Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.1437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3366 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.3295 | 0.979 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3653 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.3295 | 0.3208 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.3295 | 0.3208 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.3295 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.1238 | 0.2824 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.3295 | 0.8936 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.3295 | 0.3295 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1028 | 0.0911 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2866 | 0.2866 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0671 | 0.1993 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.3295 | 0.3208 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1238 | 0.2714 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.3295 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.1238 | 0.7399 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2625 | 0.2529 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1437 | 0.3419 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2625 | 0.2529 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1479 | 0.4395 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1187 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1238 | 0.3678 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1437 | 0.3419 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.3295 | 0.3208 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0128 | 0.0128 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1238 | 0.2714 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.3295 | 0.3295 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1028 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1192 | 0.3541 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1351 | 0.4014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.