Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in L1 stage Caenorhabditis elegans N2 assessed as viability and reproduction at 50 uM | ChEMBL. | 24273638 | |
Activity (ADMET) | Toxicity in L1 stage Caenorhabditis elegans N2 assessed as viability and reproduction at 10 uM | ChEMBL. | 24273638 | |
IC50 (functional) | = 18.8 uM | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | ChEMBL. | 24273638 |
IC50 (functional) | = 30.3 uM | Antimigratory activity in human MDA-MB-231 cells after 24 hrs by wound healing assay | ChEMBL. | 24273638 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24273638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.