Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0154 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0154 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0128 | 0.1921 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0128 | 0.1921 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0128 | 0.1921 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0154 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0128 | 0.1921 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0128 | 0.1921 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0128 | 0.1921 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0154 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0128 | 0.1921 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0128 | 0.1921 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0128 | 0.1921 | 0.1921 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0128 | 0.1921 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0128 | 0.1921 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0128 | 0.1921 | 0.1921 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.9 uM | Ability of the compound to inhibit purine nucleoside phosphorylase (PNP) | ChEMBL. | 1578487 |
Mean survival time (functional) | = 7.3 day | Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally | ChEMBL. | 2170645 |
Survivors / total (functional) | = 1 % | Tested against Forest virus infection in mice at dose 100 mg/kg administered intraperitoneally; 1/12(8) | ChEMBL. | 2170645 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.