Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.046 | 0.2921 | 1 |
Toxoplasma gondii | ThiF family protein | 0.0088 | 0.0309 | 0.0247 |
Loa Loa (eye worm) | ThiF family protein | 0.0063 | 0.0134 | 0.0071 |
Toxoplasma gondii | ThiF family protein | 0.0063 | 0.0134 | 0.0071 |
Trypanosoma brucei | NEDD8 activating enzyme subunit, putative | 0.046 | 0.2921 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0256 | 0.1487 | 0.498 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.046 | 0.2921 | 1 |
Leishmania major | adenosine kinase, putative | 0.0256 | 0.1487 | 0.498 |
Schistosoma mansoni | ubiquitin-activating enzyme E1b | 0.0053 | 0.0063 | 0.0063 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.147 | 1 | 1 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.046 | 0.2921 | 0.4038 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1 X, putative | 0.0089 | 0.0319 | 0.0361 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0126 | 0.0576 | 0.0576 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0177 | 0.0937 | 0.088 |
Schistosoma mansoni | ubiquitin-activating enzyme E1-related | 0.0053 | 0.0063 | 0.0063 |
Schistosoma mansoni | clathrin coat associated protein ap-50 | 0.0126 | 0.0576 | 0.0576 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0088 | 0.0309 | 0.0347 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0063 | 0.0134 | 0.01 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.147 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0147 | 0.0723 | 0.0932 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0096 | 0.037 | 0.1073 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0096 | 0.037 | 0.037 |
Schistosoma mansoni | ubiquitin-activating enzyme E1 | 0.0151 | 0.0753 | 0.0753 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.037 | 0.0309 |
Trypanosoma cruzi | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0088 | 0.0309 | 0.086 |
Giardia lamblia | Ubiquitin-conjugating enzyme E1 | 0.0114 | 0.0495 | 1 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.147 | 1 | 1 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0096 | 0.037 | 0.0309 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1c, putative | 0.0147 | 0.0723 | 0.0932 |
Plasmodium falciparum | ubiquitin-activating enzyme | 0.0063 | 0.0134 | 0.0247 |
Leishmania major | ubiquitin activating enzyme, putative | 0.046 | 0.2921 | 1 |
Plasmodium falciparum | ubiquitin-activating enzyme E1 | 0.0177 | 0.0937 | 0.3059 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 1 | 0.0177 | 0.0937 | 0.088 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0114 | 0.0495 | 0.1512 |
Trypanosoma brucei | adenosine kinase, putative | 0.0256 | 0.1487 | 0.498 |
Echinococcus multilocularis | ubiquitin modifier activating enzyme 6 | 0.0177 | 0.0937 | 0.088 |
Schistosoma mansoni | adenosine kinase | 0.0256 | 0.1487 | 0.1487 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0063 | 0.0134 | 0.0071 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0096 | 0.037 | 0.0309 |
Brugia malayi | ThiF family protein | 0.0096 | 0.037 | 0.0309 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0093 | 0.0348 | 0.0997 |
Onchocerca volvulus | 0.0227 | 0.1282 | 0.5 | |
Echinococcus multilocularis | adenosine kinase | 0.0256 | 0.1487 | 0.1433 |
Schistosoma mansoni | app binding protein | 0.0088 | 0.0309 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0063 | 0.0063 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0114 | 0.0495 | 0.1512 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 regulatory subunit | 0.0088 | 0.0309 | 0.0247 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.046 | 0.2921 | 1 |
Trypanosoma brucei | NEDD8-activating enzyme E1 regulatory subunit, putative | 0.0088 | 0.0309 | 0.086 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0093 | 0.0348 | 0.0997 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0147 | 0.0723 | 0.0932 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0256 | 0.1487 | 0.498 |
Mycobacterium leprae | POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY | 0.0053 | 0.0063 | 0.5 |
Loa Loa (eye worm) | ube1-prov protein | 0.0177 | 0.0937 | 0.088 |
Plasmodium vivax | ubiquitin-activating enzyme, putative | 0.0063 | 0.0134 | 0.0247 |
Echinococcus granulosus | NEDD8 activating enzyme E1 regulatory subunit | 0.0088 | 0.0309 | 0.0247 |
Plasmodium vivax | SUMO-activating enzyme subunit 2, putative | 0.0063 | 0.0134 | 0.0247 |
Schistosoma mansoni | ubiquitin-activating enzyme E1 | 0.0053 | 0.0063 | 0.0063 |
Toxoplasma gondii | hypothetical protein | 0.0096 | 0.037 | 0.0309 |
Brugia malayi | ThiF family protein | 0.0088 | 0.0309 | 0.0247 |
Trypanosoma cruzi | ubiquitin activating enzyme, putative | 0.046 | 0.2921 | 1 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0114 | 0.0495 | 0.1512 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0085 | 0.0291 | 0.0322 |
Schistosoma mansoni | adenosine kinase | 0.0256 | 0.1487 | 0.1487 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 1 | 0.0177 | 0.0937 | 0.088 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0555 | 0.3587 | 1 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.147 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.1062 | 0.7142 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0555 | 0.3587 | 1 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.147 | 1 | 1 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0096 | 0.037 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0309 | 0.0247 |
Trypanosoma brucei | adenosine kinase, putative | 0.0256 | 0.1487 | 0.498 |
Echinococcus granulosus | ubiquitin modifier activating enzyme 6 | 0.0177 | 0.0937 | 0.088 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0063 | 0.0134 | 0.01 |
Mycobacterium leprae | PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) | 0.0053 | 0.0063 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.1487 | 0.1433 |
Echinococcus granulosus | adenosine kinase | 0.0256 | 0.1487 | 0.1433 |
Leishmania major | hypothetical protein, conserved | 0.0088 | 0.0309 | 0.086 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0256 | 0.1487 | 0.1433 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0088 | 0.0309 | 0.0347 |
Entamoeba histolytica | ThiF family protein | 0.0088 | 0.0309 | 0.0247 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.147 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-activating enzyme E1, putative | 0.0083 | 0.0277 | 0.075 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0063 | 0.0134 | 0.01 |
Brugia malayi | ube1-prov protein | 0.0177 | 0.0937 | 0.088 |
Brugia malayi | Adenosine kinase-like | 0.0256 | 0.1487 | 0.1433 |
Leishmania major | ubiquitin-activating enzyme e1, putative | 0.0114 | 0.0495 | 0.1512 |
Entamoeba histolytica | ubiquitin-activating enzyme E1 1, putative | 0.0147 | 0.0723 | 0.0664 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 91.9 % | Inhibition of green coffee bean alpha-galactosidase using p-nitrophenyl glycoside as substrate assessed as residual activity at 1 mM after 25 mins by spectrophotometer analysis | ChEMBL. | No reference |
Activity (binding) | = 114 % | Inhibition of Escherichia coli beta-galactosidase using p-nitrophenyl glycoside as substrate assessed as residual activity at 1 mM after 25 mins by spectrophotometer analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.