Detailed information for compound 1851380

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 479.694 | Formula: C31H45NO3
  • H donors: 1 H acceptors: 3 LogP: 8.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)Cc2cnoc2C1(C)C)C(=O)O
  • InChi: 1S/C31H45NO3/c1-18(2)20-10-13-31(26(33)34)15-14-29(6)21(24(20)31)8-9-23-28(5)16-19-17-32-35-25(19)27(3,4)22(28)11-12-30(23,29)7/h17,20-24H,1,8-16H2,2-7H3,(H,33,34)/t20-,21+,22-,23+,24+,28-,29+,30+,31-/m0/s1
  • InChiKey: NIBNFSKXUCTRGP-AJNNAGPSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1012 0.5958 0.5958
Echinococcus granulosus tyrosine kinase 0.0642 0.2559 0.2559
Entamoeba histolytica receptor protein kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine protein kinase Fyn 0.1012 0.5958 0.5958
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1012 0.5958 0.5958
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Schistosoma mansoni tyrosine kinase 0.1073 0.6517 0.6566
Brugia malayi hypothetical protein 0.1004 0.5884 0.9028
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica serine/threonine kinase, putative 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus granulosus NCK adaptor protein 0.0371 0.0075 0.0075
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Echinococcus multilocularis tyrosine protein kinase 0.0642 0.2559 0.2559
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis tyrosine kinase 0.1004 0.5884 0.5884
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Loa Loa (eye worm) TK/Met protein kinase 0.0642 0.2559 0.3926
Echinococcus multilocularis tyrosine protein kinase Blk 0.1004 0.5884 0.5884
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Echinococcus multilocularis epidermal growth factor receptor 0.0836 0.4342 0.4342
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0642 0.2559 0.2559
Echinococcus granulosus protein tyrosine kinase 0.0642 0.2559 0.2559
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis insulin receptor 0.1073 0.6517 0.6517
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Echinococcus granulosus activated cdc42 kinase 1 0.0642 0.2559 0.2559
Loa Loa (eye worm) RGC/RGC protein kinase 0.0642 0.2559 0.3926
Onchocerca volvulus 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1012 0.5958 0.5958
Loa Loa (eye worm) TK/FAK protein kinase 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Schistosoma mansoni nck2/grb4 0.0371 0.0075 0.0075
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine protein kinase Fyn 0.1012 0.5958 0.5958
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.1004 0.5884 0.9028
Brugia malayi Guanylyl cyclase protein 23 0.0642 0.2559 0.3926
Trichomonas vaginalis AGC family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1012 0.5958 0.5958
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0642 0.2559 0.3926
Echinococcus multilocularis tyrosine protein kinase csk 0.0642 0.2559 0.2559
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0642 0.2559 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2559 0.5
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1453 1 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0642 0.2559 0.2559
Schistosoma mansoni serine/threonine protein kinase 0.0642 0.2559 0.2578
Echinococcus multilocularis FL cytokine receptor 0.0642 0.2559 0.2559
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0371 0.0075 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0642 0.2559 0.3926
Onchocerca volvulus 0.0642 0.2559 0.4349
Plasmodium vivax protein kinase, putative 0.0642 0.2559 0.5
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.1073 0.6517 1
Entamoeba histolytica cysteine surface protein, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trypanosoma cruzi protein kinase, putative 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica hypothetical protein, conserved 0.0642 0.2559 0.4349
Trichomonas vaginalis protein kinase atn1, putative 0.0642 0.2559 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1012 0.5958 0.5958
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0642 0.2559 0.2559
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0642 0.2559 0.3926
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0836 0.4342 0.4342
Schistosoma mansoni tyrosine protein kinase 0.0642 0.2559 0.2578
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1012 0.5958 0.5958
Echinococcus multilocularis tyrosine protein kinase pr2 0.0642 0.2559 0.2559
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1004 0.5884 0.5884
Trichomonas vaginalis STE family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/FER protein kinase 0.0642 0.2559 0.3926
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Brugia malayi hypothetical protein 0.0642 0.2559 0.3926
Echinococcus multilocularis protein tyrosine kinase 0.0642 0.2559 0.2559
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0371 0.0075 0.0114
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Brugia malayi SH2 domain containing protein 0.1004 0.5884 0.9028
Brugia malayi Protein kinase domain containing protein 0.0879 0.4734 0.7264
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2559 0.5
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Plasmodium falciparum protein kinase, putative 0.0642 0.2559 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0642 0.2559 0.3926
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0642 0.2559 0.2559
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0642 0.2559 0.2578
Brugia malayi Furin-like cysteine rich region family protein 0.0836 0.4342 0.6662
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0642 0.2559 0.2559
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Brugia malayi C-terminal src kinase protein 1 0.0642 0.2559 0.3926
Plasmodium vivax tyrosine kinase-like protein, putative 0.0642 0.2559 0.5
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Brugia malayi Variant SH3 domain containing protein 0.0371 0.0075 0.0114
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0642 0.2559 0.5
Echinococcus granulosus tyrosine kinase 0.1004 0.5884 0.5884
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0642 0.2559 0.3926
Echinococcus granulosus tyrosine protein kinase shark 0.1004 0.5884 0.5884
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Echinococcus granulosus tyrosine protein kinase csk 0.0642 0.2559 0.2559
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0642 0.2559 0.3926
Schistosoma mansoni serine/threonine protein kinase 0.065 0.2633 0.2653
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0642 0.2559 0.2559
Onchocerca volvulus 0.0642 0.2559 0.4349
Brugia malayi Tyrosine-protein kinase PR2 0.0642 0.2559 0.3926
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0642 0.2559 0.2559
Entamoeba histolytica serine/threonine kinase, putative 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.0836 0.4342 0.4374
Echinococcus multilocularis activated cdc42 kinase 1 0.0642 0.2559 0.2559
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0642 0.2559 0.2559
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Schistosoma mansoni tyrosine kinase 0.0836 0.4342 0.4374
Loa Loa (eye worm) TK/CSK protein kinase 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Loa Loa (eye worm) TK/FER protein kinase 0.0642 0.2559 0.3926
Schistosoma mansoni vav2 0.0367 0.0042 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus granulosus activin receptor type 0.0642 0.2559 0.2559
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine protein kinase Lyn 0.1012 0.5958 0.5958
Echinococcus multilocularis growth factor receptor bound protein 2 0.0371 0.0075 0.0075
Echinococcus multilocularis c src tyrosine kinase 0.1012 0.5958 0.5958
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0642 0.2559 0.2559
Schistosoma mansoni serine/threonine protein kinase 0.0642 0.2559 0.2578
Entamoeba histolytica ankyrin repeat protein 0.0642 0.2559 0.4349
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Brugia malayi integrin-linked kinase 0.0642 0.2559 0.3926
Brugia malayi SH2 domain containing protein 0.1004 0.5884 0.9028
Trichomonas vaginalis TK family protein kinase 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.1012 0.5958 0.6003
Echinococcus granulosus retinal guanylyl cyclase 2 0.0642 0.2559 0.2559
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis activin receptor type 0.0642 0.2559 0.2559
Giardia lamblia Kinase, NEK 0.0642 0.2559 0.5
Brugia malayi Protein kinase domain containing protein 0.1004 0.5884 0.9028
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0642 0.2559 0.2559
Echinococcus granulosus epidermal growth factor receptor 0.0836 0.4342 0.4342
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1004 0.5884 0.5884
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Echinococcus granulosus natriuretic peptide receptor 1 0.0642 0.2559 0.2559
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Entamoeba histolytica receptor protein kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Echinococcus multilocularis transfer RNA-Thr 0.0642 0.2559 0.2559
Entamoeba histolytica serine/threonine kinase, putative 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis tyrosine kinase 0.0642 0.2559 0.2559
Trypanosoma brucei Flagellum attachment zone protein 20 0.0642 0.2559 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) protein kinase domain-containing protein 0.0642 0.2559 0.3926
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Loa Loa (eye worm) hypothetical protein 0.0371 0.0075 0.0114
Onchocerca volvulus 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0642 0.2559 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Leishmania major protein kinase, putative 0.0642 0.2559 0.5
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0642 0.2559 0.2578
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0642 0.2559 0.2559
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1012 0.5958 0.5958
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Brugia malayi ephrin receptor 1 precursor 0.0642 0.2559 0.3926
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.1445 0.9925 1
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0642 0.2559 0.2559
Echinococcus multilocularis epidermal growth factor receptor 0.0836 0.4342 0.4342
Brugia malayi Protein kinase domain containing protein 0.1004 0.5884 0.9028
Plasmodium falciparum tyrosine kinase-like protein 0.0642 0.2559 0.5
Brugia malayi protein-tyrosine kinase 0.1004 0.5884 0.9028
Schistosoma mansoni tyrosine kinase 0.1012 0.5958 0.6003
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0642 0.2559 0.3926
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1004 0.5884 0.5884
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Schistosoma mansoni adapter molecule crk 0.0371 0.0075 0.0075
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0642 0.2559 0.2578
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Onchocerca volvulus 0.0642 0.2559 0.4349
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Brugia malayi SRC-1 0.1012 0.5958 0.9143
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0642 0.2559 0.2559
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1004 0.5884 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0642 0.2559 0.5
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1004 0.5884 0.5884
Leishmania major protein kinase, putative 0.0642 0.2559 0.5
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Brugia malayi Variant SH3 domain containing protein 0.0371 0.0075 0.0114
Echinococcus granulosus insulin receptor 0.1073 0.6517 0.6517
Echinococcus multilocularis raf serine:threonine protein kinase 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Entamoeba histolytica serine/threonine kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) RGC/RGC protein kinase 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) serine/threonine protein kinase 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis protein kinase 0.0642 0.2559 0.2559
Echinococcus multilocularis protein kinase 0.0642 0.2559 0.2559
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.0836 0.4342 0.4374
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/RYK protein kinase 0.0642 0.2559 0.3926
Loa Loa (eye worm) TK/FER protein kinase 0.1004 0.5884 0.9028
Echinococcus granulosus raf serine:threonine protein kinase 0.0642 0.2559 0.2559
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1004 0.5884 0.5884
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Onchocerca volvulus Tyrosine kinase homolog 0.0642 0.2559 0.4349
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0642 0.2559 0.3926
Onchocerca volvulus 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine protein kinase Src42A 0.1012 0.5958 0.5958
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Onchocerca volvulus 0.0642 0.2559 0.4349
Echinococcus multilocularis receptor type guanylyl cyclase 0.0642 0.2559 0.2559
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0642 0.2559 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0836 0.4342 0.6662
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0642 0.2559 0.2578
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.1012 0.5958 0.6003
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0642 0.2559 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1012 0.5958 0.5958
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0642 0.2559 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2559 0.5
Onchocerca volvulus 0.1004 0.5884 1
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Loa Loa (eye worm) TK/ROR protein kinase 0.0642 0.2559 0.3926
Loa Loa (eye worm) RGC/RGC protein kinase 0.0642 0.2559 0.3926
Schistosoma mansoni serine/threonine protein kinase 0.0642 0.2559 0.2578
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1012 0.5958 0.5958
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Brugia malayi Immunoglobulin I-set domain containing protein 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.1004 0.5884 0.9028
Trichomonas vaginalis protein tyrosine kinase, putative 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Echinococcus granulosus tyrosine protein kinase HCK 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/ACK protein kinase 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine protein kinase csk 0.0642 0.2559 0.2559
Echinococcus multilocularis tyrosine protein kinase shark 0.1004 0.5884 0.5884
Loa Loa (eye worm) TK/ALK protein kinase 0.0642 0.2559 0.3926
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0642 0.2559 0.2559
Brugia malayi Sex muscle abnormal protein 5 0.0371 0.0075 0.0114
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Brugia malayi Receptor family ligand binding region containing protein 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Brugia malayi bone morphogenetic protein type 1 receptor 0.0642 0.2559 0.3926
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0642 0.2559 0.2559
Echinococcus granulosus tyrosine protein kinase Fyn 0.1012 0.5958 0.5958
Echinococcus multilocularis natriuretic peptide receptor 1 0.0642 0.2559 0.2559
Loa Loa (eye worm) TK/FER protein kinase 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Echinococcus granulosus receptor type guanylyl cyclase 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0642 0.2559 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.1012 0.5958 0.5958
Echinococcus granulosus tyrosine protein kinase pr2 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) hypothetical protein 0.1004 0.5884 0.9028
Echinococcus granulosus integrin linked protein kinase 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Brugia malayi Tyrosine-protein kinase abl-1 0.1012 0.5958 0.9143
Plasmodium falciparum protein kinase, putative 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Schistosoma mansoni ephrin receptor 0.0642 0.2559 0.2578
Entamoeba histolytica tyrosin kinase, putative 0.0642 0.2559 0.4349
Trypanosoma cruzi protein kinase, putative 0.0642 0.2559 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0642 0.2559 0.2559
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2559 0.5
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Schistosoma mansoni growth factor receptor-bound protein 0.0371 0.0075 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0642 0.2559 0.4349
Entamoeba histolytica ankyrin repeat protein 0.0642 0.2559 0.4349
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0642 0.2559 0.2578
Loa Loa (eye worm) TK/EPH protein kinase 0.0642 0.2559 0.3926
Echinococcus granulosus tyrosine protein kinase ABL1 0.1004 0.5884 0.5884
Plasmodium falciparum tyrosine kinase-like protein 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Loa Loa (eye worm) TK/FER protein kinase 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0642 0.2559 0.2559
Echinococcus multilocularis tyrosine protein kinase Srms 0.1004 0.5884 0.5884
Echinococcus granulosus fibroblast growth factor receptor 4 0.0642 0.2559 0.2559
Loa Loa (eye worm) TK/INSR protein kinase 0.1073 0.6517 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0642 0.2559 0.2559
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1073 0.6517 0.6517
Plasmodium falciparum protein kinase, putative 0.0642 0.2559 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1012 0.5958 0.5958
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.1004 0.5884 0.9028
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Echinococcus granulosus kinase suppressor of Ras 1 0.0642 0.2559 0.2559
Leishmania major hypothetical protein, conserved 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.1004 0.5884 0.5928
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Brugia malayi Raf kinase 0.0642 0.2559 0.3926
Echinococcus granulosus c src tyrosine kinase 0.1012 0.5958 0.5958
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Echinococcus granulosus protein kinase 0.0642 0.2559 0.2559
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0642 0.2559 0.5
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0642 0.2559 0.3926
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) SRC-1 0.1012 0.5958 0.9143
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0642 0.2559 0.2559
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis NCK adaptor protein 0.0371 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Onchocerca volvulus 0.1004 0.5884 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0642 0.2559 0.2559
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0371 0.0075 0.0114
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.1012 0.5958 0.6003
Onchocerca volvulus 0.1004 0.5884 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0642 0.2559 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.1073 0.6517 0.6566
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0642 0.2559 0.2559
Loa Loa (eye worm) hypothetical protein 0.0367 0.0042 0.0064
Schistosoma mansoni serine/threonine RGC 0.0642 0.2559 0.2578
Echinococcus multilocularis heat shock protein 70 0.0642 0.2559 0.2559
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0642 0.2559 0.5
Onchocerca volvulus 0.1004 0.5884 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0642 0.2559 0.3926
Echinococcus granulosus activated cdc42 kinase 1 0.0642 0.2559 0.2559
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0642 0.2559 0.3926
Schistosoma mansoni growth factor receptor-bound protein 0.0371 0.0075 0.0075
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Brugia malayi Variant SH3 domain containing protein 0.0367 0.0042 0.0064
Brugia malayi hypothetical protein 0.0642 0.2559 0.3926
Echinococcus granulosus tyrosine protein kinase Blk 0.1004 0.5884 0.5884
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0642 0.2559 0.2578
Echinococcus multilocularis integrin linked protein kinase 0.0642 0.2559 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.0642 0.2559 0.5
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0642 0.2559 0.3926
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Toxoplasma gondii protein kinase domain-containing protein 0.0642 0.2559 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0642 0.2559 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0642 0.2559 0.2559
Toxoplasma gondii STE kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0642 0.2559 0.5
Giardia lamblia Kinase, NEK 0.0642 0.2559 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0371 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Onchocerca volvulus 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/ABL protein kinase 0.1004 0.5884 0.9028
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Echinococcus multilocularis protein KINase family member (kin 25) 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0642 0.2559 0.4349
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine kinase 0.1004 0.5884 0.5884
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0642 0.2559 0.3926
Echinococcus multilocularis ephrin type A receptor 4 A 0.0642 0.2559 0.2559
Giardia lamblia Kinase 0.0642 0.2559 0.5
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0642 0.2559 0.2559
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0367 0.0042 0.0064
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0642 0.2559 0.2559
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Trypanosoma brucei protein kinase, putative 0.0642 0.2559 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0642 0.2559 0.2559
Echinococcus multilocularis tyrosine protein kinase HCK 0.0642 0.2559 0.2559
Echinococcus granulosus tyrosine protein kinase 0.0642 0.2559 0.2559
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.1012 0.5958 0.6003
Schistosoma mansoni hypothetical protein 0.0642 0.2559 0.2578
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/FER protein kinase 0.0642 0.2559 0.3926
Loa Loa (eye worm) TK/FER protein kinase 0.0642 0.2559 0.3926
Echinococcus multilocularis tyrosine protein kinase csk 0.0642 0.2559 0.2559
Loa Loa (eye worm) RGC/RGC protein kinase 0.0642 0.2559 0.3926
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1012 0.5958 0.5958
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Echinococcus multilocularis tyrosine protein kinase Abl 0.1012 0.5958 0.5958
Schistosoma mansoni protein tyrosine kinase 0.0642 0.2559 0.2578
Schistosoma mansoni protein kinase 0.0642 0.2559 0.2578
Loa Loa (eye worm) TK protein kinase 0.1004 0.5884 0.9028
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0642 0.2559 0.4349
Onchocerca volvulus 0.1004 0.5884 1
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Onchocerca volvulus 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK/DDR protein kinase 0.0642 0.2559 0.3926
Loa Loa (eye worm) hypothetical protein 0.0642 0.2559 0.3926
Onchocerca volvulus 0.1004 0.5884 1
Schistosoma mansoni ephrin receptor 0.0642 0.2559 0.2578
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1073 0.6517 0.6517
Echinococcus granulosus epidermal growth factor receptor 0.0836 0.4342 0.4342
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Entamoeba histolytica hypothetical protein 0.0642 0.2559 0.4349
Entamoeba histolytica tyrosine kinase, putative 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine protein kinase csk 0.0642 0.2559 0.2559
Entamoeba histolytica protein kinase, putative 0.0642 0.2559 0.4349
Toxoplasma gondii protein kinase 0.0642 0.2559 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0642 0.2559 0.4349
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Giardia lamblia Protein 21.1 0.0642 0.2559 0.5
Trypanosoma brucei Pseudokinase, putative 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Trichomonas vaginalis TKL family protein kinase 0.0642 0.2559 0.5
Schistosoma mansoni tyrosine kinase 0.0642 0.2559 0.2578
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0642 0.2559 0.4349
Loa Loa (eye worm) TK protein kinase 0.0642 0.2559 0.3926
Brugia malayi Protein kinase domain containing protein 0.0642 0.2559 0.3926
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Entamoeba histolytica serine/threonine kinase, putative 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Entamoeba histolytica protein kinase domain containing protein 0.0642 0.2559 0.4349
Echinococcus granulosus tyrosine protein kinase Srms 0.1004 0.5884 0.5884

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 65.3 % Antiinflammatory activity against mouse J774 cells assessed as inhibition of LPS-induced MCP-1 production measured as remaining MCP-1 levels at 10 uM after 24 hrs by ELISA ChEMBL. 26915998
GI (functional) Antileishmanial activity against axenic amastigote stage of Leishmania donovani MHOM/SD/1962/1S-Cl2d assessed as parasite growth inhibition at 5 uM after 24 hrs by AlamarBlue assay (Rvb = 0.0 +/- 0.9%) ChEMBL. No reference
GI (functional) = 15.6 % Antileishmanial activity against axenic amastigote stage of Leishmania donovani MHOM/SD/1962/1S-Cl2d assessed as parasite growth inhibition at 15 uM after 24 hrs by AlamarBlue assay (Rvb = 1.5 +/- 3.8%) ChEMBL. No reference
GI (functional) = 95.7 % Antileishmanial activity against axenic amastigote stage of Leishmania donovani MHOM/SD/1962/1S-Cl2d assessed as parasite growth inhibition at 50 uM after 24 hrs by AlamarBlue assay (Rvb = 0.0 +/- 4.6%) ChEMBL. No reference
IC50 (functional) Antileishmanial activity against axenic amastigote stage of Leishmania donovani MHOM/SD/1962/1S-Cl2d assessed as parasite growth inhibition after 24 hrs by AlamarBlue assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.