Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1149 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0751 | 0.3135 | 0.5 |
Toxoplasma gondii | peptidase family M13 protein | 0.1149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1149 | 1 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1149 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1149 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0751 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0849 | 0.4828 | 0.4828 |
Onchocerca volvulus | 0.0569 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1149 | 1 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1149 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0751 | 0.3135 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1149 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1149 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0751 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5172 | 0.5172 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0751 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5172 | 0.5172 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0751 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5172 | 0.5172 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0751 | 0.3135 | 0.3009 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0849 | 0.4828 | 0.4828 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0751 | 0.3135 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0751 | 0.3135 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0643 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5172 | 0.5172 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1149 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5172 | 0.5172 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0751 | 0.3135 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0751 | 0.3135 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0849 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0849 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0849 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0751 | 0.3135 | 0.3135 |
Loa Loa (eye worm) | hypothetical protein | 0.0849 | 0.4828 | 0.4828 |
Brugia malayi | MAP kinase sur-1 | 0.0751 | 0.3135 | 0.2144 |
Trypanosoma brucei | protein kinase, putative | 0.0751 | 0.3135 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0751 | 0.3135 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0751 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5172 | 0.5172 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 50 uM | Inhibitory concentration of the compound against HeLa cell proliferation after 72 hours of incubation | ChEMBL. | 15582414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.