Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 119 | Starlite/ChEMBL | No references |
Mus musculus | G-protein coupled receptor 119 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | G protein-coupled receptor 119 | 335 aa | 274 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0148 | 0.5 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0148 | 0.5 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0148 | 0.5 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0148 | 0.5 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0148 | 0.5 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0148 | 0.5 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0148 | 0.5 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0148 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5 | 0.5 |
Brugia malayi | nicalin | 0.0148 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0148 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0148 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0148 | 0.5 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0148 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0148 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0148 | 0.5 | 0.5 | |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0148 | 0.5 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0148 | 0.5 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0148 | 0.5 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0148 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0148 | 0.5 | 0.5 |
Schistosoma mansoni | nicalin (M28 family) | 0.0148 | 0.5 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0148 | 0.5 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0148 | 0.5 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0148 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0148 | 0.5 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.0148 | 0.5 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0148 | 0.5 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0148 | 0.5 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0148 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0148 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0148 | 0.5 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0148 | 0.5 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0148 | 0.5 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0148 | 0.5 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0148 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0148 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 26 microL/min/mg | Intrinsic clearance in human liver microsomes measured | ChEMBL. | No reference |
EC50 (functional) | = 6.2 | Agonist activity at mouse GPR119 transfected in HEK293 cells assessed as cAMP accumulation after 45 mins incubation by HTRF assay | ChEMBL. | No reference |
EC50 (functional) | = 7 | Agonist activity at human GPR119 transfected in HEK293 cells assessed as cAMP accumulation after 45 mins incubation by HTRF assay | ChEMBL. | No reference |
Intrinsic activity (functional) | = 45 % | Agonist activity at mouse GPR119 transfected in HEK293 cells assessed as cAMP accumulation after 45 mins incubation by HTRF assay relative to 50 uM oleoylethanolamide | ChEMBL. | No reference |
Intrinsic activity (functional) | = 279 % | Agonist activity at human GPR119 transfected in HEK293 cells assessed as cAMP accumulation after 45 mins incubation by HTRF assay relative to 50 uM oleoylethanolamide | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.