Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.4861 | 0.7004 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.461 | 0.6641 |
Brugia malayi | Carboxylesterase family protein | 0.0455 | 0.4861 | 0.0507 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0455 | 0.4861 | 0.4449 |
Echinococcus granulosus | acetylcholinesterase | 0.0455 | 0.4861 | 0.4936 |
Loa Loa (eye worm) | carboxylesterase | 0.0455 | 0.4861 | 0.7004 |
Onchocerca volvulus | DNA ligase 3 homolog | 0.0104 | 0 | 0.5 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0795 | 0.9569 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0437 | 0.461 | 0.4666 |
Brugia malayi | Carboxylesterase family protein | 0.0455 | 0.4861 | 0.0507 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0795 | 0.9569 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0605 | 0.6941 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0455 | 0.4861 | 0.7004 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0795 | 0.9569 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0104 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0455 | 0.4861 | 0.4449 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0437 | 0.461 | 0.1413 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0437 | 0.461 | 0.4152 |
Leishmania major | DNA repair protein, putative | 0.0104 | 0 | 0.5 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0795 | 0.9569 | 1 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0313 | 0.29 | 0.4179 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0437 | 0.461 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0455 | 0.4861 | 0.4936 |
Echinococcus granulosus | acetylcholinesterase | 0.0455 | 0.4861 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.4861 | 0.7004 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0437 | 0.461 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0455 | 0.4861 | 0.4449 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0247 | 0.1982 | 0.1839 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0437 | 0.461 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0455 | 0.4861 | 0.1848 |
Brugia malayi | WGR domain containing protein | 0.0795 | 0.9569 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0247 | 0.1982 | 0.1839 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 310 nM | Inhibitory activity against thrombin | ChEMBL. | 9544200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.