Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0653 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0653 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0345 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0653 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0345 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0653 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0345 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0653 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0345 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0653 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0653 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0653 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0653 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0653 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0653 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0653 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0653 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0345 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0653 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0653 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0653 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0345 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor NHR-88 | 0.0653 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0653 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0653 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0653 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0345 | 0.1071 | 0.1071 |
Onchocerca volvulus | 0.0653 | 1 | 1 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0653 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0653 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0653 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0653 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0653 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0653 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0653 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0653 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0345 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0653 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0653 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0653 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0653 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0345 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0653 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0653 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0653 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1071 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0653 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0653 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0345 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 nM | Inhibition of p38 MAP kinase alpha (unknown origin) after 1 hr by Z'-lyte assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.