Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0069 | 0.1161 | 0.1161 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0029 | 0.0029 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1161 | 0.1161 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0069 | 0.1161 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3624 | 0.3624 |
Onchocerca volvulus | 0.0069 | 0.1161 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0029 | 0.0029 |
Echinococcus multilocularis | acetylcholinesterase | 0.0408 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0.1161 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0069 | 0.1161 | 0.1161 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0029 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1161 | 0.1161 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1161 | 0.1161 |
Onchocerca volvulus | 0.0069 | 0.1161 | 1 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0163 | 0.3624 | 0.3624 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.1161 | 0.1161 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0029 | 1 |
Echinococcus granulosus | neuroligin | 0.0069 | 0.1161 | 0.1161 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0029 | 0.0029 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1161 | 0.1161 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0069 | 0.1161 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0069 | 0.1161 | 0.1161 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Brugia malayi | Choline O-acetyltransferase | 0.0163 | 0.3624 | 0.3624 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0029 | 0.0029 |
Schistosoma mansoni | acetylcholinesterase | 0.0069 | 0.1161 | 0.1161 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0408 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0408 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1161 | 0.1161 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0163 | 0.3624 | 0.3624 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0408 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0069 | 0.1161 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0069 | 0.1161 | 0.1161 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0.1161 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Echinococcus granulosus | carboxylesterase 5A | 0.0408 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0069 | 0.1161 | 0.1161 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0408 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0029 | 0.0029 |
Onchocerca volvulus | 0.0069 | 0.1161 | 1 | |
Onchocerca volvulus | 0.0069 | 0.1161 | 1 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.0029 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.1161 | 0.1161 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0069 | 0.1161 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0163 | 0.3624 | 0.3624 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0069 | 0.1161 | 0.1161 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0069 | 0.1161 | 0.1161 |
Onchocerca volvulus | 0.0069 | 0.1161 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Schistosoma mansoni | choline o-acyltransferase | 0.0163 | 0.3624 | 0.3624 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0069 | 0.1161 | 0.1161 |
Echinococcus granulosus | acetylcholinesterase | 0.0408 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.0029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1161 | 0.1161 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0163 | 0.3624 | 0.3624 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1161 | 0.1161 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1161 | 0.1161 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0069 | 0.1161 | 0.1161 |
Echinococcus granulosus | acetylcholinesterase | 0.0408 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0408 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0408 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0069 | 0.1161 | 0.1161 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD50 (functional) | > 100 ug ml-1 | Dose required to inhibit Murine leukemia (L1210) cell proliferation by 50% | ChEMBL. | 2540332 |
CD50 (functional) | > 100 ug ml-1 | In vitro inhibition of FM3A (murine mammary carcinoma) cell proliferation. | ChEMBL. | 2540332 |
CD50 (functional) | > 100 ug ml-1 | Dose required to inhibit Human B-Lymphoblast(Raji) cell proliferation by 50% | ChEMBL. | 2540332 |
MCC (functional) | > 400 ug ml-1 | Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration required to reduce vesicular stomatitis virus induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 200 ug ml-1 | Minimum inhibitory concentration required to reduce Coxsackie virus B4 induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
MIC (functional) | > 400 ug ml-1 | Minimum inhibitory concentration required to reduce polio virus -1 induced cytopathogenicity by 50% in HeLa cells | ChEMBL. | 2540332 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.