Detailed information for compound 184892

Basic information

Technical information
  • TDR Targets ID: 184892
  • Name: 2-decylsulfonylacetamide
  • MW: 263.397 | Formula: C12H25NO3S
  • H donors: 1 H acceptors: 3 LogP: 3.05 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCS(=O)(=O)CC(=O)N
  • InChi: 1S/C12H25NO3S/c1-2-3-4-5-6-7-8-9-10-17(15,16)11-12(13)14/h2-11H2,1H3,(H2,13,14)
  • InChiKey: QNJSXDZZVJSONC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-decylsulfonylethanamide
  • 3-sulfonyltridecanamide
  • AIDS-094384
  • AIDS094384
  • FAS20013

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Brugia malayi protein-tyrosine kinase 0.222 1 1
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) SH2 domain-containing protein 0.0945 0.364 0.354
Plasmodium falciparum protein kinase, putative 0.1274 0.5281 1
Schistosoma mansoni suppressor of cytokine signaling 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine kinase 0.222 1 1
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus granulosus tm gpcr rhodopsin 0.1051 0.4166 0.4074
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica receptor protein kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein kinase csk 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK/FER protein kinase 0.1274 0.5281 0.5207
Brugia malayi RhoGAP domain containing protein 0.0945 0.364 0.354
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.1274 0.5281 1
Echinococcus multilocularis protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni serine/threonine protein kinase 0.1274 0.5281 0.5207
Brugia malayi SH2 domain containing protein 0.0945 0.364 0.354
Trichomonas vaginalis conserved hypothetical protein 0.1274 0.5281 1
Brugia malayi Tyrosine-protein kinase abl-1 0.222 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK/KIN6 protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis retinal guanylyl cyclase 2 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) TK/DDR protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica serine/threonine kinase, putative 0.1274 0.5281 0.5002
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.1274 0.5281 0.5207
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0945 0.364 0.354
Loa Loa (eye worm) SH2 domain-containing protein 0.0945 0.364 0.354
Loa Loa (eye worm) TK/ACK protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Btk29A 0.222 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.1274 0.5281 0.5207
Brugia malayi Receptor family ligand binding region containing protein 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis SHC transforming protein 3 0.0945 0.364 0.354
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis SH2 motif 0.0945 0.364 0.354
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Brugia malayi Probable tyrosine-protein kinase kin-31 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus granulosus tyrosine protein kinase shark 0.222 1 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.222 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Brugia malayi Protein kinase domain containing protein 0.222 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.222 1 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Onchocerca volvulus 0.222 1 1
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Echinococcus multilocularis c src tyrosine kinase 0.222 1 1
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Echinococcus granulosus activated cdc42 kinase 1 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) SRC-1 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1274 0.5281 0.5207
Onchocerca volvulus 0.1274 0.5281 0.5281
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0945 0.364 0.354
Trypanosoma cruzi protein kinase, putative 0.1274 0.5281 1
Brugia malayi Raf kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Onchocerca volvulus 0.1274 0.5281 0.5281
Trichomonas vaginalis conserved hypothetical protein 0.1274 0.5281 1
Onchocerca volvulus 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0945 0.364 0.354
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.1274 0.5281 0.5207
Brugia malayi hypothetical protein 0.1274 0.5281 0.5207
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0945 0.364 0.354
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0945 0.364 0.3264
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) TK/RYK protein kinase 0.1274 0.5281 0.5207
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.1274 0.5281 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.1274 0.5281 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0945 0.364 0.354
Loa Loa (eye worm) STAT protein 0.0945 0.364 0.354
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1274 0.5281 0.5207
Schistosoma mansoni growth factor receptor-bound protein 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis FL cytokine receptor 0.1274 0.5281 0.5207
Brugia malayi C-terminal src kinase protein 1 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Schistosoma mansoni ephrin receptor 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Onchocerca volvulus 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis conserved hypothetical protein 0.1274 0.5281 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Onchocerca volvulus 0.1274 0.5281 0.5281
Echinococcus multilocularis epidermal growth factor receptor 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Entamoeba histolytica serine/threonine kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.1274 0.5281 0.5207
Trypanosoma cruzi protein kinase, putative 0.1274 0.5281 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) TK/FER protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni vav2 0.0945 0.364 0.354
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Onchocerca volvulus 0.222 1 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.1274 0.5281 0.5281
Trichomonas vaginalis protein tyrosine kinase, putative 0.1274 0.5281 1
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Brugia malayi SH2 domain containing protein 0.0945 0.364 0.354
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Leishmania major protein kinase, putative 0.1274 0.5281 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0945 0.364 0.354
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0945 0.364 0.354
Entamoeba histolytica tyrosin kinase, putative 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis tyrosine kinase 0.222 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Trichomonas vaginalis serine-threonine protein kinase, putative 0.1274 0.5281 1
Echinococcus granulosus tyrosine protein kinase Srms 0.222 1 1
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Brugia malayi hypothetical protein 0.0945 0.364 0.354
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.222 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Echinococcus multilocularis signal transduction protein lnk realted 0.0945 0.364 0.354
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus N chimaerin 0.0945 0.364 0.354
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Echinococcus granulosus suppressor of cytokine signaling 6 0.0945 0.364 0.354
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Schistosoma mansoni GTPase activating protein 0.0945 0.364 0.354
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Echinococcus granulosus epidermal growth factor receptor 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Tensin 0.0945 0.364 0.354
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0247 0.0155 0.0155
Schistosoma mansoni suppressor of cytokine signaling 0.0945 0.364 0.354
Schistosoma mansoni tyrosine kinase 0.222 1 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Toxoplasma gondii protein kinase 0.1274 0.5281 1
Brugia malayi Protein kinase domain containing protein 0.222 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1051 0.4166 0.4074
Loa Loa (eye worm) TK/FER protein kinase 0.1274 0.5281 0.5207
Onchocerca volvulus 0.0945 0.364 0.364
Schistosoma mansoni tensin 0.0945 0.364 0.354
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Echinococcus granulosus retinal guanylyl cyclase 2 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK/Met protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus protein tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase Blk 0.222 1 1
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Schistosoma mansoni protein tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Lyn 0.222 1 1
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine-protein kinase fps85d 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase 0.1274 0.5281 0.5207
Brugia malayi hypothetical protein 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0945 0.364 0.364
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Schistosoma mansoni signal transduction protein lnk-related 0.0945 0.364 0.354
Entamoeba histolytica serine/threonine kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) TK/FAK protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Fyn 0.222 1 1
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Echinococcus multilocularis tyrosine protein kinase csk 0.1274 0.5281 0.5207
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0945 0.364 0.354
Entamoeba histolytica serine/threonine kinase, putative 0.1274 0.5281 0.5002
Brugia malayi Variant SH3 domain containing protein 0.0945 0.364 0.354
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis protein kinase atn1, putative 0.1274 0.5281 1
Echinococcus multilocularis 0.0945 0.364 0.354
Echinococcus multilocularis natriuretic peptide receptor 1 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase csk 0.1274 0.5281 0.5207
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trypanosoma brucei Pseudokinase, putative 0.1274 0.5281 1
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Echinococcus multilocularis tyrosine protein kinase HCK 0.1274 0.5281 0.5207
Onchocerca volvulus 0.0247 0.0155 0.0155
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Schistosoma mansoni sphingosine kinase A B 0.0328 0.0559 0.041
Echinococcus multilocularis receptor type guanylyl cyclase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.222 1 1
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Echinococcus multilocularis heat shock protein 70 0.1274 0.5281 0.5207
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0945 0.364 0.354
Trichomonas vaginalis TK family protein kinase 0.1274 0.5281 1
Brugia malayi Furin-like cysteine rich region family protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) SH2 domain-containing protein 0.0945 0.364 0.354
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Echinococcus granulosus hypothetical protein 0.0945 0.364 0.354
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.222 1 1
Onchocerca volvulus 0.1274 0.5281 0.5281
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.222 1 1
Brugia malayi SH2 domain containing protein 0.0945 0.364 0.354
Plasmodium falciparum protein kinase, putative 0.1274 0.5281 1
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Entamoeba histolytica receptor protein kinase, putative 0.1274 0.5281 0.5002
Echinococcus granulosus protein kinase 0.1274 0.5281 0.5207
Brugia malayi Tyrosine-protein kinase PR2 0.1274 0.5281 0.5207
Plasmodium vivax tyrosine kinase-like protein, putative 0.1274 0.5281 1
Loa Loa (eye worm) TK/FER protein kinase 0.1274 0.5281 0.5207
Loa Loa (eye worm) Skb1 methyltransferase 0.1118 0.45 0.4413
Echinococcus multilocularis tyrosine protein kinase Srms 0.222 1 1
Loa Loa (eye worm) hypothetical protein 0.222 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Src42A 0.0945 0.364 0.354
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica SH2 domain containing protein 0.0945 0.364 0.3264
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0945 0.364 0.354
Leishmania major protein kinase, putative 0.1274 0.5281 1
Plasmodium falciparum protein kinase, putative 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.222 1 1
Schistosoma mansoni hypothetical protein 0.1274 0.5281 0.5207
Onchocerca volvulus 0.0945 0.364 0.364
Trichomonas vaginalis conserved hypothetical protein 0.1274 0.5281 1
Echinococcus multilocularis SH2 motif 0.0945 0.364 0.354
Entamoeba histolytica SH2-protein kinase domain containing protein 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus granulosus activin receptor type 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus granulosus insulin receptor 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis sphingosine kinase 1 0.0328 0.0559 0.041
Brugia malayi integrin-linked kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) TK/ALK protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis SH2 motif 0.0945 0.364 0.354
Echinococcus multilocularis tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0945 0.364 0.354
Onchocerca volvulus Tyrosine kinase homolog 0.1274 0.5281 0.5281
Echinococcus granulosus SHC transforming protein 3 0.0945 0.364 0.354
Brugia malayi cytokine inducible SH2-containing protein 5 0.0945 0.364 0.354
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.222 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1274 0.5281 0.5207
Echinococcus multilocularis NCK adaptor protein 0.0945 0.364 0.354
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Brugia malayi Protein kinase domain containing protein 0.222 1 1
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK/ABL protein kinase 0.222 1 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1274 0.5281 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0945 0.364 0.354
Echinococcus granulosus kinase suppressor of Ras 1 0.1274 0.5281 0.5207
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) TK/FER protein kinase 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Brugia malayi hypothetical protein 0.222 1 1
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Onchocerca volvulus 0.0247 0.0155 0.0155
Echinococcus multilocularis tyrosine protein kinase Fyn 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Trypanosoma brucei Flagellum attachment zone protein 20 0.1274 0.5281 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.0559 0.041
Trypanosoma brucei protein kinase, putative 0.1274 0.5281 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.1274 0.5281 0.5207
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0945 0.364 0.354
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Brugia malayi SH2 domain containing protein 0.0945 0.364 0.354
Schistosoma mansoni sphingoid long chain base kinase 0.0328 0.0559 0.041
Loa Loa (eye worm) TK/INSR protein kinase 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.222 1 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Onchocerca volvulus 0.0247 0.0155 0.0155
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis insulin receptor 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase pr2 0.1274 0.5281 0.5207
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis kinase suppressor of Ras 1 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosin kinase, putative 0.1274 0.5281 0.5002
Echinococcus granulosus epidermal growth factor receptor 0.1274 0.5281 0.5207
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Echinococcus multilocularis tyrosine protein kinase Fgr 0.222 1 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis protein kinase 0.1274 0.5281 0.5207
Brugia malayi tRNA modification GTPase TrmE family protein 0.0945 0.364 0.354
Entamoeba histolytica ankyrin repeat protein 0.1274 0.5281 0.5002
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis STE family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.1274 0.5281 0.5207
Mycobacterium ulcerans carboxylesterase, LipT 0.0528 0.1555 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0945 0.364 0.354
Echinococcus multilocularis tyrosine protein kinase ABL1 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Echinococcus granulosus integrin linked protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus natriuretic peptide receptor 1 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0945 0.364 0.354
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1274 0.5281 1
Onchocerca volvulus 0.0945 0.364 0.364
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Schistosoma mansoni shk1 kinase-binding protein 0.1118 0.45 0.4413
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1274 0.5281 0.5207
Echinococcus granulosus SH2 motif 0.0945 0.364 0.354
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.1274 0.5281 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Brugia malayi Immunoglobulin I-set domain containing protein 0.1274 0.5281 0.5207
Echinococcus granulosus SH2 domain containing protein 7 0.0945 0.364 0.354
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.222 1 1
Echinococcus granulosus expressed conserved protein 0.0945 0.364 0.354
Schistosoma mansoni nck2/grb4 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) protein kinase domain-containing protein 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Echinococcus multilocularis tyrosine protein kinase shark 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Onchocerca volvulus 0.0247 0.0155 0.0155
Echinococcus granulosus tyrosine protein kinase csk 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Giardia lamblia Kinase, NEK 0.1274 0.5281 0.5
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Brugia malayi Variant SH3 domain containing protein 0.0945 0.364 0.354
Echinococcus granulosus tensin 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.1274 0.5281 1
Echinococcus multilocularis activin receptor type 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine kinase 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis conserved hypothetical protein 0.1274 0.5281 1
Plasmodium vivax protein kinase, putative 0.1274 0.5281 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1274 0.5281 0.5207
Echinococcus granulosus c src tyrosine kinase 0.222 1 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.1274 0.5281 0.5281
Echinococcus granulosus tyrosine protein kinase ABL1 0.222 1 1
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Schistosoma mansoni hypothetical protein 0.0945 0.364 0.354
Echinococcus granulosus NCK adaptor protein 0.0945 0.364 0.354
Onchocerca volvulus 0.0247 0.0155 0.0155
Echinococcus granulosus tyrosine protein kinase csk 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Fyn 0.222 1 1
Trichomonas vaginalis AGC family protein kinase 0.1274 0.5281 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.1274 0.5281 0.5207
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.222 1 1
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.222 1 1
Schistosoma mansoni shc transforming protein 0.0945 0.364 0.354
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0945 0.364 0.354
Entamoeba histolytica tyrosin kinase, putative 0.1274 0.5281 0.5002
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Plasmodium falciparum tyrosine kinase-like protein 0.1274 0.5281 1
Echinococcus multilocularis integrin linked protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni serine/threonine protein kinase 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Trichomonas vaginalis conserved hypothetical protein 0.1274 0.5281 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Brugia malayi Guanylyl cyclase protein 23 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Fyn 0.222 1 1
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Entamoeba histolytica hypothetical protein, conserved 0.1274 0.5281 0.5002
Echinococcus granulosus tyrosine protein kinase Src64B 0.222 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.1274 0.5281 0.5207
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine kinase 0.1274 0.5281 0.5207
Giardia lamblia Kinase, NEK 0.1274 0.5281 0.5
Mycobacterium tuberculosis Carboxylesterase LipT 0.0528 0.1555 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0945 0.364 0.354
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0945 0.364 0.354
Echinococcus granulosus fibroblast growth factor receptor 4 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Onchocerca volvulus 0.1274 0.5281 0.5281
Echinococcus multilocularis protein arginine N methyltransferase 5 0.1118 0.45 0.4413
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Giardia lamblia Kinase 0.1274 0.5281 0.5
Echinococcus multilocularis SH2 domain containing protein 7 0.0945 0.364 0.354
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Echinococcus granulosus sphingosine kinase 1 0.0328 0.0559 0.041
Schistosoma mansoni adapter molecule crk 0.0945 0.364 0.354
Schistosoma mansoni tensin 0.0945 0.364 0.354
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis ephrin type A receptor 4 A 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosin kinase, putative 0.1274 0.5281 0.5002
Brugia malayi SRC-1 0.222 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.1274 0.5281 0.5207
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0945 0.364 0.354
Echinococcus granulosus retinal guanylyl cyclase 2 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase Fyn 0.222 1 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.222 1 1
Echinococcus granulosus activated cdc42 kinase 1 0.1274 0.5281 0.5207
Plasmodium falciparum tyrosine kinase-like protein 0.1274 0.5281 1
Echinococcus multilocularis protein tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0945 0.364 0.354
Toxoplasma gondii protein kinase domain-containing protein 0.1274 0.5281 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0945 0.364 0.354
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Src42A 0.222 1 1
Onchocerca volvulus 0.0247 0.0155 0.0155
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.1274 0.5281 0.5207
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Echinococcus granulosus ephrin type A receptor 4 A 0.1274 0.5281 0.5207
Giardia lamblia Protein 21.1 0.1274 0.5281 0.5
Schistosoma mansoni tensin-related 0.0945 0.364 0.354
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Schistosoma mansoni growth factor receptor-bound protein 0.0945 0.364 0.354
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis dual specificity testis specific protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.1274 0.5281 0.5207
Echinococcus multilocularis tensin 0.0945 0.364 0.354
Loa Loa (eye worm) TK/EGFR protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Variant SH3 domain containing protein 0.0945 0.364 0.354
Onchocerca volvulus 0.1274 0.5281 0.5281
Echinococcus multilocularis activated cdc42 kinase 1 0.1274 0.5281 0.5207
Echinococcus multilocularis protein KINase family member (kin 25) 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.1274 0.5281 0.5207
Schistosoma mansoni tensin 0.0945 0.364 0.354
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.222 1 1
Echinococcus multilocularis transfer RNA-Thr 0.1274 0.5281 0.5207
Echinococcus granulosus protein arginine N methyltransferase 5 0.1118 0.45 0.4413
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Onchocerca volvulus 0.0945 0.364 0.364
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0945 0.364 0.364
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0945 0.364 0.354
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Echinococcus granulosus tyrosine protein kinase Blk 0.222 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0945 0.364 0.354
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Brugia malayi STAT protein, DNA binding domain containing protein 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Onchocerca volvulus 0.1274 0.5281 0.5281
Echinococcus granulosus tyrosine protein kinase HCK 0.1274 0.5281 0.5207
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.1274 0.5281 1
Entamoeba histolytica Skb1 methyltransferase, putative 0.1118 0.45 0.4174
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0945 0.364 0.354
Loa Loa (eye worm) RGC/RGC protein kinase 0.1274 0.5281 0.5207
Onchocerca volvulus 0.0247 0.0155 0.0155
Brugia malayi SH2 domain containing protein 0.222 1 1
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Brugia malayi Variant SH3 domain containing protein 0.0945 0.364 0.354
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Schistosoma mansoni src-type protein tyrosine kinase-related 0.1274 0.5281 0.5207
Echinococcus multilocularis tensin 0.0945 0.364 0.354
Onchocerca volvulus 0.1274 0.5281 0.5281
Echinococcus multilocularis tyrosine protein kinase Src42A 0.222 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.1274 0.5281 0.5207
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.1274 0.5281 0.5207
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0945 0.364 0.354
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Onchocerca volvulus 0.222 1 1
Schistosoma mansoni tyrosine protein kinase 0.1274 0.5281 0.5207
Onchocerca volvulus 0.0945 0.364 0.364
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Brugia malayi Sex muscle abnormal protein 5 0.0945 0.364 0.354
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi Skb1 methyltransferase family protein 0.1118 0.45 0.4413
Onchocerca volvulus 0.0247 0.0155 0.0155
Echinococcus multilocularis N chimaerin 0.0945 0.364 0.354
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.1274 0.5281 1
Echinococcus granulosus SH2 motif 0.0945 0.364 0.354
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.222 1 1
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) RGC/RGC protein kinase 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Brugia malayi SH2 domain containing protein 0.0945 0.364 0.354
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Loa Loa (eye worm) TK protein kinase 0.222 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Schistosoma mansoni tensin-related 0.0945 0.364 0.354
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Brugia malayi bone morphogenetic protein type 1 receptor 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica hypothetical protein 0.1274 0.5281 0.5002
Echinococcus granulosus dual specificity testis-specific protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Schistosoma mansoni serine/threonine RGC 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Brugia malayi SH2 domain containing protein 0.0945 0.364 0.354
Plasmodium vivax tyrosine kinase-like protein, putative 0.1274 0.5281 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.222 1 1
Entamoeba histolytica ankyrin repeat protein 0.1274 0.5281 0.5002
Schistosoma mansoni SH2A 0.0945 0.364 0.354
Schistosoma mansoni tyrosine kinase 0.222 1 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.1274 0.5281 0.5207
Echinococcus multilocularis retinal guanylyl cyclase 2 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.222 1 1
Loa Loa (eye worm) TK/EPH protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Trichomonas vaginalis conserved hypothetical protein 0.1274 0.5281 1
Onchocerca volvulus 0.222 1 1
Brugia malayi ephrin receptor 1 precursor 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Onchocerca volvulus Neuropeptide F receptor homolog 0.0247 0.0155 0.0155
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Brugia malayi Protein kinase domain containing protein 0.1274 0.5281 0.5207
Onchocerca volvulus 0.1274 0.5281 0.5281
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0945 0.364 0.354
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Onchocerca volvulus 0.0945 0.364 0.364
Schistosoma mansoni serine/threonine protein kinase 0.1274 0.5281 0.5207
Loa Loa (eye worm) TK/CSK protein kinase 0.1274 0.5281 0.5207
Echinococcus multilocularis epidermal growth factor receptor 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Brugia malayi SH2 domain containing protein 0.0945 0.364 0.354
Onchocerca volvulus 0.0247 0.0155 0.0155
Loa Loa (eye worm) serine/threonine protein kinase 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Entamoeba histolytica protein kinase, putative 0.1274 0.5281 0.5002
Leishmania major hypothetical protein, conserved 0.1274 0.5281 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0945 0.364 0.354
Echinococcus multilocularis tyrosine protein kinase Abl 0.222 1 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.1274 0.5281 0.5207
Schistosoma mansoni tyrosine kinase 0.1274 0.5281 0.5207
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.1274 0.5281 0.5002
Schistosoma mansoni hypothetical protein 0.0945 0.364 0.354
Loa Loa (eye worm) TK/FER protein kinase 0.1274 0.5281 0.5207
Echinococcus granulosus signal transduction protein lnk realted 0.0945 0.364 0.354
Schistosoma mansoni tyrosine-protein kinase fps85d 0.1274 0.5281 0.5207
Entamoeba histolytica tyrosine kinase, putative 0.1274 0.5281 0.5002
Onchocerca volvulus 0.0247 0.0155 0.0155
Echinococcus granulosus tyrosine protein kinase Fps85D 0.222 1 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0945 0.364 0.354
Loa Loa (eye worm) TK/FER protein kinase 0.222 1 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.1274 0.5281 0.5207
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Trichomonas vaginalis TKL family protein kinase 0.1274 0.5281 1
Entamoeba histolytica protein kinase domain containing protein 0.1274 0.5281 0.5002
Echinococcus granulosus raf serine:threonine protein kinase 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Loa Loa (eye worm) hypothetical protein 0.0945 0.364 0.354
Entamoeba histolytica protein kinase, putative 0.0945 0.364 0.3264
Loa Loa (eye worm) hypothetical protein 0.1274 0.5281 0.5207
Echinococcus multilocularis tyrosine protein kinase csk 0.1274 0.5281 0.5207
Trichomonas vaginalis CAMK family protein kinase 0.1274 0.5281 1
Entamoeba histolytica serine/threonine kinase, putative 0.1274 0.5281 0.5002
Schistosoma mansoni protein kinase 0.1274 0.5281 0.5207
Brugia malayi SH2 domain containing protein 0.222 1 1
Entamoeba histolytica cysteine surface protein, putative 0.1274 0.5281 0.5002
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1274 0.5281 0.5207
Toxoplasma gondii STE kinase 0.1274 0.5281 1
Schistosoma mansoni ephrin receptor 0.1274 0.5281 0.5207

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.75 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis ChEMBL. 15917508
MIC (functional) = 1.5 ug ml-1 Activity against M. tuberculosis (H37Rv) using the standard BACTEC radiometric growth assay ChEMBL. 10966749
MIC (functional) = 1.5 ug ml-1 Activity against M. tuberculosis (H37Rv) using the standard BACTEC radiometric growth assay ChEMBL. 10966749

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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