Detailed information for compound 184988

Basic information

Technical information
  • TDR Targets ID: 184988
  • Name: 5-methoxy-3-[(2-methoxy-4-nitrophenoxy)methyl ]-1,2-dimethylindole-4,7-dione
  • MW: 386.355 | Formula: C19H18N2O7
  • H donors: 0 H acceptors: 4 LogP: 2.37 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(=O)c2c(C1=O)c(COc1ccc(cc1OC)[N+](=O)[O-])c(n2C)C
  • InChi: 1S/C19H18N2O7/c1-10-12(9-28-14-6-5-11(21(24)25)7-15(14)26-3)17-18(20(10)2)13(22)8-16(27-4)19(17)23/h5-8H,9H2,1-4H3
  • InChiKey: DNCQUWNUYQPXFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methoxy-3-[(2-methoxy-4-nitro-phenoxy)methyl]-1,2-dimethyl-indole-4,7-dione
  • 5-methoxy-3-[(2-methoxy-4-nitro-phenoxy)methyl]-1,2-dimethyl-indole-4,7-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutamate receptor AMPA 0.0538 0.1169 0.1306
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.006 0.0552
Brugia malayi Glutamate receptor 2 precursor 0.0581 0.1265 0.1545
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0091 0.009
Echinococcus multilocularis neutral amino acid transporter A 0.118 0.2603 0.2602
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0059 1
Brugia malayi hypothetical protein 0.002 0.0012 0.0013
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0474 0.1026 0.1025
Leishmania major cytochrome p450-like protein 0.0016 0.0002 0.0009
Echinococcus granulosus RUN 0.002 0.0012 0.0011
Echinococcus granulosus glutamate NMDA receptor subunit 0.0538 0.1169 0.1168
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0043 0.3404
Schistosoma mansoni loxhd1 0.002 0.0012 0.0012
Loa Loa (eye worm) RGS-3 protein 0.0041 0.006 0.0058
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0002 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0043 0.0395
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0008 0.0007
Echinococcus multilocularis muscleblind protein 0.0098 0.0187 0.0185
Schistosoma mansoni metabotropic glutamate receptor 0.1864 0.4131 0.4619
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0069 0.319
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0214 0.1636
Leishmania major extracellular receptor, putative 0.0474 0.1026 1
Brugia malayi hypothetical protein 0.0474 0.1026 0.1253
Echinococcus multilocularis geminin 0.0172 0.0352 0.0351
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0214 0.2077
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0059 0.0218
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.01 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0198
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0034 0.2634
Brugia malayi nuclear receptor NHR-88 0.0018 0.0008 0.0008
Brugia malayi 6-phosphofructokinase 0.0111 0.0214 0.026
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0012 0.0011
Onchocerca volvulus Excitatory amino acid transporter homolog 0.118 0.2603 1
Echinococcus granulosus lamin 0.0056 0.0091 0.009
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0474 0.1026 0.1025
Loa Loa (eye worm) hypothetical protein 0.0055 0.0089 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0008 0.0006
Onchocerca volvulus 0.0056 0.0091 0.0322
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0058
Echinococcus granulosus neuropeptide s receptor 0.0306 0.0652 0.0651
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0214 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0122 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0036 0.0324
Echinococcus multilocularis glutamate receptor 2 0.0581 0.1265 0.1264
Chlamydia trachomatis glutamine binding protein 0.0366 0.0784 0.2922
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Chlamydia trachomatis glutamate symporter 0.118 0.2603 1
Echinococcus granulosus geminin 0.0172 0.0352 0.0351
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0034 0.3242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0048 0.0445
Schistosoma mansoni axis inhibition protein axin 0.0041 0.006 0.0065
Schistosoma mansoni hypothetical protein 0.0276 0.0585 0.0652
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0117 0.113
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0011
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0054 0.0053
Brugia malayi Metabotropic glutamate receptor precursor. 0.3674 0.8176 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.4017 0.8941 1
Brugia malayi 6-phosphofructokinase 0.0111 0.0214 0.026
Schistosoma mansoni glutamate receptor NMDA 0.1012 0.2227 0.249
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0117 0.113
Echinococcus granulosus atrial natriuretic peptide receptor 0.0474 0.1026 0.1025
Echinococcus multilocularis glutamate receptor 4 0.0043 0.0063 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0008 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0008 0.0007
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.006 0.0058
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0008 0.0007
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0117 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0069 0.0642
Schistosoma mansoni glutamate receptor kainate 0.0538 0.1169 0.1306
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.0214 0.0814
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0122 0.0135
Echinococcus multilocularis receptor type guanylyl cyclase 0.0474 0.1026 0.1025
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0307
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0523 0.1135 0.1134
Loa Loa (eye worm) hypothetical protein 0.0474 0.1026 0.1025
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0523 0.1135 0.1268
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.006 0.0552
Echinococcus multilocularis musashi 0.0056 0.0091 0.009
Brugia malayi intermediate filament protein 0.0056 0.0091 0.011
Schistosoma mansoni tyrosine kinase 0.0474 0.1026 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0034 0.0303
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0366 0.0784 0.6814
Echinococcus multilocularis neuropeptide receptor A26 0.0306 0.0652 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0008 0.0008
Brugia malayi Doublecortin family protein 0.002 0.0012 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0058
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0069 0.319
Echinococcus granulosus glutamate receptor subunit protein glur 0.0319 0.0681 0.0679
Loa Loa (eye worm) hypothetical protein 0.0474 0.1026 0.1025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0253
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.006 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0058
Echinococcus multilocularis Excitatory amino acid transporter 0.118 0.2603 0.2602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0069 0.0642
Schistosoma mansoni polycystin 1-related 0.002 0.0012 0.0012
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0214 0.1817
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0002 0.0043
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0008 0.0006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0069 0.0662
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0069 0.0068
Echinococcus multilocularis lamin 0.0056 0.0091 0.009
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0366 0.0784 0.6814
Brugia malayi hypothetical protein 0.002 0.0012 0.0013
Schistosoma mansoni tyrosine kinase 0.0474 0.1026 0.1146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0253
Echinococcus granulosus nmda type glutamate receptor 0.0642 0.1402 0.1401
Treponema pallidum sodium- and chloride- dependent transporter 0.0068 0.0118 0.0764
Brugia malayi Cytochrome P450 family protein 0.0079 0.0143 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0253
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1336 0.2953 0.2952
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0601 0.131 0.1309
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1055 0.2323 0.2322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0248
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.0926 0.0924
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0023
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.006 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0004
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0008 0.0006
Brugia malayi Receptor family ligand binding region containing protein 0.1047 0.2307 0.282
Onchocerca volvulus Poor gastrulation protein homolog 0.0573 0.1248 0.478
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.006 0.0058
Echinococcus multilocularis nmda type glutamate receptor 0.0642 0.1402 0.1401
Brugia malayi PXA domain containing protein 0.0041 0.006 0.0071
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1055 0.2323 0.2322
Plasmodium vivax SET domain protein, putative 0.0062 0.0105 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0008 0.0006
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0366 0.0784 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0079 0.0143 0.0142
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.006 0.0552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0008 0.0006
Schistosoma mansoni regulator of G protein signaling 0.0041 0.006 0.0065
Schistosoma mansoni lamin 0.0056 0.0091 0.0101
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0069 0.0357
Onchocerca volvulus 0.002 0.0012 0.0016
Echinococcus granulosus excitatory amino acid transporter 3 0.118 0.2603 0.2602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0198
Brugia malayi ecdysteroid receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis tyrosine kinase 0.0474 0.1026 0.1025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0008 0.0007
Brugia malayi Cytochrome P450 family protein 0.0016 0.0002 0.0001
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0034 0.0307
Loa Loa (eye worm) hypothetical protein 0.0106 0.0204 0.0202
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0117 0.5441
Schistosoma mansoni regulator of G protein signaling 0.0041 0.006 0.0065
Loa Loa (eye worm) RGC/RGC protein kinase 0.0474 0.1026 0.1025
Loa Loa (eye worm) cytochrome P450 0.0016 0.0002 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0105 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.006 0.0552
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0012 0.0011
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.118 0.2603 0.2602
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0122 0.0135
Schistosoma mansoni rab6-interacting 0.002 0.0012 0.0012
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.006 0.0058
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0005 0.0005
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.006 0.0071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0027 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0008 0.0008
Schistosoma mansoni lipoxygenase 0.0056 0.0093 0.0102
Schistosoma mansoni regulator of G protein signaling 0.0041 0.006 0.0065
Schistosoma mansoni regulator of G protein signaling 0.0041 0.006 0.0065
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0012
Echinococcus granulosus intermediate filament protein 0.0056 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0117
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.006 0.0071
Leishmania major cytochrome p450-like protein 0.0016 0.0002 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0122 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0016 0.066
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.0214 0.2708
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.006 0.0058
Echinococcus multilocularis excitatory amino acid transporter 2 0.118 0.2603 0.2602
Schistosoma mansoni ATP-binding cassette transporter 0.0538 0.1169 0.1306
Schistosoma mansoni glutamate receptor kainate 0.0862 0.1894 0.2117
Brugia malayi Pre-SET motif family protein 0.0062 0.0105 0.0126
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.4491 1 1
Echinococcus granulosus bloom syndrome protein 0.0022 0.0016 0.0014
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0523 0.1135 0.1134
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0523 0.1135 0.1268
Loa Loa (eye worm) hypothetical protein 0.0573 0.1248 0.1247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0059 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0069 0.0642
Trypanosoma cruzi extracellular receptor, putative 0.0474 0.1026 1
Schistosoma mansoni hypothetical protein 0.0172 0.0352 0.0392
Treponema pallidum glutamate/aspartate transporter 0.0523 0.1135 1
Schistosoma mansoni protein kinase 0.0474 0.1026 0.1146
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.006 0.0058
Loa Loa (eye worm) hypothetical protein 0.0056 0.0091 0.009
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0601 0.131 0.1309
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0002 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0008 0.0006
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0068 0.0118 0.013
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0059 0.0546
Loa Loa (eye worm) excitatory amino acid transporter 0.118 0.2603 0.2602
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0366 0.0784 0.2922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0043 0.0395
Schistosoma mansoni ap endonuclease 0.0041 0.0059 0.0065
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.006 0.0058
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0016 0.0135
Loa Loa (eye worm) RecQ helicase 0.0022 0.0016 0.0014
Brugia malayi Guanylyl cyclase protein 23 0.0474 0.1026 0.1253
Entamoeba histolytica hypothetical protein 0.0041 0.006 0.026
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0059 0.0546
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0474 0.1026 0.1253
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0034 0.2634
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0307
Schistosoma mansoni coup transcription factor 0.0018 0.0008 0.0007
Brugia malayi Receptor family ligand binding region containing protein 0.0474 0.1026 0.1253
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0034 0.3242
Loa Loa (eye worm) hypothetical protein 0.0098 0.0187 0.0185
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0474 0.1026 0.1025
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0276 0.0585 0.0583
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0034 0.4888
Echinococcus granulosus receptor type guanylyl cyclase 0.0474 0.1026 0.1025
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0012 0.0011
Onchocerca volvulus 0.0474 0.1026 0.3923
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0117 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0043 0.0395
Loa Loa (eye worm) solute carrier family 6 member 4 0.0068 0.0118 0.0117
Echinococcus granulosus muscleblind protein 0.0098 0.0187 0.0185
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.006 0.0058
Echinococcus granulosus nmda type glutamate receptor 0.0474 0.1026 0.1025
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0034 0.2634
Onchocerca volvulus 0.0474 0.1026 0.3923
Echinococcus granulosus axis inhibition protein axin 0.0041 0.006 0.0058
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.3201 0.7118 0.8705
Echinococcus multilocularis serotonin transporter 0.0068 0.0118 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0048 0.0445
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0069 0.0068
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1336 0.2953 0.2952
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0008 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0008 0.0008
Leishmania major cytochrome p450-like protein 0.0016 0.0002 0.0009
Treponema pallidum glutamate transporter 0.0523 0.1135 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0331 0.0707 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0105 0.0115
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0117 0.0142
Brugia malayi Glutamate receptor 1 precursor 0.0581 0.1265 0.1545
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0059 0.0563
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0117 0.0839
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0214 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.006 0.0065
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0214 0.2013
Brugia malayi phosphofructokinase 0.0111 0.0214 0.026
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0094 0.0177 0.0196
Echinococcus multilocularis neutral amino acid transporter A 0.118 0.2603 0.2602
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.006 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0105 0.0115
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0026
Entamoeba histolytica hypothetical protein 0.0041 0.006 0.026
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0002 0.0001
Echinococcus multilocularis Excitatory amino acid transporter 0.118 0.2603 0.2602
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0069 0.0357
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Echinococcus multilocularis metabotropic glutamate receptor 5 0.4491 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0198
Onchocerca volvulus 0.0106 0.0204 0.0754
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0012 0.0011
Echinococcus granulosus glutamate receptor 4 0.0043 0.0063 0.0062
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0034 0.0039
Echinococcus multilocularis glutamate receptor 2 0.1055 0.2323 0.2322
Loa Loa (eye worm) serotonin transporter b 0.0068 0.0118 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0002 0.0001
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0093 0.0091
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0214 0.0238
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.006 0.0071
Brugia malayi cytochrome P450 0.0016 0.0002 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0307
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0012 0.0446
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0069 0.0068
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0002 0.0009
Schistosoma mansoni cytochrome P450 0.0016 0.0002 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0069 0.0076
Loa Loa (eye worm) hypothetical protein 0.0474 0.1026 0.1025
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.006 0.0058
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0059 0.5652
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0008 0.0006
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0366 0.0784 0.3007
Loa Loa (eye worm) norepinephrine transporter 0.0068 0.0118 0.0117
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0059 0.2713
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0091 0.011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0008 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0008 0.0006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0059 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0008 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0008 0.0007
Echinococcus multilocularis neutral amino acid transporter A 0.118 0.2603 0.2602
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0011
Brugia malayi Cytochrome P450 family protein 0.0016 0.0002 0.0001
Echinococcus granulosus serotonin transporter 0.0068 0.0118 0.0117
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0214 0.2013
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0012 0.1148
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0008 0.0008
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.006 0.0058
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0117 0.0129
Brugia malayi hypothetical protein 0.0106 0.0204 0.0247
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0016 0.0017
Echinococcus granulosus neutral amino acid transporter A 0.118 0.2603 0.2602
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0058
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.0214 1
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0094 0.0177 0.0196
Brugia malayi nuclear hormone receptor 0.0018 0.0008 0.0008
Brugia malayi M-phase phosphoprotein, mpp8 0.0106 0.0204 0.0247
Loa Loa (eye worm) RGC/RGC protein kinase 0.0474 0.1026 0.1025
Loa Loa (eye worm) glutamate receptor 1 0.0581 0.1265 0.1264
Brugia malayi Cytochrome P450 family protein 0.0016 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0198
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0012 0.0011
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.006 0.0071
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.001 0.0384
Schistosoma mansoni lamin 0.0056 0.0091 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.006 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0054 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0008 0.0008
Brugia malayi Pre-SET motif family protein 0.0429 0.0926 0.1131
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0069 0.0662
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.006 0.0058
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0967 0.2127 0.2126
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.006 0.0058
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0307
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.1047 0.2307 0.2306
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.0103
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.118 0.2603 1
Schistosoma mansoni hypothetical protein 0.0573 0.1248 0.1395
Toxoplasma gondii exonuclease III APE 0.0041 0.0059 0.474
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1336 0.2953 0.2952
Echinococcus granulosus neutral amino acid transporter A 0.118 0.2603 0.2602
Echinococcus granulosus lamin dm0 0.0056 0.0091 0.009
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.006 0.0071
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0306 0.0652 0.0651
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.006 0.0058
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0016 0.0014
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0002 0.0009
Echinococcus multilocularis RUN 0.002 0.0012 0.0011
Echinococcus multilocularis lamin dm0 0.0056 0.0091 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0197
Schistosoma mansoni lipoxygenase 0.002 0.0012 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0122 0.0121
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0094 0.0177 0.0175
Loa Loa (eye worm) hypothetical protein 0.0474 0.1026 0.1025
Echinococcus multilocularis 0.0016 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.1047 0.2307 0.2306
Echinococcus granulosus excitatory amino acid transporter 2 0.118 0.2603 0.2602
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0008 0.0006
Loa Loa (eye worm) glutamate receptor 2 0.0538 0.1169 0.1168
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0214 0.1817
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0105 0.0115
Echinococcus multilocularis expressed protein 0.0807 0.1769 0.1768
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0105 0.854
Echinococcus multilocularis muscleblind protein 1 0.0098 0.0187 0.0185
Echinococcus multilocularis GPCR, family 3, C terminal 0.0573 0.1248 0.1247
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0307
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0214 0.2013
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.006 0.0058
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0049 0.0459
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0276 0.0585 0.0583
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0049 0.2212
Brugia malayi Muscleblind-like protein 0.0098 0.0187 0.0226
Schistosoma mansoni sodium/chloride dependent transporter 0.0068 0.0118 0.013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0098 0.0187 0.0185
Entamoeba histolytica hypothetical protein 0.0474 0.1026 1
Echinococcus granulosus expressed protein 0.0807 0.1769 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0048 0.0445
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0054 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0034 0.0307
Brugia malayi hypothetical protein 0.0127 0.0251 0.0306
Onchocerca volvulus 0.0056 0.0091 0.0322
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.006 0.0065
Echinococcus multilocularis excitatory amino acid transporter 3 0.118 0.2603 0.2602
Entamoeba histolytica hypothetical protein 0.0041 0.006 0.026
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.006 0.0065
Schistosoma mansoni microtubule-associated protein tau 0.0454 0.0981 0.1095
Loa Loa (eye worm) RGC/RGC protein kinase 0.0474 0.1026 0.1025
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.006 0.0552
Echinococcus multilocularis microtubule associated protein 2 0.0454 0.0981 0.0979
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0214 0.0213
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0214 0.0213
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.006 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0008 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0043 0.0395
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0059 0.0229
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0002 0.0009
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0474 0.1026 0.3923
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0131 0.0145
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0122 0.1532
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0214 0.0238
Echinococcus granulosus metabotropic glutamate receptor 2 0.3101 0.6895 0.6895
Onchocerca volvulus 0.002 0.0012 0.0016
Giardia lamblia GTOR 0.0046 0.0069 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0122 0.0121
Onchocerca volvulus 0.0073 0.0131 0.0476
Echinococcus granulosus glutamate receptor 2 0.1055 0.2323 0.2322
Echinococcus multilocularis excitatory amino acid transporter 2 0.118 0.2603 0.2602
Chlamydia trachomatis neutral amino acid transporter 0.0523 0.1135 0.4288
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0048 0.0445
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0049 0.0459
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0091 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0008 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0008 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0059 0.0071
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.006 0.0065
Echinococcus granulosus glutamate receptor 2 0.0778 0.1706 0.1705
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.1047 0.2307 0.2306
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.006 0.0071
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0059 0.0254
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0214 0.1817
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0538 0.1169 0.1168
Echinococcus granulosus Excitatory amino acid transporter 0.118 0.2603 0.2602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0008 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0069 0.0662
Echinococcus multilocularis metabotropic glutamate receptor 2 0.3101 0.6895 0.6895
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0008 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0008 0.0007
Brugia malayi Excitatory amino acid transporter 0.118 0.2603 0.3182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0043 0.0395
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0474 0.1026 0.1025
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.0214 0.2077
Brugia malayi steroid hormone receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.006 0.0058
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0059 0.0726
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0008 0.0006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0008 0.0006
Schistosoma mansoni axis inhibition protein axin 0.0041 0.006 0.0065
Echinococcus granulosus neutral amino acid transporter 0.118 0.2603 0.2602
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0062
Loa Loa (eye worm) glutamate receptor 0.3674 0.8176 0.8176
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0008 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0041 0.006 0.0065
Echinococcus granulosus excitatory amino acid transporter 2 0.118 0.2603 0.2602
Schistosoma mansoni hypothetical protein 0.0172 0.0352 0.0392
Schistosoma mansoni glutamate receptor AMPA 0.0538 0.1169 0.1306
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1336 0.2953 0.2952
Echinococcus granulosus Excitatory amino acid transporter 0.118 0.2603 0.2602
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.006 0.0058
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.006 0.0058
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0034 0.0032
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0573 0.1248 0.478
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0008 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0008 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0059 0.0563
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0002 0.0001
Echinococcus granulosus glutamate receptor 1 0.0043 0.0063 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0214 0.2013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0034 0.4888
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1336 0.2953 0.2952
Echinococcus granulosus microtubule associated protein 2 0.0454 0.0981 0.0979
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0094 0.0177 0.0175
Echinococcus granulosus tyrosine kinase 0.0474 0.1026 0.1025
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0214 0.0213
Schistosoma mansoni intermediate filament proteins 0.0056 0.0091 0.0101
Schistosoma mansoni metabotropic glutamate receptor 0.3101 0.6895 0.7711
Schistosoma mansoni rab6-interacting 0.002 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0008 0.0008
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0001
Brugia malayi PXA domain containing protein 0.0041 0.006 0.0071
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0016 0.0135
Echinococcus granulosus neuropeptide receptor A26 0.0306 0.0652 0.0651
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.006 0.0058
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0105 0.0103
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0319 0.0681 0.0679
Brugia malayi hypothetical protein 0.0041 0.006 0.0071
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0093 0.0091
Onchocerca volvulus 0.0068 0.0118 0.0425
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0008 0.0006
Echinococcus multilocularis NMDA receptor 0.0601 0.131 0.1309
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0008 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0122 0.1532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0197
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1336 0.2953 0.2952
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0068 0.0118 0.0143
Echinococcus granulosus axis inhibition protein axin 0.0041 0.006 0.0058
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.118 0.2603 0.291
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0069 0.0662
Echinococcus multilocularis sodium:dicarboxylate symporter 0.118 0.2603 0.2602
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0573 0.1248 0.1525
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0002 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0122 0.1532
Loa Loa (eye worm) glutamate receptor 0.139 0.3072 0.3071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0043 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.006 0.0552
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0117
Loa Loa (eye worm) doublecortin family protein 0.002 0.0012 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0059 0.0058
Trichomonas vaginalis set domain proteins, putative 0.0488 0.1058 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0006
Echinococcus multilocularis nmda type glutamate receptor 0.0474 0.1026 0.1025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0022 0.0197
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0059 0.7131
Brugia malayi hypothetical protein 0.0041 0.006 0.0071
Onchocerca volvulus 0.0488 0.1058 0.4047
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.006 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0008 0.0006
Onchocerca volvulus 0.0106 0.0204 0.0754
Echinococcus granulosus sodium:dicarboxylate symporter 0.118 0.2603 0.2602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0069 0.0083
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.118 0.2603 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0601 0.131 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0043 0.0395
Loa Loa (eye worm) hypothetical protein 0.0474 0.1026 0.1025
Schistosoma mansoni glutamate receptor kainate 0.0862 0.1894 0.2117
Brugia malayi metabotropic glutamate receptor type 2 0.1864 0.4131 0.5051
Echinococcus granulosus GPCR family 3 C terminal 0.0573 0.1248 0.1247
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.006 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0008 0.0008
Echinococcus multilocularis glutamate receptor 2 0.0778 0.1706 0.1705
Loa Loa (eye worm) hypothetical protein 0.0106 0.0204 0.0202
Schistosoma mansoni ap endonuclease 0.0041 0.0059 0.0065
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0008 0.0008
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0117 0.0116
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0117 0.113
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.006 0.0058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0008 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0105 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0048 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0122 0.0461
Schistosoma mansoni glutamate receptor NMDA 0.0538 0.1169 0.1306
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0062

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.51 uM Cytotoxicity against BE human colon carcinoma cell lines BE-NQ( high NQO1 activity) ChEMBL. 11563930
IC50 (functional) = 0.51 uM Cytotoxicity against BE human colon carcinoma cell lines BE-NQ( high NQO1 activity) ChEMBL. 11563930
IC50 (functional) = 1.5 uM Cytotoxicity against BE human colon carcinoma cell lines BE-WT(No NQO1 activity) ChEMBL. 11563930
Metabolism (functional) = 0.05 uM min-1mg-1 NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced ChEMBL. 11563930
Metabolism (functional) = 0.05 uM min-1mg-1 NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced ChEMBL. 11563930

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11563930

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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