TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 763.961 | Formula: C39H65N5O10
H donors: 8 H acceptors: 9 LogP: 4.2 Rotable bonds: 30
Rule of 5 violations (Lipinski): 3
SMILES: CCCC[C@@H](C(=O)N[C@H]([C@H](CC(=O)N[C@H](C(=O)N[C@H]([C@H](CC(=O)O)O)CC(C)C)C)O)CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
InChi: 1S/C39H65N5O10/c1-10-11-17-27(41-37(52)30(20-26-15-13-12-14-16-26)44-38(53)54-39(7,8)9)36(51)43-28(18-23(2)3)31(45)21-33(47)40-25(6)35(50)42-29(19-24(4)5)32(46)22-34(48)49/h12-16,23-25,27-32,45-46H,10-11,17-22H2,1-9H3,(H,40,47)(H,41,52)(H,42,50)(H,43,51)(H,44,53)(H,48,49)/t25-,27-,28-,29-,30-,31-,32-/m0/s1
InChiKey: FMSNHXJMQQDQDP-CXZRMZRFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	renin	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	eukaryotic aspartyl protease family protein	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl protease ASP1	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K01379 cathepsin D [EC3.4.23.5], putative	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	pepsinogen, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	plasmepsin	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	aspartyl protease, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	Cathepsin D precursor, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	aspartic protease BmAsp-2	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin I	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium parvum	membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin II	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Pepsinogen A1, related	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Renin, related	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	aspartyl proteinase, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium hominis	aspartyl protease precursor	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	cathepsin E, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	Get druggable targets OG5_126885	All targets in OG5_126885

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	plasmepsin X	renin	406 aa	352 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0146	0.5126	0.8766
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.5126	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0146	0.5126	0.5126
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0059	0.1751	0.2816
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0146	0.5126	0.9836
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0146	0.5126	0.9836
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Leishmania major	protein kinase, putative	0.0146	0.5126	0.5
Plasmodium vivax	plasmepsin IV, putative	0.0059	0.1751	0.3416
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0146	0.5126	0.9836
Brugia malayi	Raf kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0146	0.5126	0.5126
Brugia malayi	Tyrosine-protein kinase abl-1	0.0146	0.5126	0.5126
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0146	0.5126	0.9836
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0146	0.5126	0.9836
Onchocerca volvulus		0.0146	0.5126	1
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0146	0.5126	0.8766
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0146	0.5126	0.8766
Brugia malayi	Tyrosine-protein kinase PR2	0.0146	0.5126	0.5126
Echinococcus granulosus	tyrosine protein kinase shark	0.0146	0.5126	0.9836
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0146	0.5126	0.9836
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0146	0.5126	0.8766
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0146	0.5126	0.8766
Echinococcus multilocularis	epidermal growth factor receptor	0.0146	0.5126	0.8766
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0146	0.5126	0.8766
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0146	0.5126	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0146	0.5126	0.8766
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0146	0.5126	0.9836
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0146	0.5126	0.9836
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.5126	0.5
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.5126	1
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.5126	0.8766
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0146	0.5126	0.9836
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0146	0.5126	0.8766
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0146	0.5126	0.9836
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Schistosoma mansoni	hypothetical protein	0.0147	0.5188	0.8343
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0146	0.5126	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Schistosoma mansoni	thyroid hormone receptor	0.0159	0.5648	0.9082
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0146	0.5126	0.9836
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0146	0.5126	0.9836
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Echinococcus granulosus	insulin receptor	0.0146	0.5126	0.9836
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	receptor protein kinase, putative	0.0146	0.5126	0.5
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0146	0.5126	0.8243
Loa Loa (eye worm)	TK/INSR protein kinase	0.0146	0.5126	0.5126
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.5126	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0146	0.5126	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0146	0.5126	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0146	0.5126	0.9836
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0147	0.5188	0.8912
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	epidermal growth factor receptor	0.0146	0.5126	0.9836
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.1421	0.1421
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Brugia malayi	SRC-1	0.0146	0.5126	0.5126
Echinococcus multilocularis	transfer RNA-Thr	0.0146	0.5126	0.8766
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0159	0.5648	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0146	0.5126	0.8766
Onchocerca volvulus		0.0146	0.5126	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Onchocerca volvulus		0.0146	0.5126	1
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.5126	1
Onchocerca volvulus		0.0146	0.5126	1
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0146	0.5126	0.9836
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0146	0.5126	0.8766
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Leishmania major	hypothetical protein, conserved	0.0146	0.5126	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0146	0.5126	0.8243
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0146	0.5126	0.8766
Echinococcus granulosus	activated cdc42 kinase 1	0.0146	0.5126	0.9836
Echinococcus granulosus	receptor type guanylyl cyclase	0.0146	0.5126	0.9836
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0146	0.5126	0.8766
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	CAMK family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0146	0.5126	0.9836
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0146	0.5126	0.8766
Trypanosoma brucei	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.5126	0.8766
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.5126	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0146	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase	0.0146	0.5126	0.8766
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Echinococcus multilocularis	tyrosine protein kinase shark	0.0146	0.5126	0.8766
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0146	0.5126	1
Brugia malayi	SH2 domain containing protein	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Giardia lamblia	Kinase	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Onchocerca volvulus		0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Trypanosoma cruzi	protein kinase, putative	0.0146	0.5126	0.5
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Echinococcus granulosus	kinase suppressor of Ras 1	0.0146	0.5126	0.9836
Echinococcus granulosus	natriuretic peptide receptor 1	0.0146	0.5126	0.9836
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0146	0.5126	0.5
Toxoplasma gondii	protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0146	0.5126	0.9836
Echinococcus granulosus	integrin linked protein kinase	0.0146	0.5126	0.9836
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.5126	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0146	0.5126	0.8243
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0146	0.5126	0.8766
Plasmodium falciparum	protein kinase, putative	0.0146	0.5126	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0146	0.5126	0.8766
Echinococcus multilocularis	protein kinase	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0146	0.5126	0.9836
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Plasmodium falciparum	protein kinase, putative	0.0146	0.5126	1
Schistosoma mansoni	hypothetical protein	0.0146	0.5126	0.8243
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Echinococcus granulosus	activin receptor type	0.0146	0.5126	0.9836
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.5126	0.8766
Echinococcus granulosus	tyrosine kinase	0.0146	0.5126	0.9836
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0146	0.5126	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0146	0.5126	0.8766
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1421	0.2285
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Giardia lamblia	Protein 21.1	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0146	0.5126	0.9836
Brugia malayi	SH2 domain containing protein	0.0146	0.5126	0.5126
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.5126	0.8243
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Echinococcus granulosus	tyrosine protein kinase csk	0.0146	0.5126	0.9836
Brugia malayi	Guanylyl cyclase protein 23	0.0146	0.5126	0.5126
Onchocerca volvulus		0.0146	0.5126	1
Plasmodium falciparum	plasmepsin IV	0.0059	0.1751	0.3416
Loa Loa (eye worm)	TK/DDR protein kinase	0.0146	0.5126	0.5126
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.5126	1
Brugia malayi	integrin-linked kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0146	0.5126	0.9836
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0146	0.5126	0.8766
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	STE family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	protein kinase	0.0146	0.5126	0.9836
Echinococcus multilocularis	tyrosine kinase	0.0146	0.5126	0.8766
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0146	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0146	0.5126	0.8766
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Onchocerca volvulus		0.0146	0.5126	1
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0146	0.5126	0.8766
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.5126	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0146	0.5126	0.9836
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0146	0.5126	0.9836
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Schistosoma mansoni	serine/threonine RGC	0.0146	0.5126	0.8243
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0146	0.5126	0.8766
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.5126	0.8243
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Brugia malayi	Furin-like cysteine rich region family protein	0.0146	0.5126	0.5126
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Onchocerca volvulus		0.0146	0.5126	1
Entamoeba histolytica	tyrosin kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0146	0.5126	0.8766
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0146	0.5126	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Plasmodium falciparum	tyrosine kinase-like protein	0.0146	0.5126	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Trichomonas vaginalis	protein kinase atn1, putative	0.0146	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.5126	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0271	1	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0146	0.5126	0.8766
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.5126	1
Plasmodium vivax	aspartyl proteinase, putative	0.0059	0.1751	0.3416
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Echinococcus multilocularis	insulin receptor	0.0146	0.5126	0.8766
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Giardia lamblia	Kinase, NEK	0.0146	0.5126	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0146	0.5126	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0146	0.5126	0.9836
Brugia malayi	protein-tyrosine kinase	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0059	0.1751	0.3416
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1751	0.1751
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	cysteine surface protein, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Echinococcus multilocularis	tyrosine protein kinase csk	0.0146	0.5126	0.8766
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0146	0.5126	0.8766
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0146	0.5126	0.9836
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0146	0.5126	0.8766
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0146	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0146	0.5126	0.8766
Schistosoma mansoni	tyrosine protein kinase	0.0146	0.5126	0.8243
Echinococcus multilocularis	FL cytokine receptor	0.0146	0.5126	0.8766
Echinococcus multilocularis	activin receptor type	0.0146	0.5126	0.8766
Plasmodium falciparum	plasmepsin VI	0.0059	0.1751	0.3416
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus multilocularis	protein tyrosine kinase	0.0146	0.5126	0.8766
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Schistosoma mansoni	ephrin receptor	0.0146	0.5126	0.8243
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0146	0.5126	0.8766
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0146	0.5126	0.8243
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Plasmodium vivax	protein kinase, putative	0.0146	0.5126	1
Trichomonas vaginalis	TK family protein kinase	0.0146	0.5126	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	SRC-1	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	ankyrin repeat protein	0.0146	0.5126	0.5
Onchocerca volvulus		0.0146	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0146	0.5126	1
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Schistosoma mansoni	ephrin receptor	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Brugia malayi	hypothetical protein	0.0146	0.5126	0.5126
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0146	0.5126	0.9836
Toxoplasma gondii	STE kinase	0.0146	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0146	0.5126	0.8766
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0146	0.5126	0.5126
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Onchocerca volvulus		0.0146	0.5126	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0146	0.5126	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0146	0.5126	0.8243
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0146	0.5126	0.9836
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Echinococcus multilocularis	integrin linked protein kinase	0.0146	0.5126	0.8766
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/EPH protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Brugia malayi	hypothetical protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.5126	0.5
Plasmodium falciparum	plasmepsin II	0.0059	0.1751	0.3416
Brugia malayi	hypothetical protein	0.0146	0.5126	0.5126
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0146	0.5126	0.8766
Brugia malayi	Receptor family ligand binding region containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Echinococcus granulosus	tyrosine kinase	0.0146	0.5126	0.9836
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Loa Loa (eye worm)	TK/RYK protein kinase	0.0146	0.5126	0.5126
Echinococcus multilocularis	protein kinase	0.0146	0.5126	0.8766
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Plasmodium falciparum	protein kinase, putative	0.0146	0.5126	1
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0059	0.1751	0.0781
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0146	0.5126	0.8243
Echinococcus multilocularis	heat shock protein 70	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0146	0.5126	0.5126
Entamoeba histolytica	hypothetical protein, conserved	0.0146	0.5126	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0146	0.5126	1
Onchocerca volvulus		0.0146	0.5126	1
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0146	0.5126	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Echinococcus granulosus	ephrin type A receptor 4 A	0.0146	0.5126	0.9836
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Trypanosoma cruzi	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0146	0.5126	0.9836
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0146	0.5126	0.9836
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0059	0.1751	0.1751
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Toxoplasma gondii	aspartyl protease ASP1	0.0059	0.1751	0.3416
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	tyrosine kinase	0.0146	0.5126	0.8766
Schistosoma mansoni	protein kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0146	0.5126	0.5126
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	receptor protein kinase, putative	0.0146	0.5126	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0159	0.5648	0.9082
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.6219	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.1421	0.1421
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.5126	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0146	0.5126	0.8766
Onchocerca volvulus		0.0146	0.5126	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0146	0.5126	0.9836
Loa Loa (eye worm)	TK/ALK protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	serine/threonine kinase, putative	0.0146	0.5126	0.5
Giardia lamblia	Kinase, NEK	0.0146	0.5126	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0146	0.5126	0.5
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0146	0.5126	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0146	0.5126	0.9836
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0146	0.5126	0.8766
Echinococcus granulosus	tyrosine kinase	0.0146	0.5126	0.9836
Echinococcus granulosus	activated cdc42 kinase 1	0.0146	0.5126	0.9836
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Loa Loa (eye worm)	TK/CSK protein kinase	0.0146	0.5126	0.5126
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0146	0.5126	0.8766
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0146	0.5126	0.5126
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0146	0.5126	0.5
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0146	0.5126	0.9836
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0146	0.5126	0.5126
Echinococcus granulosus	epidermal growth factor receptor	0.0146	0.5126	0.9836
Onchocerca volvulus	Tyrosine kinase homolog	0.0146	0.5126	1
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0146	0.5126	0.5126
Loa Loa (eye worm)	hypothetical protein	0.0146	0.5126	0.5126
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.6219	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0146	0.5126	0.8766
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0147	0.5188	1
Brugia malayi	C-terminal src kinase protein 1	0.0146	0.5126	0.5126
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Entamoeba histolytica	protein kinase, putative	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0146	0.5126	0.9836
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0146	0.5126	0.5126
Onchocerca volvulus		0.0146	0.5126	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0146	0.5126	0.9836
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1421	0.2285
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0146	0.5126	0.8766
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0146	0.5126	0.8766
Onchocerca volvulus		0.0146	0.5126	1
Schistosoma mansoni	tyrosine kinase	0.0146	0.5126	0.8243
Entamoeba histolytica	tyrosine kinase, putative	0.0146	0.5126	0.5
Leishmania major	protein kinase, putative	0.0146	0.5126	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0146	0.5126	0.5126
Onchocerca volvulus		0.0146	0.5126	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0146	0.5126	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Echinococcus granulosus	protein tyrosine kinase	0.0146	0.5126	0.9836
Brugia malayi	Protein kinase domain containing protein	0.0146	0.5126	0.5126
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0146	0.5126	0.9836
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0146	0.5126	0.9836
Loa Loa (eye worm)	TK protein kinase	0.0146	0.5126	0.5126
Entamoeba histolytica	hypothetical protein	0.0146	0.5126	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1421	0.2285
Loa Loa (eye worm)	TK/ACK protein kinase	0.0146	0.5126	0.5126
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0146	0.5126	0.8766
Entamoeba histolytica	protein kinase domain containing protein	0.0146	0.5126	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0146	0.5126	0.9836
Brugia malayi	ephrin receptor 1 precursor	0.0146	0.5126	0.5126
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0059	0.1751	0.0876
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0146	0.5126	0.9836
Echinococcus granulosus	tyrosine protein kinase HCK	0.0146	0.5126	0.9836
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0146	0.5126	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0146	0.5126	0.5126
Trichomonas vaginalis	TKL family protein kinase	0.0146	0.5126	1
Entamoeba histolytica	ankyrin repeat protein	0.0146	0.5126	0.5
Plasmodium falciparum	plasmepsin I	0.0059	0.1751	0.3416
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0146	0.5126	0.9836

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= -7.52	Inhibition of human plasma renin	ChEMBL.	3316655
IC50 (binding)	= 0.0000003 M	In vitro inhibitory activity against human plasma renin	ChEMBL.	3543358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3142793

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1848013