Detailed information for compound 184916

Basic information

Technical information
  • TDR Targets ID: 184916
  • Name: 1-[8-amino-2-(5-bromofuran-2-yl)-[1,2,4]triaz olo[1,5-a]pyridine-6-carbonyl]-N,N-diethylpip eridine-3-carboxamide
  • MW: 489.366 | Formula: C21H25BrN6O3
  • H donors: 1 H acceptors: 4 LogP: 2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)C1CCCN(C1)C(=O)c1cc(N)c2n(c1)nc(n2)c1ccc(o1)Br)CC
  • InChi: 1S/C21H25BrN6O3/c1-3-26(4-2)20(29)13-6-5-9-27(11-13)21(30)14-10-15(23)19-24-18(25-28(19)12-14)16-7-8-17(22)31-16/h7-8,10,12-13H,3-6,9,11,23H2,1-2H3
  • InChiKey: BQRGSPQJKCXBSD-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-[8-amino-2-(5-bromo-2-furyl)-[1,2,4]triazolo[1,5-a]pyridine-6-carbonyl]-N,N-diethyl-piperidine-3-carboxamide
  • 1-[[8-amino-2-(5-bromo-2-furyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-oxomethyl]-N,N-diethyl-3-piperidinecarboxamide
  • 1-[[8-azanyl-2-(5-bromofuran-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]carbonyl]-N,N-diethyl-piperidine-3-carboxamide
  • 1-[8-amino-2-(5-bromo-2-furyl)-[1,2,4]triazolo[1,5-a]pyridine-6-carbonyl]-N,N-diethyl-nipecotamide
  • 1-[8-amino-2-(5-bromofuran-2-yl)[1,2,4]triazolo[5,1-f]pyridine-6-carbonyl]-N,N-diethylpiperidine-3-carboxamide
  • 1-[8-amino-2-(5-bromo-2-furyl)[1,2,4]triazolo[5,1-f]pyridine-6-carbonyl]-N,N-diethyl-piperidine-3-carboxamide
  • 1-[[8-amino-2-(5-bromo-2-furyl)-[1,2,4]triazolo[5,1-f]pyridin-6-yl]-oxomethyl]-N,N-diethyl-3-piperidinecarboxamide
  • 1-[8-amino-2-(5-bromo-2-furyl)[1,2,4]triazolo[5,1-f]pyridine-6-carbonyl]-N,N-diethyl-nipecotamide
  • 1-[[8-amino-2-(5-bromofuran-2-yl)-[1,2,4]triazolo[5,1-f]pyridin-6-yl]carbonyl]-N,N-diethyl-piperidine-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0133 0.0229
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.008 0.5263 0.5
Schistosoma mansoni biogenic amine receptor 0.0026 0.0133 0.0203
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0041 0.1551 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0133 0.0203
Mycobacterium leprae putative cytochrome p450 0.0041 0.1551 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0026 0.0133 0.0203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0133 0.0133
Brugia malayi Dopamine receptor protein 1 0.0026 0.0133 0.0133
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0133 0.0229
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0041 0.1551 0.5
Schistosoma mansoni amine GPCR 0.0026 0.0133 0.0203
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0133 0.0229
Onchocerca volvulus 0.0026 0.0133 0.5
Brugia malayi AKH receptor 0.0026 0.0133 0.0133
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0133 0.0229
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni cytochrome P450 0.0041 0.1551 0.2368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0133 0.0203
Brugia malayi Serotonin receptor 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0133 0.0203
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0133 0.0229
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0041 0.1551 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis sex peptide receptor 0.0026 0.0133 0.0229
Brugia malayi G-protein coupled receptor 0.0026 0.0133 0.0133
Echinococcus granulosus g protein coupled receptor 0.0026 0.0133 0.0229
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0061 0.3491 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0086 0.58 0.58
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0133 0.0229
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0133 0.0229
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0133 0.0229
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0133 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Echinococcus granulosus serotonin receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0133 0.0229
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0041 0.1551 0.5
Schistosoma mansoni opsin-like receptor 0.0026 0.0133 0.0203
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0133 0.0133
Echinococcus multilocularis somatostatin receptor 0.0026 0.0133 0.0229
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0041 0.1551 0.5
Onchocerca volvulus 0.0026 0.0133 0.5
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0133 0.0133
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0133 0.0229
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0133 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0041 0.1551 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.3491 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0133 0.0133
Loa Loa (eye worm) cytochrome P450 0.0041 0.1551 0.1551
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0133 0.0133
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0086 0.58 0.58
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0133 0.0133
Onchocerca volvulus 0.0026 0.0133 0.5
Trypanosoma brucei cytochrome P450, putative 0.0061 0.3491 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0133 0.0203
Schistosoma mansoni amine GPCR 0.0026 0.0133 0.0203
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0133 0.0133
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus cytochrome P450 2K1 0.0041 0.1551 0.2675
Brugia malayi cytochrome P450 0.0041 0.1551 0.1551
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0133 0.0133
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0133 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0133 0.0229
Echinococcus granulosus sex peptide receptor 0.0026 0.0133 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus granulosus neuropeptide receptor 0.0026 0.0133 0.0229
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi Cytochrome P450 family protein 0.0061 0.3491 0.3491
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0133 0.0229
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Onchocerca volvulus 0.0026 0.0133 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0041 0.1551 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0133 0.0229
Schistosoma mansoni opsin-like receptor 0.0026 0.0133 0.0203
Brugia malayi larval opioid receptor 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0133 0.0203
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Onchocerca volvulus 0.0026 0.0133 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.013 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0133 0.0229
Brugia malayi Dopamine receptor 0.0026 0.0133 0.0133
Echinococcus granulosus g protein coupled receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis serotonin receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi Cytochrome P450 family protein 0.0041 0.1551 0.1551
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Schistosoma mansoni opsin-like receptor 0.0026 0.0133 0.0203
Brugia malayi GnHR receptor homolog 0.0026 0.0133 0.0133
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Brugia malayi Melatonin receptor type 1A 0.0026 0.0133 0.0133
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0133 0.0203
Onchocerca volvulus 0.0026 0.0133 0.5
Echinococcus granulosus neuropeptide receptor 0.0026 0.0133 0.0229
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.3491 0.3491
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0133 0.0133
Brugia malayi ORL1-like opioid receptor 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni amine GPCR 0.0026 0.0133 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0041 0.1551 0.5
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0133 0.0229
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0133 0.0133
Toxoplasma gondii cytochrome p450 superfamily protein 0.0041 0.1551 0.5
Schistosoma mansoni histamine h1 receptor 0.0026 0.0133 0.0203
Schistosoma mansoni biogenic amine receptor 0.0026 0.0133 0.0203
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0133 0.0133
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0133 0.0229
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0133 0.0229
Echinococcus multilocularis 0.0041 0.1551 0.2675
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0133 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0133 0.0203
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0133 0.0229
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0086 0.58 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0133 0.0203
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0133 0.0229
Schistosoma mansoni amine GPCR 0.0026 0.0133 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0041 0.1551 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0133 0.0203
Onchocerca volvulus 0.0026 0.0133 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0133 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Schistosoma mansoni hypothetical protein 0.0026 0.0133 0.0203
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.3491 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0041 0.1551 0.5
Onchocerca volvulus 0.0026 0.0133 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0133 0.0229
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0041 0.1551 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni adenoreceptor 0.0026 0.0133 0.0203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0041 0.1551 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0041 0.1551 0.5
Onchocerca volvulus 0.0026 0.0133 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0133 0.0133
Onchocerca volvulus 0.0026 0.0133 0.5
Onchocerca volvulus 0.0026 0.0133 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0041 0.1551 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0133 0.0229
Schistosoma mansoni biogenic amine receptor 0.0026 0.0133 0.0203
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0133 0.0203
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus granulosus orexin receptor type 2 0.0026 0.0133 0.0229
Echinococcus granulosus g protein coupled receptor 0.0026 0.0133 0.0229
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0133 0.0133
Brugia malayi sulfakinin receptor protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0133 0.0229
Onchocerca volvulus 0.0026 0.0133 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0041 0.1551 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0133 0.0229
Brugia malayi Serotonin receptor 0.0026 0.0133 0.0133
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0133 0.0133
Brugia malayi G-protein coupled receptor 0.0026 0.0133 0.0133
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0133 0.0133
Loa Loa (eye worm) CYP4Cod1 0.0061 0.3491 0.3491
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0133 0.0229
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0133 0.0203
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus multilocularis serotonin receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0133 0.0229
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0041 0.1551 0.5
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Onchocerca volvulus 0.0026 0.0133 0.5
Onchocerca volvulus 0.0026 0.0133 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0041 0.1551 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0041 0.1551 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0133 0.0229
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0133 0.0229
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0133 0.0133
Schistosoma mansoni neuropeptide receptor 0.0026 0.0133 0.0203
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0133 0.0133
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0133 0.0203
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0133 0.0229
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0133 0.0229
Schistosoma mansoni neuropeptide receptor 0.0026 0.0133 0.0203
Onchocerca volvulus 0.0026 0.0133 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0133 0.0133
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0133 0.0133
Echinococcus granulosus somatostatin receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0074 0.4722 0.4722
Leishmania major cytochrome p450-like protein 0.0061 0.3491 1
Brugia malayi putative neuropeptide receptor 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0026 0.0133 0.0203
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0133 0.0203
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0086 0.58 1
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0133 0.0133
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0133 0.0203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Brugia malayi neuropeptide F receptor 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0026 0.0133 0.0203
Brugia malayi Dopamine receptor protein 2 0.0026 0.0133 0.0133
Echinococcus granulosus fmrfamide receptor 0.0026 0.0133 0.0229
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0041 0.1551 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Echinococcus granulosus hypothetical protein 0.0026 0.0133 0.0229
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0133 0.0229
Echinococcus granulosus allatostatin A receptor 0.0026 0.0133 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Mycobacterium leprae Conserved hypothetical protein 0.0041 0.1551 0.5
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0133 0.0229
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0133 0.0229
Schistosoma mansoni amine GPCR 0.0026 0.0133 0.0203
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0133 0.0203
Onchocerca volvulus 0.0026 0.0133 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0094 0.6551 1
Onchocerca volvulus 0.0026 0.0133 0.5
Schistosoma mansoni myosin xvIII 0.0026 0.0133 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0133 0.0229
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.008 0.5263 0.5
Brugia malayi Cytochrome P450 family protein 0.0061 0.3491 0.3491
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0133 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0133 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0133 0.0229
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0133 0.0229
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi RE15519p 0.0026 0.0133 0.0133
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.3491 0.3491
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0133 0.0203
Schistosoma mansoni hypothetical protein 0.0041 0.1551 0.2368
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0133 0.0229
Schistosoma mansoni voltage-gated potassium channel 0.0094 0.6551 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0133 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0041 0.1551 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0133 0.0229
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0133 0.0229
Brugia malayi neuropeptide F receptor 0.0026 0.0133 0.0133
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0133 0.0229
Brugia malayi G protein-coupled receptor 0.0026 0.0133 0.0133
Brugia malayi hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 40 nM Binding affinity against human Adenosine A2a receptor (hA2a) ChEMBL. 15149696
Ki (binding) = 40 nM Binding affinity against human Adenosine A2a receptor (hA2a) ChEMBL. 15149696
Selectivity (binding) = 66 Selectivity expressed as Ki of human Adenosine A2a receptor versus Adenosine A1 receptor ChEMBL. 15149696

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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