Detailed information for compound 1847256

Basic information

Technical information
  • TDR Targets ID: 1847256
  • Name: ethyl [[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl )-3-hydroxyoxolan-2-yl]methoxy-methoxyphospho ryl]formate
  • MW: 378.272 | Formula: C13H19N2O9P
  • H donors: 2 H acceptors: 5 LogP: -1.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)P(=O)(OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O)OC
  • InChi: 1S/C13H19N2O9P/c1-3-22-13(19)25(20,21-2)23-7-9-8(16)6-11(24-9)15-5-4-10(17)14-12(15)18/h4-5,8-9,11,16H,3,6-7H2,1-2H3,(H,14,17,18)/t8-,9+,11+,25?/m0/s1
  • InChiKey: ARFOILFYFMIVQZ-MSJVMCAESA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl [[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-methoxy-phosphoryl]formate
  • [[(2R,3S,5R)-5-(2,4-dioxo-1-pyrimidinyl)-3-hydroxy-2-tetrahydrofuranyl]methoxy-methoxyphosphoryl]formic acid ethyl ester
  • [[(2R,3S,5R)-5-(2,4-diketopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-methoxy-phosphoryl]formic acid ethyl ester
  • ethyl [[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-methoxy-phosphoryl]methanoate
  • 115365-13-4
  • AIDS-212373
  • AIDS212373
  • [[1-(2,4-Dioxo-1,2,3,4-tetrahyropyrimidin-1-yl)-2-deoxy-Beta-D-erythro-pentofuranos-5-yl]oxy]methoxyphosphine-carboxylic acid ethyl ester oxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1721 0.1721
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.46 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.1928 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.064 0.064
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0925 0.0925
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.7615 1
Echinococcus multilocularis expressed protein 0.0033 0.064 0.064
Trichomonas vaginalis rotamase, putative 0.0033 0.064 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0052 0.3606 0.3606
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.7615 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.2097 0.2221
Echinococcus granulosus jumonji domain containing protein 0.004 0.1721 0.1721
Trypanosoma brucei unspecified product 0.0036 0.1122 0.0847
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0052 0.3606 0.4842
Leishmania major DNA polymerase eta, putative 0.0077 0.7446 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0052 0.3606 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Trypanosoma brucei DNA polymerase IV, putative 0.0072 0.662 0.8598
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.7615 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.46 0.575
Echinococcus granulosus dna polymerase eta 0.0077 0.7446 0.7446
Schistosoma mansoni DNA polymerase eta 0.0077 0.7446 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.7041 0.9456
Onchocerca volvulus Alhambra homolog 0.0029 0 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0925 0.1242
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0052 0.3606 0.3606
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.7615 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.1928 0.1983
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.7615 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.2097 0.2816
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.7615 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.064 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.2097 0.2221
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.2117 0.2249
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Brugia malayi polk-prov protein 0.0042 0.2097 0.2097
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.7446 0.9762
Schistosoma mansoni rotamase 0.0033 0.064 0.086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.7615 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.7615 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.7446 0.7446
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.7615 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.2117 0.2249
Giardia lamblia DINP protein human, muc B family 0.0059 0.46 1
Leishmania major DNA polymerase eta, putative 0.0041 0.1928 0.2031
Loa Loa (eye worm) hypothetical protein 0.0049 0.314 0.4217
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.46 0.589
Plasmodium vivax hypothetical protein, conserved 0.0029 0 0.5
Leishmania major DNA polymerase kappa, putative 0.0059 0.46 0.589
Brugia malayi jmjC domain containing protein 0.0035 0.0925 0.0925
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.468 0.6285
Echinococcus multilocularis dna polymerase eta 0.0077 0.7446 0.7446
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.7615 1
Plasmodium falciparum phd finger protein, putative 0.0029 0 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0925 0.1242
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.064 0.086
Trypanosoma brucei unspecified product 0.0036 0.1122 0.0847
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.7615 1
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.7446 0.9762
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.2117 0.2249
Echinococcus granulosus dna polymerase kappa 0.0078 0.7615 0.7615
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0052 0.3606 0.4842
Echinococcus multilocularis dna polymerase kappa 0.0078 0.7615 0.7615
Trypanosoma brucei unspecified product 0.0072 0.662 0.8598
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0522 0.2705
Echinococcus granulosus expressed protein 0.0033 0.064 0.064
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.3606 0.3606
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0925 0.0925
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0925 0.1242
Loa Loa (eye worm) hypothetical protein 0.0077 0.7446 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0052 0.3606 0.4842

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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