TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 291.22 | Formula: C12H20Cl2N4
H donors: 0 H acceptors: 2 LogP: 2.7 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C(CCn1cncc1)CCCn1cncc1.Cl.Cl
InChi: 1S/C12H18N4.2ClH/c1(3-7-15-9-5-13-11-15)2-4-8-16-10-6-14-12-16;;/h5-6,9-12H,1-4,7-8H2;2*1H
InChiKey: DAGPTVFZDFDWGU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0767	0.0902
Echinococcus granulosus	neurogenic locus notch protein 4	0.0063	0.1395	0.1395
Schistosoma mansoni	septate junction protein	0.0063	0.1395	0.1951
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0606	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0935	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0606	0.0848
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Giardia lamblia	High cysteine protein	0.0063	0.1395	0.5
Brugia malayi	EGF-like domain containing protein	0.0063	0.1395	0.1951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Brugia malayi	Cadherin domain containing protein	0.0063	0.1395	0.1951
Brugia malayi	EGF-like domain containing protein	0.0063	0.1395	0.1951
Echinococcus granulosus	neurogenic locus notch protein	0.0063	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Brugia malayi	beta-lactamase family protein	0.0037	0.0606	0.0848
Brugia malayi	EGF-like domain containing protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0494	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Echinococcus granulosus	peroxidasin	0.0196	0.5363	0.5363
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0606	0.0848
Brugia malayi	Blistered cuticle protein 3	0.0196	0.5363	0.7503
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0159	0.4243	0.6164
Echinococcus granulosus	fibropellin Ia	0.0063	0.1395	0.1395
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0606	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0606	0.0848
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1402	0.1649
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0606	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0935	0.1309
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0301	0.8503	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0063	0.1395	0.1951
Onchocerca volvulus		0.0037	0.0606	0.0895
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0256	0.7147	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.1237	0.1455
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0935	0.11
Loa Loa (eye worm)	animal heme peroxidase	0.0196	0.5363	0.7503
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0573	0.0097
Schistosoma mansoni	peroxidasin	0.0196	0.5363	0.7503
Brugia malayi	Muscle positioning protein 4	0.0063	0.1395	0.1951
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0935	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0606	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0935	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Brugia malayi	RNA recognition motif domain containing protein	0.0256	0.7147	1
Brugia malayi	GCC2 and GCC3 family protein	0.0063	0.1395	0.1951
Onchocerca volvulus		0.0063	0.1395	0.2059
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0606	0.0152
Schistosoma mansoni	slit	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0573	0.0801
Schistosoma mansoni	hypothetical protein	0.0063	0.1395	0.1951
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0935	0.1309
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.6563	1
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.7147	1
Onchocerca volvulus	Peroxidase homolog	0.0196	0.5363	0.7918
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0573	0.9448
Brugia malayi	Calcium binding EGF domain containing protein	0.0063	0.1395	0.1951
Brugia malayi	Pre-SET motif family protein	0.0031	0.0417	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Schistosoma mansoni	notch	0.0063	0.1395	0.1951
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0935	0.1309
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0417	0.0584
Onchocerca volvulus		0.0037	0.0606	0.0895
Echinococcus multilocularis	neurogenic locus protein delta	0.0063	0.1395	0.1395
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0417	0.0417
Loa Loa (eye worm)	Notch2	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Onchocerca volvulus		0.0051	0.1038	0.1532
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0606	0.0152
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.6773	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0606	0.0152
Echinococcus multilocularis	tumor protein p63	0.0351	1	1
Echinococcus multilocularis	neural cadherin	0.0063	0.1395	0.1395
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0935	0.0988
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0606	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0953	0.1333
Onchocerca volvulus		0.0243	0.6773	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Onchocerca volvulus		0.0196	0.5363	0.7918
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Onchocerca volvulus	Neurogenic locus notch homolog	0.0063	0.1395	0.2059
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0417	0.0584
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0606	0.0713
Onchocerca volvulus		0.0048	0.0935	0.1381
Echinococcus multilocularis	neurogenic locus protein delta	0.0063	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0606	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.1402	0.1649
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0384	0.0384
Mycobacterium ulcerans	hypothetical protein	0.0159	0.4243	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0063	0.1395	0.1395
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.1044	0.1227
Onchocerca volvulus	Peroxidase homolog	0.0196	0.5363	0.7918
Trichomonas vaginalis	esterase, putative	0.0037	0.0606	0.0895
Brugia malayi	Calcium binding EGF domain containing protein	0.0063	0.1395	0.1951
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0767	0.0902
Mycobacterium ulcerans	lipase LipD	0.0037	0.0606	0.0091
Onchocerca volvulus	Peroxidasin homolog	0.0196	0.5363	0.7918
Schistosoma mansoni	hypothetical protein	0.0063	0.1395	0.1951
Echinococcus multilocularis	fibropellin Ia	0.0063	0.1395	0.1395
Brugia malayi	Delta serrate ligand family protein	0.0063	0.1395	0.1951
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0417	0.0584
Schistosoma mansoni	hypothetical protein	0.0063	0.1395	0.1951
Schistosoma mansoni	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1038	0.1452
Echinococcus granulosus	notch	0.0063	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0301	0.8503	1
Schistosoma mansoni	hypothetical protein	0.0063	0.1395	0.1951
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.3761	0.4424
Echinococcus granulosus	protein jagged 1	0.0063	0.1395	0.1395
Echinococcus granulosus	protein jagged 1	0.0063	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0573	0.0801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0767	0.0902
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0606	0.0152
Brugia malayi	Peroxidasin	0.0196	0.5363	0.7503
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Brugia malayi	Animal haem peroxidase family protein	0.0196	0.5363	0.7503
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Echinococcus multilocularis	slit 2 protein	0.0063	0.1395	0.1395
Onchocerca volvulus		0.0196	0.5363	0.7918
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0573	0.0801
Leishmania major	cathepsin L-like protease	0.0064	0.1402	0.1649
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0573	0.5
Plasmodium vivax	SET domain protein, putative	0.0031	0.0417	0.6884
Echinococcus granulosus	protein jagged 2	0.0063	0.1395	0.1395
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0063	0.1395	0.1395
Echinococcus granulosus	delta-like protein 1	0.0063	0.1395	0.1395
Schistosoma mansoni	cell polarity protein	0.0063	0.1395	0.1951
Brugia malayi	EGF-like domain containing protein	0.0063	0.1395	0.1951
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0606	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Echinococcus granulosus	tar DNA binding protein	0.0256	0.7147	0.7147
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0063	0.1395	0.1951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0935	0.0988
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0606	0.0895
Schistosoma mansoni	notch	0.0063	0.1395	0.1951
Brugia malayi	Pre-SET motif family protein	0.0214	0.589	0.8241
Onchocerca volvulus	Peroxidasin homolog	0.0196	0.5363	0.7918
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0935	1
Echinococcus multilocularis	tar DNA binding protein	0.0256	0.7147	0.7147
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0606	0.0152
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1402	0.1649
Echinococcus granulosus	neurogenic locus notch protein	0.0063	0.1395	0.1395
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0953	0.1333
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0995	0.1171
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.7147	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0417	0.2992
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Onchocerca volvulus	Putative cubilin	0.0063	0.1395	0.2059
Echinococcus multilocularis	peroxidasin	0.0196	0.5363	0.5363
Brugia malayi	Cadherin domain containing protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	blistered cuticle protein 3	0.0196	0.5363	0.7503
Onchocerca volvulus	Slit protein homolog	0.0063	0.1395	0.2059
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0935	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0935	0.0696
Onchocerca volvulus		0.0063	0.1395	0.2059
Echinococcus multilocularis	protein jagged 1	0.0063	0.1395	0.1395
Onchocerca volvulus		0.0063	0.1395	0.2059
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0494	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0606	0.0848
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0063	0.1395	0.1395
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0935	0.0988
Schistosoma mansoni	notch	0.0063	0.1395	0.1951
Schistosoma mansoni	hypothetical protein	0.0063	0.1395	0.1951
Echinococcus granulosus	neurogenic locus protein delta	0.0063	0.1395	0.1395
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.7147	1
Brugia malayi	EGF-like domain containing protein	0.0063	0.1395	0.1951
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0417	0.0584
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0953	0.1333
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0417	0.0417
Brugia malayi	EGF-like domain containing protein	0.0063	0.1395	0.1951
Onchocerca volvulus		0.0037	0.0606	0.0895
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0606	0.0713
Brugia malayi	beta-lactamase family protein	0.0037	0.0606	0.0848
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0142	0.3761	0.3995
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Echinococcus granulosus	neural cadherin	0.0063	0.1395	0.1395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.7147	1
Loa Loa (eye worm)	animal heme peroxidase	0.0196	0.5363	0.7503
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0573	0.0801
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0606	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0935	1
Brugia malayi	RNA binding protein	0.0256	0.7147	1
Loa Loa (eye worm)	notch protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.589	0.8241
Echinococcus multilocularis	notch	0.0063	0.1395	0.1395
Onchocerca volvulus		0.0031	0.0417	0.0616
Leishmania major	cathepsin L-like protease	0.0064	0.1402	0.1649
Brugia malayi	Animal haem peroxidase family protein	0.0196	0.5363	0.7503
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Brugia malayi	beta-lactamase	0.0037	0.0606	0.0848
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0935	0.0696
Schistosoma mansoni	notch	0.0063	0.1395	0.1951
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0606	0.0848
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0573	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0606	0.0152
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.1038	0.1452
Schistosoma mansoni	laminin gamma-3 chain	0.0063	0.1395	0.1951
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0935	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.3761	0.4424
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1402	0.1649
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.7147	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0606	0.0606
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0935	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Onchocerca volvulus		0.0196	0.5363	0.7918
Leishmania major	mitochondrial DNA polymerase beta	0.0301	0.8503	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0767	0.0203
Echinococcus multilocularis	neurogenic locus notch protein	0.0063	0.1395	0.1395
Echinococcus multilocularis	protein jagged 1	0.0063	0.1395	0.1395
Loa Loa (eye worm)	animal heme peroxidase	0.0196	0.5363	0.7503
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0606	0.0895
Brugia malayi	Animal haem peroxidase family protein	0.0196	0.5363	0.7503
Leishmania major	hypothetical protein, conserved	0.0037	0.0606	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0063	0.1395	0.1951
Brugia malayi	Animal haem peroxidase family protein	0.0196	0.5363	0.7503
Brugia malayi	notch-like transmembrane receptor	0.0063	0.1395	0.1951
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0606	0.0895
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0606	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Schistosoma mansoni	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0935	0.1309
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0606	0.0895
Loa Loa (eye worm)	animal heme peroxidase	0.0196	0.5363	0.7503
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0935	0.11
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0417	0.0584
Onchocerca volvulus		0.0063	0.1395	0.2059
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0606	0.0895
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Onchocerca volvulus		0.0063	0.1395	0.2059
Brugia malayi	TAR-binding protein	0.0256	0.7147	1
Echinococcus granulosus	slit 2 protein	0.0063	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0573	0.0801
Schistosoma mansoni	hypothetical protein	0.0033	0.0494	0.0691
Onchocerca volvulus	Chorion peroxidase homolog	0.0196	0.5363	0.7918
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1402	0.1008
Toxoplasma gondii	EGF family domain-containing protein	0.0063	0.1395	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0606	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1395	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0935	0.11
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0935	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0301	0.8503	1
Loa Loa (eye worm)	RNA binding protein	0.0256	0.7147	1
Loa Loa (eye worm)	TAR-binding protein	0.0256	0.7147	1
Brugia malayi	Animal haem peroxidase family protein	0.0196	0.5363	0.7503
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0935	0.0988
Schistosoma mansoni	notch	0.0063	0.1395	0.1951
Schistosoma mansoni	notch	0.0063	0.1395	0.1951
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0063	0.1395	0.2059
Toxoplasma gondii	ABC1 family protein	0.0037	0.0606	0.4347
Onchocerca volvulus	Dual oxidase homolog	0.0196	0.5363	0.7918
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0606	0.0091
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0606	0.0152
Echinococcus granulosus	protein jagged 2	0.0063	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0606	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5363	0.7503
Toxoplasma gondii	hypothetical protein	0.0049	0.0953	0.6832
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0953	0.1333
Echinococcus multilocularis	protein jagged 2	0.0063	0.1395	0.1395
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0606	0.0152
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0935	0.1309
Brugia malayi	hypothetical protein	0.0196	0.5363	0.7503
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0935	0.1309
Schistosoma mansoni	peroxidasin	0.0196	0.5363	0.7503
Leishmania major	cathepsin L-like protease	0.0064	0.1402	0.1649
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0606	0.0848
Brugia malayi	EGF-like domain containing protein	0.0063	0.1395	0.1951

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 90 uM	Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of parasite LDH activity after 72 hrs	ChEMBL.	21944972

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3140363

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1846230