Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.5641 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 1.4732 | 1 | 1 |
Onchocerca volvulus | 0.5448 | 0.3633 | 1 | |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Schistosoma mansoni | DNA topoisomerase II | 0.153 | 0.0945 | 0.2602 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.153 | 0.0945 | 0.2602 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2592 | 0.1674 | 0.4604 |
Loa Loa (eye worm) | hypothetical protein | 0.153 | 0.0945 | 0.2597 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.0943 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Loa Loa (eye worm) | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2592 | 0.1674 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Echinococcus granulosus | S adenosylmethionine synthase type 1 | 0.0155 | 0.0003 | 0.0007 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Schistosoma mansoni | S-adenosylmethionine synthetase | 0.0155 | 0.0003 | 0.0007 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.153 | 0.0945 | 0.0943 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 1.4732 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.153 | 0.0945 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.153 | 0.0945 | 0.2597 |
Echinococcus multilocularis | S adenosylmethionine synthase type 1 | 0.0155 | 0.0003 | 0.0007 |
Echinococcus multilocularis | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.153 | 0.0945 | 0.2597 |
Mycobacterium ulcerans | thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Giardia lamblia | DNA topoisomerase II | 0.153 | 0.0945 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 1.4732 | 1 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.7022 | 0.4713 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 1.4732 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.2592 | 0.1674 | 0.4604 |
Trypanosoma brucei | DNA topoisomerase ii | 0.153 | 0.0945 | 0.2597 |
Leishmania major | DNA topoisomerase ii | 0.153 | 0.0945 | 0.2597 |
Brugia malayi | Probable DNA topoisomerase II | 0.153 | 0.0945 | 0.2597 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.153 | 0.0945 | 0.2597 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.153 | 0.0945 | 0.2597 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.153 | 0.0945 | 0.2597 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.153 | 0.0945 | 0.2597 |
Echinococcus granulosus | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Brugia malayi | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.153 | 0.0945 | 0.0943 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5448 | 0.3633 | 0.2353 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.153 | 0.0945 | 0.2597 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.153 | 0.0945 | 0.2602 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5448 | 0.3633 | 0.3631 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 25 mg kg-1 day-1 | Antitumor activity against transplanted tumor sarcoma 180 expressed as effective dose. | ChEMBL. | 2521251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.