Detailed information for compound 1851439

Basic information

Technical information
  • TDR Targets ID: 1851439
  • Name: (2S,3R,4S,5R)-2-(6-amino-[1,2,4]triazolo[5,4- f]pyridazin-3-yl)-5-(hydroxymethyl)oxolane-3, 4-diol
  • MW: 267.241 | Formula: C10H13N5O4
  • H donors: 4 H acceptors: 6 LogP: -2.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)c1nnc2n1nc(N)cc2
  • InChi: 1S/C10H13N5O4/c11-5-1-2-6-12-13-10(15(6)14-5)9-8(18)7(17)4(3-16)19-9/h1-2,4,7-9,16-18H,3H2,(H2,11,14)/t4-,7-,8-,9-/m1/s1
  • InChiKey: PWNCUSTXLUHTNO-XCBZGROMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3R,4S,5R)-2-(6-amino-[1,2,4]triazolo[5,4-f]pyridazin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2S,3R,4S,5R)-2-(6-amino-[1,2,4]triazolo[5,4-f]pyridazin-3-yl)-5-methylol-tetrahydrofuran-3,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0092 0.0396 0.0432
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0092 0.0396 0.1491
Echinococcus granulosus geminin 0.0196 0.171 0.1658
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0162 0.1278 0.0918
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0066 0.0075 0.5
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0814 0.9481 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0092 0.0396 0.0418
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0162 0.1278 0.0918
Schistosoma mansoni hypothetical protein 0.0196 0.171 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0855 1 1
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0446 0.4853 0.4641
Echinococcus multilocularis hedgehog 0.0221 0.2029 0.2001
Trypanosoma brucei Sterol methyltransferase, putative 0.0855 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Echinococcus granulosus Desert hedgehog protein 0.0221 0.2029 0.2001
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0855 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0166 0.0175
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0396 0.2668
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0162 0.1278 1
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0162 0.1278 0.1348
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0075 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0166 0.0181
Leishmania major sterol 24-c-methyltransferase, putative 0.0855 1 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.1278 0.1395
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0855 1 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0075 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Schistosoma mansoni hypothetical protein 0.0196 0.171 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0855 1 1
Loa Loa (eye worm) hypothetical protein 0.0788 0.916 1
Brugia malayi RNA binding protein 0.0073 0.0166 0.0175
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0092 0.0396 0.1491
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0162 0.1278 0.0918
Loa Loa (eye worm) hypothetical protein 0.0417 0.4485 0.4897
Plasmodium falciparum GAF domain-related protein, putative 0.0066 0.0075 0.5
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0162 0.1278 1
Echinococcus multilocularis geminin 0.0196 0.171 0.1658
Loa Loa (eye worm) hypothetical protein 0.0722 0.8328 0.9092
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0162 0.1278 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0092 0.0396 0.0247
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0814 0.9481 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0092 0.0396 0.2668
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0814 0.9481 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0166 0.0181
Brugia malayi TAR-binding protein 0.0073 0.0166 0.0175
Loa Loa (eye worm) RNA binding protein 0.0073 0.0166 0.0181
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0162 0.1278 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0162 0.1278 1
Mycobacterium ulcerans hypothetical protein 0.0162 0.1278 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0162 0.1278 0.0918
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0417 0.4485 0.4731
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0855 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Schistosoma mansoni hypothetical protein 0.0161 0.1273 0.7167
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0066 0.0075 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0092 0.0396 0.2668
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0092 0.0396 0.0247

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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