Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0542 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0542 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0542 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0542 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0542 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0542 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0542 | 0.5 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0542 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0542 | 0.5 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0542 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0542 | 0.5 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0542 | 0.5 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0542 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0542 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0542 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0542 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0542 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0542 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0542 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0542 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0542 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0542 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 49 uM | Cytotoxicity against BE human colon carcinoma cell lines BE-WT(No NQO1 activity) | ChEMBL. | 11563930 |
IC50 (functional) | > 50 uM | Cytotoxicity against BE human colon carcinoma cell lines BE-NQ( high NQO1 activity) | ChEMBL. | 11563930 |
IC50 (functional) | > 50 uM | Cytotoxicity against BE human colon carcinoma cell lines BE-NQ( high NQO1 activity) | ChEMBL. | 11563930 |
Metabolism (functional) | = 0.23 uM min-1mg-1 | NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced | ChEMBL. | 11563930 |
Metabolism (functional) | = 0.23 uM min-1mg-1 | NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced | ChEMBL. | 11563930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.