Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hexokinase, putative | 0.1325 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.065 | 0.065 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Leishmania major | casein kinase II, putative | 0.1262 | 0.9497 | 0.9007 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.0687 | 0.493 | 0.4876 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0271 | 0.1618 | 0.1618 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Echinococcus multilocularis | hexokinase type 2 | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.1262 | 0.9497 | 0.9497 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.1262 | 0.9497 | 0.9491 |
Trypanosoma brucei | Casein kinase II | 0.1262 | 0.9497 | 0.9007 |
Plasmodium falciparum | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Brugia malayi | Blistered cuticle protein 3 | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.2815 | 0.2815 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Brugia malayi | Peroxidasin | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.1262 | 0.9497 | 0.9007 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Brugia malayi | Hexokinase family protein | 0.1325 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.065 | 0.065 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0687 | 0.493 | 0.4328 |
Onchocerca volvulus | 0.1325 | 1 | 1 | |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Plasmodium vivax | unspecified product | 0.1262 | 0.9497 | 0.9007 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0247 | 0.0247 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1262 | 0.9497 | 0.9437 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0247 | 0.0247 |
Leishmania major | hexokinase, putative | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Leishmania major | hexokinase, putative | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.1262 | 0.9497 | 0.9007 |
Brugia malayi | RNA, U transporter 1 | 0.0072 | 0.0039 | 0.0039 |
Echinococcus granulosus | hexokinase type 2 | 0.1325 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0687 | 0.493 | 0.4328 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Echinococcus multilocularis | snurportin 1 | 0.0271 | 0.1618 | 0.1527 |
Loa Loa (eye worm) | casein kinase II | 0.0201 | 0.1062 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Echinococcus granulosus | geminin | 0.0149 | 0.065 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0247 | 0.0247 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0831 | 0.6075 | 0.6032 |
Entamoeba histolytica | hexokinase 1 | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.1618 | 0.1618 |
Giardia lamblia | Kinase, CMGC CK2 | 0.1262 | 0.9497 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hexokinase | 0.0831 | 0.6075 | 0.6075 |
Brugia malayi | Casein kinase II, alpha chain | 0.1262 | 0.9497 | 0.9497 |
Loa Loa (eye worm) | hexokinase | 0.041 | 0.2725 | 0.2725 |
Onchocerca volvulus | 0.0129 | 0.0491 | 0.0388 | |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Brugia malayi | hexokinase type II | 0.0421 | 0.2815 | 0.2815 |
Trypanosoma cruzi | casein kinase II, putative | 0.1262 | 0.9497 | 0.9007 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0687 | 0.493 | 0.4876 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0687 | 0.493 | 0.4876 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Giardia lamblia | Casein kinase II beta chain | 0.0687 | 0.493 | 0.4586 |
Trypanosoma brucei | hexokinase | 0.1325 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1325 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Echinococcus multilocularis | hexokinase | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Echinococcus granulosus | hexokinase | 0.1325 | 1 | 1 |
Brugia malayi | casein kinase II, putaitve | 0.0201 | 0.1062 | 0.1062 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.1262 | 0.9497 | 0.9491 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Schistosoma mansoni | casein kinase II beta subunit | 0.0687 | 0.493 | 0.493 |
Schistosoma mansoni | protein kinase | 0.1262 | 0.9497 | 0.9497 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0904 | 0.6651 | 0.6651 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | hexokinase | 0.1325 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0831 | 0.6075 | 0.6075 |
Onchocerca volvulus | 0.0831 | 0.6075 | 0.6032 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Trypanosoma brucei | hexokinase, putative | 0.1325 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1325 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1262 | 0.9497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.2815 | 0.2815 |
Brugia malayi | Hexokinase family protein | 0.041 | 0.2725 | 0.2725 |
Echinococcus multilocularis | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1325 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.1325 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Onchocerca volvulus | 0.1325 | 1 | 1 | |
Onchocerca volvulus | 0.1325 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.1262 | 0.9497 | 0.9007 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Trypanosoma cruzi | hexokinase, putative | 0.1325 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.1262 | 0.9497 | 0.9437 |
Loa Loa (eye worm) | Csnk2b protein | 0.0687 | 0.493 | 0.493 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0107 | 0.0107 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Trypanosoma brucei | hexokinase | 0.1325 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 0.0107 | 0.0107 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0687 | 0.493 | 0.4328 |
Schistosoma mansoni | peroxidasin | 0.0081 | 0.0107 | 0.0107 |
Echinococcus multilocularis | geminin | 0.0149 | 0.065 | 0.0549 |
Entamoeba histolytica | hexokinase 2 | 0.1325 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1325 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.1325 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.1325 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Echinococcus granulosus | snurportin 1 | 0.0271 | 0.1618 | 0.1527 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0687 | 0.493 | 0.4586 |
Treponema pallidum | hexokinase (hxk) | 0.1325 | 1 | 0.5 |
Brugia malayi | Csnk2b protein | 0.0687 | 0.493 | 0.493 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.0687 | 0.493 | 0.4876 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0247 | 0.0247 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 200 uM | Cytotoxic concentration required to inhibit HEL cell growth by 50 % | ChEMBL. | 11212118 |
MCC (functional) | > 200 uM | Minimum cytotoxic concentration required to alter microscopically detectable HEL cell morphology | ChEMBL. | 11212118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.