Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain containing 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0721 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0721 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0721 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0721 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0721 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0721 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0086 | 0.0699 | 0.0699 |
Entamoeba histolytica | bromodomain-containing protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0721 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0721 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0721 | 1 | 0.5 |
Entamoeba histolytica | bromodomain-containing protein | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0721 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0721 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0721 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0221 | 0.0221 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0721 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0721 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0221 | 0.0221 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0053 | 0.0221 | 0.0221 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0721 | 1 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0086 | 0.0699 | 0.0699 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0721 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0721 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0699 | 0.0699 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0221 | 0.0221 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0721 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0137 | 0.0137 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0086 | 0.0699 | 0.0699 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0221 | 0.0221 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0721 | 1 | 0.5 |
Entamoeba histolytica | bromodomain-containing protein | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.1 | Inhibition of BRD4 bromodomain-1 (unknown origin) by AlphaScreen assay | ChEMBL. | 26682033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.