Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 1A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0534 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0534 | 1 | 0.5 |
Mycobacterium ulcerans | dehydrogenase | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0534 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0534 | 1 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1411 | 0.1411 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0017 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0534 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0017 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0534 | 1 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0135 | 0.0135 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0534 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0534 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0017 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0017 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0534 | 1 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0017 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0083 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1276 | 0.1276 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0534 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0534 | 1 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0017 | 0 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0534 | 1 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0024 | 0.0135 | 0.0135 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0534 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0534 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0534 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0534 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0534 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0534 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0017 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.009 | 0.1411 | 0.5 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1276 | 0.1276 |
Brugia malayi | SWIRM domain containing protein | 0.009 | 0.1411 | 0.1411 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0534 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0083 | 0.1276 | 0.1276 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0534 | 1 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0083 | 0.1276 | 0.1276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 20 uM | Cytotoxicity against human THP1 cells after 24 hrs | ChEMBL. | No reference |
IC50 (binding) | = 0.03 uM | Inhibition of LSD1 (unknown origin) using histone H3 (1 to 21) K4(Me1)-biotin peptide as substrate after 30 mins by HTRF assay | ChEMBL. | No reference |
IC50 (binding) | = 1.4 uM | Inhibition of LSD1 in human THP1 cells assessed as CD86 level after 24 hrs by ELISA | ChEMBL. | No reference |
IC50 (binding) | > 200 uM | Inhibition of MAO-A (unknown origin) assessed as oxidative deamination of kynuramine to 4-hydroxyquinoline after 30 mins by fluorescence assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.