Detailed information for compound 1852640

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.559 | Formula: C29H29N3O3
  • H donors: 0 H acceptors: 1 LogP: 4.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1OCCCCn1c3ccccc3c3c1cccc3)N=C[C@H]1N(C2=O)CCC1
  • InChi: 1S/C29H29N3O3/c1-34-27-17-23-24(30-19-20-9-8-15-31(20)29(23)33)18-28(27)35-16-7-6-14-32-25-12-4-2-10-21(25)22-11-3-5-13-26(22)32/h2-5,10-13,17-20H,6-9,14-16H2,1H3/t20-/m0/s1
  • InChiKey: WAJQKSAEWBVDQT-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysyl tRNA synthetase 0.0071 0.0101 0.0258
Schistosoma mansoni lipoxygenase 0.0056 0.0075 0.0075
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0065 0.1266
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0045 0.0057 0.0146
Mycobacterium leprae Probable lipase LipE 0.007 0.0098 0.009
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0045 0.0057 0.0048
Brugia malayi hypothetical protein 0.0045 0.0057 0.0057
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0078 0.0078
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2359 0.3894 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0012 0.0012
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.032 0.0513 0.1317
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0039
Loa Loa (eye worm) sugar transporter 0.0045 0.0057 0.1107
Plasmodium falciparum glycine--tRNA ligase 0.0011 0.0000077077 0.0000077077
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0014 0.0005
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0024 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0.0000077077 0.0000077077
Trypanosoma cruzi hexose transporter, putative 0.0099 0.0147 0.0147
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.6042 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.0033 0.0033
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0096 0.0141 0.0363
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.0315 0.0809
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0078 0.0078
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0015
Toxoplasma gondii sugar transporter ST3 0.0045 0.0057 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0079 0.0202
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0098 0.0253
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0009 0.0009
Echinococcus granulosus calcium dependent protein kinase 0.0092 0.0135 0.0346
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0098 0.009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0014 0.0014
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0076 0.0076
Echinococcus granulosus lamin dm0 0.0026 0.0025 0.0065
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0043
Toxoplasma gondii sugar transporter ST2 0.0045 0.0057 0.0057
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0096 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Trypanosoma cruzi hexose transporter, putative 0.0099 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0014 0.0014
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0012 0.0012
Echinococcus multilocularis General substrate transporter 0.0275 0.0438 0.1126
Echinococcus granulosus lamin 0.0026 0.0025 0.0065
Onchocerca volvulus 0.0029 0.003 0.1796
Brugia malayi mbt repeat family protein 0.005 0.0065 0.0065
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0065 0.0167
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.032 0.0513 0.1317
Trypanosoma brucei glucose transporter 2A 0.0099 0.0147 0.0147
Trichomonas vaginalis glucose transporter, putative 0.0099 0.0147 0.0377
Schistosoma mansoni hypothetical protein 0.032 0.0513 0.0513
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0079 0.0202
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0079 0.0079
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0079 0.0202
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0098 0.1918
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Schistosoma mansoni cpg binding protein 0.0031 0.0033 0.0033
Echinococcus multilocularis calcium dependent protein kinase 0.0092 0.0135 0.0346
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0099 0.0145 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.6042 1 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0071 0.0101 0.0101
Toxoplasma gondii lysine-tRNA ligase 0.0071 0.0101 0.0101
Leishmania major myo-inositol/proton symporter (MIT) 0.0045 0.0057 0.0057
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0018 0.0012 0.0031
Onchocerca volvulus 0.0045 0.0057 0.4995
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0039
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.0315 0.0809
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0067 0.1299
Toxoplasma gondii anticodon binding domain-containing protein 0.0011 0.0000077077 0.0000077077
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0014 0.0036
Trypanosoma cruzi hexose transporter 0.0099 0.0147 0.0147
Schistosoma mansoni dihydroorotate dehydrogenase 0.6042 1 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0071 0.0101 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0098 0.0098
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.032 0.0513 0.1317
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0012 0.0234
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0009 0.0173
Echinococcus granulosus solute carrier family 22 0.0045 0.0057 0.0146
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0083 0.0074
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Echinococcus granulosus General substrate transporter 0.0275 0.0438 0.1126
Onchocerca volvulus 0.0045 0.0057 0.4995
Trypanosoma cruzi histidyl-tRNA synthetase 0.0011 0.0000077077 0.0000077077
Leishmania major glycyl tRNA synthetase, putative 0.0011 0.0000077077 0.0000077077
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0009 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0173
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0065 0.0167
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0071 0.0101 0.0092
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0009 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0009 0.0023
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0061 0.0083 0.0074
Plasmodium vivax hexose transporter 0.032 0.0513 0.0513
Brugia malayi Zinc finger, C2H2 type family protein 0.2359 0.3894 0.3894
Brugia malayi beta-lactamase family protein 0.007 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0494
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0099 0.0145 0.2836
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.1918
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.1918
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.1281 0.329
Onchocerca volvulus 0.0045 0.0057 0.4995
Trichomonas vaginalis esterase, putative 0.007 0.0098 0.0253
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0015
Brugia malayi mbt repeat family protein 0.005 0.0065 0.0065
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0065 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0009 0.0022
Echinococcus multilocularis solute carrier family 22 0.0045 0.0057 0.0146
Giardia lamblia Lysyl-tRNA synthetase 0.0071 0.0101 0.7117
Chlamydia trachomatis histidine--tRNA ligase 0.0011 0.0000077077 0.0008
Treponema pallidum glycyl-tRNA synthetase 0.0011 0.0000077077 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0147 0.0377
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0078 0.0078
Plasmodium falciparum hexose transporter 0.032 0.0513 0.0513
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0079 0.0079
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0038 0.3815
Trypanosoma brucei THT1 - hexose transporter, putative 0.0099 0.0147 0.0147
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0045 0.0057 0.0057
Onchocerca volvulus 0.0045 0.0057 0.4995
Schistosoma mansoni protein kinase 0.0099 0.0145 0.0145
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0079 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Giardia lamblia Prolyl-tRNA synthetase 0.0096 0.0141 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0096 0.0141 0.0133
Echinococcus multilocularis lamin 0.0026 0.0025 0.0065
Plasmodium vivax histidine--tRNA ligase, putative 0.0011 0.0000077077 0.0000077077
Trypanosoma cruzi glucose transporter, putative 0.0045 0.0057 0.0057
Onchocerca volvulus 0.0045 0.0057 0.4995
Brugia malayi Sugar transporter family protein 0.0045 0.0057 0.0057
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0079 0.5564
Schistosoma mansoni glucose transport protein 0.032 0.0513 0.0513
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0057 0.1107
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0.0000077077 0.0000077077
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0012 0.0012
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0012 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0098 0.0253
Onchocerca volvulus 0.005 0.0065 0.598
Trypanosoma cruzi sugar transporter, putative 0.0045 0.0057 0.0057
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0112 0.0168 0.0168
Echinococcus granulosus cpg binding protein 0.0031 0.0033 0.0085
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.6042 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0076 0.149
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0045 0.0057 0.0057
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0014
Mycobacterium ulcerans sugar transporter 0.0045 0.0057 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0308 0.0492 0.0492
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0016 0.0009 0.0009
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0012 0.0012
Schistosoma mansoni polycystin 1-related 0.002 0.0015 0.0015
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2359 0.3894 0.3894
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0014 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Leishmania major hypothetical protein, conserved 0.0016 0.0009 0.0009
Trypanosoma brucei histidyl-tRNA synthetase 0.0011 0.0000077077 0.0000077077
Brugia malayi hypothetical protein 0.0045 0.0057 0.0057
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0098 0.009
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0009 0.0009
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0012 0.0012
Plasmodium vivax lysine--tRNA ligase, putative 0.0071 0.0101 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0079 0.0202
Mycobacterium ulcerans hypothetical protein 0.007 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0298
Echinococcus granulosus solute carrier family 22 0.0045 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0071 0.0101 0.1962
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0075 0.0192
Loa Loa (eye worm) doublecortin family protein 0.002 0.0015 0.0298
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0015 0.0015
Mycobacterium tuberculosis Conserved protein 0.007 0.0098 0.009
Onchocerca volvulus 0.007 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0112 0.2174
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0012 0.0003
Echinococcus multilocularis cpg binding protein 0.0031 0.0033 0.0085
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0012 0.0031
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0145 0.0374
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0025 0.0025
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0076 0.0196
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0014
Brugia malayi Sugar transporter family protein 0.032 0.0513 0.0513
Loa Loa (eye worm) MBCTL1 0.0057 0.0076 0.149
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0096 0.0141 0.0363
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0518 0.0841 0.0841
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.6042 1 1
Giardia lamblia Threonyl-tRNA synthetase 0.0018 0.0012 0.0849
Schistosoma mansoni sugar transporter 0.0045 0.0057 0.0057
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0012 0.0012
Schistosoma mansoni sugar transporter 0.0045 0.0057 0.0057
Toxoplasma gondii protein kinase, putative 0.0905 0.1483 0.1483
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Schistosoma mansoni lipoxygenase 0.002 0.0015 0.0015
Toxoplasma gondii facilitative glucose transporter GT1 0.032 0.0513 0.0513
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0065 0.0065
Onchocerca volvulus Putative transporter 0.0045 0.0057 0.4995
Plasmodium vivax CDK-related protein kinase 6, putative 0.1359 0.2236 0.2236
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0057 0.0146
Leishmania major glucose transporter, lmgt2 0.0099 0.0147 0.0147
Trypanosoma brucei THT1 - hexose transporter, putative 0.0099 0.0147 0.0147
Leishmania major histidyl-tRNA synthetase, putative 0.0011 0.0000077077 0.0000077077
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0448 0.0725 0.0717
Leishmania major protein kinase, putative 0.0099 0.0145 0.0145
Plasmodium falciparum mitogen-activated protein kinase 2 0.0518 0.0841 0.0841
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0079 0.0079
Entamoeba histolytica protein kinase, putative 0.0099 0.0145 0.0374
Echinococcus multilocularis solute carrier family 22 0.0045 0.0057 0.0146
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0065 0.0167
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0015
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0145 0.0374
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0098 0.0253
Brugia malayi Sugar transporter family protein 0.0045 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0096 0.0141 0.2756
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0098 0.0098
Onchocerca volvulus 0.007 0.0098 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0098 0.0098
Trichomonas vaginalis myo-inositol transporter, putative 0.0045 0.0057 0.0146
Onchocerca volvulus 0.0045 0.0057 0.4995
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0057 0.0057
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0079 0.0079
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0096 0.0141 0.0363
Mycobacterium tuberculosis Conserved protein 0.007 0.0098 0.009
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0079 0.0202
Schistosoma mansoni cpg binding protein 0.0029 0.003 0.003
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0098 0.009
Plasmodium falciparum protein kinase 6 0.1359 0.2236 0.2236
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0101 0.0101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0067 0.0067
Plasmodium falciparum calcium-dependent protein kinase 4 0.0099 0.0146 0.0146
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0099 0.0145 0.0374
Echinococcus multilocularis solute carrier family 22 0.0045 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0298
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0025 0.0494
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0084 0.0084
Onchocerca volvulus 0.0045 0.0057 0.4995
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0014 0.0014
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0005 0.0103
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0096 0.0141 0.0141
Onchocerca volvulus 0.0045 0.0057 0.4995
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0778
Echinococcus multilocularis RUN 0.002 0.0015 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0024
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.2359 0.3894 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0098 0.0098
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0076 0.0196
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Brugia malayi major facilitator superfamily protein 0.0045 0.0057 0.0057
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2359 0.3894 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0145 0.0374
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0015 0.0039
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0096 0.0141 0.0141
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0014
Brugia malayi hypothetical protein 0.002 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0012 0.0012
Brugia malayi hypothetical protein 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.1918
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0012 0.0003
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0057 0.0146
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0112 0.0168 0.0168
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0076 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0024 0.0024
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0012 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0098 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0078 0.0201
Giardia lamblia Glycyl-tRNA synthetase 0.0018 0.0012 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0057 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0012 0.0012
Plasmodium falciparum calcium-dependent protein kinase 2 0.0099 0.0146 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.004
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.2359 0.3894 1
Trichomonas vaginalis sugar transporter, putative 0.0099 0.0147 0.0377
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0012 0.0012
Toxoplasma gondii ABC1 family protein 0.007 0.0098 0.0098
Plasmodium falciparum dihydroorotate dehydrogenase 0.6042 1 1
Brugia malayi Cam kinase protein 1 0.0099 0.0145 0.0145
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0098 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0014 0.0014
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0057 0.0057
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0015 0.0039
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0012 0.0031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0009 0.0023
Schistosoma mansoni sugar transporter 0.0045 0.0057 0.0057
Onchocerca volvulus 0.0026 0.0025 0.1212
Echinococcus multilocularis musashi 0.0026 0.0025 0.0065
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.2359 0.3894 1
Schistosoma mansoni glucose transporter 0.0045 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Schistosoma mansoni glucose transport protein 0.032 0.0513 0.0513
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0112 0.0168 0.0168
Echinococcus granulosus Sugar transporter ERD6 protein 0.0045 0.0057 0.0146
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0001 0.0003
Leishmania major glucose transporter/membrane transporter D2, putative 0.0099 0.0147 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0025 0.0494
Trypanosoma brucei glucose transporter 1E 0.0099 0.0147 0.0147
Plasmodium falciparum calcium-dependent protein kinase 1 0.0099 0.0146 0.0146
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0063 0.0086 0.0221
Loa Loa (eye worm) hypothetical protein 0.0099 0.0145 0.2836
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0011 0.0000077077 0.0000077077
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0078 0.0201
Schistosoma mansoni glucose transport protein 0.032 0.0513 0.0513
Onchocerca volvulus 0.007 0.0098 1
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0012 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0099 0.0147 0.0377
Plasmodium vivax calcium-dependent protein kinase, putative 0.0099 0.0146 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0012 0.0031
Onchocerca volvulus 0.0026 0.0025 0.1212
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.6042 1 1
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0043
Plasmodium falciparum proline--tRNA ligase 0.0112 0.0168 0.0168
Giardia lamblia Sugar-proton symporter 0.0045 0.0057 0.4016
Toxoplasma gondii transporter, major facilitator family protein 0.0045 0.0057 0.0057
Schistosoma mansoni lamin 0.0026 0.0025 0.0025
Onchocerca volvulus 0.0045 0.0057 0.4995
Trichomonas vaginalis sugar transport protein, putative 0.0045 0.0057 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0098 0.0253
Mycobacterium leprae conserved hypothetical protein 0.007 0.0098 0.009
Leishmania major hypothetical protein, conserved 0.0025 0.0024 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0024 0.0024
Chlamydia trachomatis lysine--tRNA ligase 0.0071 0.0101 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.2359 0.3894 1
Brugia malayi hypothetical protein 0.0016 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.6042 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0098 0.009
Onchocerca volvulus 0.0045 0.0057 0.4995
Schistosoma mansoni intermediate filament proteins 0.0026 0.0025 0.0025
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0012 0.0012
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Brugia malayi CXXC zinc finger family protein 0.0029 0.003 0.003
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0071 0.0101 0.0101
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0079 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0099 0.0147 0.0377
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0011 0.0000077077 0.0000077077
Plasmodium vivax sugar transporter, putative 0.0045 0.0057 0.0057
Loa Loa (eye worm) sugar transporter 0.032 0.0513 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.2359 0.3894 1
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0098 0.0253
Trypanosoma brucei sugar transporter, putative 0.0045 0.0057 0.0057
Onchocerca volvulus 0.0045 0.0057 0.4995
Echinococcus granulosus solute carrier family 22 0.0045 0.0057 0.0146
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0076 0.0196
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Brugia malayi MAP kinase sur-1 0.0058 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0058
Onchocerca volvulus 0.0045 0.0057 0.4995
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0012 0.0234
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0076 0.0196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0067 0.0067
Mycobacterium ulcerans hypothetical protein 0.0016 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0057 0.0146
Toxoplasma gondii exonuclease III APE 0.0019 0.0014 0.0014
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0012 0.0031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0078 0.0078
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0.0000077077 0.0000077077
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.032 0.0513 0.1317
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0098 0.0098
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0057 0.1107
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0012 0.0012
Onchocerca volvulus 0.0045 0.0057 0.4995
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.032 0.0513 0.1317
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0009 0.0023
Entamoeba histolytica protein kinase, putative 0.0099 0.0145 0.0374
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0045 0.0057 0.0057
Brugia malayi major facilitator superfamily protein 0.0045 0.0057 0.0057
Onchocerca volvulus 0.0045 0.0057 0.4995
Schistosoma mansoni loxhd1 0.002 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0045 0.0057 0.0057
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0045 0.0057 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0145 0.0145
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0012 0.0012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0099 0.0147 0.0147
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0012 0.0012
Toxoplasma gondii sugar transporter ST1 0.0045 0.0057 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0079 0.0079
Echinococcus granulosus RUN 0.002 0.0015 0.0039
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0098 0.0098
Plasmodium falciparum histidine--tRNA ligase, putative 0.0011 0.0000077077 0.0000077077
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0112 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0009
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0012 0.1193
Mycobacterium tuberculosis Conserved protein 0.007 0.0098 0.009
Leishmania major glucose transporter, lmgt3 0.0099 0.0147 0.0147
Plasmodium falciparum lysine--tRNA ligase 0.0071 0.0101 0.0101
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0.0000077077 0.0000077077
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0078 0.007
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0072 0.1397
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.032 0.0513 0.1317
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0145 0.0374
Brugia malayi beta-lactamase family protein 0.007 0.0098 0.0098
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.2359 0.3894 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Brugia malayi beta-lactamase 0.007 0.0098 0.0098
Echinococcus multilocularis GPCR, family 2 0.0016 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.1918
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0099 0.0146 0.0146
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0018 0.0012 0.0031
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0099 0.0145 0.0145
Echinococcus multilocularis synaptic vesicle 2 protein 0.0045 0.0057 0.0146
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0008
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0101 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0098 0.0098
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.032 0.0513 0.1317
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0101 0.0101
Leishmania major lysyl-tRNA synthetase, putative 0.0071 0.0101 0.0101
Onchocerca volvulus 0.0045 0.0057 0.4995
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0065 0.0065
Leishmania major dihydroorotate dehydrogenase 0.6042 1 1
Brugia malayi intermediate filament protein 0.0026 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.007 0.0098 0.0098
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0039 0.0048 0.0926
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Schistosoma mansoni lamin 0.0026 0.0025 0.0025
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0065 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0057 0.0146
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0014 0.0992
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2359 0.3894 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0039
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0096 0.0141 0.0363
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Echinococcus multilocularis solute carrier family 22 0.0045 0.0057 0.0146
Plasmodium vivax proline--tRNA ligase, putative 0.0112 0.0168 0.0168
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0009
Schistosoma mansoni sugar transporter 0.0045 0.0057 0.0057
Trichomonas vaginalis glucose transporter, putative 0.0099 0.0147 0.0377
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0101 0.0101
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0098 0.0098
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0099 0.0145 0.0374
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0014 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0012 0.0012
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0079 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.004 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.003 0.0589
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.0038 0.0038
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0083 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0079 0.0202
Schistosoma mansoni protein kinase 0.0099 0.0145 0.0145
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0057 0.0057
Trypanosoma cruzi hexose transporter, putative 0.0054 0.0072 0.0072
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0099 0.0146 0.0146
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0099 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0051 0.0067 0.1299
Giardia lamblia Hexose transporter 0.0045 0.0057 0.4016
Trichomonas vaginalis conserved hypothetical protein 0.032 0.0513 0.1317
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0112 0.0168 0.0168
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0012 0.3127
Echinococcus granulosus intermediate filament protein 0.0026 0.0025 0.0065
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0011 0.0000077077 0.0000077077
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0073 0.0073
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0045 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Leishmania major glucose transporter, lmgt1 0.0099 0.0147 0.0147
Echinococcus granulosus synaptic vesicle 2 protein 0.0045 0.0057 0.0146
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0045 0.0057 0.0048
Plasmodium falciparum calcium-dependent protein kinase 3 0.0099 0.0146 0.0146
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0112 0.0168 0.0168
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0065 0.598
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0099 0.0146 0.0146
Trypanosoma brucei glucose transporter, putative 0.0099 0.0147 0.0147
Leishmania major hypothetical protein, conserved 0.0016 0.0009 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0078 0.0078
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0038 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0057 0.0146
Schistosoma mansoni protein kinase 0.0099 0.0145 0.0145
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0014 0.0036
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0098 0.0253
Mycobacterium ulcerans integral membrane transport protein 0.0045 0.0057 0.0057
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0014 0.0036
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0098 0.009
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.6042 1 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Mycobacterium ulcerans beta-lactamase 0.007 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0234
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0057 0.0057
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.6042 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.1918
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.6042 1 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0099 0.0146 0.0146
Loa Loa (eye worm) beta-lactamase 0.007 0.0098 0.1918
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.032 0.0513 0.1317
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0014 0.3653
Brugia malayi lysyl-tRNA synthetase 0.0071 0.0101 0.0101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2359 0.3894 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0014 0.0273
Echinococcus granulosus lysyl tRNA synthetase 0.0071 0.0101 0.0258
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0099 0.0146 0.0146
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.6042 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0071 0.0101 0.0258
Brugia malayi hypothetical protein 0.0025 0.0024 0.0024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0099 0.0145 0.0374
Echinococcus multilocularis lamin dm0 0.0026 0.0025 0.0065
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0079 0.1534
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0045 0.0057 0.0057
Plasmodium falciparum calcium-dependent protein kinase 5 0.0099 0.0146 0.0146
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0099 0.0145 0.0145
Plasmodium falciparum protein kinase 7 0.0905 0.1483 0.1483
Brugia malayi Doublecortin family protein 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0479
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0079 0.0079
Onchocerca volvulus 0.0045 0.0057 0.4995
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0009 0.0009
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.6042 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0098 0.009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0145 0.0374
Echinococcus granulosus solute carrier family 22 0.0045 0.0057 0.0146
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0011 0.0000077077 0.0002
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.007 0.0098 0.1918
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0096 0.0141 0.2756
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0079 0.0202
Echinococcus granulosus GPCR family 2 0.0016 0.0009 0.0023
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0099 0.0145 0.2836
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0039
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0518 0.0841 0.0841
Plasmodium vivax hypothetical protein, conserved 0.007 0.0098 0.0098
Trypanosoma brucei protein kinase, putative 0.0058 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.005 0.0065 0.1266
Mycobacterium ulcerans lipase LipD 0.007 0.0098 0.0098
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0014 0.0014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0014 0.0014
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.2359 0.3894 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0075 0.0192
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0096 0.0141 0.0141
Brugia malayi hypothetical protein 0.0045 0.0057 0.0057
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0057 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0147 0.0377
Trypanosoma cruzi hexose transporter, putative 0.0099 0.0147 0.0147
Schistosoma mansoni threonyl-tRNA synthetase 0.0011 0.0000077077 0.0000077077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0474

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 1.92 uM Growth inhibition of human A549 cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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