Detailed information for compound 1846341

Basic information

Technical information
  • TDR Targets ID: 1846341
  • Name: 3-amino-N-(2-chlorophenyl)-5-oxo-7,8-dihydro- 6H-thieno[5,4-b]quinoline-2-carboxamide
  • MW: 371.841 | Formula: C18H14ClN3O2S
  • H donors: 2 H acceptors: 3 LogP: 4.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1sc2c(c1N)cc1c(n2)CCCC1=O)Nc1ccccc1Cl
  • InChi: 1S/C18H14ClN3O2S/c19-11-4-1-2-5-13(11)21-17(24)16-15(20)10-8-9-12(22-18(10)25-16)6-3-7-14(9)23/h1-2,4-5,8H,3,6-7,20H2,(H,21,24)
  • InChiKey: RQVKPYOGSVGSSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-amino-N-(2-chlorophenyl)-5-keto-7,8-dihydro-6H-thieno[5,4-b]quinoline-2-carboxamide
  • ZINC05305762

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0069 0.9936 1
Echinococcus multilocularis orexin receptor type 2 0.0069 0.9936 1
Schistosoma mansoni cpg binding protein 0.0035 0.4678 0.4619
Echinococcus granulosus alpha 1A adrenergic receptor 0.0069 0.9936 1
Schistosoma mansoni hypothetical protein 0.0069 0.9936 0.9935
Loa Loa (eye worm) melatonin receptor type 1A 0.0069 0.9936 1
Echinococcus multilocularis g protein coupled receptor 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Echinococcus granulosus neuropeptide s receptor 0.0069 0.9936 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0525 0.2319
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Brugia malayi larval opioid receptor 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0036 0.4886 0.44
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Echinococcus multilocularis serotonin receptor 0.0069 0.9936 1
Schistosoma mansoni amine GPCR 0.0069 0.9936 0.9935
Brugia malayi AKH receptor 0.0069 0.9936 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.2264 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Trichomonas vaginalis helicase, putative 0.0007 0.0525 0.2319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Schistosoma mansoni neuropeptide receptor 0.0069 0.9936 0.9935
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0069 0.9936 1
Entamoeba histolytica hypothetical protein 0.0036 0.4886 1
Schistosoma mansoni hypothetical protein 0.0069 0.9936 0.9935
Brugia malayi G protein-coupled receptor F59B2.13 0.0069 0.9936 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.2264 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.4114 0.3543
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.9936 0.9935
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0069 0.9936 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.9936 1
Echinococcus granulosus neuropeptides capa receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus neuropeptides capa receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Onchocerca volvulus 0.0058 0.8207 0.688
Loa Loa (eye worm) hypothetical protein 0.0056 0.8045 0.7899
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi putative neuropeptide receptor NPR1 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.4114 0.3529
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus multilocularis serotonin receptor 0.0069 0.9936 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.2264 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.2264 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0069 0.9936 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Echinococcus granulosus neuropeptide Y receptor 0.0069 0.9936 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi neuropeptide F receptor 0.0069 0.9936 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.2264 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 0.2319
Echinococcus granulosus g-protein coupled receptor 0.0069 0.9936 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.9936 0.9935
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.8867 1
Loa Loa (eye worm) intermediate filament protein 0.0058 0.8207 0.8078
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0069 0.9936 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus dro:myosuppressin receptor 0.0069 0.9936 1
Brugia malayi neuropeptide F receptor 0.0069 0.9936 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.2264 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0069 0.9936 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi Dopamine receptor protein 1 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0069 0.9936 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0069 0.9936 1
Echinococcus granulosus somatostatin receptor 0.0069 0.9936 1
Echinococcus multilocularis fmrfamide receptor 0.0069 0.9936 1
Brugia malayi RE15519p 0.0069 0.9936 1
Echinococcus granulosus neuropeptide Y receptor 0.0069 0.9936 1
Echinococcus multilocularis somatostatin receptor 0.0069 0.9936 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.2264 0.1473
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0939 0.0328
Echinococcus granulosus 7TM GPCR rhodopsin 0.0069 0.9936 1
Brugia malayi Serotonin receptor 0.0069 0.9936 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0069 0.9936 1
Schistosoma mansoni opsin-like receptor 0.0069 0.9936 0.9935
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.2264 0.5
Schistosoma mansoni lamin 0.0058 0.8207 0.8187
Brugia malayi G-protein coupled receptor 0.0069 0.9936 1
Schistosoma mansoni amine GPCR 0.0069 0.9936 0.9935
Echinococcus multilocularis allatostatin A receptor 0.0069 0.9936 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0939 0.0328
Echinococcus granulosus g protein coupled receptor 0.0069 0.9936 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni amine GPCR 0.0069 0.9936 0.9935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0069 0.9936 1
Echinococcus granulosus fmrfamide receptor 0.0069 0.9936 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0069 0.9936 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.4393 0.3853
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Onchocerca volvulus 0.0069 0.9936 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.2264 0.1752
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.2264 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 0.2319
Schistosoma mansoni hypothetical protein 0.0036 0.4886 0.483
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0069 0.9936 0.9935
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.4886 0.4571
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.3485 0.2829
Echinococcus granulosus orexin receptor type 2 0.0069 0.9936 1
Schistosoma mansoni neuropeptide F-like receptor 0.0069 0.9936 0.9935
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.2264 1
Schistosoma mansoni neuropeptide receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Brugia malayi sulfakinin receptor protein 0.0069 0.9936 1
Echinococcus granulosus g protein coupled receptor 0.0069 0.9936 1
Loa Loa (eye worm) G-protein coupled receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi G protein-coupled receptor 0.0069 0.9936 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0069 0.9936 0.9935
Echinococcus multilocularis G-protein coupled receptor, putative 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.8207 0.8078
Schistosoma mansoni biogenic amine (5HT) receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.8207 0.8078
Brugia malayi intermediate filament protein 0.0058 0.8207 0.8082
Echinococcus granulosus g protein coupled receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0069 0.9936 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Echinococcus multilocularis neuropeptides capa receptor 0.0069 0.9936 1
Echinococcus granulosus G protein coupled receptor 139 0.0069 0.9936 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0069 0.9936 0.9935
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0069 0.9936 0.9935
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.2264 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.3485 0.2829
Onchocerca volvulus 0.0069 0.9936 1
Echinococcus granulosus serotonin receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni adenoreceptor 0.0069 0.9936 0.9935
Echinococcus granulosus hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0069 0.9936 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0069 0.9936 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Schistosoma mansoni neuropeptide f receptor 76f 0.0069 0.9936 0.9935
Echinococcus multilocularis neuropeptide Y receptor 0.0069 0.9936 1
Schistosoma mansoni neuropeptide F-like receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Schistosoma mansoni neuropeptide receptor 0.0069 0.9936 0.9935
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.4886 0.4571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Echinococcus granulosus peptide allatostatin:somatostatin 0.0069 0.9936 1
Schistosoma mansoni cpg binding protein 0.0035 0.4678 0.4619
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 0.2319
Echinococcus granulosus allatostatin A receptor 0.0069 0.9936 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0525 0.2319
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus multilocularis neuropeptide Y receptor 0.0069 0.9936 1
Echinococcus granulosus intermediate filament protein 0.0058 0.8207 0.8141
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.8207 0.8082
Onchocerca volvulus 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0069 0.9936 1
Echinococcus multilocularis g-protein coupled receptor 0.0069 0.9936 1
Echinococcus multilocularis musashi 0.0058 0.8207 0.8141
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0069 0.9936 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.2264 0.5
Onchocerca volvulus 0.0069 0.9936 1
Echinococcus granulosus neuropeptide receptor 0.0069 0.9936 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0069 0.9936 0.9935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.9936 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 0.2319
Brugia malayi follicle stimulating hormone receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus multilocularis neuropeptide receptor A26 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi Dopamine receptor protein 2 0.0069 0.9936 1
Echinococcus granulosus lamin dm0 0.0058 0.8207 0.8141
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Echinococcus granulosus neuropeptide receptor 0.0069 0.9936 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Schistosoma mansoni intermediate filament proteins 0.0058 0.8207 0.8187
Brugia malayi Dopamine receptor 0.0069 0.9936 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.9936 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0069 0.9936 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0069 0.9936 1
Schistosoma mansoni hypothetical protein 0.0069 0.9936 0.9935
Echinococcus granulosus biogenic amine 5HT receptor 0.0069 0.9936 1
Entamoeba histolytica hypothetical protein 0.0036 0.4886 1
Onchocerca volvulus 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) G-protein coupled receptor 0.0069 0.9936 1
Echinococcus granulosus lamin 0.0058 0.8207 0.8141
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0069 0.9936 0.9935
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.9936 1
Echinococcus granulosus cpg binding protein 0.0035 0.4678 0.4348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Brugia malayi GnHR receptor homolog 0.0069 0.9936 1
Echinococcus multilocularis neuropeptides capa receptor 0.0069 0.9936 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0069 0.9936 0.9935
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.3646 0.3238
Brugia malayi putative neuropeptide receptor 0.0069 0.9936 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.2264 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.9936 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.4393 0.3839
Echinococcus multilocularis G protein coupled receptor 139 0.0069 0.9936 1
Loa Loa (eye worm) neuropeptide F receptor 0.0069 0.9936 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0634 0.0531
Echinococcus granulosus 7tm_1 domain containing protein 0.0069 0.9936 1
Schistosoma mansoni opsin-like receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0069 0.9936 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.9936 1
Brugia malayi Melatonin receptor type 1A 0.0069 0.9936 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0069 0.9936 0.9935
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Loa Loa (eye worm) hypothetical protein 0.0028 0.3646 0.3009
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Brugia malayi ORL1-like opioid receptor 0.0069 0.9936 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0069 0.9936 1
Loa Loa (eye worm) neuropeptide F receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.4886 0.483
Brugia malayi hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni opsin-like receptor 0.0069 0.9936 0.9935
Schistosoma mansoni ap endonuclease 0.0019 0.2264 0.2179
Schistosoma mansoni neuropeptide receptor 0.0069 0.9936 0.9935
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0069 0.9936 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.3646 0.3238
Onchocerca volvulus Neuropeptide F receptor homolog 0.0069 0.9936 1
Echinococcus multilocularis g protein coupled receptor 0.0069 0.9936 1
Brugia malayi Serotonin receptor 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) TYRA-2 protein 0.0069 0.9936 1
Echinococcus multilocularis lamin dm0 0.0058 0.8207 0.8141
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.2264 0.1491
Onchocerca volvulus 0.0058 0.8207 0.688
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.9936 0.9935
Schistosoma mansoni biogenic amine receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0069 0.9936 1
Schistosoma mansoni amine GPCR 0.0069 0.9936 0.9935
Schistosoma mansoni cpg binding protein 0.0033 0.4393 0.4331
Schistosoma mansoni amine GPCR 0.0069 0.9936 0.9935
Schistosoma mansoni biogenic amine receptor 0.0069 0.9936 0.9935
Brugia malayi hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni biogenic amine receptor 0.0069 0.9936 0.9935
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0069 0.9936 0.9935
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus multilocularis neuropeptide s receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0069 0.9936 0.9935
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 0.2319
Onchocerca volvulus 0.0069 0.9936 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0069 0.9936 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 0.2319
Entamoeba histolytica hypothetical protein 0.0036 0.4886 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus sex peptide receptor 0.0069 0.9936 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0069 0.9936 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.2264 0.1752
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0069 0.9936 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0069 0.9936 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0069 0.9936 1
Entamoeba histolytica hypothetical protein 0.0036 0.4886 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.9936 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0069 0.9936 1
Schistosoma mansoni lamin 0.0058 0.8207 0.8187
Echinococcus multilocularis sex peptide receptor 0.0069 0.9936 1
Echinococcus multilocularis cpg binding protein 0.0035 0.4678 0.4348
Echinococcus multilocularis fmrfamide receptor 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Onchocerca volvulus 0.0069 0.9936 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 0.2319
Echinococcus multilocularis lamin 0.0058 0.8207 0.8141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0069 0.9936 0.9935
Echinococcus multilocularis neuropeptide FF receptor 2 0.0069 0.9936 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0069 0.9936 1
Schistosoma mansoni myosin xvIII 0.0069 0.9936 0.9935
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni histamine h1 receptor 0.0069 0.9936 0.9935
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.9936 0.9935
Echinococcus multilocularis neuropeptide receptor 0.0069 0.9936 1
Brugia malayi G-protein coupled receptor 0.0069 0.9936 1
Schistosoma mansoni hypothetical protein 0.0069 0.9936 0.9935
Echinococcus multilocularis neuropeptide receptor 0.0069 0.9936 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0069 0.9936 1
Brugia malayi hypothetical protein 0.0069 0.9936 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0069 0.9936 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.9936 1
Schistosoma mansoni ap endonuclease 0.0019 0.2264 0.2179
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.2264 1
Brugia malayi hypothetical protein 0.0069 0.9936 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 285 nM Growth inhibition of human NCI-H522 cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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