Detailed information for compound 1846221

Basic information

Technical information
  • TDR Targets ID: 1846221
  • Name: ethyl 2-[[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1- yl)-3-hydroxyoxolan-2-yl]methoxy-methoxyphosp horyl]acetate
  • MW: 392.298 | Formula: C14H21N2O9P
  • H donors: 2 H acceptors: 5 LogP: -1.66 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CP(=O)(OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O)OC
  • InChi: 1S/C14H21N2O9P/c1-3-23-13(19)8-26(21,22-2)24-7-10-9(17)6-12(25-10)16-5-4-11(18)15-14(16)20/h4-5,9-10,12,17H,3,6-8H2,1-2H3,(H,15,18,20)/t9-,10+,12+,26?/m0/s1
  • InChiKey: IKIBBWZWLJUUOH-URMPQVFFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-methoxy-phosphoryl]acetate
  • 2-[[(2R,3S,5R)-5-(2,4-dioxo-1-pyrimidinyl)-3-hydroxy-2-tetrahydrofuranyl]methoxy-methoxyphosphoryl]acetic acid ethyl ester
  • 2-[[(2R,3S,5R)-5-(2,4-diketopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-methoxy-phosphoryl]acetic acid ethyl ester
  • ethyl 2-[[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-methoxy-phosphoryl]ethanoate
  • 115365-18-9
  • AIDS-212377
  • AIDS212377
  • [[[1-(2,4-Dioxo-1,2,3,4-tetrahyropyrimidin-1-yl)-2-deoxy-Beta-D-erythro-pentofuranos-5-yl]oxy]methoxyphosphinyl]-acetic acid ethyl ester oxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0531 0.0531
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0407 0.0407
Echinococcus multilocularis geminin 0.0188 1 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0531 0.7036
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0531 0.0531
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.2533 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0583 0.2302
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0531 0.0531
Brugia malayi hypothetical protein 0.002 0.0531 0.2096
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0583 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0583 0.0583
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0057 0.2626 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0583 0.2302
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0407 0.6908
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0583 0.0583
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0057 0.2626 1
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0583 0.2182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0405 0.16
Schistosoma mansoni polycystin 1-related 0.002 0.0531 0.0531
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0583 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.0583 0.0583
Echinococcus multilocularis GPCR, family 2 0.0018 0.0405 0.0405
Brugia malayi isocitrate dehydrogenase 0.0018 0.0407 0.1606
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0407 0.1507
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0057 0.2626 0.2626
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0405 0.16
Loa Loa (eye worm) RecQ helicase 0.0021 0.0583 0.2302
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0038 0.1548 0.6112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.2533 1
Schistosoma mansoni hypothetical protein 0.0018 0.0405 0.0405
Echinococcus granulosus GPCR family 2 0.0018 0.0405 0.0405
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0531 0.0531
Schistosoma mansoni loxhd1 0.002 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0018 0.0405 0.0405
Onchocerca volvulus 0.002 0.0531 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0057 0.2626 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0057 0.2626 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0405 0.16
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0018 0.0405 0.0405
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0038 0.1548 0.1548
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0407 0.1606
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.2626 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0583 0.2302
Onchocerca volvulus 0.002 0.0531 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.253 0.253
Schistosoma mansoni DNA helicase recq1 0.0021 0.0583 0.0583
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0405 0.16
Loa Loa (eye worm) doublecortin family protein 0.002 0.0531 0.2096
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0052
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0407 0.0407
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0583 0.0794
Loa Loa (eye worm) hypothetical protein 0.0055 0.2533 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0583 0.0794
Schistosoma mansoni lipoxygenase 0.002 0.0531 0.0531
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0407 0.0407
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0583 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0407 0.7605
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0583 0.2302
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0583 1
Giardia lamblia Rrm3p helicase 0.0057 0.2626 1
Entamoeba histolytica DNA repair and recombination protein, putative 0.0057 0.2626 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0057 0.2626 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0531 0.0531
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0583 0.0583
Schistosoma mansoni hypothetical protein 0.0057 0.2626 0.2626
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0407 0.1606
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0407 0.0407
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0405 0.0405
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0407 0.6908
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0057 0.2626 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0583 0.0583
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0531 0.0531
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0405 0.0405
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.2533 1
Schistosoma mansoni hypothetical protein 0.0188 1 1
Schistosoma mansoni hypothetical protein 0.002 0.0531 0.0531
Echinococcus granulosus RUN 0.002 0.0531 0.0531
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0407 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0531 0.2096
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0407 0.0407
Brugia malayi Doublecortin family protein 0.002 0.0531 0.2096
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0407 0.1507
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0583 0.0583
Schistosoma mansoni DNA helicase recq5 0.0021 0.0583 0.0583
Brugia malayi hypothetical protein 0.002 0.0531 0.2096
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.1548 0.6112
Loa Loa (eye worm) hypothetical protein 0.002 0.0531 0.2096
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0583 0.2182
Schistosoma mansoni hypothetical protein 0.0018 0.0405 0.0405
Schistosoma mansoni rab6-interacting 0.002 0.0531 0.0531
Schistosoma mansoni lipoxygenase 0.0055 0.253 0.253
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0531 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0407 0.0407
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0583 0.2302
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0057 0.2626 1
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0013 0.5
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0057 0.2626 0.2626
Schistosoma mansoni rab6-interacting 0.002 0.0531 0.0531
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.2626 1
Schistosoma mansoni hypothetical protein 0.0188 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.253 0.253
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0407 0.0407
Echinococcus multilocularis RUN 0.002 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0052

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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