TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 704.812 | Formula: C37H48N6O8
H donors: 6 H acceptors: 7 LogP: 3.59 Rotable bonds: 21
Rule of 5 violations (Lipinski): 3
SMILES: CCC[C@@H]1CCN([C@@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CC(=O)O)C(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)OC(C)(C)C
InChi: 1S/C37H48N6O8/c1-5-11-23-16-17-43(35(49)29(42-36(50)51-37(2,3)4)19-24-21-39-26-15-10-9-14-25(24)26)31(23)34(48)41-28(20-30(44)45)33(47)40-27(32(38)46)18-22-12-7-6-8-13-22/h6-10,12-15,21,23,27-29,31,39H,5,11,16-20H2,1-4H3,(H2,38,46)(H,40,47)(H,41,48)(H,42,50)(H,44,45)/t23-,27+,28+,29+,31+/m1/s1
InChiKey: ZMALSGOXKJVYAU-UKJMRWJMSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholecystokinin B receptor	Starlite/ChEMBL	References
Cavia porcellus	Cholecystokinin A receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132882	All targets in OG5_132882
Brugia malayi	hypothetical protein	Get druggable targets OG5_132882	All targets in OG5_132882
Brugia malayi	sulfakinin receptor protein	Get druggable targets OG5_132882	All targets in OG5_132882

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Forkhead box protein biniou homolog	Cholecystokinin A receptor	430 aa	353 aa	22.1 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Cholecystokinin A receptor	430 aa	384 aa	21.4 %
Echinococcus multilocularis	dro:myosuppressin receptor	Cholecystokinin A receptor	430 aa	369 aa	23.0 %
Echinococcus multilocularis	serotonin receptor	Cholecystokinin A receptor	430 aa	427 aa	23.7 %
Echinococcus granulosus	g protein coupled receptor	Cholecystokinin A receptor	430 aa	398 aa	23.9 %
Onchocerca volvulus		Cholecystokinin A receptor	430 aa	410 aa	25.4 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Cholecystokinin A receptor	430 aa	373 aa	28.4 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Cholecystokinin A receptor	430 aa	378 aa	23.8 %
Onchocerca volvulus		Cholecystokinin A receptor	430 aa	397 aa	29.0 %
Echinococcus granulosus	rhodopsin orphan GPCR	Cholecystokinin A receptor	430 aa	363 aa	19.6 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Cholecystokinin A receptor	430 aa	373 aa	27.3 %
Echinococcus multilocularis	g protein coupled receptor	Cholecystokinin A receptor	430 aa	405 aa	24.2 %
Echinococcus granulosus	orexin receptor type 2	Cholecystokinin A receptor	430 aa	383 aa	23.2 %
Schistosoma mansoni	amine GPCR	Cholecystokinin A receptor	430 aa	409 aa	24.7 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Cholecystokinin A receptor	430 aa	356 aa	27.5 %
Echinococcus multilocularis	neuropeptides capa receptor	Cholecystokinin A receptor	430 aa	414 aa	19.8 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Cholecystokinin A receptor	430 aa	402 aa	26.1 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Cholecystokinin A receptor	430 aa	375 aa	26.4 %
Echinococcus granulosus	biogenic amine 5HT receptor	Cholecystokinin A receptor	430 aa	428 aa	23.6 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Cholecystokinin A receptor	430 aa	382 aa	25.1 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Cholecystokinin A receptor	430 aa	383 aa	22.7 %
Onchocerca volvulus	Phospholipase d-related homolog	Cholecystokinin A receptor	430 aa	359 aa	20.9 %
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	Cholecystokinin A receptor	430 aa	381 aa	21.5 %
Onchocerca volvulus		Cholecystokinin A receptor	430 aa	377 aa	22.3 %
Echinococcus multilocularis	g protein coupled receptor	Cholecystokinin A receptor	430 aa	414 aa	23.4 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Cholecystokinin A receptor	430 aa	395 aa	24.8 %
Schistosoma japonicum	FMRFamide receptor, putative	Cholecystokinin A receptor	430 aa	364 aa	22.8 %
Echinococcus multilocularis	orexin receptor type 2	Cholecystokinin A receptor	430 aa	381 aa	23.6 %
Echinococcus granulosus	g protein coupled receptor	Cholecystokinin A receptor	430 aa	415 aa	23.1 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Cholecystokinin A receptor	430 aa	363 aa	19.3 %
Echinococcus granulosus	dro:myosuppressin receptor	Cholecystokinin A receptor	430 aa	369 aa	23.0 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Cholecystokinin A receptor	430 aa	363 aa	24.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Echinococcus granulosus	epidermal growth factor receptor	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.039	0.7788	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0007	0.0001
Brugia malayi	hypothetical protein	0.0176	0.3317	0.4259
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0454	0.0575
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0454	0.0583
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.039	0.7788	1
Onchocerca volvulus		0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Brugia malayi	beta-lactamase	0.0078	0.1245	0.1599
Echinococcus granulosus	tyrosine protein kinase Srms	0.039	0.7788	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0078	0.1245	0.1592
Onchocerca volvulus		0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0007	0.0001
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.039	0.7788	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0096	0.1632	0.1626
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1245	0.1592
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0503	0.0637
Brugia malayi	integrin-linked kinase	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Brugia malayi	sulfakinin receptor protein	0.0261	0.5092	0.6538
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Mycobacterium ulcerans	lipase LipD	0.0078	0.1245	0.2164
Echinococcus multilocularis	raf serine:threonine protein kinase	0.039	0.7788	1
Echinococcus multilocularis	insulin receptor	0.039	0.7788	1
Brugia malayi	Raf kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.1245	0.1592
Brugia malayi	SH2 domain containing protein	0.039	0.7788	1
Onchocerca volvulus		0.039	0.7788	1
Echinococcus multilocularis	transfer RNA-Thr	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0006	0.0008
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.039	0.7788	1
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0007	0.0009
Entamoeba histolytica	serine/threonine kinase, putative	0.039	0.7788	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.039	0.7788	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.039	0.7788	1
Onchocerca volvulus		0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Brugia malayi	Muscleblind-like protein	0.0166	0.3103	0.3985
Trichomonas vaginalis	conserved hypothetical protein	0.039	0.7788	1
Echinococcus multilocularis	c src tyrosine kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Echinococcus granulosus	epidermal growth factor receptor	0.039	0.7788	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.039	0.7788	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.039	0.7788	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.084	0.1079
Loa Loa (eye worm)	TK/ACK protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0078	0.1245	0.1239
Echinococcus granulosus	tyrosine kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase csk	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.3103	0.3979
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.039	0.7788	1
Echinococcus granulosus	protein tyrosine kinase	0.039	0.7788	1
Echinococcus multilocularis	protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TK family protein kinase	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	beta-lactamase	0.0078	0.1245	0.1592
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.039	0.7788	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Schistosoma mansoni	ephrin receptor	0.039	0.7788	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0514	0.0653
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.039	0.7788	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.039	0.7788	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0687	0.0875
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Onchocerca volvulus		0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0687	0.0875
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0687	0.0875
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.3103	0.3979
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Entamoeba histolytica	receptor protein kinase, putative	0.039	0.7788	0.5
Brugia malayi	MH2 domain containing protein	0.0139	0.2541	0.3263
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Onchocerca volvulus		0.0176	0.3317	0.3167
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.039	0.7788	1
Onchocerca volvulus		0.039	0.7788	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0687	0.0875
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.039	0.7788	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.039	0.7788	1
Echinococcus granulosus	c src tyrosine kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Echinococcus granulosus	activated cdc42 kinase 1	0.039	0.7788	1
Plasmodium falciparum	protein kinase, putative	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Onchocerca volvulus		0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Toxoplasma gondii	STE kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0078	0.1245	0.1239
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0687	0.0875
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Onchocerca volvulus		0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Toxoplasma gondii	protein kinase domain-containing protein	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Toxoplasma gondii	protein kinase	0.039	0.7788	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.084	0.1079
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.039	0.7788	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.039	0.7788	1
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0131	0.2362	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.039	0.7788	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0096	0.1632	0.1626
Plasmodium vivax	protein kinase, putative	0.039	0.7788	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.2541	0.3257
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0063	0.0937	0.093
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0208	0.0259
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.039	0.7788	1
Trypanosoma brucei	Pseudokinase, putative	0.039	0.7788	1
Echinococcus multilocularis	heat shock protein 70	0.039	0.7788	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase	0.039	0.7788	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.039	0.7788	1
Brugia malayi	beta-lactamase family protein	0.0078	0.1245	0.1599
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.1245	0.1591
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0687	0.0882
Onchocerca volvulus		0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.1245	0.1592
Trichomonas vaginalis	CAMK family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.039	0.7788	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0208	0.0259
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0096	0.1632	0.1626
Echinococcus granulosus	insulin receptor	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0078	0.1245	0.1592
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.039	0.7788	1
Schistosoma mansoni	serine/threonine protein kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Mycobacterium tuberculosis	Conserved protein	0.0078	0.1245	0.1239
Brugia malayi	Guanylyl cyclase protein 23	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0176	0.3317	0.4255
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1245	0.1592
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0007	0.0001
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.039	0.7788	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Trypanosoma brucei	trypanothione reductase	0.0042	0.0503	0.0637
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0007	0.0001
Echinococcus granulosus	integrin linked protein kinase	0.039	0.7788	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.039	0.7788	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.039	0.7788	1
Echinococcus multilocularis	protein tyrosine kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	protein tyrosine kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein, conserved	0.039	0.7788	0.5
Entamoeba histolytica	ankyrin repeat protein	0.039	0.7788	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.039	0.7788	0.5
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0078	0.1245	0.1599
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Leishmania major	hypothetical protein, conserved	0.0028	0.0208	0.0259
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0078	0.1245	0.2164
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Echinococcus granulosus	tyrosine kinase	0.039	0.7788	1
Onchocerca volvulus		0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.039	0.7788	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Brugia malayi	hypothetical protein	0.039	0.7788	1
Toxoplasma gondii	ABC1 family protein	0.0078	0.1245	0.1591
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.039	0.7788	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.039	0.7788	1
Trichomonas vaginalis	conserved hypothetical protein	0.039	0.7788	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.039	0.7788	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0096	0.1632	0.756
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.039	0.7788	1
Entamoeba histolytica	serine/threonine kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Leishmania major	hypothetical protein, conserved	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.1245	0.1591
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Onchocerca volvulus		0.039	0.7788	1
Giardia lamblia	Kinase, NEK	0.039	0.7788	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.039	0.7788	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0208	0.0259
Brugia malayi	SH2 domain containing protein	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0687	0.0875
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.039	0.7788	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0078	0.1245	0.1239
Echinococcus multilocularis	receptor type guanylyl cyclase	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.2541	0.3257
Echinococcus granulosus	tyrosine protein kinase csk	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0007	0.0009
Giardia lamblia	Kinase, NEK	0.039	0.7788	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.039	0.7788	1
Schistosoma mansoni	serine/threonine protein kinase	0.039	0.7788	1
Onchocerca volvulus	Tyrosine kinase homolog	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0503	0.0637
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Leishmania major	protein kinase, putative	0.039	0.7788	1
Trypanosoma brucei	protein kinase, putative	0.039	0.7788	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Schistosoma mansoni	hypothetical protein	0.004	0.0454	0.0575
Leishmania major	protein kinase, putative	0.039	0.7788	1
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0503	0.0637
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0208	0.0259
Mycobacterium tuberculosis	Probable lipase LipE	0.0078	0.1245	0.1239
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Loa Loa (eye worm)	TK/Met protein kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Mycobacterium tuberculosis	Conserved protein	0.0078	0.1245	0.1239
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0078	0.1245	0.1592
Mycobacterium tuberculosis	Probable dehydrogenase	0.0096	0.1632	0.1626
Schistosoma mansoni	ephrin receptor	0.039	0.7788	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.039	0.7788	1
Brugia malayi	hypothetical protein	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.039	0.7788	0.5
Onchocerca volvulus		0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase	0.039	0.7788	1
Echinococcus multilocularis	epidermal growth factor receptor	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.039	0.7788	1
Brugia malayi	Receptor family ligand binding region containing protein	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0208	0.0259
Leishmania major	trypanothione reductase	0.0042	0.0503	0.0637
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.039	0.7788	1
Echinococcus multilocularis	muscleblind protein	0.0166	0.3103	0.3979
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus multilocularis	activin receptor type	0.039	0.7788	1
Entamoeba histolytica	serine/threonine kinase, putative	0.039	0.7788	0.5
Onchocerca volvulus		0.039	0.7788	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Echinococcus multilocularis	FL cytokine receptor	0.039	0.7788	1
Mycobacterium leprae	Probable lipase LipE	0.0078	0.1245	0.3354
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Trypanosoma cruzi	protein kinase, putative	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Brugia malayi	protein-tyrosine kinase	0.039	0.7788	1
Mycobacterium ulcerans	hypothetical protein	0.0078	0.1245	0.2164
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0107	0.1857	0.1851
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0687	0.0875
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.039	0.7788	1
Entamoeba histolytica	tyrosin kinase, putative	0.039	0.7788	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.039	0.7788	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0007	0.0001
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.039	0.7788	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Mycobacterium tuberculosis	Probable reductase	0.0096	0.1632	0.1626
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.039	0.7788	1
Trichomonas vaginalis	AGC family protein kinase	0.039	0.7788	1
Echinococcus multilocularis	epidermal growth factor receptor	0.039	0.7788	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0078	0.1245	0.3354
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1245	0.1592
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0208	0.0259
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.039	0.7788	1
Trichomonas vaginalis	conserved hypothetical protein	0.039	0.7788	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.039	0.7788	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Echinococcus granulosus	protein kinase	0.039	0.7788	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.039	0.7788	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.084	0.1071
Brugia malayi	ephrin receptor 1 precursor	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0107	0.1857	1
Entamoeba histolytica	tyrosin kinase, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.039	0.7788	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.039	0.7788	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.039	0.7788	1
Echinococcus granulosus	activin receptor type	0.039	0.7788	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.039	0.7788	1
Schistosoma mansoni	serine/threonine RGC	0.039	0.7788	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.039	0.7788	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.039	0.7788	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.039	0.7788	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0007	0.0001
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0514	0.0653
Echinococcus granulosus	tyrosine kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0208	0.0259
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0078	0.1245	0.1239
Echinococcus granulosus	kinase suppressor of Ras 1	0.039	0.7788	1
Mycobacterium tuberculosis	Probable hydrolase	0.0078	0.1245	0.1239
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.039	0.7788	1
Brugia malayi	glutathione reductase	0.0042	0.0503	0.0645
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0042	0.0503	0.0496
Echinococcus multilocularis	tyrosine kinase	0.039	0.7788	1
Schistosoma mansoni	hypothetical protein	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0096	0.1632	0.1626
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.039	0.7788	1
Plasmodium falciparum	protein kinase, putative	0.039	0.7788	1
Trypanosoma cruzi	protein kinase, putative	0.039	0.7788	1
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.1245	0.1591
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1245	0.1592
Onchocerca volvulus		0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0107	0.1857	0.1851
Echinococcus granulosus	fibroblast growth factor receptor 4	0.039	0.7788	1
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0131	0.2362	0.2357
Echinococcus multilocularis	muscleblind protein 1	0.0166	0.3103	0.3979
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1245	0.1592
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.039	0.7788	1
Entamoeba histolytica	ankyrin repeat protein	0.039	0.7788	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.039	0.7788	1
Schistosoma mansoni	serine/threonine protein kinase	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.084	0.1071
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.1245	0.1591
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.039	0.7788	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.039	0.7788	1
Trichomonas vaginalis	conserved hypothetical protein	0.039	0.7788	1
Schistosoma mansoni	tyrosine protein kinase	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1245	0.1592
Plasmodium falciparum	thioredoxin reductase	0.0042	0.0503	0.0637
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Entamoeba histolytica	serine/threonine kinase, putative	0.039	0.7788	0.5
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Brugia malayi	C-terminal src kinase protein 1	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.039	0.7788	1
Trichomonas vaginalis	conserved hypothetical protein	0.039	0.7788	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0006	0.0008
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.039	0.7788	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.039	0.7788	1
Trichomonas vaginalis	conserved hypothetical protein	0.039	0.7788	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0078	0.1245	0.1239
Giardia lamblia	Kinase	0.039	0.7788	0.5
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.039	0.7788	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.039	0.7788	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.039	0.7788	1
Brugia malayi	hypothetical protein	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Trypanosoma brucei	beta lactamase	0.0063	0.0937	0.1195
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Onchocerca volvulus		0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.039	0.7788	1
Mycobacterium tuberculosis	Conserved protein	0.0078	0.1245	0.1239
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0503	0.0637
Trichomonas vaginalis	protein kinase atn1, putative	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Leishmania major	hypothetical protein, conserved	0.0078	0.1245	0.1591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.0503	0.0637
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0687	0.0875
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.039	0.7788	1
Plasmodium falciparum	glutathione reductase	0.0042	0.0503	0.0637
Echinococcus multilocularis	tyrosine protein kinase csk	0.039	0.7788	1
Trichomonas vaginalis	conserved hypothetical protein	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.039	0.7788	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.039	0.7788	1
Brugia malayi	hypothetical protein	0.0261	0.5092	0.6538
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0007	0.0001
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0503	0.0637
Loa Loa (eye worm)	TK/FAK protein kinase	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Mycobacterium ulcerans	beta-lactamase	0.0078	0.1245	0.2164
Loa Loa (eye worm)	hypothetical protein	0.0261	0.5092	0.6535
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Brugia malayi	Thioredoxin reductase	0.0042	0.0503	0.0645
Giardia lamblia	Protein 21.1	0.039	0.7788	0.5
Brugia malayi	hypothetical protein	0.0028	0.0208	0.0267
Loa Loa (eye worm)	TK protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.7788	1
Echinococcus multilocularis	tyrosine kinase	0.039	0.7788	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.039	0.7788	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0107	0.1857	0.1851
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.039	0.7788	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.039	0.7788	1
Entamoeba histolytica	receptor protein kinase, putative	0.039	0.7788	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Echinococcus multilocularis	protein kinase	0.039	0.7788	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	serine/threonine kinase, putative	0.039	0.7788	0.5
Brugia malayi	SRC-1	0.039	0.7788	1
Plasmodium falciparum	protein kinase, putative	0.039	0.7788	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase, putative	0.039	0.7788	0.5
Loa Loa (eye worm)	SRC-1	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.039	0.7788	1
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Brugia malayi	Furin-like cysteine rich region family protein	0.039	0.7788	1
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.039	0.7788	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase shark	0.039	0.7788	1
Plasmodium falciparum	tyrosine kinase-like protein	0.039	0.7788	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.039	0.7788	1
Schistosoma mansoni	tyrosine kinase	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.039	0.7788	1
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Trichomonas vaginalis	STE family protein kinase	0.039	0.7788	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.039	0.7788	1
Echinococcus multilocularis	integrin linked protein kinase	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Brugia malayi	beta-lactamase family protein	0.0078	0.1245	0.1599
Schistosoma mansoni	protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0208	0.0259
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	hypothetical protein	0.039	0.7788	0.5
Echinococcus granulosus	muscleblind protein	0.0166	0.3103	0.3979
Trichomonas vaginalis	TKL family protein kinase	0.039	0.7788	1
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.039	0.7788	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Entamoeba histolytica	tyrosine kinase, putative	0.039	0.7788	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.039	0.7788	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.039	0.7788	1
Loa Loa (eye worm)	TK/FER protein kinase	0.039	0.7788	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0007	0.0001
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0078	0.1245	0.2164
Brugia malayi	Protein kinase domain containing protein	0.039	0.7788	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.039	0.7788	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.9 nM	Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig	ChEMBL.	1992147
IC50 (binding)	= 2700 nM	Compound was tested for its inhibitory activity in pancreatic cholecystokinin type A receptor in guinea pig	ChEMBL.	1992147

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3143186

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1851390