Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0147 | 0.0446 |
Onchocerca volvulus | 0.0012 | 0.0082 | 0.0409 | |
Onchocerca volvulus | 0.0012 | 0.0082 | 0.0409 | |
Schistosoma mansoni | amyloid beta A4 protein related | 0.0058 | 0.1045 | 0.1045 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0045 | 0.0775 | 0.1979 |
Brugia malayi | hypothetical protein | 0.0075 | 0.1388 | 0.4217 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0031 | 0.0486 | 0.1259 |
Onchocerca volvulus | Cathepsin F homolog | 0.0012 | 0.0082 | 0.0409 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0082 | 0.0248 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.0478 | 0.9849 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0031 | 0.0486 | 0.0486 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2726 | 0.8283 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.005 | 0.0865 | 0.1224 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0031 | 0.0486 | 0.0407 |
Trypanosoma brucei | protein kinase, putative | 0.0167 | 0.329 | 0.9055 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Schistosoma mansoni | microtubule-associated protein tau | 0.049 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0031 | 0.0478 | 0.0478 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0021 | 0.0267 | 0.081 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0167 | 0.329 | 0.3235 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0139 | 0.2726 | 0.2666 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Brugia malayi | Inositol-1 | 0.0031 | 0.0486 | 0.1476 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0082 | 0.1528 | 0.1528 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0031 | 0.0486 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0147 | 0.0446 |
Onchocerca volvulus | Cathepsin L homolog | 0.0012 | 0.0082 | 0.0409 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0031 | 0.0486 | 0.5 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0478 | 0.1454 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0028 | 0.0417 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0104 | 0.1994 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.3114 | 0.3114 |
Toxoplasma gondii | hypothetical protein | 0.0015 | 0.0147 | 0.0203 |
Entamoeba histolytica | cysteine protease, putative | 0.0012 | 0.0082 | 0.1679 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0167 | 0.329 | 0.9164 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0012 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | cysteine protease | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2726 | 0.8283 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0031 | 0.0478 | 0.0478 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0035 | 0.0553 | 0.0553 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0031 | 0.0486 | 0.1154 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0082 | 0.0248 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 0.329 | 0.329 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Onchocerca volvulus | 0.0012 | 0.0082 | 0.0409 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0045 | 0.0775 | 0.1979 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0045 | 0.0775 | 0.1979 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.3583 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0082 | 0.1528 | 0.1459 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0082 | 0.1528 | 0.1459 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0012 | 0.0082 | 0.1679 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 0.329 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0167 | 0.329 | 0.9164 |
Leishmania major | cathepsin L-like protease | 0.0045 | 0.0775 | 0.1979 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.0478 | 0.9849 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0167 | 0.329 | 0.9164 |
Echinococcus granulosus | geminin | 0.0158 | 0.3114 | 0.3114 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0082 | 0.1528 | 0.1459 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0031 | 0.0486 | 0.1154 |
Loa Loa (eye worm) | inositol-1 | 0.0031 | 0.0486 | 0.1476 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0012 | 0.0082 | 0.0248 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0012 | 0.0082 | 0.1679 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0998 | 0.3032 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0181 | 0.3583 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0017 | 0.0189 | 0.0189 |
Brugia malayi | abnormal cell lineage protein 10 (Protein lin-10), putative | 0.0052 | 0.0917 | 0.2788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1994 | 0.6058 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0082 | 0.0248 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0167 | 0.329 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0075 | 0.1388 | 0.1388 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0017 | 0.0189 | 0.0336 |
Leishmania major | cathepsin L-like protease | 0.0045 | 0.0775 | 0.1979 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1388 | 0.4217 |
Echinococcus multilocularis | geminin | 0.0158 | 0.3114 | 0.3057 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0021 | 0.0267 | 0.0267 |
Onchocerca volvulus | 0.0012 | 0.0082 | 0.0409 | |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0017 | 0.0189 | 0.0576 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0189 | 0.0576 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1994 | 0.6058 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0167 | 0.329 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0021 | 0.0267 | 0.0528 |
Echinococcus granulosus | muscleblind protein | 0.0139 | 0.2726 | 0.2726 |
Brugia malayi | Muscleblind-like protein | 0.0139 | 0.2726 | 0.8283 |
Brugia malayi | MAP kinase sur-1 | 0.0167 | 0.329 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.3583 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0031 | 0.0478 | 0.04 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Loa Loa (eye worm) | fibroinase | 0.0012 | 0.0082 | 0.0248 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0167 | 0.329 | 0.9164 |
Echinococcus multilocularis | sodium channel protein | 0.0035 | 0.0553 | 0.0476 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.3114 | 0.3114 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0012 | 0.0082 | 0.0082 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0021 | 0.0267 | 0.0187 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0012 | 0.0082 | 0.0082 |
Schistosoma mansoni | voltage-gated cation channel | 0.0082 | 0.1528 | 0.1528 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0082 | 0.1528 | 0.1528 |
Leishmania major | hypothetical protein, conserved | 0.0181 | 0.3583 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0167 | 0.329 | 0.9164 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0045 | 0.0775 | 0.1979 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0031 | 0.0486 | 0.1476 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0082 | 0.1528 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0998 | 0.3032 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0031 | 0.0486 | 0.1154 |
Loa Loa (eye worm) | X11 protein | 0.0058 | 0.1045 | 0.3176 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0082 | 0.1528 | 0.4644 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0012 | 0.0082 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0031 | 0.0486 | 0.1476 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0082 | 0.1528 | 0.1459 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0082 | 0.1528 | 0.1528 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1994 | 0.6058 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0021 | 0.0267 | 0.0528 |
Loa Loa (eye worm) | ctsf protein | 0.0012 | 0.0082 | 0.0248 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.0478 | 0.9849 |
Echinococcus multilocularis | muscleblind protein | 0.0139 | 0.2726 | 0.2666 |
Schistosoma mansoni | inositol monophosphatase | 0.0031 | 0.0486 | 0.0486 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0012 | 0.0082 | 0.5 |
Echinococcus multilocularis | amyloid beta A4 protein | 0.0058 | 0.1045 | 0.0972 |
Plasmodium vivax | vivapain-2 | 0.0012 | 0.0082 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0021 | 0.0267 | 0.0528 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Schistosoma mansoni | inositol monophosphatase | 0.0031 | 0.0486 | 0.0486 |
Onchocerca volvulus | 0.0012 | 0.0082 | 0.0409 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0082 | 0.0248 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0031 | 0.0486 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0082 | 0.0248 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0167 | 0.329 | 0.329 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0036 | 0.0573 | 0.1405 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0012 | 0.0082 | 0.5 |
Echinococcus granulosus | amyloid beta A4 protein | 0.0058 | 0.1045 | 0.1045 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0082 | 0.1528 | 0.1528 |
Onchocerca volvulus | Cathepsin L homolog | 0.0012 | 0.0082 | 0.0409 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0031 | 0.0486 | 0.1476 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0167 | 0.329 | 0.329 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0012 | 0.0082 | 0.0248 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.049 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0082 | 0.1528 | 0.1459 |
Onchocerca volvulus | 0.0012 | 0.0082 | 0.0409 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0041 | 0.0693 | 0.1746 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1528 | 0.4644 |
Plasmodium vivax | vivapain-2 | 0.0012 | 0.0082 | 0.5 |
Loa Loa (eye worm) | calcium channel | 0.0082 | 0.1528 | 0.4644 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 0.329 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0167 | 0.329 | 0.9164 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1388 | 0.4217 |
Onchocerca volvulus | Huntingtin homolog | 0.0104 | 0.1994 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.005 | 0.0865 | 0.2237 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0012 | 0.0082 | 0.0248 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 0.329 | 1 |
Leishmania major | cathepsin L-like protease | 0.0045 | 0.0775 | 0.1979 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0028 | 0.0417 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0045 | 0.0775 | 0.0933 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0167 | 0.329 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.0478 | 0.9849 |
Onchocerca volvulus | 0.0012 | 0.0082 | 0.0409 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0167 | 0.329 | 0.3235 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0012 | 0.0082 | 0.0082 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0082 | 0.1528 | 0.1459 |
Echinococcus granulosus | cathepsin l1 | 0.0012 | 0.0082 | 0.0082 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0082 | 0.1528 | 0.1528 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0478 | 0.0478 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0082 | 0.0248 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0167 | 0.329 | 0.9055 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0167 | 0.329 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 5 % | Inhibition of KAT3B (965 to 1810) (unknown origin) using biotinylated histone H3 as substrate at 50 uM after 10 mins by TR-FRET analysis relative to control | ChEMBL. | No reference |
Inhibition (binding) | = 6 % | Inhibition of KAT2A (362 to 837) (unknown origin) using biotinylated histone H3 as substrate at 50 uM after 10 mins by TR-FRET analysis relative to control | ChEMBL. | No reference |
Inhibition (binding) | = 8 % | Inhibition of human recombinant N-terminal His-tagged PCAF histone acetyltransferase catalytic domain expressed in Escherichia coli BL21 D3 using biotinylated histone H3 as substrate at 50 uM after 10 mins by TR-FRET analysis relative to control | ChEMBL. | No reference |
Inhibition (binding) | = 25 % | Inhibition of KAT3A (1319 to 1710) (unknown origin) using biotinylated histone H3 as substrate at 50 uM after 10 mins by TR-FRET analysis relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.