TDR Targets

Basic information

Technical information

TDR Targets ID: 1847192
Name: [(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hyd roxyoxolan-2-yl]methyl diphenyl phosphate
MW: 460.374 | Formula: C21H21N2O8P
H donors: 2 H acceptors: 4 LogP: 1.73 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O[C@H]1C[C@@H](O[C@@H]1COP(=O)(Oc1ccccc1)Oc1ccccc1)n1ccc(=O)[nH]c1=O
InChi: 1S/C21H21N2O8P/c24-17-13-20(23-12-11-19(25)22-21(23)26)29-18(17)14-28-32(27,30-15-7-3-1-4-8-15)31-16-9-5-2-6-10-16/h1-12,17-18,20,24H,13-14H2,(H,22,25,26)/t17-,18+,20+/m0/s1
InChiKey: IHWNCZRHSNSIGL-NLWGTHIKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl diphenyl phosphate
phosphoric acid [(2R,3S,5R)-5-(2,4-dioxo-1-pyrimidinyl)-3-hydroxy-2-tetrahydrofuranyl]methyl diphenyl ester
phosphoric acid [(2R,3S,5R)-5-(2,4-diketopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl diphenyl ester
[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methyl diphenyl phosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	multidrug resistance protein 1	0.00197218	0.000900114	0.00125373
Trypanosoma brucei	alpha tubulin	0.0171756	0.526614	0.732087
Onchocerca volvulus		0.00255429	0.0210286	0.0252784
Echinococcus granulosus	beta tubulin	0.0227089	0.71795	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0171756	0.526614	0.660218
Trypanosoma brucei	epsilon tubulin	0.0123034	0.35814	0.496187
Entamoeba histolytica	ABC transporter, putative	0.00704352	0.176261	0.220227
Echinococcus multilocularis	tubulin alpha chain	0.0171756	0.526614	0.733497
Brugia malayi	Tubulin beta-1 chain	0.0227089	0.71795	0.900507
Plasmodium vivax	ABC transporter G family member 2, putative	0.00704352	0.176261	0.244559
Plasmodium vivax	hypothetical protein, conserved	0.00217364	0.00786626	0.009715
Trichomonas vaginalis	tubulin beta chain, putative	0.0171756	0.526614	0.660218
Trichomonas vaginalis	tubulin, putative	0.00534198	0.117424	0.146336
Echinococcus multilocularis	tubulin subunit beta	0.0227089	0.71795	1
Loa Loa (eye worm)	hypothetical protein	0.0101797	0.284707	0.357145
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00197218	0.000900114	0.00125373
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.00534198	0.117424	0.162504
Plasmodium vivax	tubulin alpha chain, putative	0.0171756	0.526614	0.733162
Schistosoma mansoni	amine oxidase	0.00217364	0.00786626	0.009715
Echinococcus granulosus	ATP binding cassette sub family G	0.00704352	0.176261	0.245506
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Leishmania major	beta tubulin	0.0227089	0.71795	1
Loa Loa (eye worm)	tubulin alpha chain	0.0171756	0.526614	0.660601
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0171756	0.526614	0.660601
Loa Loa (eye worm)	hypothetical protein	0.00217364	0.00786626	0.00986768
Echinococcus multilocularis	tubulin subunit TubB	0.0171756	0.526614	0.733497
Leishmania major	beta tubulin	0.0227089	0.71795	1
Echinococcus granulosus	ATP binding cassette sub family G	0.00704352	0.176261	0.245506
Echinococcus multilocularis	protoporphyrinogen oxidase	0.00217364	0.00786626	0.0109566
Onchocerca volvulus	Peroxidase homolog	0.00255429	0.0210286	0.0252784
Brugia malayi	amine oxidase, flavin-containing family protein	0.00217364	0.00786626	0.00874843
Schistosoma mansoni	alpha tubulin	0.0171756	0.526614	0.733162
Giardia lamblia	Beta tubulin	0.0227089	0.71795	0.883452
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.00534198	0.117424	0.5
Leishmania major	p450 reductase, putative	0.00205537	0.00377683	0.00401187
Brugia malayi	Peroxidasin	0.00255429	0.0210286	0.0252784
Toxoplasma gondii	beta tubulin	0.0227089	0.71795	1
Loa Loa (eye worm)	hypothetical protein	0.00197218	0.000900114	0.00112913
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00197218	0.000900114	0.00125373
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0113509	0.325205	0.452963
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.025	0.797174	1
Echinococcus granulosus	death domain containing protein	0.00882757	0.237951	0.331431
Loa Loa (eye worm)	hypothetical protein	0.00217364	0.00786626	0.00986768
Trypanosoma brucei	zeta tubulin, putative	0.00534198	0.117424	0.159131
Leishmania major	beta tubulin	0.0227089	0.71795	1
Trypanosoma cruzi	ABC transporter, putative	0.00704352	0.176261	0.241516
Giardia lamblia	Beta tubulin	0.0227089	0.71795	0.883452
Plasmodium vivax	tubulin alpha chain, putative	0.0171756	0.526614	0.733162
Giardia lamblia	ABC transporter	0.00701749	0.175361	0.085233
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.00217364	0.00786626	0.009715
Loa Loa (eye worm)	tubulin beta-2A chain	0.0227089	0.71795	0.90062
Leishmania major	beta tubulin	0.0227089	0.71795	1
Leishmania major	beta tubulin	0.0227089	0.71795	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.00217364	0.00786626	0.009715
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00197218	0.000900114	0.00125373
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0118336	0.341895	0.428238
Plasmodium vivax	tubulin epsilon chain, putative	0.0123034	0.35814	0.498208
Giardia lamblia	Beta tubulin	0.0227089	0.71795	0.883452
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.025	0.797174	0.796405
Leishmania major	beta tubulin	0.0227089	0.71795	1
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Plasmodium falciparum	ABC transporter G family member 2	0.00704352	0.176261	0.244559
Plasmodium falciparum	nitric oxide synthase, putative	0.00205537	0.00377683	0.00401187
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0227089	0.71795	0.900507
Schistosoma mansoni	tumor necrosis factor receptor related	0.0113509	0.325205	0.452276
Trypanosoma cruzi	UDP-galactopyranose mutase	0.00217364	0.00786626	0.0057261
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Echinococcus multilocularis	ATP binding cassette sub family G	0.00704352	0.176261	0.245506
Echinococcus granulosus	Tubulin alpha 1 chain	0.0171756	0.526614	0.733497
Schistosoma mansoni	tubulin subunit beta	0.0227089	0.71795	1
Schistosoma mansoni	tubulin subunit gamma	0.0123034	0.35814	0.498208
Loa Loa (eye worm)	blistered cuticle protein 3	0.00255429	0.0210286	0.026379
Brugia malayi	alpha-tubulin	0.0171756	0.526614	0.660218
Trichomonas vaginalis	tubulin alpha chain, putative	0.0069614	0.173421	0.21666
Schistosoma mansoni	tubulin subunit beta	0.0227089	0.71795	1
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Loa Loa (eye worm)	hypothetical protein	0.00217364	0.00786626	0.00986768
Brugia malayi	Tubulin alpha-2 chain	0.0171756	0.526614	0.660218
Loa Loa (eye worm)	tubulin alpha 2	0.0118336	0.341895	0.428884
Echinococcus granulosus	multidrug resistance protein 1	0.00197218	0.000900114	0.00125373
Leishmania major	beta tubulin	0.0227089	0.71795	1
Schistosoma mansoni	ABC transporter	0.00600032	0.140188	0.194252
Echinococcus multilocularis	tubulin alpha chain	0.0171756	0.526614	0.733497
Loa Loa (eye worm)	hypothetical protein	0.00217364	0.00786626	0.00986768
Brugia malayi	hypothetical protein	0.00217364	0.00786626	0.00874843
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00882757	0.237951	0.2977
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.025	0.797174	1
Giardia lamblia	Gamma tubulin	0.0123034	0.35814	0.354125
Echinococcus granulosus	tubulin alpha chain	0.0171756	0.526614	0.733497
Echinococcus multilocularis	peroxisome assembly protein 26	0.0171756	0.526614	0.733497
Echinococcus granulosus	peroxidasin	0.00255429	0.0210286	0.0292898
Echinococcus multilocularis	tubulin epsilon chain	0.0123034	0.35814	0.498837
Loa Loa (eye worm)	beta-tubulin	0.0227089	0.71795	0.90062
Trypanosoma brucei	alpha tubulin	0.0171756	0.526614	0.732087
Toxoplasma gondii	alpha-tubulin I, putative	0.0171756	0.526614	0.733162
Mycobacterium leprae	cell division protein FtsZ	0.00534198	0.117424	1
Trichomonas vaginalis	tubulin, putative	0.0069614	0.173421	0.21666
Schistosoma mansoni	tubulin subunit beta	0.0227089	0.71795	1
Schistosoma mansoni	tubulin subunit beta	0.0227089	0.71795	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.025	0.797174	1
Mycobacterium ulcerans	monoamine oxidase	0.00217364	0.00786626	0.00410493
Loa Loa (eye worm)	hypothetical protein	0.00882757	0.237951	0.298493
Brugia malayi	Animal haem peroxidase family protein	0.00255429	0.0210286	0.0252784
Echinococcus granulosus	tubulin alpha 3 chain	0.0171756	0.526614	0.733497
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0308656	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0123034	0.35814	0.44864
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.00704352	0.176261	0.244559
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.00205537	0.00377683	0.00526057
Toxoplasma gondii	histone lysine-specific demethylase	0.00217364	0.00786626	0.009715
Echinococcus multilocularis	Tubulin beta 2C chain	0.0227089	0.71795	1
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.00704352	0.176261	0.244559
Schistosoma mansoni	peroxidasin	0.00255429	0.0210286	0.0280713
Echinococcus granulosus	Tubulin alpha 1 chain	0.0171756	0.526614	0.733497
Trichomonas vaginalis	tubulin gamma chain, putative	0.00534198	0.117424	0.146336
Entamoeba histolytica	tubulin gamma chain	0.0123034	0.35814	0.44864
Brugia malayi	Tubulin beta chain	0.00534198	0.117424	0.146336
Echinococcus multilocularis	tubulin alpha chain	0.0171756	0.526614	0.733497
Echinococcus multilocularis	tubulin alpha 3 chain	0.0171756	0.526614	0.733497
Trypanosoma cruzi	tubulin delta chain	0.00534198	0.117424	0.159131
Echinococcus multilocularis	ATP binding cassette sub family G	0.00704352	0.176261	0.245506
Echinococcus multilocularis	Ankyrin	0.00882757	0.237951	0.331431
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0113509	0.325205	0.452963
Trypanosoma cruzi	zeta tubulin, putative	0.00534198	0.117424	0.159131
Loa Loa (eye worm)	animal heme peroxidase	0.00255429	0.0210286	0.026379
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0171756	0.526614	0.733497
Echinococcus granulosus	tubulin alpha chain	0.0171756	0.526614	0.733497
Trypanosoma cruzi	beta tubulin, putative	0.0227089	0.71795	1
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.00217364	0.00786626	0.009715
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00197218	0.000900114	0.00125373
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.00534198	0.117424	0.162504
Trichomonas vaginalis	tubulin gamma chain, putative	0.0227089	0.71795	0.900507
Trypanosoma brucei	tubulin gamma chain	0.0123034	0.35814	0.496187
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Leishmania major	delta tubulin, putative	0.00534198	0.117424	0.162504
Echinococcus granulosus	Tubulin beta 2C chain	0.0227089	0.71795	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.00217364	0.00786626	0.009715
Mycobacterium ulcerans	oxidoreductase	0.00217364	0.00786626	0.00410493
Trypanosoma brucei	beta tubulin	0.0227089	0.71795	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0171756	0.526614	0.660218
Echinococcus granulosus	ATP binding cassette sub family G	0.00704352	0.176261	0.245506
Loa Loa (eye worm)	alpha-tubulin	0.0171756	0.526614	0.660601
Trichomonas vaginalis	conserved hypothetical protein	0.00534198	0.117424	0.146336
Echinococcus granulosus	tubulin alpha 3 chain	0.0171756	0.526614	0.733497
Leishmania major	beta tubulin	0.0227089	0.71795	1
Brugia malayi	tubulin alpha chain - mouse	0.0171756	0.526614	0.660218
Trypanosoma brucei	tubulin delta chain	0.00534198	0.117424	0.159131
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.00882757	0.237951	0.331431
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0069614	0.173421	0.21666
Loa Loa (eye worm)	tubulin gamma chain	0.0123034	0.35814	0.449262
Trypanosoma brucei	ABC transporter, putative	0.00704352	0.176261	0.241516
Leishmania major	beta tubulin	0.0227089	0.71795	1
Mycobacterium ulcerans	dehydrogenase	0.00217364	0.00786626	0.00410493
Trichomonas vaginalis	tubulin gamma chain, putative	0.0123034	0.35814	0.44864
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.00205537	0.00377683	0.00526057
Schistosoma mansoni	tubulin subunit alpha	0.0171756	0.526614	0.733162
Toxoplasma gondii	alpha tubulin TUBA1	0.0171756	0.526614	0.733162
Entamoeba histolytica	tubulin family protein	0.0227089	0.71795	0.900507
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.00217364	0.00786626	0.009715
Loa Loa (eye worm)	tubulin alpha chain	0.0171756	0.526614	0.660601
Onchocerca volvulus	Peroxidasin homolog	0.00255429	0.0210286	0.0252784
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.028692	0.924838	1
Plasmodium falciparum	alpha tubulin 2	0.0171756	0.526614	0.733162
Brugia malayi	tubulin alpha-2 chain	0.0171756	0.526614	0.660218
Trypanosoma brucei	epsilon tubulin	0.0123034	0.35814	0.496187
Loa Loa (eye worm)	hypothetical protein	0.0171756	0.526614	0.660601
Echinococcus granulosus	tubulin alpha	0.0123034	0.35814	0.498837
Trypanosoma cruzi	tubulin delta chain	0.00534198	0.117424	0.159131
Schistosoma mansoni	cytochrome P450 reductase	0.00205537	0.00377683	0.00401187
Echinococcus multilocularis	tubulin alpha 1C chain	0.0171756	0.526614	0.733497
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0171756	0.526614	0.660218
Loa Loa (eye worm)	ABC transporter	0.00600032	0.140188	0.175857
Leishmania major	beta tubulin	0.0227089	0.71795	1
Leishmania major	beta tubulin	0.0227089	0.71795	1
Brugia malayi	Tubulin beta chain	0.0069614	0.173421	0.21666
Leishmania major	beta tubulin	0.0227089	0.71795	1
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Schistosoma mansoni	tubulin subunit delta	0.00534198	0.117424	0.162504
Echinococcus granulosus	beta tubulin	0.0227089	0.71795	1
Echinococcus granulosus	tubulin alpha chain	0.0171756	0.526614	0.733497
Giardia lamblia	Alpha-tubulin	0.0171756	0.526614	0.601972
Loa Loa (eye worm)	tubulin beta-4 chain	0.0227089	0.71795	0.90062
Echinococcus multilocularis	Tubulin beta 2C chain	0.0227089	0.71795	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0171756	0.526614	0.733497
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0102142	0.285897	0.358639
Echinococcus granulosus	tubulin alpha 1C chain	0.0171756	0.526614	0.733497
Echinococcus granulosus	multidrug resistance protein 1	0.00197218	0.000900114	0.00125373
Echinococcus multilocularis	netrin receptor unc 5	0.00882757	0.237951	0.331431
Leishmania major	beta tubulin	0.0227089	0.71795	1
Brugia malayi	hypothetical protein	0.00255429	0.0210286	0.0252784
Brugia malayi	ABC transporter family protein	0.00600032	0.140188	0.174925
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0171756	0.526614	0.733497
Trypanosoma brucei	alpha tubulin	0.0171756	0.526614	0.732087
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.00704352	0.176261	0.173138
Entamoeba histolytica	tubulin alpha chain, putative	0.0171756	0.526614	0.660218
Trichomonas vaginalis	tubulin beta chain, putative	0.0171756	0.526614	0.660218
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0227089	0.71795	1
Onchocerca volvulus		0.00255429	0.0210286	0.0252784
Brugia malayi	Tubulin alpha chain	0.00534198	0.117424	0.146336
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.025	0.797174	1
Echinococcus multilocularis	tubulin alpha	0.0123034	0.35814	0.498837
Loa Loa (eye worm)	hypothetical protein	0.00510557	0.109249	0.137045
Schistosoma mansoni	amine oxidase	0.00217364	0.00786626	0.009715
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.025	0.797174	1
Loa Loa (eye worm)	hypothetical protein	0.00882757	0.237951	0.298493
Echinococcus granulosus	Tubulin beta 2C chain	0.0227089	0.71795	1
Echinococcus multilocularis	hypothetical protein	0.0171756	0.526614	0.733497
Plasmodium falciparum	tubulin gamma chain	0.0123034	0.35814	0.498208
Loa Loa (eye worm)	tubulin beta-1 chain	0.0227089	0.71795	0.90062
Trypanosoma brucei	beta tubulin	0.0123034	0.35814	0.496187
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Echinococcus multilocularis	beta tubulin	0.0227089	0.71795	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.00882757	0.237951	0.331431
Echinococcus multilocularis	multidrug resistance protein 1	0.00197218	0.000900114	0.00125373
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.00205537	0.00377683	0.00401187
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Echinococcus multilocularis	tubulin gamma 1 chain	0.0123034	0.35814	0.498837
Echinococcus multilocularis	Tubulin beta 2C chain	0.0227089	0.71795	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0227089	0.71795	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.025	0.797174	1
Brugia malayi	beta-tubulin, identical	0.0227089	0.71795	0.900507
Echinococcus granulosus	Tubulin beta 2C chain	0.0227089	0.71795	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.00197218	0.000900114	0.00112913
Loa Loa (eye worm)	alpha-tubulin	0.0171756	0.526614	0.660601
Trichomonas vaginalis	tubulin beta chain, putative	0.0171756	0.526614	0.660218
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.00197218	0.000900114	0.00112913
Trypanosoma brucei	zeta tubulin	0.00534198	0.117424	0.159131
Echinococcus granulosus	Tubulin beta 2C chain	0.0227089	0.71795	1
Echinococcus granulosus	tubulin alpha chain	0.0171756	0.526614	0.733497
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.00704352	0.176261	0.244559
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00197218	0.000900114	0.00125373
Schistosoma mansoni	hypothetical protein	0.00597429	0.139288	0.192996
Leishmania major	beta tubulin	0.0227089	0.71795	1
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.00217364	0.00786626	0.0109566
Trichomonas vaginalis	tubulin beta chain, putative	0.0171756	0.526614	0.660218
Loa Loa (eye worm)	tubulin alpha 2	0.0118336	0.341895	0.428884
Echinococcus granulosus	tubulin alpha chain	0.0171756	0.526614	0.733497
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.00217364	0.00786626	0.009715
Echinococcus multilocularis	tubulin alpha chain	0.0171756	0.526614	0.733497
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Schistosoma mansoni	alpha tubulin	0.0171756	0.526614	0.733162
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0102142	0.285897	0.357914
Echinococcus granulosus	tubulin epsilon chain	0.0123034	0.35814	0.498837
Mycobacterium tuberculosis	Cell division protein FtsZ	0.00534198	0.117424	0.126116
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00197218	0.000900114	0.00125373
Mycobacterium ulcerans	cell division protein FtsZ	0.00534198	0.117424	0.114078
Trypanosoma cruzi	alpha tubulin, putative	0.0171756	0.526614	0.732087
Trypanosoma brucei	epsilon tubulin	0.0123034	0.35814	0.496187
Leishmania major	zeta tubulin, putative	0.00534198	0.117424	0.162504
Loa Loa (eye worm)	hypothetical protein	0.0188883	0.585838	0.734894
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.025	0.797174	1
Loa Loa (eye worm)	animal heme peroxidase	0.00255429	0.0210286	0.026379
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Echinococcus multilocularis	tubulin alpha 1C chain	0.0171756	0.526614	0.733497
Onchocerca volvulus	Peroxidase homolog	0.00255429	0.0210286	0.0252784
Leishmania major	epsilon tubulin, putative	0.0123034	0.35814	0.498208
Loa Loa (eye worm)	tubulin alpha 2	0.00487218	0.101178	0.126922
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.00205537	0.00377683	0.00401187
Trichomonas vaginalis	tubulin alpha chain, putative	0.0069614	0.173421	0.21666
Trichomonas vaginalis	tubulin beta chain, putative	0.0069614	0.173421	0.21666
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.025	0.797174	1
Toxoplasma gondii	beta-tubulin, putative	0.0227089	0.71795	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0171756	0.526614	0.660218
Echinococcus multilocularis	Tubulin beta 2C chain	0.0227089	0.71795	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0227089	0.71795	0.900507
Onchocerca volvulus	Netrin receptor homolog	0.00882757	0.237951	0.2977
Leishmania major	beta tubulin	0.0227089	0.71795	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.00217364	0.00786626	0.00753962
Plasmodium falciparum	protoporphyrinogen oxidase	0.00217364	0.00786626	0.009715
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.00704352	0.176261	0.244559
Echinococcus granulosus	netrin receptor unc 5	0.00882757	0.237951	0.331431
Echinococcus granulosus	lysine specific histone demethylase 1A	0.00217364	0.00786626	0.0109566
Loa Loa (eye worm)	BEN-1 protein	0.0227089	0.71795	0.90062
Trypanosoma brucei	beta tubulin	0.0227089	0.71795	1
Brugia malayi	Blistered cuticle protein 3	0.00255429	0.0210286	0.0252784
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00197218	0.000900114	0.00125373
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.00534198	0.117424	0.146336
Trichomonas vaginalis	tubulin epsilon chain, putative	0.00534198	0.117424	0.146336
Echinococcus multilocularis	beta tubulin	0.0227089	0.71795	1
Schistosoma mansoni	tubulin subunit alpha	0.0171756	0.526614	0.733162
Echinococcus multilocularis	tubulin delta chain	0.00534198	0.117424	0.163554
Schistosoma mansoni	tubulin subunit alpha	0.0171756	0.526614	0.733162
Trypanosoma cruzi	epsilon tubulin, putative	0.0123034	0.35814	0.496187
Onchocerca volvulus		0.025	0.797174	1
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Echinococcus multilocularis	multidrug resistance protein 1	0.00197218	0.000900114	0.00125373
Echinococcus multilocularis	tubulin alpha chain	0.0171756	0.526614	0.733497
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.00704352	0.176261	0.173138
Loa Loa (eye worm)	hypothetical protein	0.00205537	0.00377683	0.00473777
Trichomonas vaginalis	tubulin, putative	0.0069614	0.173421	0.21666
Brugia malayi	Protein kinase domain containing protein	0.00882757	0.237951	0.2977
Brugia malayi	Animal haem peroxidase family protein	0.00255429	0.0210286	0.0252784
Brugia malayi	flavodoxin family protein	0.00205537	0.00377683	0.00361272
Loa Loa (eye worm)	hypothetical protein	0.0118336	0.341895	0.428884
Echinococcus granulosus	tubulin delta chain	0.00534198	0.117424	0.163554
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Echinococcus granulosus	lysine specific histone demethylase 1A	0.00217364	0.00786626	0.0109566
Onchocerca volvulus	Dual oxidase homolog	0.00255429	0.0210286	0.0252784
Schistosoma mansoni	ankyrin 23/unc44	0.00882757	0.237951	0.330592
Trichomonas vaginalis	sulfite reductase, putative	0.00205537	0.00377683	0.00361272
Echinococcus granulosus	tubulin subunit beta	0.0227089	0.71795	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.00882757	0.237951	0.330592
Leishmania major	UDP-galactopyranose mutase	0.00217364	0.00786626	0.009715
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.025	0.797174	1
Trichomonas vaginalis	conserved hypothetical protein	0.00534198	0.117424	0.146336
Schistosoma mansoni	peroxidasin	0.00255429	0.0210286	0.0280713
Leishmania major	beta tubulin	0.0227089	0.71795	1
Schistosoma mansoni	tubulin subunit beta	0.0227089	0.71795	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.00205537	0.00377683	0.00473777
Leishmania major	beta tubulin	0.0227089	0.71795	1
Loa Loa (eye worm)	hypothetical protein	0.00217364	0.00786626	0.00986768
Plasmodium vivax	tubulin gamma chain, putative	0.0123034	0.35814	0.498208
Echinococcus multilocularis	tubulin alpha 3 chain	0.0171756	0.526614	0.733497
Brugia malayi	Tubulin gamma chain	0.0123034	0.35814	0.44864
Loa Loa (eye worm)	hypothetical protein	0.0102142	0.285897	0.358639
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0308656	1	1
Trypanosoma brucei	beta tubulin	0.0227089	0.71795	1
Schistosoma mansoni	tubulin subunit epsilon	0.0123034	0.35814	0.498208
Echinococcus multilocularis	tubulin beta 1 chain	0.0227089	0.71795	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.00217364	0.00786626	0.0057261
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.00205537	0.00377683	0.00526057
Echinococcus multilocularis		0.00217364	0.00786626	0.0109566
Loa Loa (eye worm)	hypothetical protein	0.00197218	0.000900114	0.00112913
Echinococcus granulosus	alpha tubulin	0.0171756	0.526614	0.733497
Treponema pallidum	cell division protein FtsZ	0.00534198	0.117424	0.5
Schistosoma mansoni	netrin receptor unc5	0.00882757	0.237951	0.330592
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.00217364	0.00786626	0.009715
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Trichomonas vaginalis	tubulin, putative	0.0227089	0.71795	0.900507
Loa Loa (eye worm)	BEN-1 protein	0.0227089	0.71795	0.90062
Brugia malayi	Death domain containing protein	0.00882757	0.237951	0.2977
Schistosoma mansoni	alpha tubulin	0.0171756	0.526614	0.733162
Onchocerca volvulus		0.00255429	0.0210286	0.0252784
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00197218	0.000900114	0.00125373
Echinococcus granulosus	tubulin subunit TubB	0.0171756	0.526614	0.733497
Plasmodium vivax	hypothetical protein, conserved	0.00217364	0.00786626	0.009715
Trichomonas vaginalis	tubulin alpha chain, putative	0.0069614	0.173421	0.21666
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Brugia malayi	Uncoordinated protein 44	0.00882757	0.237951	0.2977
Brugia malayi	Animal haem peroxidase family protein	0.00255429	0.0210286	0.0252784
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Loa Loa (eye worm)	tubulin beta chain	0.0227089	0.71795	0.90062
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0123034	0.35814	0.498208
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.00870855	0.233836	0.324852
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Loa Loa (eye worm)	hypothetical protein	0.00217364	0.00786626	0.00986768
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0118336	0.341895	0.428884
Echinococcus granulosus	tubulin beta 1 chain	0.0227089	0.71795	1
Brugia malayi	Animal haem peroxidase family protein	0.00255429	0.0210286	0.0252784
Mycobacterium tuberculosis	Possible oxidoreductase	0.00217364	0.00786626	0.00753962
Chlamydia trachomatis	protoporphyrinogen oxidase	0.00217364	0.00786626	1
Schistosoma mansoni	hypothetical protein	0.00882757	0.237951	0.330592
Trypanosoma cruzi	epsilon tubulin, putative	0.0123034	0.35814	0.496187
Giardia lamblia	Alpha-tubulin	0.0171756	0.526614	0.601972
Plasmodium falciparum	alpha tubulin 1	0.0171756	0.526614	0.733162
Plasmodium falciparum	tubulin delta chain, putative	0.00534198	0.117424	0.162504
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Echinococcus multilocularis	peroxidasin	0.00255429	0.0210286	0.0292898
Trypanosoma brucei	beta tubulin	0.0227089	0.71795	1
Loa Loa (eye worm)	tubulin beta chain	0.00534198	0.117424	0.1473
Plasmodium falciparum	tubulin beta chain	0.0227089	0.71795	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0171756	0.526614	0.660218
Echinococcus granulosus	Ankyrin	0.00882757	0.237951	0.331431
Brugia malayi	Cell division protein ftsZ	0.00534198	0.117424	0.146336
Echinococcus granulosus	peroxisome assembly protein 26	0.0171756	0.526614	0.733497
Plasmodium vivax	tubulin beta chain, putative	0.0227089	0.71795	1
Onchocerca volvulus		0.00217364	0.00786626	0.00874843
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00197218	0.000900114	0.00125373
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Trypanosoma cruzi	ATP-binding cassette protein, putative	0.00704352	0.176261	0.241516
Plasmodium vivax	delta tubulin, putative	0.00534198	0.117424	0.162504
Entamoeba histolytica	tubulin family protein	0.0227089	0.71795	0.900507
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.00205537	0.00377683	0.00526057
Schistosoma mansoni	tubulin subunit beta	0.0227089	0.71795	1
Trypanosoma cruzi	zeta tubulin, putative	0.00534198	0.117424	0.159131
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.025	0.797174	0.861825
Brugia malayi	Tubulin alpha chain	0.0171756	0.526614	0.660218
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.00597429	0.139288	0.149781
Onchocerca volvulus		0.0069614	0.173421	0.21666
Leishmania major	beta tubulin	0.0227089	0.71795	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0171756	0.526614	0.733497
Leishmania major	alpha tubulin	0.0171756	0.526614	0.733162
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.025	0.797174	1
Brugia malayi	Amyloid A4 extracellular domain containing protein	0.0239624	0.761296	0.954943
Trypanosoma cruzi	tubulin gamma chain	0.0123034	0.35814	0.496187
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.025	0.797174	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0227089	0.71795	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0171756	0.526614	0.733497
Leishmania major	gamma-tubulin	0.0123034	0.35814	0.498208
Schistosoma mansoni	tubulin subunit alpha	0.00534198	0.117424	0.162504
Loa Loa (eye worm)	hypothetical protein	0.00255429	0.0210286	0.026379
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.00217364	0.00786626	0.00410493
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0113509	0.325205	0.452963
Brugia malayi	SWIRM domain containing protein	0.00217364	0.00786626	0.00874843
Echinococcus granulosus	tubulin gamma 1 chain	0.0123034	0.35814	0.498837
Plasmodium falciparum	tubulin epsilon chain, putative	0.0123034	0.35814	0.498208
Trichomonas vaginalis	tubulin alpha chain, putative	0.0227089	0.71795	0.900507
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.00704352	0.176261	0.173138
Loa Loa (eye worm)	animal heme peroxidase	0.00255429	0.0210286	0.026379
Brugia malayi	Tubulin alpha-2 chain	0.0171756	0.526614	0.660218
Trypanosoma brucei	alpha tubulin, putative	0.0069614	0.173421	0.237539
Echinococcus multilocularis	ATP binding cassette sub family G	0.00704352	0.176261	0.245506
Trypanosoma brucei	alpha tubulin	0.0171756	0.526614	0.732087
Loa Loa (eye worm)	animal heme peroxidase	0.00255429	0.0210286	0.026379
Schistosoma mansoni	tubulin subunit beta	0.00534198	0.117424	0.162504
Trypanosoma brucei	ATP-binding cassette protein, putative	0.00704352	0.176261	0.241516
Echinococcus granulosus	Tubulin beta 2C chain	0.0227089	0.71795	1
Brugia malayi	FAD binding domain containing protein	0.00205537	0.00377683	0.00361272
Onchocerca volvulus	Peroxidasin homolog	0.00255429	0.0210286	0.0252784
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0113509	0.325205	0.452963
Trichomonas vaginalis	tubulin beta chain, putative	0.0227089	0.71795	0.900507
Echinococcus multilocularis	Tubulin beta 2C chain	0.0227089	0.71795	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0123034	0.35814	0.44864
Trichomonas vaginalis	tubulin beta chain, putative	0.0171756	0.526614	0.660218
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00882757	0.237951	0.298493
Brugia malayi	Animal haem peroxidase family protein	0.00255429	0.0210286	0.0252784
Onchocerca volvulus	Chorion peroxidase homolog	0.00255429	0.0210286	0.0252784

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 11 uM	In vitro growth inhibitory activity against Plasmodium falciparum upon incubation at 37 degrees C with compound dissolved in DMSO using [3H]-hypoxanthine (50 uL)	ChEMBL.	16161998
IC50 (functional)	= 52 uM	Inhibitory constant against Trypanosoma brucei rhodesiense upon incubation with the compound at 37 degrees C under a 5% CO2 atmosphere for 72 hours	ChEMBL.	16161998
IC50 (functional)	> 65 uM	In vitro growth inhibitory activity against Leishmania donovani amastigotes at 37 degrees C under a 5% CO2 atmosphere for 96 hours	ChEMBL.	16161998
IC50 (functional)	> 196 uM	In vitro growth inhibitory activity against Trypanosoma cruzi in rat L-6 cells upon incubation at 37 degrees C in 5% CO2 atmosphere for 4 days	ChEMBL.	16161998
Ki (binding)	> 1 mM	Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolase	ChEMBL.	16161998
Ki (binding)	= 135 uM	Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells	ChEMBL.	16161998
Ki (binding)	= 238 uM	Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in E. coli BL21 (DE3) cells	ChEMBL.	16161998
SI (binding)	= 0.6	Selectivity index for Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase defined as (Ki Human)/(Ki P. falciparum)	ChEMBL.	16161998

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	16161998

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3143775

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1847192