Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 207 aa | 30.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 1 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.017 | 0 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 1 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.017 | 0 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 1 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | 0.017 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
7-day weight change (functional) | = 6 % | Inoculation of 10 e5 L1210 cells ,ip ,on day 0, & treatment was started on day 1 with the administration of the compound, ip, in groups of five B6D2F1J male mice at dose 10 mg/kg | ChEMBL. | 6737432 |
7-day weight change (functional) | = 10 % | Inoculation of 10 e5 L1210 cells ,ip ,on day 0, & treatment was started on day 1 with the administration of the compound, ip, in groups of five B6D2F1J male mice at dose 20 mg/kg | ChEMBL. | 6737432 |
7-day weight change (functional) | = 10 % | Inoculation of 10 e5 L1210 cells ,ip ,on day 0, & treatment was started on day 1 with the administration of the compound, ip, in groups of five B6D2F1J male mice at dose 40 mg/kg | ChEMBL. | 6737432 |
IC50 (binding) | = 140 nM | Inhibitory activity of the compound towards dihydrofolate reductase in L1210 murine leukemia cell lines | ChEMBL. | 6737432 |
IC50 (functional) | = 2.9 uM | Growth inhibition of L1210 cell lines | ChEMBL. | 6737432 |
ILS (functional) | = 33 % | Inoculation of 10 e5 L1210 cells, ip, on day 0, & treatment was started on day1 with the administration of the compound, ip, in groups of five B6D2F1J male mice at dose 10 mg/kg | ChEMBL. | 6737432 |
ILS (functional) | = 33 % | Inoculation of 10 e5 L1210 cells, ip, on day 0, & treatment was started on day1 with the administration of the compound, ip, in groups of five B6D2F1J male mice at dose 20 mg/kg | ChEMBL. | 6737432 |
ILS (functional) | = 55 % | Inoculation of 10 e5 L1210 cells, ip, on day 0, & treatment was started on day1 with the administration of the compound, ip, in groups of five B6D2F1J male mice at dose 40 mg/kg | ChEMBL. | 6737432 |
Relative activity (binding) | = 0.36 | Activity of the compound relative to methotrexate for inhibition of Dihydrofolate reductase from L1210 murine leukemia cell lines | ChEMBL. | 6737432 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 6737432 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.