Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0792 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0351 | 0.9113 | 0.5 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0165 | 0.0792 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.037 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 21 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of growth of epimastigotes at 25 uM after 5 days by MTT assay relative to control | ChEMBL. | 18706821 |
IC50 (functional) | = 67 uM | Inhibition of arachidonic acid (AA) induced human platelet aggregation. | ChEMBL. | 1324320 |
IC50 (functional) | = 67 uM | Inhibition of arachidonic acid (AA) induced human platelet aggregation. | ChEMBL. | 1324320 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.