Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Echinococcus multilocularis | S adenosylmethionine synthase type 1 | 0.0155 | 0.0003 | 0.0007 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.7022 | 0.4713 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.153 | 0.0945 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.153 | 0.0945 | 0.2597 |
Trypanosoma brucei | DNA topoisomerase ii | 0.153 | 0.0945 | 0.2597 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5448 | 0.3633 | 0.2353 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 1.4732 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.153 | 0.0945 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.5641 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.153 | 0.0945 | 0.2597 |
Brugia malayi | hypothetical protein | 0.2592 | 0.1674 | 0.4604 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.153 | 0.0945 | 0.2597 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2592 | 0.1674 | 0.4604 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.153 | 0.0945 | 0.0943 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 1.4732 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.153 | 0.0945 | 0.2602 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5448 | 0.3633 | 0.3631 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.153 | 0.0945 | 0.2602 |
Schistosoma mansoni | S-adenosylmethionine synthetase | 0.0155 | 0.0003 | 0.0007 |
Mycobacterium ulcerans | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Loa Loa (eye worm) | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.153 | 0.0945 | 0.0943 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Schistosoma mansoni | DNA topoisomerase II | 0.153 | 0.0945 | 0.2602 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Onchocerca volvulus | 0.5448 | 0.3633 | 1 | |
Plasmodium falciparum | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Leishmania major | DNA topoisomerase ii | 0.153 | 0.0945 | 0.2597 |
Plasmodium vivax | DNA gyrase subunit A, putative | 1.4732 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.153 | 0.0945 | 0.2597 |
Giardia lamblia | DNA topoisomerase II | 0.153 | 0.0945 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2592 | 0.1674 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.153 | 0.0945 | 0.2597 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 1.4732 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.153 | 0.0945 | 0.2597 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.153 | 0.0945 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.153 | 0.0945 | 0.2597 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.0943 |
Echinococcus granulosus | S adenosylmethionine synthase type 1 | 0.0155 | 0.0003 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 14 mg kg-1 day-1 | Antitumor activity against transplanted tumor sarcoma 180 expressed as effective dose. | ChEMBL. | 2521251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.