.113 0.4381
Brugia malayi Bromodomain containing protein 0.0078 0.0969 0.2819
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus fmrfamide receptor 0.0087 0.113 0.113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0383 0.1108
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus tachykinin peptides receptor 99D 0.0087 0.113 0.113
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0087 0.113 0.113
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0383 0.1108
Brugia malayi EGF-like domain containing protein 0.0024 0.0004 0.0001
Echinococcus granulosus hypothetical protein 0.0087 0.113 0.113
Schistosoma mansoni amine GPCR 0.0087 0.113 0.4381
Echinococcus granulosus G protein coupled receptor 139 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0379 0.0379
Brugia malayi Melatonin receptor type 1A 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.113 0.4381
Echinococcus granulosus alpha 1A adrenergic receptor 0.0087 0.113 0.113
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0087 0.113 0.3289
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0379 0.1095
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0213 0.0213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0379 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0523
Brugia malayi sulfakinin receptor protein 0.0087 0.113 0.3289
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0379 0.1468
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0379 0.1468
Brugia malayi Serotonin receptor 0.0087 0.113 0.3289
Echinococcus multilocularis pikachurin 0.0024 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0379 0.0379
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.113 0.113
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.004 0.0292 0.0843
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0379 0.0379
Onchocerca volvulus 0.0087 0.113 0.2602
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0247 0.0247
Onchocerca volvulus 0.0087 0.113 0.2602
Brugia malayi putative neuropeptide receptor 0.0087 0.113 0.3289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0383 0.0383
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0379 0.1468
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0087 0.113 0.113
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1785 0.1785
Echinococcus granulosus sex peptide receptor 0.0087 0.113 0.113
Brugia malayi Tachykinin-like peptides receptor 99D 0.0087 0.113 0.3289
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Echinococcus granulosus g protein coupled receptor 0.0087 0.113 0.113
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0379 0.1468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0379 0.1095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0379 0.1095
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.113 0.3289
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0379 0.1095
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni hypothetical protein 0.0087 0.113 0.4381
Onchocerca volvulus 0.0087 0.113 0.2602
Schistosoma mansoni biogenic amine receptor 0.0087 0.113 0.4381
Onchocerca volvulus 0.0045 0.0379 0.0637
Echinococcus granulosus neuropeptide receptor 0.0087 0.113 0.113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.045 0.1745
Brugia malayi jmjC domain containing protein 0.0061 0.067 0.1946
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Brugia malayi steroid hormone receptor 0.0045 0.0379 0.1095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0379 0.1095
Echinococcus granulosus orexin receptor type 2 0.0087 0.113 0.113
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0379 0.1095
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Brugia malayi nuclear receptor NHR-88 0.0045 0.0379 0.1095
Echinococcus granulosus g-protein coupled receptor 0.0087 0.113 0.113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0587 1 1
Schistosoma mansoni bromodomain containing protein 0.0066 0.0753 0.2918
Echinococcus granulosus 7tm_1 domain containing protein 0.0087 0.113 0.113
Onchocerca volvulus 0.0087 0.113 0.2602
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.113 0.4381
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0379 0.0379
Brugia malayi G-protein coupled receptor 0.0087 0.113 0.3289
Echinococcus multilocularis dro:myosuppressin receptor 0.0087 0.113 0.113
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0087 0.113 0.4381
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0087 0.113 0.113
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0379 0.0637
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Brugia malayi jmjC domain containing protein 0.0063 0.0706 0.2049
Echinococcus granulosus neuropeptide FF receptor 2 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.113 0.4381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Echinococcus granulosus serotonin receptor 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0001
Brugia malayi PHD-finger family protein 0.0026 0.0044 0.0117
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0379 0.1468
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0379 0.1095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0379 0.1095
Echinococcus multilocularis serotonin receptor 0.0087 0.113 0.113
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0087 0.113 0.4381
Schistosoma mansoni opsin-like receptor 0.0087 0.113 0.4381
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0379 0.0637
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.113 0.113
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.113 0.113
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0087 0.113 0.4381
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Brugia malayi follicle stimulating hormone receptor 0.0087 0.113 0.3289
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0379 0.1095
Brugia malayi Bromodomain containing protein 0.004 0.0291 0.084
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni slit 0.0024 0.0004 0.0015
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.067 0.067
Echinococcus granulosus dro:myosuppressin receptor 0.0087 0.113 0.113
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0004 0.0004
Brugia malayi laminin alpha chain 0.0024 0.0004 0.0001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0087 0.113 0.113
Echinococcus multilocularis g-protein coupled receptor 0.0087 0.113 0.113
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.067 0.067
Echinococcus multilocularis G protein coupled receptor 139 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus neuropeptide receptor A26 0.0087 0.113 0.113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0379 0.1095
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0379 0.1095
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0087 0.113 0.113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0379 0.1468
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0379 0.1095
Schistosoma mansoni thyroid hormone receptor 0.0169 0.258 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0336 0.0971
Schistosoma mansoni hypothetical protein 0.0087 0.113 0.4381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.113 0.113
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1785 0.1785
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0379 0.0379
Schistosoma mansoni opsin-like receptor 0.0087 0.113 0.4381
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0087 0.113 0.4381
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Onchocerca volvulus 0.0087 0.113 0.2602
Schistosoma mansoni hypothetical protein 0.0087 0.113 0.4381
Plasmodium vivax SET domain protein, putative 0.0031 0.0135 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0087 0.113 0.3289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0004 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.113 0.113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0004 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0087 0.113 0.113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0687 0.0687
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.113 0.4381
Echinococcus granulosus 7TM GPCR rhodopsin 0.0087 0.113 0.113
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.045 0.045
Schistosoma mansoni histamine h1 receptor 0.0087 0.113 0.4381
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.113 0.113
Echinococcus granulosus g protein coupled receptor 0.0087 0.113 0.113
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0383 0.1485
Echinococcus granulosus neuropeptide s receptor 0.0087 0.113 0.113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0379 0.1095
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni neuropeptide f receptor 76f 0.0087 0.113 0.4381
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0379 0.0379
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0087 0.113 0.2602
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0049 0.045 0.1304
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.1095
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0087 0.113 0.113
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.045 0.045
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Brugia malayi neuropeptide F receptor 0.0087 0.113 0.3289
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Schistosoma mansoni amine GPCR 0.0087 0.113 0.4381
Brugia malayi hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.113 0.3289
Schistosoma mansoni neuropeptide receptor 0.0087 0.113 0.4381
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0379 0.1468
Schistosoma mansoni thyroid hormone receptor 0.0169 0.258 1
Echinococcus multilocularis g protein coupled receptor 0.0087 0.113 0.113
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.113 0.113
Echinococcus granulosus g protein coupled receptor 0.0087 0.113 0.113
Echinococcus multilocularis thyroid hormone receptor alpha 0.0169 0.258 0.258
Brugia malayi ORL1-like opioid receptor 0.0087 0.113 0.3289
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0379 0.1095
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.113 0.4381
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0087 0.113 0.3289
Loa Loa (eye worm) hypothetical protein 0.0087 0.113 0.3289
Echinococcus granulosus allatostatin A receptor 0.0087 0.113 0.113
Echinococcus multilocularis somatostatin receptor 0.0087 0.113 0.113
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0379 0.0379
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.067 0.067
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0379 0.1095
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0087 0.113 0.3289
Schistosoma mansoni amine GPCR 0.0087 0.113 0.4381
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0706 0.2735
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0379 0.1095
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.113 0.113
Brugia malayi neuropeptide F receptor 0.0087 0.113 0.3289

Activities

Activity type Activity value Assay description Source Reference
Dosage (ADMET) = 800 mg kg-1 Maximum soluble dosage of the compound which induces toxicity in mice when administered intraperitoneally was determined ChEMBL. 8289192

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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