Detailed information for compound 1848469
Basic information
Technical information
- Name: Unnamed compound
- MW: 370.489 | Formula: C21H30N4O2
-
H donors: 0
H acceptors: 4
LogP: 3.41
Rotable bonds: 2
Rule of 5 violations (Lipinski): 1 - SMILES: CC(=O)O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3Cc3n(C2)nnn3)C)C1)C
- InChi: 1S/C21H30N4O2/c1-13(26)27-15-6-9-21(3)14(10-15)4-5-16-17(21)7-8-20(2)12-25-19(11-18(16)20)22-23-24-25/h4,15-18H,5-12H2,1-3H3/t15-,16+,17-,18-,20+,21-/m0/s1
- InChiKey: FBRVTNPGRZJMME-DVFHKXEWSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus granulosus | mitogen activated protein kinase | 0.039 | 0.8239 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1086 | 0.1318 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.039 | 0.8239 | 0.5 |
| Giardia lamblia | Kinase, CMGC MAPK | 0.039 | 0.8239 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.8745 | 0.8595 |
| Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.039 | 0.8239 | 1 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.039 | 0.8239 | 0.5 |
| Echinococcus granulosus | MAM | 0.0056 | 0.1086 | 0.1318 |
| Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.039 | 0.8239 | 1 |
| Onchocerca volvulus | 0.0056 | 0.1086 | 0.5 | |
| Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.039 | 0.8239 | 0.8028 |
| Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.039 | 0.8239 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1086 | 0.1318 |
| Echinococcus multilocularis | MAM | 0.0056 | 0.1086 | 0.1318 |
| Echinococcus granulosus | mitogen activated protein kinase 3 | 0.039 | 0.8239 | 1 |
| Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.039 | 0.8239 | 1 |
| Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.039 | 0.8239 | 1 |
| Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.039 | 0.8239 | 1 |
| Onchocerca volvulus | 0.0056 | 0.1086 | 0.5 | |
| Plasmodium falciparum | protein kinase, putative | 0.0006 | 0 | 0.5 |
| Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.039 | 0.8239 | 1 |
| Echinococcus multilocularis | mitogen activated protein kinase | 0.039 | 0.8239 | 1 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.039 | 0.8239 | 0.5 |
| Loa Loa (eye worm) | TK/ALK protein kinase | 0.0471 | 0.9997 | 1 |
| Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.039 | 0.8239 | 1 |
| Trypanosoma brucei | protein kinase, putative | 0.039 | 0.8239 | 1 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.039 | 0.8239 | 1 |
| Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.039 | 0.8239 | 1 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.039 | 0.8239 | 0.5 |
| Brugia malayi | MAP kinase sur-1 | 0.039 | 0.8239 | 0.8025 |
| Entamoeba histolytica | protein kinase domain containing protein | 0.0006 | 0 | 0.5 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| IC50 (ADMET) | > 100 uM | Cytotoxicity against human MRC5 cells expressing estrogen receptor after 48 hrs by MTT assay | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL3218623
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.