Detailed information for compound 1847148

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.357 | Formula: C15H26N3O7P
  • H donors: 3 H acceptors: 4 LogP: -2.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCc1cn([C@H]2C[C@H]3[C@H](O2)COP(=O)(O3)O)c(=O)[nH]c1=O.N
  • InChi: 1S/C15H23N2O7P.H3N/c1-2-3-4-5-6-10-8-17(15(19)16-14(10)18)13-7-11-12(23-13)9-22-25(20,21)24-11;/h8,11-13H,2-7,9H2,1H3,(H,20,21)(H,16,18,19);1H3/t11-,12+,13+;/m0./s1
  • InChiKey: MYCHXEYOXRNIQJ-LUHWTZLKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hexokinase, putative 0.0082 0.0334 0.1216
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0362 0.1673 0.3217
Schistosoma mansoni P2X receptor subunit 0.2102 1 1
Echinococcus multilocularis histone deacetylase 6 0.0054 0.0199 0.0199
Brugia malayi Bromodomain containing protein 0.0041 0.0135 0.026
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0012 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0405 0.0405
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0098
Leishmania major hexokinase, putative 0.0082 0.0334 0.1234
Trypanosoma brucei histone deacetylase 3 0.0051 0.0184 0.0668
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0006 0.0024
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0006 0.0024
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0012 0.0023
Toxoplasma gondii histone deacetylase HDAC2 0.0045 0.0157 0.0568
Mycobacterium tuberculosis Cell division protein FtsZ 0.0148 0.065 0.2645
Echinococcus multilocularis histone deacetylase 3 0.0045 0.0157 0.0157
Echinococcus granulosus ecdysone induced protein 78C 0.1026 0.4852 0.4852
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0136 0.0136
Loa Loa (eye worm) tubulin alpha chain 0.051 0.2383 0.4582
Plasmodium vivax hypothetical protein, conserved 0.004 0.0129 0.0443
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0342 0.1575 0.5903
Brugia malayi Nuclear hormone receptor family member nhr-49 0.1026 0.4852 0.9328
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0137 0.0494
Loa Loa (eye worm) hypothetical protein 0.0177 0.0787 0.1513
Trypanosoma cruzi zeta tubulin, putative 0.0148 0.065 0.2422
Echinococcus granulosus Tubulin beta 2C chain 0.0569 0.2664 0.2664
Echinococcus granulosus tubulin subunit TubB 0.051 0.2383 0.2383
Trichomonas vaginalis bromodomain-containing protein, putative 0.0025 0.0061 0.021
Echinococcus granulosus tubulin beta 4A class IVa 0.0569 0.2664 0.2664
Brugia malayi Histone deacetylase 1 0.0045 0.0157 0.0302
Brugia malayi Cell division protein ftsZ 0.0148 0.065 0.1249
Trypanosoma brucei epsilon tubulin 0.0342 0.1575 0.5903
Plasmodium vivax histone deacetylase 1, putative 0.0045 0.0157 0.0548
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0595 0.0595
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0048 0.0181
Echinococcus multilocularis histone deacetylase 7 0.0051 0.0184 0.0184
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.004 0.0129 0.0443
Leishmania major beta tubulin 0.0569 0.2664 1
Giardia lamblia Beta tubulin 0.0569 0.2664 1
Giardia lamblia Epsilon tubulin 0.0148 0.065 0.2362
Trichomonas vaginalis tubulin beta chain, putative 0.0193 0.0865 0.3233
Brugia malayi Protein kinase domain containing protein 0.0024 0.0054 0.0105
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0249
Schistosoma mansoni alpha tubulin 0.051 0.2383 0.2383
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0484 0.2257 0.2257
Loa Loa (eye worm) blistered cuticle protein 3 0.0683 0.3212 0.6174
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0595 0.0595
Brugia malayi histone deacetylase 1 (HD1) 0.0045 0.0157 0.0302
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Brugia malayi hypothetical protein 0.0279 0.1275 0.2452
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.1026 0.4852 0.4852
Echinococcus granulosus carbonic anhydrase II 0.0377 0.1743 0.1743
Schistosoma mansoni retinoic acid receptor RXR 0.1026 0.4852 0.4852
Leishmania major beta tubulin 0.0569 0.2664 1
Plasmodium vivax tubulin alpha chain, putative 0.051 0.2383 0.8941
Brugia malayi cytochrome P450 0.0014 0.0006 0.0012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0484 0.2257 0.2257
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0018 0.0027 0.0081
Trypanosoma cruzi tubulin gamma chain 0.0342 0.1575 0.5903
Entamoeba histolytica hexokinase 2 0.0082 0.0334 0.1236
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0016 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1026 0.4852 0.9328
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0024 0.0054 0.0105
Schistosoma mansoni tubulin subunit beta 0.0148 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.1026 0.4852 0.9328
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.065 0.2424
Onchocerca volvulus 0.0077 0.0308 0.0591
Brugia malayi MH2 domain containing protein 0.0113 0.0483 0.0928
Brugia malayi Tubulin beta chain 0.0148 0.065 0.1249
Trypanosoma brucei hexokinase, putative 0.0082 0.0334 0.1234
Loa Loa (eye worm) hypothetical protein 0.0096 0.0398 0.0765
Plasmodium vivax tubulin gamma chain, putative 0.0342 0.1575 0.5894
Loa Loa (eye worm) histone deacetylase 11 0.0022 0.0045 0.0086
Echinococcus granulosus Tubulin beta 2C chain 0.0569 0.2664 0.2664
Echinococcus granulosus mitogen activated protein kinase 11 0.0069 0.0273 0.0273
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.0186
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0317
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0006 0.0024
Giardia lamblia Histone deacetylase 0.0045 0.0157 0.0494
Echinococcus granulosus histone deacetylase 6 0.0054 0.0199 0.0199
Trichomonas vaginalis tubulin beta chain, putative 0.0569 0.2664 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0129 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.003 0.0084 0.0162
Echinococcus multilocularis carbonic anhydrase II 0.0377 0.1743 0.1743
Brugia malayi tubulin alpha chain - mouse 0.051 0.2383 0.4582
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.0181
Leishmania major beta tubulin 0.0569 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Onchocerca volvulus 0.0069 0.0272 0.0523
Echinococcus multilocularis cyclin dependent kinase 0.0024 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0048 0.0161
Leishmania major UDP-galactopyranose mutase 0.004 0.0129 0.0463
Loa Loa (eye worm) hypothetical protein 0.0056 0.0209 0.0401
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0484 0.2257 0.4339
Loa Loa (eye worm) cytochrome P450 0.0014 0.0006 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1026 0.4852 0.4852
Trypanosoma brucei PAB1-binding protein , putative 0.0016 0.0016 0.0036
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0045 0.0157 0.057
Giardia lamblia Alpha-tubulin 0.051 0.2383 0.8935
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0484 0.2257 0.2257
Trypanosoma cruzi hexokinase, putative 0.0082 0.0334 0.1234
Leishmania major hexokinase, putative 0.0082 0.0334 0.1234
Echinococcus granulosus Tubulin beta 2C chain 0.0569 0.2664 0.2664
Echinococcus multilocularis p2X purinoceptor 4 0.2102 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.0181
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0044 0.0151 0.029
Loa Loa (eye worm) hypothetical protein 0.0279 0.1275 0.2452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.1026 0.4852 0.9328
Trypanosoma brucei zeta tubulin, putative 0.0148 0.065 0.2422
Entamoeba histolytica tubulin gamma chain 0.0342 0.1575 0.5904
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.004 0.0129 0.0443
Plasmodium vivax tubulin alpha chain, putative 0.051 0.2383 0.8941
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0044 0.0151 0.029
Mycobacterium ulcerans monoamine oxidase 0.004 0.0129 0.0492
Loa Loa (eye worm) tubulin beta chain 0.0569 0.2664 0.5122
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0177 0.0787 0.1513
Brugia malayi conserved hypotetical protein 0.0484 0.2257 0.4339
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0039
Chlamydia trachomatis protoporphyrinogen oxidase 0.004 0.0129 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0013 0.0026
Echinococcus granulosus histone deacetylase 3 0.0045 0.0157 0.0157
Echinococcus multilocularis tubulin alpha chain 0.051 0.2383 0.2383
Loa Loa (eye worm) hypothetical protein 0.1026 0.4852 0.9328
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0127 0.0547 0.0547
Giardia lamblia Kinase, CMGC CDK 0.0024 0.0054 0.0104
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0044 0.0151 0.029
Echinococcus granulosus hexokinase 0.0082 0.0334 0.0334
Echinococcus multilocularis expressed conserved protein 0.009 0.037 0.037
Echinococcus granulosus Tubulin beta 2C chain 0.0569 0.2664 0.2664
Echinococcus multilocularis Tubulin alpha 1 chain 0.051 0.2383 0.2383
Schistosoma mansoni carbonic anhydrase-related 0.0177 0.0787 0.0787
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0033 0.0099 0.0328
Schistosoma mansoni tubulin subunit alpha 0.051 0.2383 0.2383
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0125
Schistosoma mansoni carbonic anhydrase-related 0.0177 0.0787 0.0787
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0012 0.002
Brugia malayi hypothetical protein 0.004 0.0129 0.0249
Trichomonas vaginalis tubulin beta chain, putative 0.051 0.2383 0.8944
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0099 0.0348
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0129 0.0463
Loa Loa (eye worm) hypothetical protein 0.0542 0.2535 0.4873
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0048 0.0159
Brugia malayi isocitrate dehydrogenase 0.0015 0.0012 0.0023
Leishmania major histone deacetylase, putative 0.0051 0.0184 0.0668
Schistosoma mansoni histone deacetylase 0.0045 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.1026 0.4852 0.9328
Echinococcus multilocularis Tubulin beta 2C chain 0.0569 0.2664 0.2664
Plasmodium vivax tubulin epsilon chain, putative 0.0342 0.1575 0.5894
Echinococcus granulosus tumor protein p63 0.0321 0.1476 0.1476
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0148 0.065 0.5
Giardia lamblia NADPH oxidoreductase, putative 0.0055 0.0203 0.0666
Echinococcus granulosus carbonic anhydrase 0.0177 0.0787 0.0787
Leishmania major beta tubulin 0.0569 0.2664 1
Onchocerca volvulus 0.0077 0.0308 0.0591
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0129 0.0463
Echinococcus multilocularis hexokinase 0.0082 0.0334 0.0334
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0006 0.0024
Loa Loa (eye worm) tubulin beta chain 0.0148 0.065 0.1249
Onchocerca volvulus 0.0044 0.0151 0.029
Leishmania major histone deacetylase, putative 0.0051 0.0184 0.0668
Echinococcus multilocularis histone deacetylase 1 0.0045 0.0157 0.0157
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0012
Brugia malayi nuclear receptor NHR-88 0.1026 0.4852 0.9328
Loa Loa (eye worm) carbonic anhydrase 3 0.0377 0.1743 0.3351
Leishmania major hypothetical protein, conserved 0.0033 0.0099 0.0347
Mycobacterium ulcerans protoporphyrinogen oxidase 0.004 0.0129 0.0492
Schistosoma mansoni tubulin subunit alpha 0.051 0.2383 0.2383
Onchocerca volvulus 0.0077 0.0308 0.0591
Trypanosoma brucei cdc2-related kinase 1 0.0024 0.0054 0.0181
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0177 0.0787 0.1513
Brugia malayi cell division control protein 2 homolog 0.0024 0.0054 0.0105
Trichomonas vaginalis tubulin gamma chain, putative 0.0148 0.065 0.2424
Echinococcus multilocularis carbonic anhydrase 0.0177 0.0787 0.0787
Leishmania major beta tubulin 0.0569 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Plasmodium vivax ataxin-2 like protein, putative 0.0016 0.0016 0.0016
Toxoplasma gondii histone lysine-specific demethylase 0.004 0.0129 0.0463
Echinococcus multilocularis tubulin beta 1 chain 0.0569 0.2664 0.2664
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0152
Trypanosoma brucei alpha tubulin 0.051 0.2383 0.8943
Leishmania major beta tubulin 0.0569 0.2664 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0006 0.0024
Brugia malayi nuclear hormone receptor 0.0484 0.2257 0.4339
Echinococcus multilocularis cyclin dependent kinase 1 0.0024 0.0054 0.0054
Schistosoma mansoni tubulin subunit epsilon 0.0342 0.1575 0.1575
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0058 0.0216 0.0216
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0484 0.2257 0.4339
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1026 0.4852 0.9328
Giardia lamblia NADPH oxidoreductase, putative 0.0055 0.0203 0.0666
Onchocerca volvulus 0.0052 0.0187 0.036
Echinococcus multilocularis Tubulin beta 2C chain 0.0569 0.2664 0.2664
Echinococcus multilocularis bromodomain containing 2 0.0041 0.0135 0.0135
Echinococcus granulosus tubulin alpha 0.0342 0.1575 0.1575
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Entamoeba histolytica bromodomain-containing protein 0.0018 0.0027 0.0081
Echinococcus multilocularis protoporphyrinogen oxidase 0.004 0.0129 0.0129
Echinococcus granulosus geminin 0.0268 0.1221 0.1221
Toxoplasma gondii histone deacetylase HDAC4 0.0022 0.0045 0.0144
Trypanosoma brucei histone deacetylase 2 0.0022 0.0045 0.0144
Brugia malayi LBP/BPI 0.0033 0.0097 0.0186
Echinococcus multilocularis 0.0014 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.004 0.0129 0.0129
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0006 0.0024
Trypanosoma cruzi beta tubulin, putative 0.0569 0.2664 1
Echinococcus granulosus tubulin alpha 3 chain 0.051 0.2383 0.2383
Loa Loa (eye worm) alpha-tubulin 0.051 0.2383 0.4582
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0193 0.0865 0.3233
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Echinococcus multilocularis carbonic anhydrase 0.0177 0.0787 0.0787
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Mycobacterium ulcerans oxidoreductase 0.004 0.0129 0.0492
Schistosoma mansoni nuclear receptor nhr-48 0.0484 0.2257 0.2257
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Schistosoma mansoni peroxidasin 0.0683 0.3212 0.3212
Trypanosoma brucei beta tubulin 0.0569 0.2664 1
Onchocerca volvulus Peroxidase homolog 0.0683 0.3212 0.6174
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0069 0.0273 0.0524
Onchocerca volvulus 0.0047 0.0165 0.0317
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.004 0.0129 0.0443
Echinococcus multilocularis Tubulin alpha 1 chain 0.051 0.2383 0.2383
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-40 0.1026 0.4852 0.9328
Trichomonas vaginalis tubulin epsilon chain, putative 0.051 0.2383 0.8944
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.051 0.2383 0.8944
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Onchocerca volvulus Protein ultraspiracle homolog 0.1026 0.4852 0.9328
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Schistosoma mansoni RAR-like nuclear receptor 0.1026 0.4852 0.4852
Schistosoma mansoni steroid hormone receptor ad4bp 0.1026 0.4852 0.4852
Echinococcus multilocularis microtubule associated protein 2 0.0655 0.3077 0.3077
Trypanosoma brucei beta tubulin 0.0569 0.2664 1
Giardia lamblia Beta tubulin 0.0569 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.1026 0.4852 0.9328
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0136 0.0262
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0377 0.1743 0.1743
Toxoplasma gondii hypothetical protein 0.0177 0.0787 0.2937
Echinococcus multilocularis carbonic anhydrase 0.0177 0.0787 0.0787
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Brugia malayi hypothetical protein 0.0044 0.0151 0.029
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0016 0.0016
Trichomonas vaginalis tubulin alpha chain, putative 0.0569 0.2664 1
Echinococcus granulosus tubulin subunit beta 0.0569 0.2664 0.2664
Entamoeba histolytica bromodomain-containing protein 0.0018 0.0027 0.0081
Loa Loa (eye worm) tubulin beta-1 chain 0.0569 0.2664 0.5122
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0024 0.0054 0.0181
Brugia malayi Cytochrome P450 family protein 0.0014 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0039
Echinococcus multilocularis protein dispatched 1 0.0047 0.0164 0.0164
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.1026 0.4852 0.4852
Echinococcus granulosus cyclin dependent kinase 0.0024 0.0054 0.0054
Giardia lamblia Alpha-tubulin 0.051 0.2383 0.8935
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0012 0.0012
Echinococcus granulosus tubulin alpha chain 0.051 0.2383 0.2383
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0092
Toxoplasma gondii alpha-tubulin I, putative 0.051 0.2383 0.8943
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0045 0.0144
Trypanosoma brucei alpha tubulin 0.051 0.2383 0.8943
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.0084 0.0162
Schistosoma mansoni coup transcription factor 0.1026 0.4852 0.4852
Trypanosoma brucei carbonic anhydrase-like protein 0.0377 0.1743 0.6534
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Echinococcus multilocularis FTZ F1 alpha 0.1026 0.4852 0.4852
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0016 0.0036
Leishmania major beta tubulin 0.0569 0.2664 1
Echinococcus granulosus tissue type plasminogen activator 0.0033 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0249
Trichomonas vaginalis tubulin epsilon chain, putative 0.0569 0.2664 1
Brugia malayi nuclear receptor NHR-67 0.0484 0.2257 0.4339
Onchocerca volvulus 0.0279 0.1275 0.2452
Entamoeba histolytica hypothetical protein 0.0034 0.0103 0.0368
Brugia malayi Nuclear hormone receptor E75 0.0484 0.2257 0.4339
Trypanosoma cruzi zeta tubulin, putative 0.0148 0.065 0.2422
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0398 0.0398
Toxoplasma gondii beta-1 tubulin, putative 0.0569 0.2664 1
Toxoplasma gondii beta-tubulin, putative 0.0569 0.2664 1
Echinococcus granulosus nuclear receptor nhr 48 0.0484 0.2257 0.2257
Echinococcus granulosus peroxidasin 0.0683 0.3212 0.3212
Echinococcus multilocularis histone deacetylase 0.0051 0.0184 0.0184
Entamoeba histolytica hexokinase 1 0.0082 0.0334 0.1236
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Echinococcus multilocularis p2X purinoceptor 4 0.2102 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0484 0.2257 0.4339
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0006 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0048 0.017
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0092
Schistosoma mansoni alpha tubulin 0.051 0.2383 0.2383
Trichomonas vaginalis tubulin, putative 0.0193 0.0865 0.3233
Schistosoma mansoni cytochrome P450 0.0014 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0016 0.0016 0.0036
Schistosoma mansoni nuclear receptor 0.0484 0.2257 0.2257
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Leishmania major beta tubulin 0.0569 0.2664 1
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0184 0.0184
Onchocerca volvulus 0.0033 0.0099 0.019
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0069 0.0273 0.1002
Entamoeba histolytica hypothetical protein 0.0034 0.0103 0.0368
Loa Loa (eye worm) tubulin alpha 2 0.0362 0.1673 0.3217
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.1026 0.4852 0.9328
Brugia malayi Tubulin beta chain 0.0193 0.0865 0.1663
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0182
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0398 0.1476
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0148 0.065 0.2422
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0006 0.0024
Echinococcus granulosus hexokinase 0.0082 0.0334 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0156
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0157 0.057
Echinococcus multilocularis histone deacetylase 8 0.0022 0.0045 0.0045
Brugia malayi Cytochrome P450 family protein 0.0014 0.0006 0.0012
Echinococcus multilocularis geminin 0.0268 0.1221 0.1221
Echinococcus multilocularis mitogen activated protein kinase 14 0.0069 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0032 0.0094 0.0182
Mycobacterium ulcerans hypothetical protein 0.0023 0.0048 0.0181
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0024 0.0054 0.0181
Plasmodium falciparum alpha tubulin 1 0.051 0.2383 0.8941
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.1026 0.4852 0.9328
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0039
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0377 0.1743 0.3351
Trypanosoma cruzi tubulin delta chain 0.0148 0.065 0.2422
Echinococcus multilocularis tubulin alpha 1C chain 0.051 0.2383 0.2383
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0006 0.0024
Entamoeba histolytica cell division protein kinase 2, putative 0.0024 0.0054 0.0184
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0249
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0249
Trypanosoma cruzi alpha tubulin, putative 0.051 0.2383 0.8943
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0024 0.0054 0.0105
Echinococcus granulosus GPCR family 2 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0061 0.021
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0157 0.057
Onchocerca volvulus 0.0077 0.0308 0.0591
Loa Loa (eye worm) tubulin beta-4 chain 0.0569 0.2664 0.5122
Leishmania major beta tubulin 0.0569 0.2664 1
Trichomonas vaginalis tubulin, putative 0.0148 0.065 0.2424
Brugia malayi hypothetical protein 0.0542 0.2535 0.4873
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.002 0.0033
Echinococcus multilocularis tubulin epsilon chain 0.0342 0.1575 0.1575
Plasmodium vivax protein kinase Crk2 0.0024 0.0054 0.0161
Loa Loa (eye worm) hypothetical protein 0.0542 0.2535 0.4873
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0097 0.0343
Echinococcus granulosus tubulin alpha chain 0.051 0.2383 0.2383
Toxoplasma gondii beta tubulin 0.0569 0.2664 1
Entamoeba histolytica tubulin alpha chain, putative 0.051 0.2383 0.8944
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0484 0.2257 0.2257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1026 0.4852 0.9328
Onchocerca volvulus 0.0143 0.0627 0.1205
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Trypanosoma brucei epsilon tubulin 0.0342 0.1575 0.5903
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0129 0.0129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0216 0.0821
Echinococcus multilocularis tubulin alpha chain 0.051 0.2383 0.2383
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0024 0.0054 0.0105
Trypanosoma cruzi histone deacetylase 1, putative 0.0045 0.0157 0.0568
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0484 0.2257 0.2257
Schistosoma mansoni thyroid hormone receptor 0.1026 0.4852 0.4852
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0045 0.0157 0.057
Leishmania major delta tubulin, putative 0.0148 0.065 0.2422
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0012 0.0012
Leishmania major histone deacetylase, putative 0.0045 0.0157 0.0568
Brugia malayi Cytochrome P450 family protein 0.0014 0.0006 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.1026 0.4852 0.9328
Leishmania major beta tubulin 0.0569 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.0279 0.1275 0.2452
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0002 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0683 0.3212 0.6174
Echinococcus granulosus carbonic anhydrase 0.0177 0.0787 0.0787
Plasmodium vivax delta tubulin, putative 0.0148 0.065 0.2406
Brugia malayi P38 map kinase family protein 2 0.0069 0.0273 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Echinococcus multilocularis tubulin subunit TubB 0.051 0.2383 0.2383
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0012
Entamoeba histolytica cell division protein kinase 2, putative 0.0024 0.0054 0.0184
Echinococcus multilocularis cyclin dependent kinase 5 0.0024 0.0054 0.0054
Loa Loa (eye worm) nuclear receptor NHR-67 0.0484 0.2257 0.4339
Echinococcus multilocularis tubulin alpha 1C chain 0.051 0.2383 0.2383
Schistosoma mansoni patched 1 0.0041 0.0136 0.0136
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0006 0.0024
Echinococcus granulosus histone deacetylase 6 0.0051 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Giardia lamblia Kinase, CMGC CDK 0.0024 0.0054 0.0104
Brugia malayi nuclear receptor RXR 0.0484 0.2257 0.4339
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0006 0.0024
Schistosoma mansoni histone deacetylase hda2 0.0054 0.0199 0.0199
Leishmania major beta tubulin 0.0569 0.2664 1
Leishmania major beta tubulin 0.0569 0.2664 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0177 0.0787 0.1513
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0167 0.032
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0048 0.0156
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0484 0.2257 0.2257
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Plasmodium falciparum tubulin gamma chain 0.0342 0.1575 0.5894
Trypanosoma cruzi cdc2-related kinase 3 0.0024 0.0054 0.0181
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0103 0.0103
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0058 0.0216 0.0861
Brugia malayi hypothetical protein 0.0484 0.2257 0.4339
Loa Loa (eye worm) hexokinase 0.0082 0.0334 0.0642
Echinococcus granulosus peroxisome assembly protein 26 0.051 0.2383 0.2383
Trichomonas vaginalis bromodomain-containing protein, putative 0.0025 0.0061 0.021
Brugia malayi SWIRM domain containing protein 0.004 0.0129 0.0249
Toxoplasma gondii aldehyde dehydrogenase 0.0058 0.0216 0.0789
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0216 0.0216
Schistosoma mansoni tubulin subunit beta 0.0569 0.2664 0.2664
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0013 0.0002 0.0003
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.029
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0136 0.0136
Brugia malayi tailless protein 0.0484 0.2257 0.4339
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0103 0.0103
Loa Loa (eye worm) runx1 0.0035 0.0107 0.0207
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Plasmodium falciparum protein kinase 5 0.0024 0.0054 0.0161
Schistosoma mansoni microtubule-associated protein tau 0.0655 0.3077 0.3077
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0032 0.0095 0.0257
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0086
Loa Loa (eye worm) tubulin alpha-3 chain 0.0317 0.1458 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Echinococcus granulosus FTZ F1 alpha 0.1026 0.4852 0.4852
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Loa Loa (eye worm) hexokinase type II 0.0082 0.0334 0.0642
Loa Loa (eye worm) hypothetical protein 0.0542 0.2535 0.4873
Onchocerca volvulus 0.0077 0.0308 0.0591
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0045 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.1026 0.4852 0.9328
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0157 0.057
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0484 0.2257 0.2257
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.0167 0.032
Brugia malayi Tubulin beta-1 chain 0.0569 0.2664 0.5122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0484 0.2257 0.2257
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0077 0.0308 0.0591
Loa Loa (eye worm) animal heme peroxidase 0.0683 0.3212 0.6174
Echinococcus multilocularis beta tubulin 0.0569 0.2664 0.2664
Brugia malayi Nuclear hormone receptor family member nhr-1 0.1026 0.4852 0.9328
Trichomonas vaginalis tubulin alpha chain, putative 0.0193 0.0865 0.3233
Trichomonas vaginalis CMGC family protein kinase 0.0024 0.0054 0.0184
Schistosoma mansoni hypothetical protein 0.0014 0.0006 0.0006
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0032 0.0095 0.0095
Schistosoma mansoni nuclear hormone receptor 0.1026 0.4852 0.4852
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Trichomonas vaginalis bromodomain-containing protein, putative 0.0025 0.0061 0.021
Brugia malayi Kringle domain containing protein 0.0033 0.0099 0.019
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0028 0.0076 0.0146
Loa Loa (eye worm) BEN-1 protein 0.0569 0.2664 0.5122
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Toxoplasma gondii histone deacetylase HDAC1 0.0051 0.0184 0.0668
Echinococcus multilocularis tubulin subunit beta 0.0569 0.2664 0.2664
Echinococcus granulosus Tubulin alpha 1 chain 0.051 0.2383 0.2383
Trypanosoma brucei tubulin delta chain 0.0148 0.065 0.2422
Echinococcus granulosus Tubulin beta 2C chain 0.0569 0.2664 0.2664
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0006 0.0024
Loa Loa (eye worm) nuclear hormone receptor 0.0484 0.2257 0.4339
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0092
Loa Loa (eye worm) TK/ROR protein kinase 0.0033 0.0099 0.019
Trypanosoma brucei beta tubulin 0.0569 0.2664 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0148 0.065 0.2424
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0216 0.0821
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0048 0.0159
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0041 0.0135 0.0135
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0012 0.002
Echinococcus granulosus tubulin alpha 1C chain 0.051 0.2383 0.2383
Loa Loa (eye worm) steroid hormone receptor 0.1026 0.4852 0.9328
Leishmania major epsilon tubulin, putative 0.0342 0.1575 0.5903
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0542 0.2535 0.4873
Echinococcus multilocularis tubulin alpha chain 0.051 0.2383 0.2383
Onchocerca volvulus 0.0077 0.0308 0.0591
Loa Loa (eye worm) MH2 domain-containing protein 0.0113 0.0483 0.0928
Echinococcus granulosus p2X purinoceptor 4 0.2102 1 1
Schistosoma mansoni tubulin subunit beta 0.0569 0.2664 0.2664
Trypanosoma brucei histone deacetylase 4 0.0051 0.0184 0.0668
Echinococcus multilocularis Tubulin beta 2C chain 0.0569 0.2664 0.2664
Schistosoma mansoni thyroid hormone receptor 0.1026 0.4852 0.4852
Loa Loa (eye worm) histone deacetylase 0.0051 0.0184 0.0354
Schistosoma mansoni hypothetical protein 0.004 0.0129 0.0129
Echinococcus multilocularis tubulin alpha chain 0.051 0.2383 0.2383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.1026 0.4852 0.9328
Onchocerca volvulus 0.0484 0.2257 0.4339
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0044 0.0151 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0136 0.0493
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0077 0.0308 0.0591
Trichomonas vaginalis tubulin beta chain, putative 0.051 0.2383 0.8944
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0006 0.0012
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0055 0.0203 0.0741
Echinococcus multilocularis mitogen activated protein kinase 11 0.0069 0.0273 0.0273
Loa Loa (eye worm) hexokinase 0.0082 0.0334 0.0642
Trichomonas vaginalis tubulin beta chain, putative 0.051 0.2383 0.8944
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0157 0.057
Echinococcus granulosus mitogen activated protein kinase 14 0.0069 0.0273 0.0273
Loa Loa (eye worm) hexokinase 0.0052 0.0187 0.036
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Brugia malayi Animal haem peroxidase family protein 0.0683 0.3212 0.6174
Brugia malayi ecdysone receptor 0.0484 0.2257 0.4339
Loa Loa (eye worm) hypothetical protein 0.0542 0.2535 0.4873
Schistosoma mansoni hypothetical protein 0.0034 0.0103 0.0103
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Loa Loa (eye worm) hypothetical protein 0.0317 0.1458 0.2803
Schistosoma mansoni hypothetical protein 0.0268 0.1221 0.1221
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0362 0.1673 0.6273
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.0186
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.1026 0.4852 0.4852
Loa Loa (eye worm) hypothetical protein 0.1026 0.4852 0.9328
Loa Loa (eye worm) animal heme peroxidase 0.0683 0.3212 0.6174
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0048 0.0092
Echinococcus granulosus Tubulin alpha 1 chain 0.051 0.2383 0.2383
Toxoplasma gondii bromodomain-containing protein 0.0018 0.0027 0.0078
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0045 0.0157 0.057
Trypanosoma cruzi cdc2-related kinase 1 0.0024 0.0054 0.0181
Echinococcus granulosus Tubulin alpha 1 chain 0.051 0.2383 0.2383
Schistosoma mansoni hypothetical protein 0.004 0.0129 0.0129
Brugia malayi Animal haem peroxidase family protein 0.0683 0.3212 0.6174
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.0186
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0177 0.0787 0.1513
Echinococcus granulosus alpha tubulin 0.051 0.2383 0.2383
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0058 0.0216 0.0789
Echinococcus granulosus expressed conserved protein 0.009 0.037 0.037
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0484 0.2257 0.2257
Trypanosoma brucei beta tubulin 0.0342 0.1575 0.5903
Plasmodium falciparum histone deacetylase 2 0.0051 0.0184 0.0649
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0055 0.0203 0.0741
Echinococcus granulosus microtubule associated protein 2 0.0655 0.3077 0.3077
Leishmania major carbonic anhydrase-like protein 0.0377 0.1743 0.6534
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0484 0.2257 0.2257
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0013 0.0002 0.0003
Brugia malayi Stress-activated protein kinase jnk-1 0.0127 0.0547 0.1051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0092
Schistosoma mansoni nuclear receptor 0.0484 0.2257 0.2257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.1026 0.4852 0.9328
Trichomonas vaginalis tubulin epsilon chain, putative 0.051 0.2383 0.8944
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.002 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.1026 0.4852 0.4852
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0048 0.0181
Echinococcus multilocularis GPCR, family 2 0.0015 0.0012 0.0012
Onchocerca volvulus 0.0082 0.0334 0.0642
Plasmodium falciparum tubulin epsilon chain, putative 0.0342 0.1575 0.5894
Toxoplasma gondii histone deacetylase HDAC3 0.0045 0.0157 0.0568
Echinococcus multilocularis Tubulin beta 2C chain 0.0569 0.2664 0.2664
Brugia malayi Blistered cuticle protein 3 0.0683 0.3212 0.6174
Brugia malayi beta-tubulin, identical 0.0569 0.2664 0.5122
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0127 0.0547 0.1051
Echinococcus multilocularis tumor protein p63 0.0321 0.1476 0.1476
Schistosoma mansoni Lysine-specific histone demethylase 1 0.004 0.0129 0.0129
Trypanosoma brucei alpha tubulin 0.051 0.2383 0.8943
Echinococcus multilocularis tubulin alpha 3 chain 0.051 0.2383 0.2383
Echinococcus multilocularis tubulin delta chain 0.0148 0.065 0.065
Loa Loa (eye worm) animal heme peroxidase 0.0683 0.3212 0.6174
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0048 0.0643
Onchocerca volvulus Hexokinase homolog 0.0052 0.0187 0.036
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0013 0.0026
Echinococcus granulosus beta tubulin 0.0569 0.2664 0.2664
Loa Loa (eye worm) tubulin alpha-2 chain 0.051 0.2383 0.4582
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.1026 0.4852 0.4852
Leishmania major beta tubulin 0.0569 0.2664 1
Brugia malayi nuclear receptor RXR 0.0542 0.2535 0.4873
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0184 0.0184
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0006 0.0024
Echinococcus multilocularis p2X purinoceptor 4 0.2102 1 1
Trypanosoma brucei alpha tubulin, putative 0.0193 0.0865 0.3231
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0006 0.0024
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0184 0.0668
Brugia malayi hypothetical protein 0.0033 0.0097 0.0186
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0184 0.0668
Echinococcus granulosus tubulin alpha chain 0.051 0.2383 0.2383
Echinococcus multilocularis tubulin alpha 0.0342 0.1575 0.1575
Schistosoma mansoni peroxidasin 0.0683 0.3212 0.3212
Brugia malayi hypothetical protein 0.0015 0.0014 0.0027
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Trichomonas vaginalis tubulin beta chain, putative 0.051 0.2383 0.8944
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0177 0.0787 0.1513
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0542 0.2535 0.2535
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0012 0.0022
Trypanosoma brucei cdc2-related kinase 3 0.0024 0.0054 0.0181
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0184 0.0184
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0184 0.0668
Leishmania major beta tubulin 0.0569 0.2664 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1026 0.4852 0.9328
Plasmodium falciparum tubulin delta chain, putative 0.0148 0.065 0.2406
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0377 0.1743 0.3351
Treponema pallidum cell division protein FtsZ 0.0148 0.065 1
Brugia malayi Nuclear hormone receptor-like 1 0.0542 0.2535 0.4873
Trypanosoma brucei zeta tubulin 0.0148 0.065 0.2422
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.002 0.0058
Echinococcus granulosus tubulin alpha 3 chain 0.051 0.2383 0.2383
Onchocerca volvulus Peroxidase homolog 0.0683 0.3212 0.6174
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.1026 0.4852 0.4852
Plasmodium falciparum cysteine repeat modular protein 1 0.0033 0.0099 0.0328
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0012 0.002
Echinococcus multilocularis mitogen activated protein kinase 14 0.0069 0.0273 0.0273
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0542 0.2535 0.2535
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Schistosoma mansoni hypothetical protein 0.0032 0.0095 0.0095
Trypanosoma brucei histone deacetylase 1 0.0045 0.0157 0.0568
Toxoplasma gondii histone deacetylase HDAC5 0.0022 0.0045 0.0144
Loa Loa (eye worm) histone deacetylase 1 0.0045 0.0157 0.0302
Brugia malayi steroid hormone receptor 0.1026 0.4852 0.9328
Loa Loa (eye worm) hypothetical protein 0.0045 0.0157 0.0302
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0033
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Echinococcus multilocularis thyroid hormone receptor alpha 0.1026 0.4852 0.4852
Schistosoma mansoni hexokinase 0.0082 0.0334 0.0334
Loa Loa (eye worm) tubulin beta-2A chain 0.0569 0.2664 0.5122
Onchocerca volvulus 0.0082 0.0334 0.0642
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0542 0.2535 0.2535
Giardia lamblia NADPH oxidoreductase, putative 0.0055 0.0203 0.0666
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0032 0.0095 0.0095
Trypanosoma cruzi epsilon tubulin, putative 0.0342 0.1575 0.5903
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0072 0.0282 0.0282
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0048 0.0643
Plasmodium vivax tubulin beta chain, putative 0.0569 0.2664 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Echinococcus granulosus cyclin dependent kinase 1 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0683 0.3212 0.6174
Brugia malayi Histone deacetylase family protein 0.0051 0.0184 0.0354
Schistosoma mansoni retinoid-x-receptor (RXR) 0.1026 0.4852 0.4852
Trypanosoma cruzi tubulin delta chain 0.0148 0.065 0.2422
Giardia lamblia Beta tubulin 0.0569 0.2664 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0006 0.0024
Schistosoma mansoni hypothetical protein 0.004 0.0129 0.0129
Onchocerca volvulus Dual oxidase homolog 0.0683 0.3212 0.6174
Echinococcus multilocularis hexokinase 0.0082 0.0334 0.0334
Plasmodium falciparum histone deacetylase 1 0.0045 0.0157 0.0548
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0148 0.065 0.2422
Echinococcus granulosus tubulin delta chain 0.0148 0.065 0.065
Echinococcus granulosus tubulin alpha chain 0.051 0.2383 0.2383
Brugia malayi Nuclear hormone receptor-like 1 0.1026 0.4852 0.9328
Trypanosoma cruzi epsilon tubulin, putative 0.0342 0.1575 0.5903
Trichomonas vaginalis tubulin, putative 0.0569 0.2664 1
Trypanosoma brucei alpha tubulin 0.051 0.2383 0.8943
Brugia malayi histone deacetylase 11 0.0022 0.0045 0.0086
Echinococcus granulosus tubulin alpha chain 0.051 0.2383 0.2383
Brugia malayi Tubulin gamma chain 0.0342 0.1575 0.3028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.1026 0.4852 0.4852
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0377 0.1743 0.1743
Leishmania major beta tubulin 0.0569 0.2664 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.0167 0.032
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0012 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0177 0.0787 0.0787
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0216 0.0821
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Trypanosoma cruzi cdc2-related kinase 1 0.0024 0.0054 0.0181
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0016 0.0016
Brugia malayi tubulin alpha-2 chain 0.051 0.2383 0.4582
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0048 0.0159
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0095 0.0095
Plasmodium vivax histone deacetylase 2, putative 0.0051 0.0184 0.0649
Echinococcus granulosus histone deacetylase 6 0.0051 0.0184 0.0184
Echinococcus multilocularis hypothetical protein 0.051 0.2383 0.2383
Brugia malayi Steroid receptor seven-up type 2 0.1026 0.4852 0.9328
Onchocerca volvulus 0.0193 0.0865 0.1663
Brugia malayi Tubulin alpha chain 0.0148 0.065 0.1249
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0095 0.0182
Onchocerca volvulus 0.0683 0.3212 0.6174
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Brugia malayi Histone deacetylase family protein 0.0051 0.0184 0.0354
Brugia malayi hypothetical protein 0.0034 0.0103 0.0199
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0006 0.0012
Brugia malayi hypothetical protein 0.0484 0.2257 0.4339
Brugia malayi Tubulin alpha chain 0.051 0.2383 0.4582
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0249
Brugia malayi hypothetical protein 0.0016 0.0016 0.0031
Echinococcus multilocularis mitogen activated protein kinase 11 0.0069 0.0273 0.0273
Trichomonas vaginalis tubulin gamma chain, putative 0.0342 0.1575 0.5904
Loa Loa (eye worm) hypothetical protein 0.0077 0.0308 0.0591
Brugia malayi alpha-tubulin 0.051 0.2383 0.4582
Schistosoma mansoni zinc finger protein 0.0484 0.2257 0.2257
Onchocerca volvulus Chorion peroxidase homolog 0.0683 0.3212 0.6174
Schistosoma mansoni P2X receptor subunit 0.2102 1 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0562 0.2629 1
Echinococcus multilocularis tubulin alpha 3 chain 0.051 0.2383 0.2383
Echinococcus granulosus bromodomain containing 2 0.0041 0.0135 0.0135
Toxoplasma gondii alpha tubulin TUBA1 0.051 0.2383 0.8943
Leishmania major beta tubulin 0.0569 0.2664 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0135 0.0488
Loa Loa (eye worm) tubulin alpha chain 0.051 0.2383 0.4582
Brugia malayi nuclear hormone receptor family member nhr-6 0.0484 0.2257 0.4339
Loa Loa (eye worm) BEN-1 protein 0.0569 0.2664 0.5122
Schistosoma mansoni amine oxidase 0.004 0.0129 0.0129
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.1026 0.4852 0.4852
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1026 0.4852 0.4852
Loa Loa (eye worm) hypothetical protein 0.0033 0.0097 0.0186
Echinococcus granulosus p2X purinoceptor 4 0.2102 1 1
Echinococcus multilocularis beta tubulin 0.0569 0.2664 0.2664
Echinococcus multilocularis 0.004 0.0129 0.0129
Entamoeba histolytica hypothetical protein 0.0034 0.0103 0.0368
Loa Loa (eye worm) hypothetical protein 0.0569 0.2664 0.5122
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0136 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1026 0.4852 0.9328
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0028 0.0076 0.0146
Loa Loa (eye worm) hypothetical protein 0.1099 0.5202 1
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0157 0.057
Echinococcus multilocularis tissue type plasminogen activator 0.0033 0.0099 0.0099
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Echinococcus granulosus carbonic anhydrase 0.0177 0.0787 0.0787
Echinococcus multilocularis protein patched 0.0041 0.0136 0.0136
Schistosoma mansoni tubulin subunit beta 0.0569 0.2664 0.2664
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.1026 0.4852 0.4852
Schistosoma mansoni tubulin subunit alpha 0.0148 0.065 0.065
Mycobacterium ulcerans cell division protein FtsZ 0.0148 0.065 0.2472
Brugia malayi Nuclear hormone receptor family member nhr-14 0.1026 0.4852 0.9328
Schistosoma mansoni tubulin subunit beta 0.0569 0.2664 0.2664
Brugia malayi amine oxidase, flavin-containing family protein 0.004 0.0129 0.0249
Trypanosoma brucei histone deacetylase, putative 0.0051 0.0184 0.0668
Schistosoma mansoni carbonic anhydrase 0.0177 0.0787 0.0787
Schistosoma mansoni tubulin subunit beta 0.0569 0.2664 0.2664
Brugia malayi CHE-14 protein 0.0041 0.0136 0.0262
Trichomonas vaginalis tubulin alpha chain, putative 0.0193 0.0865 0.3233
Echinococcus multilocularis Protein lozenge 0.0035 0.0107 0.0107
Echinococcus granulosus histone deacetylase 0.0051 0.0184 0.0184
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0006 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Echinococcus multilocularis lysine specific histone demethylase 1A 0.004 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Echinococcus granulosus cyclin dependent kinase 5 0.0024 0.0054 0.0054
Brugia malayi hexokinase type II 0.0026 0.0065 0.0125
Entamoeba histolytica tubulin alpha-1 chain 0.051 0.2383 0.8944
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.1026 0.4852 0.9328
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.077 0.3626 0.3626
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0027 0.0081
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0722 0.3397 0.653
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0024 0.0054 0.0054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0044 0.0151 0.029
Trypanosoma brucei beta tubulin 0.0569 0.2664 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0055 0.0203 0.0741
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0048 0.017
Plasmodium falciparum alpha tubulin 2 0.051 0.2383 0.8941
Loa Loa (eye worm) hypothetical protein 0.0306 0.1404 0.2698
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0077 0.0308 0.0591
Trichomonas vaginalis tubulin epsilon chain, putative 0.0148 0.065 0.2424
Echinococcus granulosus Nuclear hormone receptor HR96 0.0484 0.2257 0.2257
Schistosoma mansoni P2X receptor subunit 0.2102 1 1
Entamoeba histolytica tubulin family protein 0.0569 0.2664 1
Giardia lamblia Delta tubulin 0.0148 0.065 0.2362
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0103 0.0103
Toxoplasma gondii LsmAD domain-containing protein 0.0016 0.0016 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.065 0.2424
Echinococcus granulosus beta tubulin 0.0569 0.2664 0.2664
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Echinococcus granulosus tubulin gamma 1 chain 0.0342 0.1575 0.1575
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0012
Trypanosoma brucei epsilon tubulin 0.0342 0.1575 0.5903
Loa Loa (eye worm) hypothetical protein 0.051 0.2383 0.4582
Trichomonas vaginalis tubulin gamma chain, putative 0.0569 0.2664 1
Echinococcus granulosus hexokinase 0.0082 0.0334 0.0334
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.002 0.0078
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0006 0.0024
Onchocerca volvulus 0.0082 0.0334 0.0642
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0012 0.002
Brugia malayi ecdysteroid receptor 0.1099 0.5202 1
Schistosoma mansoni lozenge 0.0035 0.0107 0.0107
Echinococcus multilocularis tubulin gamma 1 chain 0.0342 0.1575 0.1575
Plasmodium vivax histone deacetylase, putative 0.0022 0.0045 0.0124
Trypanosoma brucei tubulin gamma chain 0.0342 0.1575 0.5903
Toxoplasma gondii kringle domain-containing protein 0.0033 0.0099 0.0347
Mycobacterium ulcerans dehydrogenase 0.004 0.0129 0.0492
Loa Loa (eye worm) hypothetical protein 0.1026 0.4852 0.9328
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0377 0.1743 0.6534
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0069 0.0273 0.1002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.004
Plasmodium falciparum protoporphyrinogen oxidase 0.004 0.0129 0.0443
Trichomonas vaginalis tubulin beta chain, putative 0.051 0.2383 0.8944
Loa Loa (eye worm) beta-tubulin 0.0569 0.2664 0.5122
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0054 0.0054
Echinococcus multilocularis Tubulin alpha 1 chain 0.051 0.2383 0.2383
Schistosoma mansoni histone deacetylase 1 2 3 0.0022 0.0045 0.0045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0135 0.0488
Brugia malayi histone deacetylase 3 (HD3) 0.0045 0.0157 0.0302
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0177 0.0787 0.1513
Loa Loa (eye worm) hypothetical protein 0.0177 0.0787 0.1513
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0562 0.2629 1
Loa Loa (eye worm) histone deacetylase 7A 0.0051 0.0184 0.0354
Brugia malayi Animal haem peroxidase family protein 0.0683 0.3212 0.6174
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.004 0.0129 0.0463
Entamoeba histolytica histone deacetylase, putative 0.0045 0.0157 0.057
Trichomonas vaginalis tubulin, putative 0.0193 0.0865 0.3233
Trichomonas vaginalis tubulin beta chain, putative 0.051 0.2383 0.8944
Echinococcus multilocularis peroxidasin 0.0683 0.3212 0.3212
Onchocerca volvulus 0.0023 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.029
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0522 0.244 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0048 0.0181
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0216 0.0216
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0542 0.2535 0.4873
Brugia malayi Trypsin family protein 0.0069 0.0272 0.0523
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Onchocerca volvulus Peroxidasin homolog 0.0683 0.3212 0.6174
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Entamoeba histolytica tubulin family protein 0.0569 0.2664 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0181 0.0347
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1026 0.4852 0.4852
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0006 0.0024
Brugia malayi Protein kinase domain containing protein 0.0033 0.0099 0.019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.004
Loa Loa (eye worm) alpha-tubulin 0.051 0.2383 0.4582
Onchocerca volvulus 0.1026 0.4852 0.9328
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0398 0.0765
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0177 0.0787 0.1513
Plasmodium falciparum hexokinase 0.0082 0.0334 0.1216
Plasmodium falciparum tubulin beta chain 0.0569 0.2664 1
Brugia malayi Peroxidasin 0.0683 0.3212 0.6174
Brugia malayi hypothetical protein 0.0542 0.2535 0.4873
Entamoeba histolytica bromodomain-containing protein 0.0018 0.0027 0.0081
Schistosoma mansoni tubulin subunit delta 0.0148 0.065 0.065
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0002 0.0002
Schistosoma mansoni P2X receptor subunit 0.2102 1 1
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0263 0.12 0.12
Trichomonas vaginalis tubulin alpha chain, putative 0.0193 0.0865 0.3233
Loa Loa (eye worm) hypothetical protein 0.0041 0.0135 0.026
Echinococcus granulosus hexokinase type 2 0.0082 0.0334 0.0334
Echinococcus granulosus tubulin epsilon chain 0.0342 0.1575 0.1575
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Loa Loa (eye worm) tubulin alpha 2 0.0169 0.0748 0.1438
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0377 0.1743 0.6534
Brugia malayi Hexokinase family protein 0.0082 0.0334 0.0642
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.0167 0.032
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1026 0.4852 0.9328
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0377 0.1743 0.3351
Brugia malayi photoreceptor-specific nuclear receptor 0.1026 0.4852 0.9328
Trichomonas vaginalis bromodomain containing protein, putative 0.0025 0.0061 0.021
Onchocerca volvulus 0.0018 0.0027 0.0052
Loa Loa (eye worm) hypothetical protein 0.0069 0.0272 0.0523
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.0165 0.0165
Brugia malayi Hexokinase family protein 0.0025 0.0062 0.0119
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0028 0.0076 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1026 0.4852 0.4852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.1026 0.4852 0.9328
Loa Loa (eye worm) tubulin alpha 2 0.0362 0.1673 0.3217
Brugia malayi nuclear hormone receptor family member odr-7 0.0484 0.2257 0.4339
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0028 0.0076 0.0076
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0032 0.0095 0.0095
Onchocerca volvulus 0.0057 0.0212 0.0408
Toxoplasma gondii hexokinase 0.0082 0.0334 0.1234
Onchocerca volvulus 0.0044 0.0151 0.029
Schistosoma mansoni histone deacetylase 0.0045 0.0157 0.0157
Trichomonas vaginalis tubulin gamma chain, putative 0.0342 0.1575 0.5904
Loa Loa (eye worm) tubulin gamma chain 0.0342 0.1575 0.3028
Loa Loa (eye worm) hypothetical protein 0.0033 0.0099 0.019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0182
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0069 0.0273 0.1002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0102
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.004 0.0129 0.0129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0012 0.0022
Schistosoma mansoni tubulin subunit gamma 0.0342 0.1575 0.1575
Trypanosoma brucei hexokinase 0.0082 0.0334 0.1234
Loa Loa (eye worm) DR-78 0.0484 0.2257 0.4339
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0262
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0024 0.0054 0.0181
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0249
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0077 0.0308 0.0591
Echinococcus multilocularis peroxisome assembly protein 26 0.051 0.2383 0.2383
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0317 0.1458 0.5464
Echinococcus multilocularis ecdysone induced protein 78C 0.1026 0.4852 0.4852
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0033 0.0099 0.0099
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0569 0.2664 0.2664
Onchocerca volvulus 0.0033 0.0097 0.0186
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0012 0.0022
Trypanosoma cruzi hexokinase, putative 0.0082 0.0334 0.1234
Trichomonas vaginalis histone deacetylase, putative 0.0045 0.0157 0.057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1026 0.4852 0.9328
Onchocerca volvulus 0.0683 0.3212 0.6174
Loa Loa (eye worm) histone deacetylase 3 0.0045 0.0157 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0006 0.0012
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0027 0.0052
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.029
Leishmania major zeta tubulin, putative 0.0148 0.065 0.2422
Echinococcus multilocularis nuclear receptor nhr 48 0.0484 0.2257 0.2257
Echinococcus multilocularis tubulin alpha chain 0.051 0.2383 0.2383
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0012 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0113 0.0483 0.0928
Trypanosoma brucei hexokinase 0.0082 0.0334 0.1234
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1026 0.4852 0.4852
Brugia malayi Animal haem peroxidase family protein 0.0683 0.3212 0.6174
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Echinococcus multilocularis hexokinase 0.0082 0.0334 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.1026 0.4852 0.9328
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0542 0.2535 0.2535
Loa Loa (eye worm) hypothetical protein 0.0069 0.0272 0.0523
Schistosoma mansoni histone deacetylase hda2 0.0022 0.0045 0.0045
Trypanosoma cruzi histone deacetylase 1, putative 0.0045 0.0157 0.0568
Loa Loa (eye worm) hexokinase 0.0025 0.0062 0.0119
Onchocerca volvulus 0.004 0.0129 0.0249
Loa Loa (eye worm) hypothetical protein 0.0153 0.0671 0.1289
Loa Loa (eye worm) hypothetical protein 0.0362 0.1673 0.3217
Brugia malayi Tubulin alpha-2 chain 0.051 0.2383 0.4582
Onchocerca volvulus 0.0683 0.3212 0.6174
Leishmania major beta tubulin 0.0569 0.2664 1
Schistosoma mansoni amine oxidase 0.004 0.0129 0.0129
Echinococcus multilocularis Tubulin beta 2C chain 0.0569 0.2664 0.2664
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0398 0.0398
Brugia malayi hypothetical protein 0.0143 0.0627 0.1205
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Mycobacterium leprae cell division protein FtsZ 0.0148 0.065 1
Entamoeba histolytica hypothetical protein 0.0034 0.0103 0.0368
Brugia malayi orphan nuclear receptor NR2E1 0.0484 0.2257 0.4339
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0099 0.0347
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.1026 0.4852 0.4852
Trichomonas vaginalis tubulin epsilon chain, putative 0.0569 0.2664 1
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0048 0.0181
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0058 0.0216 0.0216
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.1026 0.4852 0.4852
Onchocerca volvulus 0.0484 0.2257 0.4339
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Loa Loa (eye worm) hypothetical protein 0.0143 0.0627 0.1205
Brugia malayi nuclear receptor NHR-88 0.0484 0.2257 0.4339
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0129 0.0506
Leishmania major gamma-tubulin 0.0342 0.1575 0.5903
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.004
Echinococcus granulosus thyroid hormone receptor alpha 0.0484 0.2257 0.2257
Onchocerca volvulus Peroxidasin homolog 0.0683 0.3212 0.6174
Echinococcus multilocularis cyclin dependent kinase 1 0.0024 0.0054 0.0054
Brugia malayi Bromodomain containing protein 0.0041 0.0135 0.026
Onchocerca volvulus 0.0077 0.0308 0.0591
Schistosoma mansoni tubulin subunit alpha 0.051 0.2383 0.2383
Brugia malayi Animal haem peroxidase family protein 0.0683 0.3212 0.6174
Trichomonas vaginalis tubulin alpha chain, putative 0.0342 0.1575 0.5904
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0184 0.0184
Trypanosoma cruzi cdc2-related kinase 3 0.0024 0.0054 0.0181
Plasmodium vivax histone deacetylase, putative 0.0051 0.0184 0.0649
Brugia malayi Nuclear hormone receptor E75 0.0484 0.2257 0.4339
Plasmodium vivax protoporphyrinogen oxidase, putative 0.004 0.0129 0.0443
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0006 0.0024
Brugia malayi hypothetical protein 0.0044 0.0151 0.029
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0484 0.2257 0.4339
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.004 0.0129 0.1911
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0032 0.0095 0.0095
Echinococcus granulosus histone deacetylase 1 0.0045 0.0157 0.0157
Leishmania major alpha tubulin 0.051 0.2383 0.8943
Schistosoma mansoni nuclear hormone receptor 0.0484 0.2257 0.2257
Trichomonas vaginalis CMGC family protein kinase 0.0024 0.0054 0.0184
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0006 0.0012
Brugia malayi hexokinase 0.0082 0.0334 0.0642
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0069 0.0273 0.1002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0484 0.2257 0.2257
Echinococcus granulosus tubulin alpha 1C chain 0.051 0.2383 0.2383
Trichomonas vaginalis bromodomain-containing protein, putative 0.0018 0.0027 0.0081
Onchocerca volvulus 0.0077 0.0308 0.0591
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.029
Schistosoma mansoni alpha tubulin 0.051 0.2383 0.2383
Plasmodium falciparum histone deacetylase, putative 0.0051 0.0184 0.0649
Leishmania major beta tubulin 0.0569 0.2664 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0012 0.0022
Schistosoma mansoni carbonic anhydrase-related 0.0177 0.0787 0.0787
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0018 0.0027 0.0081
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.004 0.0129 0.0443
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0012 0.0023
Plasmodium falciparum carbonic anhydrase 0.0177 0.0787 0.2922
Trichomonas vaginalis CMGC family protein kinase 0.0024 0.0054 0.0184
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0484 0.2257 0.4339
Brugia malayi Nuclear hormone receptor-like 1 0.0542 0.2535 0.4873
Echinococcus multilocularis hexokinase type 2 0.0082 0.0334 0.0334
Brugia malayi nuclear hormone receptor 0.1026 0.4852 0.9328
Onchocerca volvulus Bile acid receptor homolog 0.1099 0.5202 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.1026 0.4852 0.4852
Schistosoma mansoni tubulin subunit beta 0.0569 0.2664 0.2664
Onchocerca volvulus Histone deacetylase 10 homolog 0.0022 0.0045 0.0086
Trichomonas vaginalis bromodomain containing protein, putative 0.0018 0.0027 0.0081
Brugia malayi Hexokinase family protein 0.0052 0.0187 0.036
Brugia malayi Tubulin alpha-2 chain 0.051 0.2383 0.4582
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0048 0.0181
Loa Loa (eye worm) hypothetical protein 0.0683 0.3212 0.6174
Schistosoma mansoni hypothetical protein 0.0268 0.1221 0.1221
Onchocerca volvulus Arrow homolog 0.0015 0.0013 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0203 0.0741
Echinococcus granulosus c-Jun N-terminal kinases 0.0127 0.0547 0.0547
Onchocerca volvulus 0.003 0.0084 0.0162
Leishmania major histone deacetylase, putative 0.0045 0.0157 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-3 0.1026 0.4852 0.9328
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0129 0.0506
Echinococcus granulosus tubulin beta 1 chain 0.0569 0.2664 0.2664
Brugia malayi Cytochrome P450 family protein 0.0014 0.0006 0.0012
Echinococcus granulosus histone deacetylase 7 0.0051 0.0184 0.0184
Echinococcus multilocularis Bromodomain containing protein 0.0018 0.0027 0.0027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.1026 0.4852 0.4852
Echinococcus granulosus histone deacetylase 8 0.0022 0.0045 0.0045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0069 0.0272 0.0272
Giardia lamblia Gamma tubulin 0.0342 0.1575 0.5871

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) > 500 ug ml-1 Cytostatic activity against proliferation of L1210/0 cells ChEMBL. 3959027
ID50 (functional) > 500 ug ml-1 Cytostatic activity against proliferation of L1210/BdU cells ChEMBL. 3959027
ID50 (functional) > 500 ug ml-1 Cytostatic activity against proliferation of Raji/0 cells ChEMBL. 3959027
ID50 (functional) > 500 ug ml-1 Cytostatic activity against proliferation of Raji/TK cells ChEMBL. 3959027

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.