TDR Targets

Basic information

Technical information

TDR Targets ID: 184939
Name: 1-[2,6-di(propan-2-yl)phenyl]-3-[(1-phenylcyc lopropyl)methyl]urea
MW: 350.497 | Formula: C23H30N2O
H donors: 2 H acceptors: 1 LogP: 5.42 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1c(cccc1C(C)C)C(C)C)NCC1(CC1)c1ccccc1
InChi: 1S/C23H30N2O/c1-16(2)19-11-8-12-20(17(3)4)21(19)25-22(26)24-15-23(13-14-23)18-9-6-5-7-10-18/h5-12,16-17H,13-15H2,1-4H3,(H2,24,25,26)
InChiKey: YUSXDKAMKYRWKK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2,6-diisopropylphenyl)-3-[(1-phenylcyclopropyl)methyl]urea
3-[2,6-di(propan-2-yl)phenyl]-1-[(1-phenylcyclopropyl)methyl]urea
3-(2,6-diisopropylphenyl)-1-[(1-phenylcyclopropyl)methyl]urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Acyl-CoA:cholesterol acyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487
Echinococcus granulosus	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487
Echinococcus multilocularis	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Schistosoma japonicum	ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative	Get druggable targets OG5_133487	All targets in OG5_133487
Schistosoma mansoni	sterol O-acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Dictyostelium discoideum	diacylglycerol O-acyltransferase 1	Acyl-CoA:cholesterol acyltransferase	305 aa	278 aa	21.9 %
Neospora caninum	sterol O-acyltransferase, putative	Acyl-CoA:cholesterol acyltransferase	305 aa	258 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	vacuolar protein sorting 26	0.0026	0.0118	0.0933
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.017	0.1144	1
Onchocerca volvulus		0.0239	0.1636	0.9207
Echinococcus multilocularis	mitogen activated protein kinase 3	0.003	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1766	0.1766
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0026	0.0118	1
Onchocerca volvulus		0.0239	0.1636	0.9207
Giardia lamblia	Fructose-bisphosphate aldolase	0.017	0.1144	1
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0026	0.0118	0.0118
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Loa Loa (eye worm)	carboxylesterase	0.1415	1	1
Leishmania major	DNA polymerase kappa, putative	0.0012	0.0022	0.107
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0118	0.065
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0118	0.0118
Treponema pallidum	alginate O-acetylation protein (algI)	0.0026	0.0118	0.0933
Loa Loa (eye worm)	hypothetical protein	0.1415	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0118	0.065
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1636	0.1636
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0011	0.0013	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1636	0.1636
Trypanosoma cruzi	GUP1, putative	0.0026	0.0118	0.5692
Treponema pallidum	fructose-bisphosphate aldolase	0.017	0.1144	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0024	0.0105	0.0587
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0118	0.0118
Brugia malayi	Carboxylesterase family protein	0.1415	1	1
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0026	0.0118	0.0118
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0239	0.1636	0.1636
Brugia malayi	MBOAT family protein	0.0026	0.0118	0.0118
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0118	0.0118
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0178	0.0178
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0239	0.1636	0.1636
Brugia malayi	Carboxylesterase family protein	0.0239	0.1636	0.1636
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0064	0.0064
Leishmania major	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0118	0.0933
Brugia malayi	hypothetical protein	0.0258	0.1766	0.1766
Brugia malayi	jmjC domain containing protein	0.0034	0.0178	0.0178
Brugia malayi	Carboxylesterase family protein	0.0239	0.1636	0.1636
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0178	0.0178
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Loa Loa (eye worm)	carboxylesterase	0.0239	0.1636	0.1636
Loa Loa (eye worm)	hhat protein	0.0026	0.0118	0.0118
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0038	0.0208	0.0208
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.003	0.0146	0.0816
Onchocerca volvulus		0.0239	0.1636	0.9207
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0064	0.0356
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0239	0.1636	1
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1628	0.1628
Schistosoma mansoni	zinc finger protein	0.0026	0.0118	0.0118
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0083	0.0525	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0239	0.1636	0.1636
Echinococcus granulosus	mitogen activated protein kinase	0.003	0.0146	0.0146
Loa Loa (eye worm)	runx1	0.0032	0.0165	0.0165
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0038	0.0208	0.0208
Echinococcus granulosus	microtubule associated protein 2	0.0401	0.2788	0.2788
Trypanosoma brucei	DNA polymerase kappa, putative	0.001	0.0004	0.0021
Leishmania major	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1636	0.1636
Giardia lamblia	Kinase, CMGC MAPK	0.003	0.0146	0.1176
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0118	0.0662
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Echinococcus multilocularis	transcription factor Dp 1	0.0022	0.0093	0.0093
Schistosoma mansoni	ap endonuclease	0.0011	0.0013	0.0013
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0038	0.0208	0.1726
Schistosoma mansoni	hypothetical protein	0.0026	0.0118	0.0118
Echinococcus granulosus	carboxylesterase 5A	0.1415	1	1
Echinococcus granulosus	transcription factor Dp 1	0.0022	0.0093	0.0093
Trypanosoma brucei	unspecified product	0.002	0.0078	0.0434
Trypanosoma cruzi	GUP1, putative	0.0026	0.0118	0.5692
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0024	0.0105	0.5043
Loa Loa (eye worm)	carboxylesterase	0.0239	0.1636	0.1636
Onchocerca volvulus		0.0239	0.1636	0.9207
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0011	0.0013	0.109
Brugia malayi	MBOAT family protein	0.0026	0.0118	0.0118
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.003	0.0146	0.0146
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0026	0.0118	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0024	0.0105	0.5043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1636	0.1636
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.003	0.0146	0.7008
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0026	0.0118	0.0118
Schistosoma mansoni	jumonji domain containing protein	0.0034	0.0178	0.0178
Trichomonas vaginalis	CMGC family protein kinase	0.003	0.0146	0.0819
Leishmania major	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0026	0.0118	0.0118
Leishmania major	hypothetical protein, conserved	0.0026	0.0118	0.5692
Schistosoma mansoni	gliotactin	0.0239	0.1636	0.1636
Brugia malayi	MBOAT family protein	0.0026	0.0118	0.0118
Echinococcus multilocularis	mitogen activated protein kinase	0.003	0.0146	0.0146
Echinococcus multilocularis	sterol O acyltransferase 1	0.0264	0.1812	0.1812
Toxoplasma gondii	exonuclease III APE	0.0011	0.0013	0.0885
Echinococcus multilocularis	Protein lozenge	0.0032	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0264	0.1812	0.1812
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0083	0.0525	0.3158
Trypanosoma brucei	DNA polymerase kappa, putative	0.001	0.0004	0.0021
Trichomonas vaginalis	spcc417.12 protein, putative	0.0239	0.1636	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0118	0.0118
Toxoplasma gondii	hypothetical protein	0.0026	0.0118	0.8122
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0038	0.0208	0.0208
Leishmania major	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0239	0.1636	0.1636
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.003	0.0146	0.7008
Brugia malayi	Carboxylesterase family protein	0.0239	0.1636	0.1636
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0239	0.1636	0.1636
Brugia malayi	MAP kinase sur-1	0.003	0.0146	0.0146
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Brugia malayi	MBOAT family protein	0.0026	0.0118	0.0118
Echinococcus granulosus	dna polymerase kappa	0.0024	0.0105	0.0105
Echinococcus granulosus	neuroligin	0.0239	0.1636	0.1636
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0011	0.0013	0.0621
Leishmania major	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Brugia malayi	hypothetical protein	0.0239	0.1636	0.1636
Echinococcus granulosus	acetylcholinesterase	0.1415	1	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0038	0.0208	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0239	0.1636	0.1636
Trichomonas vaginalis	CMGC family protein kinase	0.003	0.0146	0.0819
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.017	0.1144	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0083	0.0525	0.3158
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.003	0.0146	0.7008
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0026	0.0118	0.0118
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0118	0.0118
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0118	0.0118
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0118	0.0933
Schistosoma mansoni	sterol O-acyltransferase 1	0.0264	0.1812	0.1812
Echinococcus multilocularis	para nitrobenzyl esterase	0.0239	0.1636	0.1636
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Entamoeba histolytica	hypothetical protein	0.0026	0.0118	0.0933
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0011	0.0013	0.0013
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0078	0.0434
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0024	0.0105	0.0567
Loa Loa (eye worm)	acetylcholinesterase 1	0.1415	1	1
Echinococcus granulosus	sterol O acyltransferase 1	0.0264	0.1812	0.1812
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0026	0.0118	0.0118
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0024	0.0105	0.5043
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Trypanosoma brucei	protein kinase, putative	0.003	0.0146	0.0816
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Brugia malayi	jmjC domain containing protein	0.0034	0.0178	0.0178
Schistosoma mansoni	BC026374 protein (S09 family)	0.0239	0.1636	0.1636
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0026	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0118	0.5692
Mycobacterium ulcerans	carboxylesterase, LipT	0.0239	0.1636	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1636	0.1636
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0011	0.0013	0.0072
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0038	0.0208	0.1164
Echinococcus multilocularis	microtubule associated protein 2	0.0401	0.2788	0.2788
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0012	0.0022	0.107
Trichomonas vaginalis	CMGC family protein kinase	0.003	0.0146	0.0819
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0064	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1636	0.1636
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.003	0.0146	0.7008
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0026	0.0118	0.0118
Echinococcus granulosus	acetylcholinesterase	0.1415	1	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0011	0.0013	0.0013
Mycobacterium ulcerans	DNA polymerase IV	0.0024	0.0105	0.0567
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0026	0.0118	0.8122
Schistosoma mansoni	ap endonuclease	0.0011	0.0013	0.0013
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.003	0.0146	1
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0026	0.0118	0.0118
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0118	0.0118
Schistosoma mansoni	acetylcholinesterase	0.0239	0.1636	0.1636
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0178	0.0178
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0011	0.0013	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.0024	0.0105	0.0567
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0118	0.0118
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0026	0.0118	0.0118
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.017	0.1144	0.6967
Brugia malayi	Hhat protein	0.0026	0.0118	0.0118
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0026	0.0118	0.0118
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0011	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1636	0.1636
Onchocerca volvulus		0.0239	0.1636	0.9207
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0012	0.0022	0.0058
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0118	0.0118
Loa Loa (eye worm)	hhat protein	0.0026	0.0118	0.0118
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0239	0.1636	1
Loa Loa (eye worm)	hypothetical protein	0.1415	1	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.003	0.0146	0.7008
Trypanosoma brucei	DNA polymerase IV, putative	0.0024	0.0105	0.0587
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0034	0.0178	0.0178
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0034	0.0178	0.0178
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0011	0.0013	0.109
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0146	0.0146
Echinococcus multilocularis	acetylcholinesterase	0.1415	1	1
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0118	0.0662
Echinococcus multilocularis	dna polymerase kappa	0.0024	0.0105	0.0105
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0118	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0011	0.0013	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Echinococcus multilocularis	neuroligin	0.0239	0.1636	0.1636
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.003	0.0146	0.7008
Trypanosoma brucei	RNA helicase, putative	0.0261	0.1788	1
Brugia malayi	Carboxylesterase family protein	0.0239	0.1636	0.1636
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0038	0.0208	0.0208
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1415	1	1
Schistosoma mansoni	microtubule-associated protein tau	0.0401	0.2788	0.2788
Trypanosoma brucei	DNA polymerase kappa, putative	0.0012	0.0022	0.0125
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0026	0.0118	0.065
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0.0118	0.0933
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0038	0.0208	1
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0026	0.0118	0.0118
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0239	0.1636	1
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0026	0.0118	0.0118
Echinococcus granulosus	BC026374 protein S09 family	0.0239	0.1636	0.1636
Brugia malayi	diacylglycerol acyltransferase	0.0026	0.0118	0.0118
Trichomonas vaginalis	CMGC family protein kinase	0.003	0.0146	0.0819
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Echinococcus multilocularis	acetylcholinesterase	0.1415	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0239	0.1636	0.1636
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1766	0.1766
Trichomonas vaginalis	porcupine, putative	0.0026	0.0118	0.065
Giardia lamblia	DINP protein human, muc B family	0.0012	0.0022	0.0083
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0026	0.0118	0.8122
Echinococcus granulosus	para nitrobenzyl esterase	0.0239	0.1636	0.1636
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0024	0.0105	0.5043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0118	0.0118
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0105	0.0587
Schistosoma mansoni	hypothetical protein	0.0261	0.1788	0.1788
Trichomonas vaginalis	DNA polymerase eta, putative	0.0024	0.0105	0.0567
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0118	0.065
Brugia malayi	polk-prov protein	0.0018	0.0064	0.0064
Schistosoma mansoni	lozenge	0.0032	0.0165	0.0165
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0026	0.0118	0.0118
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0178	0.0178
Brugia malayi	MBOAT family protein	0.0026	0.0118	0.0118
Brugia malayi	exodeoxyribonuclease III family protein	0.0011	0.0013	0.0013
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0038	0.0208	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0118	0.0118
Echinococcus granulosus	mitogen activated protein kinase 3	0.003	0.0146	0.0146
Echinococcus multilocularis	carboxylesterase 5A	0.1415	1	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0239	0.1636	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.001	0.0004	0.0021
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0026	0.0118	0.0118
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0038	0.0208	0.0208
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0118	0.0118
Onchocerca volvulus		0.0258	0.1766	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.018 uM	In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase using intestinal microsomes isolated from cholesterol fed rabbits	ChEMBL.	8230120
IC50 (binding)	= 0.018 uM	In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase using intestinal microsomes isolated from cholesterol fed rabbits	ChEMBL.	8230120

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 14977525

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 184939