Detailed information for compound 1847779

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.217 | Formula: C12H14F3N2O8P
  • H donors: 2 H acceptors: 4 LogP: -1.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@@H](O[C@@H]1COP1(=O)OCC(CO1)(F)F)n1cc(F)c(=O)[nH]c1=O
  • InChi: 1S/C12H14F3N2O8P/c13-6-2-17(11(20)16-10(6)19)9-1-7(18)8(25-9)3-22-26(21)23-4-12(14,15)5-24-26/h2,7-9,18H,1,3-5H2,(H,16,19,20)/t7-,8+,9+/m0/s1
  • InChiKey: FYGRTDORVQJECG-DJLDLDEBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.004 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0906 0.6199 0.9085
Echinococcus granulosus dynamin 1 0.009 0.0512 0.0742
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.0031 0.0031
Echinococcus multilocularis cyclins 0.0071 0.0385 0.0556
Entamoeba histolytica cyclin, putative 0.014 0.0863 0.0841
Echinococcus multilocularis muscleblind protein 0.0153 0.0957 0.1395
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0167 0.0167
Echinococcus granulosus mitogen activated protein kinase 15 0.002 0.0024 0.0027
Onchocerca volvulus 0.009 0.0512 0.5903
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus multilocularis Pleckstrin y 0.009 0.0512 0.0742
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni serine/threonine kinase 0.002 0.0024 0.0027
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0167 0.0167
Loa Loa (eye worm) Plekhf2 protein 0.009 0.0512 0.0512
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.002 0.0031 0.0037
Trypanosoma cruzi cyclin 6, putative 0.014 0.0863 0.1234
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus multilocularis calcium dependent secretion activator 1 0.009 0.0512 0.0742
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trypanosoma brucei protein kinase, putative 0.0101 0.0593 0.057
Schistosoma mansoni cyclin G2 0.002 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus multilocularis dynamin 1 0.009 0.0512 0.0742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0346
Schistosoma mansoni goodpasture antigen-binding protein 0.009 0.0512 0.0742
Entamoeba histolytica PH domain containing protein 0.009 0.0512 0.0489
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0055 0.0268 0.2482
Echinococcus multilocularis Pleckstrin y 0.009 0.0512 0.0742
Entamoeba histolytica PH domain containing protein kinase, putative 0.0101 0.0593 0.057
Entamoeba histolytica protein kinase, putative 0.1452 1 1
Schistosoma mansoni cyclin B 0.014 0.0863 0.1257
Echinococcus granulosus cyclins 0.0071 0.0385 0.0556
Trichomonas vaginalis cyclins, putative 0.0071 0.0385 0.0379
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0906 0.6199 1
Onchocerca volvulus 0.009 0.0512 0.5903
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0101 0.0593 0.5785
Entamoeba histolytica hypothetical protein, conserved domain containing 0.009 0.0512 0.0489
Echinococcus granulosus oxysterol binding protein 9 0.009 0.0512 0.0742
Echinococcus multilocularis nervana 2 0.0895 0.6118 0.8967
Echinococcus multilocularis cyclins 0.0071 0.0385 0.0556
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0101 0.0593 0.0836
Leishmania major mitotic cyclin, putative 0.002 0.0031 0.0067
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0125 0.0716
Mycobacterium tuberculosis Carboxylesterase LipT 0.0148 0.092 0.5507
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0268 0.0262
Trypanosoma brucei PH domain containing protein, putative 0.009 0.0512 0.0489
Loa Loa (eye worm) hypothetical protein 0.0045 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0153 0.0957 0.0957
Schistosoma mansoni hypothetical protein 0.009 0.0512 0.0742
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0468 0.3147 0.4608
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Echinococcus multilocularis cyclin B 0.014 0.0863 0.1257
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0153 0.0147
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0031
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.009 0.0512 0.0742
Brugia malayi GTP-ase activating protein for Arf containing protein 0.009 0.0512 0.0512
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0268 0.0359
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0468 0.3147 0.4608
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.3147 0.4608
Echinococcus multilocularis Pleckstrin y 0.009 0.0512 0.0742
Schistosoma mansoni atypical protein kinase C 0.0468 0.3147 0.4608
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.002 0.0024 0.0027
Trichomonas vaginalis cyclin B, putative 0.014 0.0863 0.0858
Onchocerca volvulus 0.003 0.0097 0.106
Toxoplasma gondii AtPH1 family protein 0.009 0.0512 0.0515
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Echinococcus multilocularis myotubularin protein 13 0.009 0.0512 0.0742
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0461
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.009 0.0512 0.078
Echinococcus multilocularis cyclins 0.0071 0.0385 0.0556
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0101 0.0593 0.0587
Trichomonas vaginalis AGC family protein kinase 0.1452 1 1
Onchocerca volvulus Protein CNPPD1 homolog 0.002 0.0031 0.0291
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0071 0.0385 0.0556
Trichomonas vaginalis cyclin B3, putative 0.0071 0.0385 0.0379
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.1666 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0167 0.0968
Toxoplasma gondii Oxysterol-binding protein 0.009 0.0512 0.0515
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.0031 0.0031
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.0031 0.0031
Trichomonas vaginalis AGC family protein kinase 0.1452 1 1
Trypanosoma cruzi hypothetical protein 0.009 0.0512 0.0717
Loa Loa (eye worm) intermediate filament protein 0.003 0.0097 0.0097
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0101 0.0593 0.0836
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Brugia malayi Hr1 repeat family protein 0.0468 0.3147 0.3147
Trichomonas vaginalis cyclin D, putative 0.0071 0.0385 0.0379
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Giardia lamblia Cyclin A 0.0071 0.0385 0.0584
Echinococcus granulosus serine/threonine protein kinase 0.0996 0.6822 1
Echinococcus granulosus NDR protein kinase 0.0468 0.3147 0.4608
Trichomonas vaginalis AGC family protein kinase 0.1452 1 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0468 0.3147 0.3147
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0101 0.0593 0.0836
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.1363 0.9376 0.9376
Echinococcus granulosus cyclin y 0.002 0.0031 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0062 0.0062
Echinococcus granulosus cytohesin 1 0.009 0.0512 0.0742
Schistosoma mansoni Cyclin fold protein 0.002 0.0031 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0167 0.0161
Schistosoma mansoni hypothetical protein 0.0166 0.1043 0.1522
Echinococcus granulosus cyclin G2 0.002 0.0031 0.0037
Trypanosoma cruzi mitotic cyclin, putative 0.002 0.0031 0.001
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0153 0.5
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Trypanosoma cruzi hypothetical protein 0.009 0.0512 0.0717
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.3147 0.4608
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.009 0.0512 0.0742
Plasmodium vivax protein kinase Crk2 0.0055 0.0268 0.0395
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0033 0.0122 0.017
Loa Loa (eye worm) hypothetical protein 0.0069 0.0367 0.0367
Brugia malayi Carboxylesterase family protein 0.0017 0.0006 0.0006
Trichomonas vaginalis protein transport protein sec7, putative 0.009 0.0512 0.0506
Brugia malayi protein kinase C II. 0.0468 0.3147 0.3147
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0332 0.0478
Brugia malayi Plekhf2 protein 0.009 0.0512 0.0512
Onchocerca volvulus outspread protein homolog 0.009 0.0512 0.5903
Trichomonas vaginalis CMGC family protein kinase 0.002 0.0024 0.0018
Schistosoma mansoni hypothetical protein 0.0166 0.1043 0.1522
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus multilocularis cyclins 0.0071 0.0385 0.0556
Loa Loa (eye worm) acetylcholinesterase 1 0.0017 0.0006 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0167 0.0161
Entamoeba histolytica protein kinase, putative 0.0101 0.0593 0.057
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.3147 0.4608
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0702 0.0702
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus neuropeptide s receptor 0.0478 0.3218 0.4713
Trypanosoma cruzi PH domain containing protein, putative 0.009 0.0512 0.0717
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0468 0.3147 0.4608
Brugia malayi Carboxylesterase family protein 0.0017 0.0006 0.0006
Echinococcus granulosus geminin 0.0166 0.1043 0.1522
Entamoeba histolytica PH domain containing protein 0.009 0.0512 0.0489
Schistosoma mansoni lamin 0.003 0.0097 0.0133
Onchocerca volvulus 0.009 0.0512 0.5903
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Brugia malayi Protein kinase domain containing protein 0.0468 0.3147 0.3147
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Entamoeba histolytica hypothetical protein, conserved domain containing 0.009 0.0512 0.0489
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0167 0.0161
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.009 0.0512 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.3147 0.4608
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Entamoeba histolytica ARF GTPase activating protein, putative 0.009 0.0512 0.0489
Schistosoma mansoni rhogef and pleckstrin domain protein 0.009 0.0512 0.0742
Brugia malayi Variant SH3 domain containing protein 0.009 0.0512 0.0512
Trichomonas vaginalis centaurin/arf, putative 0.009 0.0512 0.0506
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0167 0.0968
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Trichomonas vaginalis cyclins, putative 0.014 0.0863 0.0858
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Trypanosoma brucei cyclin 3 0.002 0.0031 0.0007
Echinococcus granulosus pleckstrin y domain containing family A 0.009 0.0512 0.0742
Echinococcus granulosus Pleckstrin y 0.009 0.0512 0.0742
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0461
Brugia malayi cyclin fold protein 1 variant b 0.002 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.0122 0.0116
Echinococcus multilocularis musashi 0.003 0.0097 0.0133
Giardia lamblia Kinase, AGC PKA 0.0906 0.6199 1
Schistosoma mansoni lamin 0.003 0.0097 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Loa Loa (eye worm) cyclin C 0.0089 0.0505 0.0505
Onchocerca volvulus 0.009 0.0512 0.5903
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis cyclin B, putative 0.014 0.0863 0.0858
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0469 0.3156 0.3156
Toxoplasma gondii hypothetical protein 0.0051 0.0242 0.0226
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0055 0.0268 0.0268
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0101 0.0593 0.0836
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.009 0.0512 0.0742
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.002 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Echinococcus granulosus protein kinase c epsilon type 0.0468 0.3147 0.4608
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.3147 0.4608
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0323 0.0465
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Trypanosoma brucei cdc2-related kinase 3 0.0055 0.0268 0.0245
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Schistosoma mansoni oxysterol-binding protein 1 0.009 0.0512 0.0742
Mycobacterium ulcerans lipase LipD 0.004 0.0167 0.1104
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.009 0.0512 0.0742
Trichomonas vaginalis AGC family protein kinase 0.1452 1 1
Onchocerca volvulus 0.004 0.0167 0.1875
Echinococcus multilocularis cyclin y 0.002 0.0031 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0167 0.0236
Echinococcus multilocularis actin binding protein anillin 0.009 0.0512 0.0742
Entamoeba histolytica hypothetical protein 0.0101 0.0593 0.057
Echinococcus multilocularis cytohesin 1 0.009 0.0512 0.0742
Echinococcus multilocularis serine:threonine protein kinase N2 0.0468 0.3147 0.4608
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0124 0.0749 0.0768
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0101 0.0593 0.0836
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0153 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0167 0.0968
Leishmania major hypothetical protein, conserved 0.004 0.0167 0.1449
Trypanosoma cruzi CYC2-like cyclin, putative 0.014 0.0863 0.1234
Echinococcus granulosus cyclin 0.0089 0.0505 0.0732
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0161 0.1007 1
Toxoplasma gondii AGC kinase 0.1363 0.9376 1
Schistosoma mansoni dynamin 0.009 0.0512 0.0742
Plasmodium falciparum cyclin 0.0071 0.0385 0.0574
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0265 0.1733 0.1713
Brugia malayi Oxysterol binding protein 0.009 0.0512 0.0512
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.009 0.0512 0.078
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Leishmania major protein kinase, putative 0.0101 0.0593 0.5785
Brugia malayi hypothetical protein 0.002 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0895 0.6118 0.8967
Leishmania major folate/biopterin transporter, putative 0.0101 0.0593 0.5785
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0203 0.0203
Trichomonas vaginalis cyclin B, putative 0.0071 0.0385 0.0379
Plasmodium vivax hypothetical protein, conserved 0.004 0.0167 0.0231
Echinococcus granulosus cyclins 0.0071 0.0385 0.0556
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.009 0.0512 0.0506
Trypanosoma brucei mitotic cyclin 0.002 0.0031 0.0007
Schistosoma mansoni vav2 0.009 0.0512 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis centaurin/arf, putative 0.009 0.0512 0.0506
Giardia lamblia G2/mitotic-specific cyclin B 0.014 0.0863 0.1358
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.0031 0.0031
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0055 0.0268 0.2482
Brugia malayi Cytochrome P450 family protein 0.0025 0.0062 0.0062
Echinococcus granulosus nervana 2 0.0895 0.6118 0.8967
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.009 0.0512 0.0506
Echinococcus multilocularis cyclins 0.0071 0.0385 0.0556
Brugia malayi hypothetical protein 0.009 0.0512 0.0512
Loa Loa (eye worm) PH domain-containing protein 0.009 0.0512 0.0512
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0332 0.0478
Entamoeba histolytica protein kinase, putative 0.0468 0.3147 0.313
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0323 0.2756
Echinococcus multilocularis serine:threonine protein kinase 38 0.0468 0.3147 0.4608
Echinococcus multilocularis oxysterol binding protein 9 0.009 0.0512 0.0742
Schistosoma mansoni intermediate filament proteins 0.003 0.0097 0.0133
Trichomonas vaginalis cyclins, putative 0.0089 0.0509 0.0504
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.009 0.0512 0.0506
Loa Loa (eye worm) uncoordinated protein 104 0.009 0.0512 0.0512
Trichomonas vaginalis cyclin B, putative 0.014 0.0863 0.0858
Trichomonas vaginalis CMGC family protein kinase 0.002 0.0024 0.0018
Onchocerca volvulus Huntingtin homolog 0.0126 0.0765 0.8852
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0323 0.0465
Echinococcus granulosus protein kinase c iota type 0.0468 0.3147 0.4608
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0268 0.0262
Echinococcus granulosus cyclin dependent kinase 1 0.0055 0.0268 0.0385
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0101 0.0593 0.057
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.002 0.0024 0.0024
Echinococcus multilocularis ubiquitin specific protease 41 0.0033 0.0122 0.017
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0089 0.0505 0.0732
Echinococcus multilocularis pdz domain containing protein 0.009 0.0512 0.0742
Schistosoma mansoni guanyl-nucleotide exchange factor 0.009 0.0512 0.0742
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.009 0.0512 0.078
Echinococcus multilocularis cyclin A3 4 0.002 0.0031 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Entamoeba histolytica PH domain containing protein kinase, putative 0.0101 0.0593 0.057
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0055 0.0268 0.0385
Echinococcus multilocularis rac serine:threonine kinase 0.0996 0.6822 1
Brugia malayi p70 ribosomal S6 kinase beta 0.1363 0.9376 0.9376
Brugia malayi Inositol-1 0.0038 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0126 0.0765 0.0765
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.009 0.0512 0.0717
Trichomonas vaginalis cyclin B3, putative 0.002 0.0031 0.0025
Entamoeba histolytica PH domain containing protein kinase, putative 0.0996 0.6822 0.6815
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0101 0.0593 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0025
Mycobacterium leprae Probable lipase LipE 0.004 0.0167 1
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.3218 0.4713
Plasmodium vivax PH domain containing protein 0.009 0.0512 0.079
Plasmodium falciparum protein kinase 5 0.0055 0.0268 0.0385
Echinococcus multilocularis protein kinase c epsilon type 0.0468 0.3147 0.4608
Entamoeba histolytica hypothetical protein 0.0101 0.0593 0.057
Toxoplasma gondii ABC1 family protein 0.004 0.0167 0.0145
Echinococcus multilocularis beta 1 syntrophin 0.009 0.0512 0.0742
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0161 0.1007 0.1446
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0167 0.0209
Schistosoma mansoni rho gtpase activating protein 0.009 0.0512 0.0742
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.0031 0.0031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0332 0.2852
Echinococcus granulosus ubiquitin specific protease 41 0.0033 0.0122 0.017
Loa Loa (eye worm) CYL-1 protein 0.002 0.0031 0.0031
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0033 0.0122 0.017
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.009 0.0512 0.0742
Echinococcus multilocularis pleckstrin y domain containing family A 0.009 0.0512 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Entamoeba histolytica hypothetical protein 0.009 0.0512 0.0489
Schistosoma mansoni inositol monophosphatase 0.0038 0.0153 0.0215
Echinococcus multilocularis serine:threonine protein kinase N2 0.0468 0.3147 0.4608
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.009 0.0512 0.079
Brugia malayi beta-lactamase family protein 0.004 0.0167 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0025
Echinococcus granulosus intermediate filament protein 0.003 0.0097 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Onchocerca volvulus 0.009 0.0512 0.5903
Echinococcus granulosus cyclin dependent kinase 5 0.0055 0.0268 0.0385
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0062 0.0062
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.009 0.0512 0.0742
Brugia malayi RNA binding protein 0.0062 0.032 0.032
Brugia malayi Protein kinase domain containing protein 0.0055 0.0268 0.0268
Echinococcus granulosus oxysterol binding protein 1 0.009 0.0512 0.0742
Brugia malayi Carboxylesterase family protein 0.0017 0.0006 0.0006
Onchocerca volvulus 0.009 0.0512 0.5903
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0203 0.0203
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0268 0.0385
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0161 0.1007 0.0985
Trichomonas vaginalis cyclin B, putative 0.014 0.0863 0.0858
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0167 0.0209
Loa Loa (eye worm) AGC/PKN protein kinase 0.0468 0.3147 0.3147
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.0122 0.0116
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.009 0.0512 0.0742
Mycobacterium ulcerans carboxylesterase, LipT 0.0148 0.092 0.9083
Loa Loa (eye worm) hypothetical protein 0.003 0.0097 0.0097
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.002 0.0031 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.3147 0.4608
Echinococcus multilocularis oxysterol binding protein 3 0.009 0.0512 0.0742
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0332 0.3129
Plasmodium falciparum PH domain-containing protein, putative 0.009 0.0512 0.078
Brugia malayi TAR-binding protein 0.0062 0.032 0.032
Trichomonas vaginalis cyclins, putative 0.014 0.0863 0.0858
Entamoeba histolytica protein kinase, putative 0.0101 0.0593 0.057
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0153 0.1305
Loa Loa (eye worm) AGC/NDR protein kinase 0.0468 0.3147 0.3147
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Schistosoma mansoni syntrophin 0.009 0.0512 0.0742
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0468 0.3147 0.3147
Schistosoma mansoni hypothetical protein 0.009 0.0512 0.0742
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0268 0.0268
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.0031 0.0031
Echinococcus granulosus cyclin dependent kinase 0.0055 0.0268 0.0385
Entamoeba histolytica protein kinase, putative 0.1452 1 1
Schistosoma mansoni hypothetical protein 0.002 0.0031 0.0037
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.009 0.0512 0.0512
Echinococcus granulosus calcium dependent secretion activator 1 0.009 0.0512 0.0742
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Schistosoma mansoni inositol monophosphatase 0.0038 0.0153 0.0215
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Entamoeba histolytica protein kinase, putative 0.0101 0.0593 0.057
Echinococcus granulosus cyclin t1 0.002 0.0031 0.0037
Loa Loa (eye worm) cytohesin 3 0.009 0.0512 0.0512
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0033 0.0122 0.017
Trichomonas vaginalis CMGC family protein kinase 0.002 0.0024 0.0018
Plasmodium falciparum oxysterol-binding protein, putative 0.009 0.0512 0.078
Schistosoma mansoni cyclin k 0.002 0.0031 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0031 0.001
Schistosoma mansoni myotubularin-related protein 0.009 0.0512 0.0742
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0268 0.0262
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0323 0.2756
Plasmodium vivax cyclin homologue, putative 0.002 0.0031 0.0011
Trypanosoma cruzi cyclin 9, putative 0.002 0.0031 0.001
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0268 0.0385
Trichomonas vaginalis cyclins, putative 0.002 0.0031 0.0025
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.009 0.0512 0.0512
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.002 0.0031 0.0031
Giardia lamblia Hypothetical protein 0.002 0.0031 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0167 0.0143
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0062 0.0038
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0323 0.1907
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0033 0.0122 0.017
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Schistosoma mansoni growth factor receptor-bound protein 0.009 0.0512 0.0742
Onchocerca volvulus 0.009 0.0512 0.5903
Schistosoma mansoni cyclin d 0.002 0.0031 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.0031 0.0031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.032 0.032
Schistosoma mansoni serine/threonine-protein kinase 0.0996 0.6822 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0122 0.0097
Trichomonas vaginalis cyclins, putative 0.014 0.0863 0.0858
Echinococcus multilocularis lamin 0.003 0.0097 0.0133
Brugia malayi Cytohesin 3 0.009 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus granulosus protein kinase C gamma type 0.0468 0.3147 0.4608
Echinococcus granulosus oxysterol binding protein 3 0.009 0.0512 0.0742
Leishmania major hypothetical protein, conserved 0.009 0.0512 0.4962
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus tar DNA binding protein 0.0062 0.032 0.0461
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0167 0.0968
Toxoplasma gondii hypothetical protein 0.009 0.0512 0.0515
Schistosoma mansoni oxysterol-binding protein 1 0.009 0.0512 0.0742
Schistosoma mansoni g1/s-specific cyclin C 0.0089 0.0505 0.0732
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0323 0.3036
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0456 0.3066 0.3062
Entamoeba histolytica PH domain containing protein kinase, putative 0.0101 0.0593 0.057
Schistosoma mansoni cyclin B3 0.0071 0.0385 0.0556
Trichomonas vaginalis AGC family protein kinase 0.1452 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0268 0.0385
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0153 0.0189
Giardia lamblia Cyclin B-like protein 0.002 0.0031 0.0011
Trichomonas vaginalis cyclin B, putative 0.002 0.0031 0.0025
Brugia malayi follicle stimulating hormone receptor 0.0469 0.3156 0.3156
Schistosoma mansoni hypothetical protein 0.009 0.0512 0.0742
Loa Loa (eye worm) hypothetical protein 0.0468 0.3147 0.3147
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0153 0.0129
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.009 0.0512 0.0742
Echinococcus granulosus Protein kinase C brain isozyme 0.0468 0.3147 0.4608
Schistosoma mansoni goodpasture antigen-binding protein 0.009 0.0512 0.0742
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0996 0.6822 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.0031 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0167 0.0161
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0033 0.0122 0.0097
Trypanosoma cruzi Protein kinase B 0.0996 0.6822 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0101 0.0593 0.0836
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Schistosoma mansoni dynamin 0.009 0.0512 0.0742
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.009 0.0512 0.0717
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0167 0.0968
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0071 0.0385 0.0556
Trypanosoma cruzi cyclin, putative 0.014 0.0863 0.1234
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0268 0.0395
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0268 0.0385
Echinococcus multilocularis serine:threonine protein kinase NLK 0.002 0.0024 0.0027
Echinococcus multilocularis cyclin b3 0.0071 0.0385 0.0556
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0062 0.0056
Trichomonas vaginalis alpha chimerin, putative 0.009 0.0512 0.0506
Plasmodium vivax cyclin 4, putative 0.002 0.0031 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus Rho GTPase activating protein 24 0.009 0.0512 0.0742
Brugia malayi Carboxylesterase family protein 0.0017 0.0006 0.0006
Schistosoma mansoni centaurin alpha 0.009 0.0512 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus multilocularis cyclin G2 0.002 0.0031 0.0037
Entamoeba histolytica cyclin family protein 0.0071 0.0385 0.0361
Brugia malayi Cyclin, N-terminal domain containing protein 0.014 0.0863 0.0863
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0089 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0153 0.0957 0.0957
Onchocerca volvulus 0.004 0.0167 0.1875
Echinococcus granulosus lamin 0.003 0.0097 0.0133
Entamoeba histolytica PH domain containing protein kinase, putative 0.0996 0.6822 0.6815
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.002 0.0031 0.0011
Echinococcus multilocularis oxysterol binding protein 1 0.009 0.0512 0.0742
Echinococcus granulosus serine:threonine protein kinase NLK 0.002 0.0024 0.0027
Brugia malayi cell division control protein 2 homolog 0.0055 0.0268 0.0268
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Brugia malayi Cyclin C 0.0089 0.0505 0.0505
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Loa Loa (eye worm) RNA binding protein 0.0062 0.032 0.032
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Loa Loa (eye worm) RhoGEF domain-containing protein 0.009 0.0512 0.0512
Schistosoma mansoni zinc finger protein 0.009 0.0512 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Giardia lamblia Cyclin fold protein 1, putative 0.002 0.0031 0.0011
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.009 0.0512 0.0742
Entamoeba histolytica hypothetical protein, conserved domain containing 0.009 0.0512 0.0489
Echinococcus multilocularis cyclin G2 0.002 0.0031 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0033 0.0122 0.017
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trichomonas vaginalis AGC family protein kinase 0.0468 0.3147 0.3143
Trichomonas vaginalis cyclin H, putative 0.0064 0.0332 0.0327
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0097 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0461
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trichomonas vaginalis centaurin gamma, putative 0.009 0.0512 0.0506
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0468 0.3147 0.4608
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Echinococcus granulosus muscleblind protein 0.0153 0.0957 0.1395
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.009 0.0512 0.0742
Echinococcus multilocularis Glutaredoxin protein 5 0.0895 0.6118 0.8967
Loa Loa (eye worm) hypothetical protein 0.014 0.0863 0.0863
Echinococcus multilocularis nervana 2 0.0895 0.6118 0.8967
Trichomonas vaginalis cyclin A, putative 0.014 0.0863 0.0858
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0153 0.0189
Echinococcus granulosus cyclin B 0.014 0.0863 0.1257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Brugia malayi hypothetical protein 0.002 0.0031 0.0031
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0906 0.6199 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Loa Loa (eye worm) syntrophin-1 0.009 0.0512 0.0512
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0101 0.0593 0.057
Entamoeba histolytica PH domain containing protein kinase, putative 0.0101 0.0593 0.057
Loa Loa (eye worm) hypothetical protein 0.014 0.0863 0.0863
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0468 0.3147 0.3147
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Brugia malayi probable spectrin beta chain 0.009 0.0512 0.0512
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.009 0.0512 0.078
Echinococcus granulosus cyclin dependent kinase 7 0.0089 0.0505 0.0733
Onchocerca volvulus 0.003 0.0097 0.106
Entamoeba histolytica protein kinase 2, putative 0.0906 0.6199 0.6189
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0167 0.0161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0167 0.0236
Leishmania major protein kinase, putative 0.0101 0.0593 0.5785
Toxoplasma gondii hypothetical protein 0.009 0.0512 0.0515
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus pdz domain containing protein 0.009 0.0512 0.0742
Echinococcus granulosus Oxysterol binding protein 11 0.009 0.0512 0.0742
Onchocerca volvulus Cyclin L homolog 0.002 0.0031 0.0291
Schistosoma mansoni cyclin G 0.002 0.0031 0.0037
Plasmodium falciparum calcium-dependent protein kinase 7 0.0101 0.0593 0.0911
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.0031 0.0031
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.009 0.0512 0.0742
Trypanosoma brucei mitotic cyclin 6 0.014 0.0863 0.0841
Toxoplasma gondii phosphatidylinositol transfer protein 0.009 0.0512 0.0515
Entamoeba histolytica hypothetical protein 0.002 0.0031 0.0007
Trichomonas vaginalis centaurin alpha, putative 0.009 0.0512 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Mycobacterium tuberculosis Conserved protein 0.004 0.0167 0.0968
Leishmania major hypothetical protein, conserved 0.009 0.0512 0.4962
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.009 0.0512 0.0742
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0089 0.0505 0.0732
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0167 0.0968
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus multilocularis GRB2 associated binding protein 3 0.009 0.0512 0.0742
Brugia malayi Cyclin, N-terminal domain containing protein 0.0152 0.0949 0.0949
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0265 0.1733 0.1713
Echinococcus granulosus cyclin G2 0.002 0.0031 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0702 0.0702
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0153 0.0955
Loa Loa (eye worm) cyclin domain-containing protein 0.0071 0.0385 0.0385
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Onchocerca volvulus Huntingtin homolog 0.0126 0.0765 0.8852
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0101 0.0593 0.5785
Schistosoma mansoni protein kinase 0.002 0.0024 0.0027
Echinococcus granulosus cyclins 0.0071 0.0385 0.0556
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0505 0.0733
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Loa Loa (eye worm) haspin protein kinase 0.002 0.0024 0.0024
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.009 0.0512 0.0489
Echinococcus multilocularis cyclins 0.0071 0.0385 0.0556
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0101 0.0593 0.057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0122 0.0143
Trypanosoma cruzi hypothetical protein 0.009 0.0512 0.0717
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0033 0.0122 0.0158
Echinococcus granulosus Glutaredoxin protein 5 0.0895 0.6118 0.8967
Schistosoma mansoni zinc finger protein 0.009 0.0512 0.0742
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0131 0.0804 0.1262
Trichomonas vaginalis AGC family protein kinase 0.0558 0.377 0.3767
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Echinococcus granulosus cyclin B3 1 0.0071 0.0385 0.0556
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trypanosoma cruzi PH domain containing protein, putative 0.009 0.0512 0.0717
Echinococcus granulosus Cell division cycle 2 protein kinase 0.002 0.0024 0.0027
Entamoeba histolytica hypothetical protein 0.009 0.0512 0.0489
Echinococcus multilocularis Oxysterol binding protein 11 0.009 0.0512 0.0742
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0161 0.1007 1
Echinococcus granulosus cyclins 0.0071 0.0385 0.0556
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0033 0.0122 0.0122
Brugia malayi Dynamin 0.009 0.0512 0.0512
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0167 0.0236
Entamoeba histolytica hypothetical protein 0.0064 0.0332 0.0309
Loa Loa (eye worm) TAR-binding protein 0.0062 0.032 0.032
Trypanosoma cruzi hypothetical protein 0.009 0.0512 0.0717
Trypanosoma brucei rac serine-threonine kinase, putative 0.1452 1 1
Brugia malayi beta-lactamase 0.004 0.0167 0.0167
Brugia malayi Cytochrome P450 family protein 0.0025 0.0062 0.0062
Echinococcus multilocularis lamin dm0 0.003 0.0097 0.0133
Echinococcus multilocularis cyclin dependent kinase 7 0.0089 0.0505 0.0733
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0468 0.3147 0.3147
Echinococcus multilocularis cyclin y 0.002 0.0031 0.0037
Trichomonas vaginalis hypothetical protein 0.009 0.0512 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Brugia malayi Pleckstrin Homology Domain 0.009 0.0512 0.0512
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0906 0.6199 0.9085
Brugia malayi Carboxylesterase family protein 0.0017 0.0006 0.0006
Echinococcus multilocularis tar DNA binding protein 0.0062 0.032 0.0461
Trichomonas vaginalis esterase, putative 0.004 0.0167 0.0161
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0122 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Trichomonas vaginalis protein transport protein sec7, putative 0.009 0.0512 0.0506
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0323 0.0312
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0323 0.2756
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0101 0.0593 0.0836
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0062 0.0056
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.009 0.0512 0.0506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0346
Schistosoma mansoni cyclin l 0.002 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi GTP-ase activating protein for Arf containing protein 0.009 0.0512 0.0512
Mycobacterium ulcerans hypothetical protein 0.004 0.0167 0.1104
Leishmania major cyclin 9, putative 0.002 0.0031 0.0067
Brugia malayi Protein kinase domain containing protein 0.0468 0.3147 0.3147
Echinococcus multilocularis cyclin B3 1 0.0071 0.0385 0.0556
Plasmodium vivax hypothetical protein, conserved 0.009 0.0512 0.079
Trichomonas vaginalis protein kinase atmrk1, putative 0.002 0.0024 0.0018
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Leishmania major cytochrome p450-like protein 0.0025 0.0062 0.0387
Loa Loa (eye worm) AGC/AKT protein kinase 0.1452 1 1
Brugia malayi intermediate filament protein 0.003 0.0097 0.0097
Loa Loa (eye worm) carboxylesterase 0.0017 0.0006 0.0006
Brugia malayi Syntrophin-1 0.009 0.0512 0.0512
Trichomonas vaginalis AGC family protein kinase 0.0468 0.3147 0.3143
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.009 0.0512 0.0742
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0323 0.0465
Schistosoma mansoni serine/threonine-protein kinase 0.0996 0.6822 1
Schistosoma mansoni cyclins 0.0071 0.0385 0.0556
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0031
Giardia lamblia Hypothetical protein 0.0071 0.0385 0.0584
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0268 0.0268
Schistosoma mansoni serine/threonine kinase 0.0468 0.3147 0.4608
Entamoeba histolytica cyclin family protein 0.0071 0.0385 0.0361
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0332 0.1962
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0153 0.013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0122 0.0122
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0018
Onchocerca volvulus 0.004 0.0167 0.1875
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.002 0.0024 0.0018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0167 0.1104
Leishmania major serine/threonine-protein kinase a, putative 0.0101 0.0593 0.5785
Entamoeba histolytica hypothetical protein 0.009 0.0512 0.0489
Schistosoma mansoni hypothetical protein 0.009 0.0512 0.0742
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.0031 0.0031
Trichomonas vaginalis cyclin B, putative 0.002 0.0031 0.0025
Loa Loa (eye worm) carboxylesterase 0.0017 0.0006 0.0006
Brugia malayi hypothetical protein 0.0126 0.0765 0.0765
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0461
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0323 0.0465
Brugia malayi Oxysterol-binding protein 0.009 0.0512 0.0512
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0268 0.0359
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0242 0.0242
Trichomonas vaginalis serine/threonine kinase, putative 0.002 0.0024 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0346
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Mycobacterium tuberculosis Conserved protein 0.004 0.0167 0.0968
Echinococcus granulosus Cyclin L1 0.002 0.0031 0.0037
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Brugia malayi Cytochrome P450 family protein 0.0058 0.029 0.029
Entamoeba histolytica hypothetical protein 0.009 0.0512 0.0489
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Loa Loa (eye worm) cyclin domain-containing protein 0.0152 0.0949 0.0949
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0468 0.3147 0.4608
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.009 0.0512 0.5903
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Onchocerca volvulus Cyclin L homolog 0.002 0.0031 0.0291
Echinococcus granulosus beta 1 syntrophin 0.009 0.0512 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Giardia lamblia Hypothetical protein 0.002 0.0031 0.0011
Brugia malayi Cyclin, N-terminal domain containing protein 0.014 0.0863 0.0863
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trichomonas vaginalis cyclin B3, putative 0.002 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0161 0.1007 0.6029
Echinococcus granulosus G1:S specific cyclin D1 0.002 0.0031 0.0037
Echinococcus granulosus DCC interacting protein 13 beta 0.009 0.0512 0.0742
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus granulosus cyclin A3 4 0.002 0.0031 0.0037
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.002 0.0024 0.0024
Trichomonas vaginalis kinesin light chain, putative 0.009 0.0512 0.0506
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0153 0.0147
Echinococcus granulosus cyclin dependent kinase 9 0.002 0.0024 0.0027
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.009 0.0512 0.0717
Trypanosoma cruzi hypothetical protein 0.009 0.0512 0.0717
Entamoeba histolytica hypothetical protein 0.009 0.0512 0.0489
Echinococcus granulosus cyclin k 0.002 0.0031 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0346
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0167
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.014 0.0863 0.8535
Leishmania major cyclin 0.014 0.0863 0.8535
Echinococcus granulosus Pleckstrin domain containing protein family B 0.009 0.0512 0.0742
Brugia malayi Protein kinase domain containing protein 0.002 0.0024 0.0024
Trypanosoma cruzi PH domain containing protein, putative 0.009 0.0512 0.0717
Entamoeba histolytica hypothetical protein, conserved 0.009 0.0512 0.0489
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Trypanosoma brucei cdc2-related kinase 1 0.0055 0.0268 0.0245
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0332 0.0478
Trichomonas vaginalis AGC family protein kinase 0.1452 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.3218 0.4713
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0101 0.0593 0.057
Brugia malayi beta-lactamase family protein 0.004 0.0167 0.0167
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis cyclins, putative 0.014 0.0863 0.0858
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus granulosus cyclin b3 0.0071 0.0385 0.0556
Loa Loa (eye worm) hypothetical protein 0.0043 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis cyclin dependent kinase 9 0.002 0.0024 0.0027
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0468 0.3147 0.4608
Echinococcus granulosus Pleckstrin y 0.009 0.0512 0.0742
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.0268 0.0245
Loa Loa (eye worm) beta-lactamase 0.004 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0346
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0302 0.0302
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0097 0.0097
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0268 0.0395
Loa Loa (eye worm) inositol-1 0.0038 0.0153 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus granulosus serine:threonine protein kinase N2 0.0468 0.3147 0.4608
Brugia malayi PH domain containing protein 0.009 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.009 0.0512 0.0742
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0055 0.0268 0.0254
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0957 0.1395
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0906 0.6199 0.9083
Entamoeba histolytica protein kinase, putative 0.0101 0.0593 0.057
Trypanosoma cruzi hypothetical protein 0.009 0.0512 0.0717
Echinococcus multilocularis cyclin k 0.002 0.0031 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.029 0.029
Echinococcus granulosus GRB2 associated binding protein 3 0.009 0.0512 0.0742
Echinococcus multilocularis cyclin dependent kinase 5 0.0055 0.0268 0.0385
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.3147 0.4608
Schistosoma mansoni hypothetical protein 0.0031 0.0103 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0153 0.0215
Brugia malayi MH2 domain containing protein 0.0117 0.0702 0.0702
Onchocerca volvulus Putative zinc finger protein 0.009 0.0512 0.5903
Toxoplasma gondii protein kinase domain-containing protein 0.0101 0.0593 0.0601
Echinococcus multilocularis cyclin 0.0089 0.0505 0.0732
Echinococcus multilocularis Rho GTPase activating protein 24 0.009 0.0512 0.0742
Trichomonas vaginalis cyclins, putative 0.002 0.0031 0.0025
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0895 0.6118 0.8967
Mycobacterium ulcerans beta-lactamase 0.004 0.0167 0.1104
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trypanosoma brucei cyclin 9 0.002 0.0031 0.0007
Brugia malayi Cell division protein kinase 2 0.002 0.0024 0.0024
Trypanosoma cruzi NIMA-related kinase, putative 0.0101 0.0593 0.0836
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0167 0.0968
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0593 0.0587
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.009 0.0512 0.0506
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0161 0.1007 0.1446
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0167 0.0968
Trypanosoma cruzi cyclin, putative 0.014 0.0863 0.1234
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.0031 0.0031
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0268 0.0359
Schistosoma mansoni hypothetical protein 0.002 0.0031 0.0037
Schistosoma mansoni hypothetical protein 0.009 0.0512 0.0742
Brugia malayi Cadps2 protein 0.009 0.0512 0.0512
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0167 0.0236
Brugia malayi Carboxylesterase family protein 0.0017 0.0006 0.0006
Trypanosoma cruzi mitotic cyclin, putative 0.002 0.0031 0.001
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.009 0.0512 0.0489
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.009 0.0512 0.0742
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0103 0.0103
Echinococcus granulosus Pleckstrin y 0.009 0.0512 0.0742
Echinococcus multilocularis serine threonine protein kinase 0.0468 0.3147 0.4608
Echinococcus granulosus myotubularin protein 13 0.009 0.0512 0.0742
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.002 0.0031 0.0037
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.032 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0385 0.0379
Entamoeba histolytica cell division protein kinase 2, putative 0.0062 0.0323 0.03
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Loa Loa (eye worm) carboxylesterase 0.0017 0.0006 0.0006
Entamoeba histolytica hypothetical protein, conserved domain containing 0.009 0.0512 0.0489
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.009 0.0512 0.5903
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.3218 0.4713
Entamoeba histolytica cyclin, domain containing protein 0.002 0.0031 0.0007
Brugia malayi Uncoordinated protein 104 0.009 0.0512 0.0512
Echinococcus multilocularis geminin 0.0166 0.1043 0.1522
Echinococcus multilocularis protein kinase c iota type 0.0468 0.3147 0.4608
Entamoeba histolytica cyclin, domain containing protein 0.002 0.0031 0.0007
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0153 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0476 0.3202 0.3198
Trichomonas vaginalis cyclin A, putative 0.002 0.0031 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Onchocerca volvulus Protein melted homolog 0.009 0.0512 0.5903
Onchocerca volvulus 0.002 0.0031 0.0291
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.009 0.0512 0.0742
Echinococcus granulosus cyclins 0.0071 0.0385 0.0556
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0332 0.2852
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0101 0.0593 0.0601
Entamoeba histolytica p21-activated kinase 0.0101 0.0593 0.057
Plasmodium vivax conserved Plasmodium protein, unknown function 0.009 0.0512 0.079
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0153 0.0129
Loa Loa (eye worm) hypothetical protein 0.0265 0.1733 0.1733
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0461
Trichomonas vaginalis AGC family protein kinase 0.1452 1 1
Echinococcus multilocularis Ras associated and pleckstrin y 0.009 0.0512 0.0742
Loa Loa (eye worm) hypothetical protein 0.0126 0.0765 0.0765
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0025
Loa Loa (eye worm) variant SH3 domain-containing protein 0.009 0.0512 0.0512
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0101 0.0593 0.0836
Brugia malayi Variant SH3 domain containing protein 0.009 0.0512 0.0512
Echinococcus granulosus serine threonine protein kinase nrc 0.0906 0.6199 0.9085
Brugia malayi Cyclin, N-terminal domain containing protein 0.0071 0.0385 0.0385
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.009 0.0512 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Trypanosoma cruzi PH domain containing protein, putative 0.009 0.0512 0.0717
Echinococcus granulosus cyclins 0.002 0.0031 0.0037
Brugia malayi cyclin-dependent kinase 7 homolog 0.0097 0.0561 0.0561
Plasmodium vivax hypothetical protein, conserved 0.002 0.0031 0.0011
Trypanosoma cruzi NIMA-related kinase, putative 0.0101 0.0593 0.0836
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.009 0.0512 0.0506
Entamoeba histolytica PH domain containing protein 0.009 0.0512 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0512 0.0506
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0033 0.0122 0.099
Entamoeba histolytica protein kinase, putative 0.1363 0.9376 0.9375
Brugia malayi MAX-1A 0.009 0.0512 0.0512
Onchocerca volvulus 0.014 0.0863 1
Brugia malayi Muscleblind-like protein 0.0153 0.0957 0.0957
Trichomonas vaginalis cyclin D, putative 0.0071 0.0385 0.0379
Trypanosoma cruzi hypothetical protein 0.009 0.0512 0.0717
Echinococcus multilocularis cyclin dependent kinase 0.0055 0.0268 0.0385
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0167 0.1104
Loa Loa (eye worm) oxysterol binding protein 0.009 0.0512 0.0512
Echinococcus multilocularis G1:S specific cyclin D1 0.002 0.0031 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.009 0.0512 0.0512
Echinococcus multilocularis Cyclin L1 0.002 0.0031 0.0037
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0033 0.0122 0.017
Trichomonas vaginalis centaurin beta, putative 0.009 0.0512 0.0506
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0505 0.0733
Echinococcus granulosus nervana 2 0.0895 0.6118 0.8967
Brugia malayi Dynamin 0.009 0.0512 0.0512
Echinococcus multilocularis cyclins 0.0071 0.0385 0.0556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0242 0.0242
Entamoeba histolytica cyclin C, putative 0.002 0.0031 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis cyclin D, putative 0.002 0.0031 0.0025
Echinococcus multilocularis DCC interacting protein 13 beta 0.009 0.0512 0.0742
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0468 0.3147 0.4608
Trichomonas vaginalis CAMK family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.002 0.0024 0.0018
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0101 0.0593 0.0587
Echinococcus granulosus lamin dm0 0.003 0.0097 0.0133
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0268 0.0359
Entamoeba histolytica cyclin, putative 0.0071 0.0385 0.0361
Plasmodium falciparum MO15-related protein kinase 0.0131 0.0804 0.1253
Entamoeba histolytica protein kinase, putative 0.0101 0.0593 0.057
Brugia malayi TBC domain containing protein 0.009 0.0512 0.0512
Loa Loa (eye worm) rho-GTPase-activating 0.009 0.0512 0.0512
Echinococcus granulosus cyclin y 0.002 0.0031 0.0037
Leishmania major mitotic cyclin, putative 0.002 0.0031 0.0067
Echinococcus multilocularis cyclin t1 0.002 0.0031 0.0037
Entamoeba histolytica hypothetical protein, conserved domain containing 0.009 0.0512 0.0489

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 0.003 ug ml-1 Dose of the compound inhibiting L1210/0 murine leukemia cell proliferation by 50% ChEMBL. 6708047
ID50 (functional) = 0.036 ug ml-1 Dose of the compound inhibiting L1210/0 murine leukemia cell proliferation by 50% in presence of 500 ug/mL of dCyd. ChEMBL. 6708047
ID50 (functional) = 0.048 ug ml-1 Dose of the compound inhibiting L1210/0 murine leukemia cell proliferation by 50% in presence of 125 ug/mL of dUrd. ChEMBL. 6708047
ID50 (functional) = 2.42 ug ml-1 Dose of the compound inhibiting L1210/Br-dUrd murine leukemia cell proliferation by 50% ChEMBL. 6708047
ID50 (functional) = 270 ug ml-1 Dose of the compound inhibiting L1210/0 murine leukemia cell proliferation by 50% in presence of 5 ug/mL of dThd. ChEMBL. 6708047

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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