Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1263 | 0.5192 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1045 | 0.418 | 0.4106 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1263 | 0.5192 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1045 | 0.418 | 0.4106 |
Loa Loa (eye worm) | hypothetical protein | 0.1253 | 0.5143 | 0.1655 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0704 | 0.2593 | 0.2498 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0146 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1263 | 0.5192 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0235 | 0.0413 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1263 | 0.5192 | 0.513 |
Brugia malayi | MAP kinase sur-1 | 0.1263 | 0.5192 | 0.1738 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.0708 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1263 | 0.5192 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1263 | 0.5192 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1263 | 0.5192 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1045 | 0.418 | 0.4106 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0146 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1263 | 0.5192 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1045 | 0.418 | 0.4106 |
Schistosoma mansoni | tyrosine kinase | 0.1027 | 0.4094 | 0.4018 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1263 | 0.5192 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1027 | 0.4094 | 0.4018 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1263 | 0.5192 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 0.0708 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2298 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1263 | 0.5192 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1263 | 0.5192 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1263 | 0.5192 | 0.513 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1263 | 0.5192 | 0.513 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1045 | 0.418 | 0.4106 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1263 | 0.5192 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1045 | 0.418 | 0.4106 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0704 | 0.2593 | 0.2498 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1263 | 0.5192 | 0.513 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0704 | 0.2593 | 0.2498 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.0708 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.2298 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1263 | 0.5192 | 0.513 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1263 | 0.5192 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1027 | 0.4094 | 0.4018 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1045 | 0.418 | 0.4106 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1263 | 0.5192 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2298 | 1 | 1 |
Echinococcus multilocularis | 0.03 | 0.0718 | 0.06 | |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.2298 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1263 | 0.5192 | 0.1738 |
Echinococcus multilocularis | insulin receptor | 0.2298 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1045 | 0.418 | 0.4106 |
Echinococcus granulosus | insulin receptor | 0.2298 | 1 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.2298 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1271 | 0.523 | 0.1803 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by microbroth dilution technique | ChEMBL. | No reference |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution technique | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.