TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.521 | Formula: C27H26N4O2
H donors: 2 H acceptors: 3 LogP: 6.62 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)O[C@@H]1CC[C@H](CC1)Nc1nc(Nc2ccccc2)c2c(n1)cccc2
InChi: 1S/C27H26N4O2/c32-26(19-9-3-1-4-10-19)33-22-17-15-21(16-18-22)29-27-30-24-14-8-7-13-23(24)25(31-27)28-20-11-5-2-6-12-20/h1-14,21-22H,15-18H2,(H2,28,29,30,31)/t21-,22-
InChiKey: GSYQNPWHUNGFJL-HZCBDIJESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptide Y receptor Y5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	diacylglycerol kinase	0.0031	0.0085	0.0247
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0043	0.0179	0.0518
Onchocerca volvulus	Fatty acid synthase homolog	0.0033	0.0107	0.0129
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0032	0.0046
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0085	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0075	0.0217
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0092	0.0076
Plasmodium vivax	acyl carrier protein, putative	0.0033	0.0107	1
Plasmodium falciparum	acyl carrier protein	0.0033	0.0107	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0301	0.0579
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0176	0.0533
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.0452	0.0436
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.157	0.452
Echinococcus granulosus	RNA directed DNA polymerase	0.0199	0.1333	0.1319
Schistosoma mansoni	vav2	0.0031	0.0085	0.0069
Schistosoma mansoni	diacylglycerol kinase theta	0.0031	0.0085	0.0069
Echinococcus granulosus	geminin	0.0169	0.111	0.1096
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.2041	0.5907
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Schistosoma mansoni	importin beta-1	0.0029	0.0072	0.0056
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0075	0.0217
Loa Loa (eye worm)	transcriptional regulator	0.0122	0.0762	0.2205
Brugia malayi	RhoGEF domain containing protein	0.0031	0.0085	0.0247
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0486	0.3455	1
Chlamydia trachomatis	acyl carrier protein	0.0033	0.0107	0.5
Entamoeba histolytica	protein kinase, putative	0.0043	0.0179	0.2183
Schistosoma mansoni	glutaminase	0.0276	0.1904	0.1891
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0031	0.0085	0.0069
Schistosoma mansoni	chromatin regulatory protein sir2	0.0122	0.0762	0.0747
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0043	0.0179	0.0163
Onchocerca volvulus		0.0033	0.0107	0.0129
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0199	0.1333	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0132	0.0383
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0033	0.0107	0.031
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0179	0.0518
Schistosoma mansoni	unc-13 (munc13)	0.0037	0.0132	0.0116
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0486	0.3455	1
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0179	0.0163
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0122	0.0762	0.2205
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Onchocerca volvulus	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog	0.0261	0.1787	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0031	0.0085	0.0247
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Brugia malayi	Protein kinase c protein 2	0.0237	0.1613	0.4667
Echinococcus multilocularis	geminin	0.0169	0.111	0.1096
Schistosoma mansoni	serine/threonine protein kinase	0.0279	0.1925	0.1912
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0043	0.0179	0.0163
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0043	0.0179	0.0518
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0122	0.0762	0.2205
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0033	0.0107	0.1223
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0295	0.2041	0.5907
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0033	0.0107	0.031
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0043	0.0179	0.0518
Mycobacterium ulcerans	membrane protein ComEA	0.0108	0.0661	0.1913
Echinococcus multilocularis	snurportin 1	0.0307	0.2131	0.2118
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0301	0.0871
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0197	0.0181
Leishmania major	acyl carrier protein, putative	0.0033	0.0107	0.031
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0016	0.0046
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0179	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0107	0.031
Entamoeba histolytica	protein kinase, putative	0.0043	0.0179	0.2183
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0233	0.0675
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0031	0.0092	0.0076
Toxoplasma gondii	hypothetical protein	0.0048	0.0211	0.6852
Schistosoma mansoni	chromobox protein	0.0071	0.0384	0.0369
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0033	0.0107	0.031
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0033	0.0107	0.031
Schistosoma mansoni	protein kinase C	0.0037	0.0132	0.0116
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0206	0.1387	0.4014
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0179	0.0163
Schistosoma mansoni	acyl carrier protein	0.0033	0.0107	0.0091
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0033	0.0107	0.031
Loa Loa (eye worm)	acyl carrier protein	0.0033	0.0107	0.031
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0075	0.0059
Echinococcus granulosus	protein kinase c iota type	0.0074	0.0405	0.0389
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0033	0.0107	0.5
Brugia malayi	Pre-SET motif family protein	0.0029	0.0075	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Toxoplasma gondii	AGC kinase	0.0043	0.0179	0.5715
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0092	0.0267
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0154	0.0402
Brugia malayi	RhoGAP domain containing protein	0.0031	0.0085	0.0247
Echinococcus multilocularis	Acyl carrier protein, mitochondrial	0.0033	0.0107	0.0091
Echinococcus granulosus	NADH dehydrogenase	0.0033	0.0107	0.0091
Loa Loa (eye worm)	glutaminase 2	0.0276	0.1904	0.5511
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0043	0.0179	0.0163
Echinococcus granulosus	chromobox protein 1	0.0071	0.0384	0.0369
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0042	0.0172	0.0453
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0197	0.0181
Mycobacterium ulcerans	polyketide synthase Pks9	0.0033	0.0107	0.031
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0166	0.0481
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase I subunit F	0.0486	0.3455	1
Brugia malayi	Pre-SET motif family protein	0.0203	0.1363	0.3944
Brugia malayi	protein kinase C3,putative	0.0031	0.0092	0.0267
Echinococcus granulosus	myotubularin protein 13	0.0031	0.0085	0.0069
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0033	0.0107	0.32
Schistosoma mansoni	diacylglycerol kinase theta	0.0031	0.0085	0.0069
Entamoeba histolytica	diacylglycerol kinase, putative	0.0031	0.0085	0.0928
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0033	0.0107	0.5
Echinococcus multilocularis	protein kinase c epsilon type	0.008	0.0452	0.0436
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0043	0.0179	0.0163
Schistosoma mansoni	unc-13 (munc13)	0.0037	0.0132	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0179	0.0518
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0197	0.0181
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0033	0.0107	0.031
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0122	0.0762	0.2205
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0037	0.0132	0.0116
Brugia malayi	NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor	0.0486	0.3455	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0072	0.1972
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative	0.0486	0.3455	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0033	0.0107	0.031
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0033	0.0107	0.031
Mycobacterium ulcerans	acyl carrier protein	0.0033	0.0107	0.031
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0072	0.6162
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0033	0.0107	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0179	0.0163
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.0892	0.2581
Entamoeba histolytica	diacylglycerol kinase, putative	0.0031	0.0085	0.0928
Brugia malayi	RhoGAP domain containing protein	0.0031	0.0085	0.0247
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0043	0.0179	0.0163
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0032	0.0046
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0197	0.0181
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0301	0.0871
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0166	0.0481
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0031	0.0085	0.0069
Schistosoma mansoni	hypothetical protein	0.0307	0.2131	0.2118
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0068	0.015
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0301	0.0285
Schistosoma mansoni	chromobox protein	0.0071	0.0384	0.0369
Echinococcus multilocularis	microtubule associated protein 2	0.1371	1	1
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0384	0.0369
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0043	0.0179	0.0518
Mycobacterium ulcerans	hypothetical protein	0.0033	0.0107	0.031
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0033	0.0107	0.031
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0033	0.0107	0.031
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0043	0.0179	0.0518
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0033	0.0107	0.031
Mycobacterium ulcerans	non-ribosomal peptide synthetase	0.0033	0.0107	0.031
Mycobacterium ulcerans	polyketide synthase MbtD	0.0033	0.0107	0.031
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0043	0.0179	0.0518
Leishmania major	mitochondrial DNA polymerase beta	0.0295	0.2041	0.5907
Echinococcus multilocularis	AMP dependent ligase	0.0033	0.0107	0.0091
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0016	0.0046
Leishmania major	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0486	0.3455	1
Echinococcus granulosus	chromatin regulatory protein sir2	0.0122	0.0762	0.0747
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0075	0.0217
Echinococcus granulosus	NDR protein kinase	0.0043	0.0179	0.0163
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0033	0.0107	0.32
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0072	0.0209
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0486	0.3455	1
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0486	0.3455	1
Echinococcus multilocularis	protein kinase c iota type	0.0074	0.0405	0.0389
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0075	0.0059
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0301	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.0892	0.2581
Onchocerca volvulus		0.0041	0.0161	0.0445
Brugia malayi	Heterochromatin protein 1	0.0071	0.0384	0.1112
Mycobacterium ulcerans	polyketide synthase	0.0033	0.0107	0.031
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0384	0.0369
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0792	0.5716	0.571
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0197	0.057
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0031	0.0085	0.0247
Echinococcus multilocularis	NADH dehydrogenase	0.0033	0.0107	0.0091
Brugia malayi	Pleckstrin Homology Domain	0.0031	0.0085	0.0247
Echinococcus multilocularis	RNA directed DNA polymerase	0.0199	0.1333	0.1319
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0197	0.057
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0033	0.0107	0.1223
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0176	0.0465
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)	0.0486	0.3455	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0016	0.0046
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0384	0.1071
Loa Loa (eye worm)	raf kinase	0.0031	0.0085	0.0247
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0122	0.0762	0.0747
Brugia malayi	Phosphopantetheine attachment site family protein	0.0033	0.0107	0.031
Brugia malayi	RNA, U transporter 1	0.0082	0.0465	0.1345
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Schistosoma mansoni	serine/threonine protein kinase	0.0279	0.1925	0.1912
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0016	0.0046
Mycobacterium ulcerans	polyketide synthase Pks13	0.0033	0.0107	0.031
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0016	0.0046
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0043	0.0179	0.0518
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.0384	0.1112
Brugia malayi	chromobox protein homolog 3	0.004	0.0154	0.0444
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0122	0.0762	0.0747
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0301	0.0285
Echinococcus granulosus	acyl carrier protein mitochondrial	0.0033	0.0107	0.0091
Toxoplasma gondii	diacylglycerol kinase, putative	0.0031	0.0085	0.243
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0037	0.0132	0.0116
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.0892	0.2581
Mycobacterium ulcerans	acyl carrier protein	0.0033	0.0107	0.031
Brugia malayi	p70 ribosomal S6 kinase beta	0.0043	0.0179	0.0518
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0301	0.0871
Brugia malayi	C1-like domain containing protein	0.0031	0.0092	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0033	0.0107	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1363	0.3944
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0031	0.0092	0.0076
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0.0486	0.3455	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.0261
Echinococcus multilocularis	unc 13 (munc13)	0.0037	0.0132	0.0116
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0043	0.0179	0.0163
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0122	0.0762	0.2169
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0161	0.0145
Loa Loa (eye worm)	glutaminase	0.0276	0.1904	0.5511
Leishmania major	silent information regulator 2, putative	0.0122	0.0762	0.2205
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0075	0.0059
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.2041	0.5907
Echinococcus granulosus	protein kinase c eta type	0.0031	0.0085	0.0069
Onchocerca volvulus		0.0037	0.0132	0.0276
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0067	0.0051
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0122	0.0762	0.2169
Schistosoma mansoni	atypical protein kinase C	0.0074	0.0405	0.0389
Echinococcus granulosus	NADH dehydrogenase ubiquinone flavoprotein 1	0.0486	0.3455	0.3444
Brugia malayi	AMP-binding enzyme family protein	0.0033	0.0107	0.031
Schistosoma mansoni	protein kinase C mu	0.0031	0.0085	0.0069
Echinococcus granulosus	Protein kinase C brain isozyme	0.0279	0.1925	0.1912
Loa Loa (eye worm)	phosphopantetheine attachment site family protein	0.0033	0.0107	0.031
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0301	0.0285
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0122	0.0762	1
Brugia malayi	protein kinase C II.	0.008	0.0452	0.1307
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0166	0.0481
Echinococcus granulosus	N chimaerin	0.0031	0.0085	0.0069
Echinococcus multilocularis	protein kinase c eta type	0.0031	0.0085	0.0069
Echinococcus granulosus	Rac GTPase activating protein 1	0.0031	0.0085	0.0069
Schistosoma mansoni	hypothetical protein	0.0033	0.0107	0.0091
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0032	0.0046
Schistosoma mansoni	hypothetical protein	0.0169	0.111	0.1096
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0166	0.0481
Schistosoma mansoni	hypothetical protein	0.0031	0.0085	0.0069
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0033	0.0107	0.5
Loa Loa (eye worm)	NADH-ubiquinone oxidoreductase 51 kDa subunit	0.0486	0.3455	1
Trichomonas vaginalis	glutaminase, putative	0.0276	0.1904	0.549
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0043	0.0179	0.0163
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0384	0.1071
Loa Loa (eye worm)	hypothetical protein	0.023	0.1559	0.4512
Brugia malayi	Ras association domain family 1 isoform A	0.0031	0.0085	0.0247
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	0.0033	0.0107	0.031
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0031	0.0092	0.0267
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Echinococcus granulosus	protein kinase C gamma type	0.0249	0.1699	0.1686
Trypanosoma brucei	Acyl carrier protein, mitochondrial	0.0033	0.0107	0.031
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0033	0.0107	0.031
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0075	0.2071
Echinococcus granulosus	serine:threonine protein kinase N2	0.0043	0.0179	0.0163
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0033	0.0107	0.031
Mycobacterium ulcerans	NADH dehydrogenase I subunit F	0.0486	0.3455	1
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0072	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0031	0.0085	0.0069
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0031	0.0085	0.0069
Mycobacterium leprae	Polyketide synthase Pks13	0.0033	0.0107	0.5
Toxoplasma gondii	type I fatty acid synthase, putative	0.0033	0.0107	0.32
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0122	0.0762	0.0747
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0031	0.0085	0.0069
Brugia malayi	glutaminase DH11.1	0.0276	0.1904	0.5511
Treponema pallidum	nitrogen fixation protein (rnfC)	0.0108	0.0661	1
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0179	0.0518
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0043	0.0179	0.0518
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0031	0.0085	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Echinococcus granulosus	AMP dependent ligase	0.0033	0.0107	0.0091
Leishmania major	GTP-binding protein, putative	0.0021	0.0016	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Loa Loa (eye worm)	hypothetical protein	0.004	0.0154	0.0444
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0107	0.5
Brugia malayi	acyl carrier protein, mitochondrial precursor, putative	0.0033	0.0107	0.031
Brugia malayi	AMP-binding enzyme family protein	0.0033	0.0107	0.031
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0075	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0197	0.0181
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0197	0.0181
Loa Loa (eye worm)	acyl carrier protein	0.0033	0.0107	0.031
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0032	0.0092
Plasmodium falciparum	importin beta, putative	0.0029	0.0072	0.6162
Schistosoma mansoni	hypothetical protein	0.0169	0.111	0.1096
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.0486	0.3455	0.3444
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1333	0.3858
Schistosoma mansoni	chromatin regulatory protein sir2	0.0122	0.0762	0.0747
Entamoeba histolytica	hypothetical protein	0.0023	0.0032	0.0214
Mycobacterium ulcerans	glutaminase	0.0276	0.1904	0.5511
Schistosoma mansoni	chromatin regulatory protein sir2	0.0122	0.0762	0.0747
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0032	0.0092
Echinococcus granulosus	chromobox protein 1	0.0071	0.0384	0.0369
Echinococcus granulosus	Diacylglycerol kinase theta	0.0031	0.0085	0.0069
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0033	0.0107	0.5
Schistosoma mansoni	protein kinase C mu	0.0031	0.0092	0.0076
Brugia malayi	diacylglycerol kinase	0.0031	0.0085	0.0247
Echinococcus multilocularis	N chimaerin	0.0031	0.0085	0.0069
Onchocerca volvulus		0.0033	0.0107	0.0129
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.0486	0.3455	0.3444
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0154	0.04
Giardia lamblia	Hypothetical protein	0.0122	0.0762	1
Entamoeba histolytica	protein kinase, putative	0.0043	0.0179	0.2183
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0075	0.0059
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0108	0.0661	0.1654
Onchocerca volvulus		0.0031	0.009	0.0028
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0122	0.0762	0.2205
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0068	0.015
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0092	0.0076
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0179	0.0473
Echinococcus granulosus	protein kinase c epsilon type	0.008	0.0452	0.0436
Toxoplasma gondii	acyl carrier protein ACP	0.0033	0.0107	0.32
Onchocerca volvulus	Acyl carrier protein, mitochondrial homolog	0.0033	0.0107	0.0129
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0122	0.0762	1
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0033	0.0107	0.5
Brugia malayi	Hr1 repeat family protein	0.0043	0.0179	0.0518
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0154	0.04
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0301	0.0871
Schistosoma mansoni	rac gtpase activating protein	0.0031	0.0085	0.0069
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0307	0.2131	0.6169
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0031	0.0085	0.0069
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0043	0.0179	0.0163
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0033	0.0107	0.031
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.1008	0.2692
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0072	0.0209
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0033	0.0107	0.031
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0085	0.0247
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0279	0.1925	0.1912
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0072	0.0209
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0301	1
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0031	0.0092	0.0267
Mycobacterium ulcerans	polyketide synthase	0.0033	0.0107	0.031
Echinococcus granulosus	unc 13 munc13	0.0037	0.0132	0.0116
Schistosoma mansoni	serine/threonine kinase	0.0043	0.0179	0.0163
Onchocerca volvulus		0.0231	0.157	0.8729
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.008	0.0452	0.1307
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0179	0.0518
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0033	0.0107	0.031
Mycobacterium leprae	conserved hypothetical protein	0.0033	0.0107	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0031	0.0085	0.0069
Echinococcus multilocularis	myotubularin protein 13	0.0031	0.0085	0.0069
Echinococcus multilocularis	serine threonine protein kinase	0.0249	0.1699	0.1686
Plasmodium vivax	SET domain protein, putative	0.0029	0.0075	0.647
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0075	0.0059
Echinococcus granulosus	snurportin 1	0.0307	0.2131	0.2118
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Toxoplasma gondii	type I fatty acid synthase, putative	0.0033	0.0107	0.32
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0176	0.0465
Mycobacterium ulcerans	acyl-CoA synthetase	0.0033	0.0107	0.031
Onchocerca volvulus		0.0033	0.0107	0.0129
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0043	0.0179	0.0163
Entamoeba histolytica	hypothetical protein	0.0031	0.0085	0.0928
Schistosoma mansoni	microtubule-associated protein tau	0.1371	1	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0031	0.0092	0.0267
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0033	0.0107	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0197	0.0181
Trypanosoma cruzi	Acyl carrier protein, mitochondrial, putative	0.0033	0.0107	0.031
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0031	0.0085	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0247
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0072	0.0056
Mycobacterium ulcerans	hypothetical protein	0.0155	0.1008	0.2919
Echinococcus granulosus	raf serine:threonine protein kinase	0.0031	0.0085	0.0069
Brugia malayi	Importin beta-1 subunit	0.0029	0.0072	0.0209
Entamoeba histolytica	protein kinase, putative	0.0043	0.0179	0.2183
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0033	0.0107	0.031

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 400 nM	Antagonistic activity against neuropeptide Y receptor type 5 subtype stably expressed in LM(tk-)cells	ChEMBL.	10866375
IC50 (functional)	= 400 nM	Antagonistic activity against neuropeptide Y receptor type 5 subtype stably expressed in LM(tk-)cells	ChEMBL.	10866375

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 18519