Detailed information for compound 1847849

Basic information

Technical information
  • TDR Targets ID: 1847849
  • Name: [[(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)- 3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphory l]formic acid
  • MW: 375.231 | Formula: C11H14N5O8P
  • H donors: 5 H acceptors: 9 LogP: -2.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@@H](O[C@@H]1COP(=O)(C(=O)O)O)n1cnc2c1nc(N)nc2O
  • InChi: 1S/C11H14N5O8P/c12-10-14-8-7(9(18)15-10)13-3-16(8)6-1-4(17)5(24-6)2-23-25(21,22)11(19)20/h3-6,17H,1-2H2,(H,19,20)(H,21,22)(H3,12,14,15,18)/t4-,5+,6+/m0/s1
  • InChiKey: RXAOQNWBWWXYNT-KVQBGUIXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [[(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]formic acid
  • [[(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxy-2-tetrahydrofuranyl]methoxy-hydroxyphosphoryl]formic acid
  • [[(2R,3S,5R)-5-(2-amino-6-keto-3H-purin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]formic acid
  • [[(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]methanoic acid
  • 104532-18-5
  • 6H-Purin-6-one, 2-amino-9-[5-O-(carboxyhydroxyphosphinyl)-2-deoxy-.beta.-D-erythro-pentofuranosyl]-1,9-dihydro-
  • AIDS-191179
  • AIDS191179

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Schistosoma mansoni opsin-like receptor 0.0102 0.0083 0.0136
Schistosoma mansoni biogenic amine (5HT) receptor 0.0102 0.0083 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Echinococcus granulosus neuropeptide FF receptor 2 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.32 0.5817 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus tachykinin peptides receptor 99D 0.0102 0.0083 0.0201
Echinococcus multilocularis dihydrofolate reductase 0.0927 0.1609 0.3923
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus heat shock protein 0.0073 0.0027 0.0067
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Schistosoma mansoni amine GPCR 0.0102 0.0083 0.0136
Schistosoma mansoni neuropeptide f receptor 76f 0.0102 0.0083 0.0136
Echinococcus multilocularis fmrfamide receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi Serotonin receptor 0.0102 0.0083 0.0055
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0102 0.0083 0.0136
Echinococcus granulosus neuropeptides capa receptor 0.0102 0.0083 0.0201
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0102 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0102 0.0083 0.0136
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0102 0.0083 0.0201
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0058 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0102 0.0083 0.0201
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis fmrfamide receptor 0.0102 0.0083 0.0201
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0102 0.0083 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Schistosoma mansoni neuropeptide receptor 0.0102 0.0083 0.0136
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0102 0.0083 0.0055
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.32 0.5817 1
Mycobacterium tuberculosis Hypothetical protein 0.1082 0.1895 0.462
Brugia malayi Dopamine receptor protein 2 0.0102 0.0083 0.0055
Echinococcus multilocularis allatostatin A receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus heat shock protein 90 0.0073 0.0027 0.0067
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis serotonin receptor 0.0102 0.0083 0.0201
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0102 0.0083 0.0136
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0102 0.0083 0.0136
Echinococcus multilocularis g protein coupled receptor 0.0102 0.0083 0.0201
Mycobacterium ulcerans thymidylate synthase 0.2273 0.4101 1
Loa Loa (eye worm) neuropeptide F receptor 0.0102 0.0083 0.0055
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0102 0.0083 0.0201
Brugia malayi putative neuropeptide receptor NPR1 0.0102 0.0083 0.0055
Brugia malayi dihydrofolate reductase family protein 0.0927 0.1609 0.1586
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus neuropeptide s receptor 0.0102 0.0083 0.0201
Echinococcus multilocularis g-protein coupled receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0102 0.0083 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Brugia malayi neuropeptide F receptor 0.0102 0.0083 0.0055
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0102 0.0083 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Echinococcus granulosus g protein coupled receptor 0.0102 0.0083 0.0201
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi AKH receptor 0.0102 0.0083 0.0055
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.2273 0.4101 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0102 0.0083 0.0055
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Echinococcus granulosus g-protein coupled receptor 0.0102 0.0083 0.0201
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0102 0.0083 0.0136
Brugia malayi follicle stimulating hormone receptor 0.0102 0.0083 0.0055
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0927 0.1609 0.3923
Schistosoma mansoni histamine h1 receptor 0.0102 0.0083 0.0136
Echinococcus multilocularis sex peptide receptor 0.0102 0.0083 0.0201
Schistosoma mansoni myosin xvIII 0.0102 0.0083 0.0136
Loa Loa (eye worm) neuropeptide F receptor 0.0102 0.0083 0.0055
Echinococcus multilocularis neuropeptide Y receptor 0.0102 0.0083 0.0201
Schistosoma mansoni neuropeptide receptor 0.0102 0.0083 0.0136
Schistosoma mansoni neuropeptide F-like receptor 0.0102 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus neuropeptide receptor 0.0102 0.0083 0.0201
Trypanosoma cruzi heat shock protein 90, putative 0.0073 0.0027 0.0047
Echinococcus granulosus alpha 1A adrenergic receptor 0.0102 0.0083 0.0201
Echinococcus multilocularis neuropeptide FF receptor 2 0.0102 0.0083 0.0201
Echinococcus multilocularis neuropeptides capa receptor 0.0102 0.0083 0.0201
Echinococcus granulosus dihydrofolate reductase 0.0927 0.1609 0.3923
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Entamoeba histolytica heat shock protein 90, putative 0.0073 0.0027 0.5
Brugia malayi G-protein coupled receptor 0.0102 0.0083 0.0055
Brugia malayi hypothetical protein 0.1082 0.1895 0.1873
Echinococcus granulosus biogenic amine 5HT receptor 0.0102 0.0083 0.0201
Schistosoma mansoni hypothetical protein 0.0102 0.0083 0.0136
Echinococcus multilocularis heat shock protein 90 0.0073 0.0027 0.0067
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis neuropeptide receptor A26 0.0102 0.0083 0.0201
Trichomonas vaginalis heat shock protein, putative 0.0073 0.0027 0.0144
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis neuropeptide Y receptor 0.0102 0.0083 0.0201
Schistosoma mansoni amine GPCR 0.0102 0.0083 0.0136
Trypanosoma cruzi Heat shock protein 83, putative 0.0073 0.0027 0.0047
Schistosoma mansoni biogenic amine receptor 0.0102 0.0083 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.546 1 1
Brugia malayi Dopamine receptor protein 1 0.0102 0.0083 0.0055
Schistosoma mansoni opsin-like receptor 0.0102 0.0083 0.0136
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1082 0.1895 0.3258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Schistosoma mansoni dihydrofolate reductase 0.0927 0.1609 0.3882
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Schistosoma mansoni opsin-like receptor 0.0102 0.0083 0.0136
Brugia malayi ORL1-like opioid receptor 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Echinococcus multilocularis thymidylate synthase 0.2273 0.4101 1
Loa Loa (eye worm) dihydrofolate reductase 0.0927 0.1609 0.1586
Onchocerca volvulus 0.2273 0.4101 1
Brugia malayi neuropeptide F receptor 0.0102 0.0083 0.0055
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0102 0.0083 0.0055
Echinococcus multilocularis somatostatin receptor 0.0102 0.0083 0.0201
Echinococcus granulosus neuropeptides capa receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Leishmania major dihydrofolate reductase-thymidylate synthase 0.32 0.5817 1
Brugia malayi G protein-coupled receptor 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0102 0.0083 0.0201
Echinococcus multilocularis orexin receptor type 2 0.0102 0.0083 0.0201
Echinococcus multilocularis G protein coupled receptor 139 0.0102 0.0083 0.0201
Entamoeba histolytica heat shock protein 90, putative 0.0073 0.0027 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0102 0.0083 0.0136
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.0083 0.0201
Schistosoma mansoni amine GPCR 0.0102 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus fmrfamide receptor 0.0102 0.0083 0.0201
Echinococcus granulosus 7tm_1 domain containing protein 0.0102 0.0083 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.0083 0.0201
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0927 0.1609 0.3923
Echinococcus multilocularis neuropeptide receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi putative neuropeptide receptor 0.0102 0.0083 0.0055
Schistosoma mansoni amine GPCR 0.0102 0.0083 0.0136
Brugia malayi Serotonin receptor 0.0102 0.0083 0.0055
Giardia lamblia Heat shock protein HSP 90-alpha 0.0073 0.0027 1
Schistosoma mansoni hypothetical protein 0.0102 0.0083 0.0136
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0102 0.0083 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Schistosoma mansoni alpha-1 adrenergic receptor 0.0102 0.0083 0.0136
Echinococcus granulosus allatostatin A receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.32 0.5817 1
Schistosoma mansoni biogenic amine receptor 0.0102 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0102 0.0083 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.0083 0.0201
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi thymidylate synthase 0.2273 0.4101 0.4085
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.32 0.5817 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0102 0.0083 0.0201
Schistosoma mansoni biogenic amine receptor 0.0102 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi GnHR receptor homolog 0.0102 0.0083 0.0055
Brugia malayi Melatonin receptor type 1A 0.0102 0.0083 0.0055
Trypanosoma cruzi heat shock protein 85, putative 0.0073 0.0027 0.0047
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0102 0.0083 0.0201
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0102 0.0083 0.0055
Echinococcus multilocularis g protein coupled receptor 0.0102 0.0083 0.0201
Schistosoma mansoni hypothetical protein 0.0102 0.0083 0.0136
Echinococcus multilocularis dro:myosuppressin receptor 0.0102 0.0083 0.0201
Echinococcus granulosus g protein coupled receptor 0.0102 0.0083 0.0201
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0102 0.0083 0.0201
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0102 0.0083 0.0201
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0102 0.0083 0.0136
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Echinococcus granulosus neuropeptide Y receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0102 0.0083 0.0055
Echinococcus multilocularis heat shock protein 0.0073 0.0027 0.0067
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0102 0.0083 0.0201
Echinococcus granulosus sex peptide receptor 0.0102 0.0083 0.0201
Brugia malayi sulfakinin receptor protein 0.546 1 1
Echinococcus granulosus hypothetical protein 0.0102 0.0083 0.0201
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.0083 0.0201
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus somatostatin receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0102 0.0083 0.0201
Brugia malayi Dopamine receptor 0.0102 0.0083 0.0055
Brugia malayi RE15519p 0.0102 0.0083 0.0055
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.0083 0.0136
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.2273 0.4101 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0102 0.0083 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Chlamydia trachomatis dihydrofolate reductase 0.0927 0.1609 0.5
Echinococcus granulosus orexin receptor type 2 0.0102 0.0083 0.0201
Echinococcus granulosus dro:myosuppressin receptor 0.0102 0.0083 0.0201
Schistosoma mansoni amine GPCR 0.0102 0.0083 0.0136
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Brugia malayi G-protein coupled receptor 0.0102 0.0083 0.0055
Echinococcus multilocularis neuropeptides capa receptor 0.0102 0.0083 0.0201
Trypanosoma cruzi heat shock protein 85, putative 0.0073 0.0027 0.0047
Brugia malayi Dihydrofolate reductase 0.0927 0.1609 0.1586
Echinococcus multilocularis neuropeptide receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus thymidylate synthase 0.2273 0.4101 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus neuropeptide Y receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Echinococcus granulosus tm gpcr rhodopsin 0.0102 0.0083 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Trypanosoma cruzi heat shock protein 85, putative 0.0073 0.0027 0.0047
Echinococcus granulosus serotonin receptor 0.0102 0.0083 0.0201
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0102 0.0083 0.0055
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0102 0.0083 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Schistosoma mansoni neuropeptide receptor 0.0102 0.0083 0.0136
Loa Loa (eye worm) TYRA-2 protein 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi larval opioid receptor 0.0102 0.0083 0.0055
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0102 0.0083 0.0201
Echinococcus granulosus g protein coupled receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0102 0.0083 0.0136
Schistosoma mansoni neuropeptide F-like receptor 0.0102 0.0083 0.0136
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Echinococcus granulosus peptide allatostatin:somatostatin 0.0102 0.0083 0.0201
Loa Loa (eye worm) G-protein coupled receptor 0.0102 0.0083 0.0055
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0102 0.0083 0.0201
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi G protein-coupled receptor F59B2.13 0.0102 0.0083 0.0055
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0927 0.1609 0.3923
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0102 0.0083 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Echinococcus granulosus G protein coupled receptor 139 0.0102 0.0083 0.0201
Schistosoma mansoni biogenic amine (5HT) receptor 0.0102 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Echinococcus granulosus neuropeptide receptor 0.0102 0.0083 0.0201
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0102 0.0083 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.0083 0.0136
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0102 0.0083 0.0136
Brugia malayi hypothetical protein 0.0102 0.0083 0.0055
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0102 0.0083 0.0055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Loa Loa (eye worm) thymidylate synthase 0.2273 0.4101 0.4085
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0102 0.0083 0.0136
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0102 0.0083 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.1895 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.32 0.5817 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0102 0.0083 0.0055
Echinococcus granulosus 7TM GPCR rhodopsin 0.0102 0.0083 0.0201
Schistosoma mansoni adenoreceptor 0.0102 0.0083 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0102 0.0083 0.0201
Loa Loa (eye worm) G-protein coupled receptor 0.0102 0.0083 0.0055
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0102 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0102 0.0083 0.0055
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Schistosoma mansoni neuropeptide receptor 0.0102 0.0083 0.0136
Leishmania major heat shock protein 83-1 0.0073 0.0027 0.0047
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.2273 0.4101 1
Echinococcus granulosus neuropeptide receptor A26 0.0102 0.0083 0.0201
Echinococcus multilocularis serotonin receptor 0.0102 0.0083 0.0201
Treponema pallidum heat shock protein 90 0.0058 0 0.5
Schistosoma mansoni hypothetical protein 0.0102 0.0083 0.0136
Schistosoma mansoni growth hormone secretagogue receptor 0.0102 0.0083 0.0136
Echinococcus granulosus biogenic amine 5HT receptor 0.0102 0.0083 0.0201

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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