TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 318.243 | Formula: C10H11N2O6PS
H donors: 3 H acceptors: 5 LogP: 0.21 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCSC(=O)c1oc(nc1c1ccc(o1)P(=O)(O)O)N
InChi: 1S/C10H11N2O6PS/c1-2-20-9(13)8-7(12-10(11)18-8)5-3-4-6(17-5)19(14,15)16/h3-4H,2H2,1H3,(H2,11,12)(H2,14,15,16)
InChiKey: RRWZUSKSBARQGT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Fructose-1,6-bisphosphatase	Starlite/ChEMBL	No references
Homo sapiens	fructose-1,6-bisphosphatase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus granulosus	fructose 16 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania mexicana	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania major		Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei gambiense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma mansoni	fructose-16-bisphosphatase-related	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Candida albicans	similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Toxoplasma gondii	fructose-bisphospatase II	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania donovani	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma japonicum	ko:K03841 fructose-1,6-bisphosphatase I, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania braziliensis	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Neospora caninum	Fructose-1 6-biphosphatase, related	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania infantum	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	fructose-bisphospatase I	fructose-1,6-bisphosphatase 1	338 aa	326 aa	31.0 %
Onchocerca volvulus	CES-1 homolog	Fructose-1,6-bisphosphatase	363 aa	319 aa	60.5 %
Toxoplasma gondii	fructose-bisphospatase I	Fructose-1,6-bisphosphatase	363 aa	326 aa	31.3 %
Neospora caninum	fructose-1,6-bisphosphatase, putative	Fructose-1,6-bisphosphatase	363 aa	298 aa	32.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	G-protein coupled receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	tm gpcr rhodopsin	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Leishmania major		0.0378	1	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	neuropeptide receptor	0.0073	0.1418	0.1418
Brugia malayi	putative neuropeptide receptor NPR1	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	serotonin receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	7tm_1 domain containing protein	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptide Y receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	neuropeptide F-like receptor	0.0073	0.1418	0.1418
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.1402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	orexin receptor type 2	0.0073	0.1418	0.1418
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptide receptor	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0077	0.1545	0.1545
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	neuropeptide F-like receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0073	0.1418	0.1418
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	amine GPCR	0.0073	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0073	0.1418	0.5
Echinococcus multilocularis	sex peptide receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0073	0.1418	0.1418
Brugia malayi	follicle stimulating hormone receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	neuropeptide receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptide receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptide s receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptides capa receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Toxoplasma gondii	fructose-bisphospatase II	0.0378	1	1
Echinococcus granulosus	serotonin receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0073	0.1418	0.1418
Echinococcus granulosus	somatostatin receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0073	0.1418	0.1418
Echinococcus granulosus	g protein coupled receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	g-protein coupled receptor	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Schistosoma mansoni	myosin xvIII	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0073	0.1418	0.1418
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0378	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0073	0.1418	0.1418
Brugia malayi	putative neuropeptide receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine receptor	0.0073	0.1418	0.1418
Brugia malayi	RE15519p	0.0073	0.1418	0.1418
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0073	0.1418	0.1418
Echinococcus multilocularis	orexin receptor type 2	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	histamine h1 receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptide Y receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	g protein coupled receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	TYRA-2 protein	0.0073	0.1418	0.1418
Echinococcus granulosus	allatostatin A receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	g protein coupled receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	dro:myosuppressin receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus granulosus	sex peptide receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	opsin-like receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Echinococcus multilocularis	somatostatin receptor	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0077	0.1545	0.1545
Brugia malayi	G-protein coupled receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	neuropeptide F receptor	0.0073	0.1418	0.1418
Brugia malayi	AKH receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptide Y receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0378	1	1
Brugia malayi	Dopamine receptor protein 2	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	amine GPCR	0.0073	0.1418	0.1418
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0073	0.1418	0.5
Brugia malayi	G protein-coupled receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	neuropeptide receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.1745	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	amine GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0073	0.1418	0.1418
Brugia malayi	neuropeptide F receptor	0.0073	0.1418	0.1418
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0378	1	1
Schistosoma mansoni	adenoreceptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	neuropeptide F receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	amine GPCR	0.0073	0.1418	0.1418
Brugia malayi	G-protein coupled receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptides capa receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptide s receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	opsin-like receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	allatostatin A receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	G protein coupled receptor 139	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptide Y receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	neuropeptide f receptor 76f	0.0073	0.1418	0.1418
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0073	0.1418	0.1418
Brugia malayi	Melatonin receptor type 1A	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptides capa receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	dro:myosuppressin receptor	0.0073	0.1418	0.1418
Brugia malayi	neuropeptide F receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0073	0.1418	0.1418
Echinococcus granulosus	7TM GPCR rhodopsin	0.0073	0.1418	0.1418
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0077	0.1545	0.1545
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.1402	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Brugia malayi	Serotonin receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptides capa receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	biogenic amine 5HT receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Brugia malayi	ORL1-like opioid receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0378	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	serotonin receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptide receptor A26	0.0073	0.1418	0.1418
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0073	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	fmrfamide receptor	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0073	0.1418	0.1418
Echinococcus granulosus	fmrfamide receptor	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0073	0.1418	0.1418
Brugia malayi	G protein-coupled receptor F59B2.13	0.0073	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0378	1	1
Onchocerca volvulus		0.0073	0.1418	0.5
Schistosoma mansoni	amine GPCR	0.0073	0.1418	0.1418
Brugia malayi	Serotonin receptor	0.0073	0.1418	0.1418
Brugia malayi	larval opioid receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1258	0.1258
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.1745	0.1745
Onchocerca volvulus		0.0073	0.1418	0.5
Onchocerca volvulus		0.0073	0.1418	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	melatonin receptor type 1A	0.0073	0.1418	0.1418
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	g protein coupled receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	G protein coupled receptor 139	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	g protein coupled receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0077	0.1545	0.1545
Brugia malayi	Dopamine receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	neuropeptide receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0378	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0073	0.1418	0.1418
Brugia malayi	sulfakinin receptor protein	0.0073	0.1418	0.1418
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0073	0.1418	0.1418
Loa Loa (eye worm)	G-protein coupled receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	tm gpcr rhodopsin	0.0073	0.1418	0.1418
Brugia malayi	GnHR receptor homolog	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Echinococcus multilocularis	neuropeptide receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	tm gpcr rhodopsin	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0073	0.1418	0.1418
Schistosoma mansoni	opsin-like receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	hypothetical protein	0.0073	0.1418	0.1418
Brugia malayi	hypothetical protein	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.1418	0.1418
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	g protein coupled receptor	0.0073	0.1418	0.1418
Echinococcus granulosus	biogenic amine 5HT receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptide receptor	0.0073	0.1418	0.1418
Brugia malayi	Dopamine receptor protein 1	0.0073	0.1418	0.1418
Schistosoma mansoni	growth hormone secretagogue receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	fmrfamide receptor	0.0073	0.1418	0.1418
Echinococcus multilocularis	g-protein coupled receptor	0.0073	0.1418	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1418	0.1418
Echinococcus granulosus	neuropeptide FF receptor 2	0.0073	0.1418	0.1418
Onchocerca volvulus		0.0073	0.1418	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.03 uM	Inhibition of human liver FBPase	ChEMBL.	No reference
IC50 (binding)	= 2.3 uM	Inhibition of rat liver FBPase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3218207

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1848381