Detailed information for compound 1846436

Basic information

Technical information
  • TDR Targets ID: 1846436
  • Name: 5-fluoro-1-[(2R,3S,4S,5R)-4-hydroxy-5-(hydrox ymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-d ione
  • MW: 260.219 | Formula: C10H13FN2O5
  • H donors: 3 H acceptors: 4 LogP: -0.58 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@H]([C@@H]1O)C)n1cc(F)c(=O)[nH]c1=O
  • InChi: 1S/C10H13FN2O5/c1-4-7(15)6(3-14)18-9(4)13-2-5(11)8(16)12-10(13)17/h2,4,6-7,9,14-15H,3H2,1H3,(H,12,16,17)/t4-,6+,7-,9+/m0/s1
  • InChiKey: VEIPDPYFJUUBOQ-WOPPDYDQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-fluoro-1-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione
  • 5-fluoro-1-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyl-2-tetrahydrofuranyl]pyrimidine-2,4-dione
  • 5-fluoro-1-[(2R,3S,4S,5R)-4-hydroxy-3-methyl-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone
  • 5-fluoro-1-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyl-oxolan-2-yl]pyrimidine-2,4-dione
  • AIDS-218462
  • AIDS218462
  • SMFU
  • 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-methyl-b-D-arabinofuranosyl)-5-fluoro-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.5608 0.5559
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.5608 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.1908 0.2108
Echinococcus granulosus somatostatin receptor 0.0037 0.5608 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 1
Schistosoma mansoni lamin 0.0028 0.4088 0.4023
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.5608 1
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.5608 1
Echinococcus multilocularis somatostatin receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.5608 0.5559
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.5608 1
Echinococcus granulosus neuropeptide receptor 0.0037 0.5608 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0939 0.0613
Echinococcus granulosus intermediate filament protein 0.0028 0.4088 0.6945
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.5608 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Schistosoma mansoni cpg binding protein 0.0031 0.4678 0.4619
Echinococcus granulosus g protein coupled receptor 0.0037 0.5608 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.5608 0.5559
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.5608 0.5559
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Brugia malayi neuropeptide F receptor 0.0037 0.5608 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.5608 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.5608 0.5559
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.5608 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0939 0.0613
Onchocerca volvulus 0.0037 0.5608 1
Brugia malayi follicle stimulating hormone receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Schistosoma mansoni cpg binding protein 0.0031 0.4678 0.4619
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.5608 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.4088 0.6745
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.1572 0.1356
Onchocerca volvulus 0.0037 0.5608 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Schistosoma mansoni cpg binding protein 0.0029 0.4393 0.4331
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.5608 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Brugia malayi intermediate filament protein 0.0028 0.4088 0.6759
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis allatostatin A receptor 0.0037 0.5608 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.4393 0.7399
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.5608 0.5559
Schistosoma mansoni amine GPCR 0.0037 0.5608 0.5559
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Brugia malayi hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Brugia malayi ORL1-like opioid receptor 0.0037 0.5608 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.5608 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.4002 0.6561
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.5608 1
Schistosoma mansoni neuropeptide receptor 0.0037 0.5608 0.5559
Onchocerca volvulus 0.0037 0.5608 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.1658 0.2059
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.5608 1
Brugia malayi Dopamine receptor 0.0037 0.5608 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.5608 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.5608 1
Schistosoma mansoni opsin-like receptor 0.0037 0.5608 0.5559
Schistosoma mansoni hypothetical protein 0.0037 0.5608 0.5559
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus granulosus g protein coupled receptor 0.0037 0.5608 1
Echinococcus granulosus serotonin receptor 0.0037 0.5608 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.5608 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.5608 0.5559
Brugia malayi hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.4088 0.6745
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Onchocerca volvulus 0.0037 0.5608 1
Schistosoma mansoni histamine h1 receptor 0.0037 0.5608 0.5559
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.5608 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.5608 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0525 1
Schistosoma mansoni myosin xvIII 0.0037 0.5608 0.5559
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.5608 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.8867 0.5
Schistosoma mansoni intermediate filament proteins 0.0028 0.4088 0.4023
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.5608 1
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.5608 1
Echinococcus granulosus cpg binding protein 0.0031 0.4678 0.8131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.5608 0.5559
Schistosoma mansoni adenoreceptor 0.0037 0.5608 0.5559
Brugia malayi hypothetical protein 0.0037 0.5608 1
Brugia malayi Melatonin receptor type 1A 0.0037 0.5608 1
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.5608 0.5559
Brugia malayi hypothetical protein 0.0037 0.5608 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.1658 0.154
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.1908 0.2075
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis fmrfamide receptor 0.0037 0.5608 1
Echinococcus multilocularis serotonin receptor 0.0037 0.5608 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.5608 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.5608 1
Schistosoma mansoni hypothetical protein 0.0037 0.5608 0.5559
Schistosoma mansoni opsin-like receptor 0.0037 0.5608 0.5559
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Echinococcus granulosus fmrfamide receptor 0.0037 0.5608 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Brugia malayi RE15519p 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.5608 0.5559
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.5608 1
Schistosoma mansoni neuropeptide receptor 0.0037 0.5608 0.5559
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Echinococcus granulosus lamin dm0 0.0028 0.4088 0.6945
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.5608 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Brugia malayi hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Brugia malayi putative neuropeptide receptor 0.0037 0.5608 1
Echinococcus multilocularis orexin receptor type 2 0.0037 0.5608 1
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.5608 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0525 1
Echinococcus granulosus allatostatin A receptor 0.0037 0.5608 1
Echinococcus multilocularis musashi 0.0028 0.4088 0.6945
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.5608 1
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Echinococcus multilocularis neuropeptide receptor 0.0037 0.5608 1
Schistosoma mansoni neuropeptide receptor 0.0037 0.5608 0.5559
Echinococcus multilocularis cpg binding protein 0.0031 0.4678 0.8131
Schistosoma mansoni biogenic amine receptor 0.0037 0.5608 0.5559
Brugia malayi hypothetical protein 0.0037 0.5608 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.5608 0.5559
Echinococcus multilocularis sex peptide receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Echinococcus granulosus neuropeptide receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.5608 0.5559
Echinococcus multilocularis g protein coupled receptor 0.0037 0.5608 1
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis neuropeptide receptor 0.0037 0.5608 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.5608 0.5559
Echinococcus multilocularis g protein coupled receptor 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Echinococcus granulosus g-protein coupled receptor 0.0037 0.5608 1
Echinococcus granulosus sex peptide receptor 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.5608 1
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.5608 1
Brugia malayi hypothetical protein 0.0037 0.5608 1
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.5608 1
Schistosoma mansoni neuropeptide receptor 0.0037 0.5608 0.5559
Schistosoma mansoni amine GPCR 0.0037 0.5608 0.5559
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.5608 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.5608 1
Echinococcus multilocularis serotonin receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.5608 1
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.5608 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.5608 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.5608 1
Echinococcus granulosus g protein coupled receptor 0.0037 0.5608 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.5608 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.5608 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.4088 0.6759
Schistosoma mansoni amine GPCR 0.0037 0.5608 0.5559
Brugia malayi CXXC zinc finger family protein 0.0029 0.4393 0.741
Schistosoma mansoni lamin 0.0028 0.4088 0.4023
Brugia malayi AKH receptor 0.0037 0.5608 1
Schistosoma mansoni hypothetical protein 0.0037 0.5608 0.5559
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0634 0.0531
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.5608 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Trichomonas vaginalis helicase, putative 0.0007 0.0525 1
Brugia malayi hypothetical protein 0.0037 0.5608 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.5608 1
Echinococcus granulosus orexin receptor type 2 0.0037 0.5608 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.5608 0.5559
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.5608 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.5608 0.5559
Loa Loa (eye worm) hypothetical protein 0.0028 0.4088 0.6745
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Brugia malayi hypothetical protein 0.0037 0.5608 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.5608 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Brugia malayi Serotonin receptor 0.0037 0.5608 1
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.5608 0.5559
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.5608 1
Brugia malayi GnHR receptor homolog 0.0037 0.5608 1
Brugia malayi larval opioid receptor 0.0037 0.5608 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.5608 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.5608 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.5608 0.5559
Onchocerca volvulus 0.0037 0.5608 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.5608 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.5608 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.5608 0.5559
Brugia malayi G-protein coupled receptor 0.0037 0.5608 1
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.5608 1
Brugia malayi sulfakinin receptor protein 0.0037 0.5608 1
Echinococcus multilocularis lamin 0.0028 0.4088 0.6945
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.5608 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Brugia malayi G protein-coupled receptor 0.0037 0.5608 1
Echinococcus multilocularis g protein coupled receptor 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Brugia malayi Serotonin receptor 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.5608 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Onchocerca volvulus 0.0029 0.4393 0.2007
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Echinococcus granulosus hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis lamin dm0 0.0028 0.4088 0.6945
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0525 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.5608 1
Schistosoma mansoni biogenic amine receptor 0.0037 0.5608 0.5559
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.5608 1
Brugia malayi Dopamine receptor protein 2 0.0037 0.5608 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.1658 0.2059
Brugia malayi Dopamine receptor protein 1 0.0037 0.5608 1
Schistosoma mansoni opsin-like receptor 0.0037 0.5608 0.5559
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Schistosoma mansoni hypothetical protein 0.0037 0.5608 0.5559
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.5608 0.5559
Schistosoma mansoni biogenic amine receptor 0.0037 0.5608 0.5559
Echinococcus granulosus lamin 0.0028 0.4088 0.6945
Brugia malayi neuropeptide F receptor 0.0037 0.5608 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.5608 1
Echinococcus multilocularis fmrfamide receptor 0.0037 0.5608 1
Schistosoma mansoni amine GPCR 0.0037 0.5608 0.5559
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.5608 0.5559
Loa Loa (eye worm) hypothetical protein 0.0013 0.1572 0.1356
Brugia malayi hypothetical protein 0.0037 0.5608 1
Brugia malayi G-protein coupled receptor 0.0037 0.5608 1
Onchocerca volvulus 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.5608 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.5608 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.5608 0.5559
Echinococcus granulosus neuropeptide s receptor 0.0037 0.5608 1
Schistosoma mansoni amine GPCR 0.0037 0.5608 0.5559
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.5608 1
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.5608 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.5608 1

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 100 ug ml-1 Cytotoxic concentration required to inhibit NC-37 cells by 50% ChEMBL. No reference
EC50 (functional) > 100 ug ml-1 Concentration required to reduce HSV-1 (KOS strain) induced cytopathogenicity in NC-37 cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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