Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 5 | Starlite/ChEMBL | References |
Homo sapiens | integrin, alpha V | References | |
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | integrin alpha ps | integrin, alpha V | 1002 aa | 908 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0838 | 0.7897 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0569 | 0.4554 | 0.4554 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0247 | 0.0538 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.6527 | 0.6527 |
Brugia malayi | Carboxylesterase family protein | 0.0728 | 0.6527 | 0.6329 |
Echinococcus multilocularis | acetylcholinesterase | 0.0728 | 0.6527 | 0.8016 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0728 | 0.6527 | 0.8016 |
Loa Loa (eye worm) | integrin beta-2 | 0.0817 | 0.7645 | 0.7645 |
Loa Loa (eye worm) | hypothetical protein | 0.1007 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0728 | 0.6527 | 0.6527 |
Echinococcus multilocularis | integrin beta 2 | 0.0602 | 0.4958 | 0.5746 |
Echinococcus granulosus | acetylcholinesterase | 0.0728 | 0.6527 | 0.8016 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0942 | 0.0942 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0817 | 0.7645 | 0.7511 |
Echinococcus granulosus | carboxylesterase 5A | 0.0728 | 0.6527 | 0.8016 |
Schistosoma mansoni | integrin beta subunit | 0.0475 | 0.3383 | 0.2959 |
Echinococcus granulosus | integrin beta 2 | 0.0602 | 0.4958 | 0.5746 |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.6527 | 0.6527 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0369 | 0.2062 | 0.1611 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0728 | 0.6527 | 0.6527 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0838 | 0.7897 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0728 | 0.6527 | 0.8016 |
Echinococcus granulosus | acetylcholinesterase | 0.0728 | 0.6527 | 0.8016 |
Brugia malayi | Carboxylesterase family protein | 0.0728 | 0.6527 | 0.6329 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.1074 | 0.1074 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0279 | 0.0942 | 0.0427 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0728 | 0.6527 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Absorption (ADMET) | = 95 % | Oral absorption of the compound was determined using Caco-2 cell monolayers. | ChEMBL. | 12392735 |
Absorption (ADMET) | = 95 % | Oral absorption of the compound was determined using Caco-2 cell monolayers. | ChEMBL. | 12392735 |
IC50 (binding) | = 0.8 nM | Displacement of vitronectin from human integrin alphaV-beta5 | ChEMBL. | 12392735 |
IC50 (binding) | = 0.8 nM | Displacement of vitronectin from human integrin alphaV-beta5 | ChEMBL. | 12392735 |
IC50 (binding) | = 1 nM | Antagonist activity at alphavbeta5 integrin receptor (unknown origin) by cell-free ELISA | ChEMBL. | 24568695 |
IC50 (binding) | = 1.9 nM | Displacement of vitronectin from Human integrin alphaV-beta3 | ChEMBL. | 12392735 |
IC50 (binding) | = 1.9 nM | Displacement of vitronectin from Human integrin alphaV-beta3 | ChEMBL. | 12392735 |
IC50 (functional) | = 2 nM | Cellular adhesion inhibitory concentration of the compound was determined with IGROV-1 cell line. | ChEMBL. | 12392735 |
IC50 (binding) | = 2 nM | Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-free ELISA | ChEMBL. | 24568695 |
IC50 (functional) | = 2 nM | Cellular adhesion inhibitory concentration of the compound was determined with IGROV-1 cell line. | ChEMBL. | 12392735 |
IC50 (binding) | = 4360 nM | Displacement of fibrinogen from Human integrin alphaIIb-beta3 | ChEMBL. | 12392735 |
IC50 (binding) | = 4360 nM | Displacement of fibrinogen from Human integrin alphaIIb-beta3 | ChEMBL. | 12392735 |
Stability (ADMET) | = 77 % | First pass metabolism and metabolic bioavailability of the compound was determined using human hepatic microsomes | ChEMBL. | 12392735 |
Stability (ADMET) | = 83 % | First pass metabolism and metabolic bioavailability of the compound was determined using rat hepatic microsomes | ChEMBL. | 12392735 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12392735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.