Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0407 | 0.1451 |
Chlamydia trachomatis | sulfite reductase | 0.0092 | 0.1609 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0075 | 0.1254 | 0.4402 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0278 | 0.0992 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0053 | 0.0018 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.0791 | 0.2731 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0057 | 0.0875 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0057 | 0.0875 | 0.3033 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0017 | 0.0034 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0758 | 0.2704 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.0407 | 0.1345 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0053 | 0.0018 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.0187 | 0.0666 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.0791 | 0.2731 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0035 | 0.0407 | 0.1451 |
Onchocerca volvulus | 0.0029 | 0.0278 | 0.3366 | |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0407 | 0.1345 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0057 | 0.0875 | 1 |
Onchocerca volvulus | 0.0051 | 0.0758 | 1 | |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0407 | 0.1345 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0057 | 0.0875 | 0.3119 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.0407 | 0.1345 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0149 | 0.2804 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0278 | 0.0244 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0017 | 0.0034 | 0.0123 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0132 | 0.2449 | 0.8717 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0053 | 0.0018 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0035 | 0.0407 | 0.3116 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0074 | 0.123 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.0791 | 0.3133 |
Mycobacterium ulcerans | pyruvate kinase | 0.0035 | 0.0407 | 0.1345 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.0791 | 0.2731 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.0791 | 0.282 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0057 | 0.0875 | 0.1951 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0791 | 0.1601 |
Brugia malayi | flavodoxin family protein | 0.0149 | 0.2804 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0057 | 0.0875 | 0.3033 |
Echinococcus granulosus | tumor protein p63 | 0.0352 | 0.7051 | 0.7041 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0035 | 0.0407 | 0.1345 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0149 | 0.2804 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.025 | 0.0891 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0149 | 0.2804 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0791 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0278 | 0.0992 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0407 | 0.5147 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.0791 | 0.2731 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0149 | 0.2804 | 0.2779 |
Echinococcus multilocularis | methionine synthase reductase | 0.0092 | 0.1609 | 0.158 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0057 | 0.0875 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.0791 | 0.0759 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0149 | 0.2804 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0149 | 0.2804 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0278 | 0.0244 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0057 | 0.0875 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0017 | 0.0034 | 0.0123 |
Treponema pallidum | flavodoxin | 0.0057 | 0.0875 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0149 | 0.2804 | 0.2779 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0407 | 0.1451 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0187 | 0.0666 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0057 | 0.0875 | 0.3033 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0053 | 0.0018 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.0791 | 0.0759 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0053 | 0.0018 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.0407 | 0.1345 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.0791 | 0.2731 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0149 | 0.2804 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0149 | 0.2804 | 0.2779 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2804 | 1 |
Brugia malayi | flavodoxin family protein | 0.0057 | 0.0875 | 0.3119 |
Leishmania major | hypothetical protein, conserved | 0.0057 | 0.0875 | 0.3033 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.0407 | 0.2366 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0018 | 0.0053 | 0.0153 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0057 | 0.0875 | 0.3033 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0492 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0018 | 0.0053 | 0.0076 |
Leishmania major | pyruvate kinase | 0.0035 | 0.0407 | 0.1345 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0057 | 0.0875 | 0.1951 |
Giardia lamblia | Pyruvate kinase | 0.0035 | 0.0407 | 0.1543 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0278 | 0.0992 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0278 | 0.0244 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0149 | 0.2804 | 0.2779 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0092 | 0.1609 | 0.5684 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0492 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0035 | 0.0407 | 0.5 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0278 | 0.0244 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0149 | 0.2804 | 1 |
Onchocerca volvulus | 0.0029 | 0.0278 | 0.3366 | |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0407 | 0.5147 |
Schistosoma mansoni | lamin | 0.0029 | 0.0278 | 0.0879 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0132 | 0.2449 | 0.8518 |
Echinococcus granulosus | methionine synthase reductase | 0.0092 | 0.1609 | 0.158 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0035 | 0.0407 | 0.1345 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0053 | 0.0018 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0407 | 0.0374 |
Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.0791 | 0.2731 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0057 | 0.0875 | 0.1951 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.0791 | 0.2731 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.025 | 0.0891 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0267 | 0.0952 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0254 | 0.022 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0407 | 0.1451 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0149 | 0.2804 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.0791 | 0.282 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0407 | 0.0374 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0092 | 0.1609 | 0.5737 |
Leishmania major | pyruvate kinase | 0.0035 | 0.0407 | 0.1345 |
Brugia malayi | FAD binding domain containing protein | 0.0149 | 0.2804 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0074 | 0.123 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0053 | 0.0791 | 0.2731 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0791 | 0.1601 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0492 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0278 | 0.0992 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0407 | 0.0374 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0407 | 0.1451 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0057 | 0.0875 | 0.3033 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.0791 | 0.2731 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0149 | 0.2804 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0092 | 0.1609 | 0.5737 |
Echinococcus multilocularis | tumor protein p63 | 0.0352 | 0.7051 | 0.7041 |
Leishmania major | cytochrome P450 reductase, putative | 0.0132 | 0.2449 | 0.8717 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0149 | 0.2804 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0074 | 0.123 | 0.4316 |
Echinococcus granulosus | lamin | 0.0029 | 0.0278 | 0.0244 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0035 | 0.0407 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0132 | 0.2449 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0278 | 0.0244 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0018 | 0.0053 | 0.0066 |
Schistosoma mansoni | lamin | 0.0029 | 0.0278 | 0.0879 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0278 | 0.0992 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0278 | 0.0879 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0057 | 0.0875 | 0.3033 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0057 | 0.0875 | 0.1951 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.0791 | 0.0759 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0791 | 0.1601 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0407 | 0.0374 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0035 | 0.0407 | 0.1451 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.0407 | 0.1345 |
Giardia lamblia | Hypothetical protein | 0.0132 | 0.2449 | 1 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0018 | 0.0053 | 0.0066 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0407 | 0.5147 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.0791 | 0.6328 |
Trypanosoma cruzi | p450 reductase, putative | 0.0149 | 0.2804 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0149 | 0.2804 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0149 | 0.2804 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0149 | 0.2804 | 1 |
Leishmania major | p450 reductase, putative | 0.0149 | 0.2804 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.0791 | 0.0759 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0758 | 0.2613 |
Schistosoma mansoni | pyruvate kinase | 0.0018 | 0.0053 | 0.0066 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0057 | 0.0875 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0057 | 0.0875 | 0.3033 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0149 | 0.2804 | 1 |
Brugia malayi | diaphorase | 0.0017 | 0.0034 | 0.0123 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | 0 % | Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptor at a concentration of 10e-8 M; Not determined | ChEMBL. | 11934581 |
Inhibition (binding) | 0 % | Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptor at a concentration of 10e-9 M; Not determined | ChEMBL. | 11934581 |
Inhibition (binding) | = 15.6 % | Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptor at a concentration of 10e-7 M | ChEMBL. | 11934581 |
Inhibition (binding) | = 15.6 % | Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptor at a concentration of 10e-7 M | ChEMBL. | 11934581 |
Inhibition (binding) | = 77.2 % | Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptor at a concentration of 10e-6 M | ChEMBL. | 11934581 |
Inhibition (binding) | = 77.2 % | Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptor at a concentration of 10e-6 M | ChEMBL. | 11934581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.