Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.0028 | 0.0169 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0035 | 0.0397 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0018 | 0.0005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1705 | 0.408 | 0.8751 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.0028 | 0.0015 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0035 | 0.0016 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.4141 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.4141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.4141 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4141 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.4141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.0028 | 0.0028 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0037 | 0.0028 | 0.0266 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0018 | 0.001 |
Leishmania major | pyruvate kinase | 0.0037 | 0.0028 | 0.0015 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.0504 | 0.0487 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0035 | 0.0397 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.0028 | 0.0028 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0035 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0035 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0028 | 0.0028 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.0028 | 0.0019 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1943 | 0.4658 | 1 |
Onchocerca volvulus | 0.004 | 0.0035 | 0.0297 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0035 | 0.0022 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0035 | 0.0035 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0035 | 0.0022 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1705 | 0.408 | 0.4072 |
Echinococcus multilocularis | protein patched | 0.1705 | 0.408 | 0.4075 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0035 | 0.0022 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0018 | 0.0005 |
Schistosoma mansoni | patched 1 | 0.1705 | 0.408 | 0.4072 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0035 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0035 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0037 | 0.0028 | 0.001 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4141 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1705 | 0.408 | 0.4072 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0035 | 0.0026 |
Echinococcus multilocularis | protein MICAL 3 | 0.0031 | 0.0013 | 0.0004 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0035 | 0.0016 |
Echinococcus multilocularis | ubiquinone biosynthesis monooxygenase COQ6 | 0.0031 | 0.0013 | 0.0004 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0035 | 0.0016 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.0028 | 0.0028 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0035 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.026 | 0.0568 | 0.0551 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1705 | 0.408 | 0.4075 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.0028 | 0.0015 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0035 | 0.0017 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.0028 | 0.0015 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0018 | 0.2336 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.0028 | 0.0015 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.0028 | 0.0169 |
Leishmania major | pyruvate kinase | 0.0037 | 0.0028 | 0.0015 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0018 | 0.0005 |
Mycobacterium ulcerans | pyruvate kinase | 0.0037 | 0.0028 | 0.0015 |
Brugia malayi | beta-lactamase | 0.004 | 0.0035 | 0.0017 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0037 | 0.0028 | 0.0015 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4141 | 1 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0035 | 0.0022 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0018 | 0.0005 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0037 | 0.0028 | 0.6705 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0035 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0035 | 0.0397 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4141 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0037 | 0.0028 | 0.0015 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0035 | 0.0022 |
Plasmodium falciparum | pyruvate kinase | 0.0037 | 0.0028 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0035 | 0.0017 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0035 | 0.0397 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0035 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0013 | 0.0013 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0035 | 0.0022 |
Brugia malayi | CHE-14 protein | 0.1705 | 0.408 | 0.4069 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1943 | 0.4658 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0035 | 0.0397 |
Wolbachia endosymbiont of Brugia malayi | 2-polyprenyl-6-methoxyphenol 4-hydroxylase | 0.0031 | 0.0013 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0018 | 0.2336 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1705 | 0.408 | 0.4075 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 0.408 | 0.408 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1943 | 0.4658 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0037 | 0.0028 | 0.6705 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.0028 | 0.0019 |
Trichomonas vaginalis | set domain proteins, putative | 0.0266 | 0.0583 | 0.1199 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.4141 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0037 | 0.0028 | 0.001 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0035 | 0.0397 |
Onchocerca volvulus | 0.004 | 0.0035 | 0.0297 | |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0035 | 0.0397 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.0504 | 0.0504 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0037 | 0.0028 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.026 | 0.0568 | 0.0568 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0035 | 0.0022 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0035 | 0.0016 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0018 | 0.001 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0035 | 0.0022 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1705 | 0.408 | 0.4072 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Onchocerca volvulus | 0.004 | 0.0035 | 0.0297 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0035 | 0.0022 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0035 | 0.0022 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1705 | 0.408 | 0.4072 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0015 | 0.0002 |
Chlamydia trachomatis | pyruvate kinase | 0.0037 | 0.0028 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0037 | 0.0028 | 0.0015 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1705 | 0.408 | 0.408 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0035 | 0.0017 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0037 | 0.0028 | 0.6705 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0018 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Onchocerca volvulus | 0.0266 | 0.0583 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0035 | 0.0016 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0035 | 0.0397 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.0028 | 0.0169 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0035 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0035 | 0.0035 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0258 | 0.0564 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1943 | 0.4658 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0035 | 0.0035 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0035 | 0.0022 |
Echinococcus multilocularis | protein dispatched 1 | 0.1705 | 0.408 | 0.4075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 22 uM | Cytotoxic concentration of the compound required to reduce rate of L1210 cell proliferation after 48 hr | ChEMBL. | 4068000 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.