Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | aldo-keto reductase, putative | 0.0216 | 0.1556 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0529 | 0.6557 | 0.6557 |
Giardia lamblia | Aldose reductase | 0.0745 | 1 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 0.0605 | 0.0605 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 0.0605 | 0.0605 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0216 | 0.1556 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0216 | 0.1556 | 0.1012 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0745 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0745 | 1 | 0.5 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0216 | 0.1556 | 0.1012 |
Leishmania major | aldo-keto reductase-like protein | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0216 | 0.1556 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0216 | 0.1556 | 0.1556 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0745 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0745 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0745 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0216 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0216 | 0.1556 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0745 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0216 | 0.1556 | 0.1556 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 0.0605 | 0.0605 |
Trypanosoma brucei | prostaglandin f synthase | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0216 | 0.1556 | 0.1012 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0529 | 0.6557 | 0.5922 |
Leishmania major | prostaglandin f synthase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0745 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0529 | 0.6557 | 0.6557 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0216 | 0.1556 | 0.1556 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Km (binding) | = 85 uM | Compound was evaluated in vitro for its inhibitory effect Vitamin K dependent carboxylase of Phe-Leu-Glu-Glu-Leu in rat microsomal protein | ChEMBL. | 6332196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.