TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 504.022 | Formula: C25H34ClN5O4
H donors: 2 H acceptors: 3 LogP: 5.24 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)Nc1ccc(cc1C)Nc1ncnc2c1cc(OC)c(c2)OCCN(CC)CC.Cl
InChi: 1S/C25H33N5O4.ClH/c1-6-30(7-2)11-12-34-23-15-21-19(14-22(23)32-5)24(27-16-26-21)28-18-9-10-20(17(4)13-18)29-25(31)33-8-3;/h9-10,13-16H,6-8,11-12H2,1-5H3,(H,29,31)(H,26,27,28);1H
InChiKey: BZIDOYRTKAPMGX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	No references
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.1476	1	1
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0005	0.0005
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.1476	1	1
Loa Loa (eye worm)	hypothetical protein	0.078	0.5237	0.5237
Brugia malayi	tailless protein	0.0696	0.4666	0.4666
Echinococcus multilocularis	nuclear receptor nhr 48	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Trypanosoma brucei	beta tubulin	0.0014	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0696	0.4666	0.4666
Brugia malayi	nuclear receptor RXR	0.0696	0.4666	0.4666
Trypanosoma brucei	epsilon tubulin	0.0014	0	0.5
Onchocerca volvulus		0.0696	0.4666	0.4045
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0184	0.1159	0.1159
Leishmania major	beta tubulin	0.0014	0	0.5
Trypanosoma brucei	beta tubulin	0.0014	0	0.5
Leishmania major	beta tubulin	0.0014	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0098	0.0572	0.0572
Echinococcus multilocularis	epidermal growth factor receptor	0.0098	0.0572	0.0572
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0696	0.4666	0.4666
Schistosoma mansoni	steroid hormone receptor ad4bp	0.1476	1	1
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.1476	1	1
Leishmania major	alpha tubulin	0.0014	0	0.5
Plasmodium vivax	tubulin epsilon chain, putative	0.0014	0	0.5
Plasmodium falciparum	tubulin beta chain	0.0014	0	0.5
Trichomonas vaginalis	tubulin gamma chain, putative	0.0014	0	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.1476	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.1476	1	1
Leishmania major	beta tubulin	0.0014	0	0.5
Brugia malayi	nuclear receptor NHR-88	0.0696	0.4666	0.4666
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.078	0.5237	0.5237
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.1476	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.1476	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.1476	1	1
Leishmania major	alpha tubulin	0.0014	0	0.5
Brugia malayi	conserved hypotetical protein	0.0696	0.4666	0.4666
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0696	0.4666	0.4045
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.1476	1	1
Brugia malayi	ecdysone receptor	0.0696	0.4666	0.4666
Trypanosoma brucei	alpha tubulin	0.0014	0	0.5
Toxoplasma gondii	beta-tubulin, putative	0.0014	0	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0098	0.0572	0.0572
Trypanosoma cruzi	alpha tubulin, putative	0.0014	0	0.5
Trypanosoma brucei	beta tubulin	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.1476	1	1
Giardia lamblia	Beta tubulin	0.0014	0	0.5
Brugia malayi	hypothetical protein	0.078	0.5237	0.5237
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.1476	1	1
Entamoeba histolytica	tubulin family protein	0.0014	0	0.5
Leishmania major	alpha tubulin	0.0014	0	0.5
Leishmania major	beta tubulin	0.0014	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.1159	0.1159
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.1476	1	1
Schistosoma mansoni	zinc finger protein	0.0696	0.4666	0.4666
Leishmania major	alpha tubulin	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.1476	1	1
Leishmania major	alpha tubulin	0.0014	0	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.1476	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.1476	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0696	0.4666	0.4666
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0696	0.4666	0.4666
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.1476	1	1
Leishmania major	beta tubulin	0.0014	0	0.5
Plasmodium vivax	tubulin beta chain, putative	0.0014	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0096	0.0558	0.0558
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.1476	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0014	0	0.5
Trypanosoma brucei	beta tubulin	0.0014	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.1476	1	1
Leishmania major	beta tubulin	0.0014	0	0.5
Schistosoma mansoni	nuclear receptor nhr-48	0.0696	0.4666	0.4666
Giardia lamblia	Alpha-tubulin	0.0014	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.0696	0.4666	0.4666
Echinococcus granulosus	nuclear receptor nhr 48	0.0696	0.4666	0.4666
Echinococcus multilocularis	epidermal growth factor receptor	0.0181	0.1142	0.1142
Leishmania major	alpha tubulin	0.0014	0	0.5
Giardia lamblia	Beta tubulin	0.0014	0	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0696	0.4666	0.4666
Giardia lamblia	Alpha-tubulin	0.0014	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.078	0.5237	0.5237
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0696	0.4666	0.4666
Echinococcus granulosus	FTZ F1 alpha	0.1476	1	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.0558	0.0558
Trichomonas vaginalis	tubulin, putative	0.0014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.1476	1	1
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0025	0.0025
Echinococcus multilocularis	FTZ F1 alpha	0.1476	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0181	0.1142	0.1142
Brugia malayi	orphan nuclear receptor NR2E1	0.0696	0.4666	0.4666
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0014	0	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.1476	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0014	0	0.5
Leishmania major	beta tubulin	0.0014	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.1476	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.1476	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.1476	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0059	0.0304	0.0304
Leishmania major	alpha tubulin	0.0014	0	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.1476	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.1476	1	1
Leishmania major	beta tubulin	0.0014	0	0.5
Leishmania major	beta tubulin	0.0014	0	0.5
Toxoplasma gondii	alpha-tubulin I, putative	0.0014	0	0.5
Schistosoma mansoni	nephrin	0.0014	0.0000030904	0.0000030904
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0025	0.0025
Toxoplasma gondii	beta-1 tubulin, putative	0.0014	0	0.5
Plasmodium falciparum	alpha tubulin 2	0.0014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0014	0	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0098	0.0572	0.0572
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0696	0.4666	0.4045
Entamoeba histolytica	tubulin gamma chain	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.1476	1	1
Leishmania major	beta tubulin	0.0014	0	0.5
Leishmania major	beta tubulin	0.0014	0	0.5
Echinococcus granulosus	neuroglian	0.0014	0.0000030904	0.0000030904
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.078	0.5237	0.5237
Schistosoma mansoni	tyrosine kinase	0.0098	0.0572	0.0572
Schistosoma mansoni	retinoic acid receptor RXR	0.1476	1	1
Leishmania major	beta tubulin	0.0014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1476	1	1
Brugia malayi	hypothetical protein	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin alpha chain, putative	0.0014	0	0.5
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0005	0.0005
Schistosoma mansoni	coup transcription factor	0.1476	1	1
Plasmodium falciparum	tubulin gamma chain	0.0014	0	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0059	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.078	0.5237	0.5237
Brugia malayi	Furin-like cysteine rich region family protein	0.0181	0.1142	0.1142
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0	0.5
Trypanosoma cruzi	tubulin gamma chain	0.0014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Brugia malayi	nuclear hormone receptor	0.1476	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0014	0	0.5
Loa Loa (eye worm)	DR-78	0.0696	0.4666	0.4666
Plasmodium falciparum	alpha tubulin 1	0.0014	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.1476	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.1476	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.1476	1	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0696	0.4666	0.4666
Toxoplasma gondii	beta tubulin	0.0014	0	0.5
Trypanosoma cruzi	beta tubulin, putative	0.0014	0	0.5
Brugia malayi	nuclear receptor RXR	0.078	0.5237	0.5237
Loa Loa (eye worm)	hypothetical protein	0.078	0.5237	0.5237
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.1476	1	1
Leishmania major	alpha tubulin	0.0014	0	0.5
Trypanosoma brucei	epsilon tubulin	0.0014	0	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.1476	1	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.0558	0.0558
Trichomonas vaginalis	tubulin gamma chain, putative	0.0014	0	0.5
Brugia malayi	hypothetical protein	0.078	0.5237	0.5237
Leishmania major	beta tubulin	0.0014	0	0.5
Trypanosoma cruzi	epsilon tubulin, putative	0.0014	0	0.5
Onchocerca volvulus		0.0696	0.4666	0.4045
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.1476	1	1
Trypanosoma brucei	alpha tubulin	0.0014	0	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.1476	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0014	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Echinococcus multilocularis		0.0056	0.0285	0.0285
Trypanosoma brucei	alpha tubulin	0.0014	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.1476	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0696	0.4666	0.4666
Giardia lamblia	Gamma tubulin	0.0014	0	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0181	0.1142	0.1142
Schistosoma mansoni	tyrosine kinase	0.0059	0.0304	0.0304
Onchocerca volvulus	Bile acid receptor homolog	0.1476	1	1
Schistosoma mansoni	tyrosine kinase	0.0181	0.1142	0.1142
Leishmania major	beta tubulin	0.0014	0	0.5
Brugia malayi	steroid hormone receptor	0.1476	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.1476	1	1
Onchocerca volvulus		0.1476	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0014	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.1476	1	1
Giardia lamblia	Beta tubulin	0.0014	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.1476	1	1
Leishmania major	epsilon tubulin, putative	0.0014	0	0.5
Echinococcus granulosus	twitchin	0.0014	0.0000030904	0.0000030904
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0014	0	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0696	0.4666	0.4666
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0014	0	0.5
Entamoeba histolytica	tubulin alpha-1 chain	0.0014	0	0.5
Trypanosoma brucei	alpha tubulin	0.0014	0	0.5
Leishmania major	gamma-tubulin	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.1476	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.1476	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0696	0.4666	0.4666
Brugia malayi	nuclear hormone receptor family member odr-7	0.0696	0.4666	0.4666
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0696	0.4666	0.4666
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.078	0.5237	0.5237
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.1476	1	1
Brugia malayi	nuclear receptor NHR-67	0.0696	0.4666	0.4666
Echinococcus granulosus	roundabout 2	0.0018	0.0025	0.0025
Trypanosoma brucei	epsilon tubulin	0.0014	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0696	0.4666	0.4666
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.1476	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0014	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0696	0.4666	0.4666
Echinococcus multilocularis	neuroglian	0.0014	0.0000030904	0.0000030904
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0014	0	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0	0.5
Leishmania major	alpha tubulin	0.0014	0	0.5
Plasmodium vivax	tubulin alpha chain, putative	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.1476	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin beta chain, putative	0.0014	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.1476	1	1
Echinococcus multilocularis	roundabout 2	0.0018	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Trichomonas vaginalis	tubulin alpha chain, putative	0.0014	0	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0014	0	0.5
Echinococcus granulosus	insulin receptor	0.0059	0.0304	0.0304
Leishmania major	beta tubulin	0.0014	0	0.5
Brugia malayi	nuclear hormone receptor	0.0696	0.4666	0.4666
Brugia malayi	Nuclear hormone receptor E75	0.0696	0.4666	0.4666
Brugia malayi	nuclear receptor NHR-88	0.1476	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.078	0.5237	0.5237
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.1476	1	1
Loa Loa (eye worm)	hypothetical protein	0.078	0.5237	0.5237
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Loa Loa (eye worm)	hypothetical protein	0.078	0.5237	0.5237
Loa Loa (eye worm)	hypothetical protein	0.0696	0.4666	0.4666
Trypanosoma brucei	beta tubulin	0.0014	0	0.5
Entamoeba histolytica	tubulin family protein	0.0014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1476	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.1476	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0696	0.4666	0.4666
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0059	0.0304	0.0304
Onchocerca volvulus	Tyrosine kinase homolog	0.0172	0.1077	0.0038
Leishmania major	alpha tubulin	0.0014	0	0.5
Schistosoma mansoni	nuclear receptor	0.0696	0.4666	0.4666
Schistosoma mansoni	nuclear receptor	0.0696	0.4666	0.4666
Echinococcus granulosus	thyroid hormone receptor alpha	0.0696	0.4666	0.4666
Onchocerca volvulus	Protein ultraspiracle homolog	0.1476	1	1
Leishmania major	alpha tubulin	0.0014	0	0.5
Leishmania major	beta tubulin	0.0014	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.1476	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.078	0.5237	0.5237
Leishmania major	beta tubulin	0.0014	0	0.5
Brugia malayi	hypothetical protein	0.0696	0.4666	0.4666
Leishmania major	alpha tubulin	0.0014	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.1476	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.1476	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.1476	1	1
Schistosoma mansoni	tyrosine kinase	0.0059	0.0304	0.0304
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.078	0.5237	0.5237
Leishmania major	beta tubulin	0.0014	0	0.5
Trypanosoma brucei	tubulin gamma chain	0.0014	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.1476	1	1
Echinococcus multilocularis	insulin receptor	0.0059	0.0304	0.0304

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.7 uM	Inhibition of VEGFR2 (unknown origin)	LITERATURE.	No reference
IC50 (functional)	> 10 uM	Antiproliferative activity against human PC3 cells at 10 uM by MTS assay	ChEMBL.	No reference
IC50 (binding)	> 10 uM	Inhibition of EGFR (unknown origin)	LITERATURE.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3221267

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1849987