Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Torpedo californica | Acetylcholinesterase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuroligin | Acetylcholinesterase | 586 aa | 493 aa | 21.5 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 564 aa | 29.4 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 586 aa | 648 aa | 32.6 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 586 aa | 551 aa | 40.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 509 aa | 24.8 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 562 aa | 25.1 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 586 aa | 602 aa | 24.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 480 aa | 24.6 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 586 aa | 535 aa | 31.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 586 aa | 588 aa | 28.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 546 aa | 29.3 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 586 aa | 643 aa | 32.2 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 571 aa | 25.0 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 586 aa | 552 aa | 37.7 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 592 aa | 28.0 % |
Schistosoma mansoni | gliotactin | Acetylcholinesterase | 586 aa | 474 aa | 31.6 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 586 aa | 487 aa | 23.0 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Acetylcholinesterase | 586 aa | 577 aa | 33.6 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 612 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0175 | 0.3684 | 0.3684 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0323 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.026 | 0.7313 | 0.4676 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0175 | 0.3684 | 0.3684 |
Loa Loa (eye worm) | TTK protein kinase | 0.0323 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0205 | 0.4953 | 0.4953 |
Schistosoma mansoni | serine/threonine kinase | 0.026 | 0.7313 | 0.7313 |
Trichomonas vaginalis | CAMK family protein kinase | 0.026 | 0.7313 | 0.5746 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0323 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0323 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.4953 | 0.4953 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0323 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0205 | 0.4953 | 0.4953 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.4953 | 0.4953 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.4953 | 0.4953 |
Giardia lamblia | Kinase, TTK | 0.0323 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.4953 | 0.4953 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.026 | 0.7313 | 0.4676 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0323 | 1 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0323 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.4953 | 0.4953 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.59 nM | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate assessed as ROS-induced enzyme inactivation preincubated for 10 mins followed by substrate addition measured every 30 secs for 20 mins in presence of horseradish peroxidase and H2O2 | ChEMBL. | No reference |
IC50 (binding) | = 17 nM | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.